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Conserved domains on  [gi|1338686321|ref|NP_001347312|]
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F-box only protein 16 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
84-138 8.71e-34

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438943  Cd Length: 55  Bit Score: 117.38  E-value: 8.71e-34
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1338686321  84 EALDFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNW 138
Cdd:cd22172     1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKCLRFGW 55
 
Name Accession Description Interval E-value
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
84-138 8.71e-34

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 117.38  E-value: 8.71e-34
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1338686321  84 EALDFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNW 138
Cdd:cd22172     1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKCLRFGW 55
F-box-like pfam12937
F-box-like; This is an F-box-like family.
92-129 9.46e-11

F-box-like; This is an F-box-like family.


Pssm-ID: 432889 [Multi-domain]  Cd Length: 45  Bit Score: 55.96  E-value: 9.46e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
92-129 1.76e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.49  E-value: 1.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1338686321   92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
 
Name Accession Description Interval E-value
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
84-138 8.71e-34

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 117.38  E-value: 8.71e-34
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1338686321  84 EALDFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNW 138
Cdd:cd22172     1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKCLRFGW 55
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
87-138 4.84e-25

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 94.40  E-value: 4.84e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1338686321  87 DFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNW 138
Cdd:cd22173     1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMPKCVKFGW 52
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
87-135 1.99e-24

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 92.89  E-value: 1.99e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1338686321  87 DFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLR 135
Cdd:cd22094     1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWLPKCLR 49
F-box-like pfam12937
F-box-like; This is an F-box-like family.
92-129 9.46e-11

F-box-like; This is an F-box-like family.


Pssm-ID: 432889 [Multi-domain]  Cd Length: 45  Bit Score: 55.96  E-value: 9.46e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
88-133 2.81e-10

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 54.63  E-value: 2.81e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1338686321  88 FTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKC 133
Cdd:cd22147     1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
88-133 4.02e-10

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 54.30  E-value: 4.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1338686321  88 FTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKC 133
Cdd:cd22134     3 FDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
91-123 6.96e-09

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 50.88  E-value: 6.96e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1338686321  91 KLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLA 123
Cdd:cd22115     6 KLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLA 38
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
89-129 1.56e-08

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 49.64  E-value: 1.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1338686321  89 TTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22118     1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
92-133 2.86e-08

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 48.85  E-value: 2.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAE-LDQLWMLKC 133
Cdd:cd22113     4 LPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIEnSDYLWRPHC 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
90-124 6.49e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 47.82  E-value: 6.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1338686321  90 TKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAE 124
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
75-129 9.05e-08

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 48.19  E-value: 9.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1338686321  75 RKLQEKI-PAEALDFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22133     3 RHMMQVIePQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 58
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
87-119 1.33e-07

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 46.94  E-value: 1.33e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1338686321  87 DFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYW 119
Cdd:cd22131     1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQW 33
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
92-133 1.86e-07

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 46.60  E-value: 1.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKC 133
Cdd:cd22137     3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
88-129 2.32e-07

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 46.51  E-value: 2.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1338686321  88 FTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22148     1 FISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELW 42
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
92-129 2.92e-07

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 46.17  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22124     4 LPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
88-124 2.82e-06

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 43.39  E-value: 2.82e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1338686321  88 FTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAE 124
Cdd:cd22136     1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTE 37
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
100-129 5.31e-06

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 42.70  E-value: 5.31e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1338686321 100 IFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22109    14 VFSYLDTKSLLRCAEVCREWRDVSRHPALW 43
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
90-135 7.36e-06

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 42.40  E-value: 7.36e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1338686321  90 TKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLR 135
Cdd:cd22085     4 NHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFLLR 49
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
92-133 1.25e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 41.46  E-value: 1.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKC 133
Cdd:cd22139     4 LPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
91-129 2.29e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 2.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1338686321  91 KLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
91-133 5.11e-05

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 40.00  E-value: 5.11e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1338686321  91 KLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKC 133
Cdd:cd22151     2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
91-129 1.65e-03

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 35.68  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1338686321  91 KLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22117     3 LLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
92-129 1.76e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.49  E-value: 1.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1338686321   92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
90-129 7.12e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 33.71  E-value: 7.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1338686321  90 TKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLW 129
Cdd:cd22162     2 EDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVW 41
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
92-122 7.16e-03

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 34.01  E-value: 7.16e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1338686321  92 LPRVLSvYIFSFLDPRSLCRCAQVSWYWKSL 122
Cdd:cd22086     8 CPHILS-KILSYLSPEDLCRVSCVSKTWRQI 37
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
92-130 7.27e-03

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 33.73  E-value: 7.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1338686321  92 LPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWM 130
Cdd:cd20090     5 LPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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