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Conserved domains on  [gi|1344538211|ref|NP_001347836|]
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NF-kappa-B inhibitor delta [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13333862)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-292 1.94e-09

Ankyrin repeats (3 copies);


:

Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 200 LTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGlprgdlRAFVNMKAHGNTALHMAAALppGppQEAIVR 279
Cdd:pfam12796  10 LELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE------HADVNLKDNGRTALHYAARS--G--HLEIVK 78
                          90
                  ....*....|...
gi 1344538211 280 HLLAAGADPTLRN 292
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 super family cl33707
ankyrin-like protein; Provisional
60-301 6.09e-09

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  60 DEEGDTLLHLFaargLRWAAYAAAEVLQMYRQ----LDIREHKGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA03095   44 GEYGKTPLHLY----LHYSSEKVKDIVRLLLEagadVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 135 VLHVAATyGL---PGVLSAVFKSGIqvDLEARDFEGLTPLHtaVLalnaamlpasvcprMQNSQARDRLtcVQMLLQMGA 211
Cdd:PHA03095  120 PLHVYLS-GFninPKVIRLLLRKGA--DVNALDLYGMTPLA--VL--------------LKSRNANVEL--LRLLIDAGA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 212 SHTSQEIkSNKTILHLAVQA--ANPTLVQLLLGlpRGDLRAFVNMkaHGNTALHMAAALppGPPQEAIVRHLLAAGADPT 289
Cdd:PHA03095  179 DVYAVDD-RFRSLLHHHLQSfkPRARIVRELIR--AGCDPAATDM--LGNTPLHSMATG--SSCKRSLVLPLLIAGISIN 251
                         250
                  ....*....|..
gi 1344538211 290 LRNLENEQPVHL 301
Cdd:PHA03095  252 ARNRYGQTPLHY 263
 
Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-292 1.94e-09

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 200 LTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGlprgdlRAFVNMKAHGNTALHMAAALppGppQEAIVR 279
Cdd:pfam12796  10 LELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE------HADVNLKDNGRTALHYAARS--G--HLEIVK 78
                          90
                  ....*....|...
gi 1344538211 280 HLLAAGADPTLRN 292
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
60-301 6.09e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  60 DEEGDTLLHLFaargLRWAAYAAAEVLQMYRQ----LDIREHKGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA03095   44 GEYGKTPLHLY----LHYSSEKVKDIVRLLLEagadVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 135 VLHVAATyGL---PGVLSAVFKSGIqvDLEARDFEGLTPLHtaVLalnaamlpasvcprMQNSQARDRLtcVQMLLQMGA 211
Cdd:PHA03095  120 PLHVYLS-GFninPKVIRLLLRKGA--DVNALDLYGMTPLA--VL--------------LKSRNANVEL--LRLLIDAGA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 212 SHTSQEIkSNKTILHLAVQA--ANPTLVQLLLGlpRGDLRAFVNMkaHGNTALHMAAALppGPPQEAIVRHLLAAGADPT 289
Cdd:PHA03095  179 DVYAVDD-RFRSLLHHHLQSfkPRARIVRELIR--AGCDPAATDM--LGNTPLHSMATG--SSCKRSLVLPLLIAGISIN 251
                         250
                  ....*....|..
gi 1344538211 290 LRNLENEQPVHL 301
Cdd:PHA03095  252 ARNRYGQTPLHY 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-216 4.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 50.12  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 103 LLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKsgiQVDLEARDfEGLTPLHTAVLAlnaam 182
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKD-NGRTALHYAARS----- 71
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1344538211 183 lpasvcprmqnsqarDRLTCVQMLLQMGASHTSQ 216
Cdd:pfam12796  72 ---------------GHLEIVKLLLEKGADINVK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-241 1.03e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 52.13  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  90 RQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPG-----VLSAVFKSGIQVD-LEAR 163
Cdd:COG0666    64 RHLAARDLDGRLPLHSAASKGDDKIVKLLLASGADVNAKDADGDTPLHLAALNGNPPegnieVAKLLLEAGADLDvNNLR 143
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211 164 DFEGLTPLHTAVLALNAAMlpasvcprmqnsqardrltcVQMLLQMGASHTSQEIKSNkTILHLAVQAANPTLVQLLL 241
Cdd:COG0666   144 DEDGNTPLHWAALNGDADI--------------------VELLLEAGADPNSRNSYGV-TALDPAAKNGRIELVKLLL 200
PHA03100 PHA03100
ankyrin repeat protein; Provisional
101-301 2.47e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 101 TPLLVAAAANQPLIVEDLLSLGAEPN--ATDHQGRSVLHVAATYGLPGVLSAV---FKSGiqVDLEARDFEGLTPLHTAV 175
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIVkllLEYG--ANVNAPDNNGITPLLYAI 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 176 lalnaamlpasvCPRMQNsqardrLTCVQMLLQMGA---SHTSqeikSNKTILHLAVQAANPTL--VQLLLglprgDLRA 250
Cdd:PHA03100  115 ------------SKKSNS------YSIVEYLLDNGAnvnIKNS----DGENLLHLYLESNKIDLkiLKLLI-----DKGV 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211 251 FVNMK-----------------AHGNTALHMAAALPpgppQEAIVRHLLAAGADPTLRNLENEQPVHL 301
Cdd:PHA03100  168 DINAKnrvnyllsygvpinikdVYGFTPLHYAVYNN----NPEFVKYLLDLGANPNLVNKYGDTPLHI 231
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
63-241 1.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  63 GDTLLHLFAARGLRWAAYAAAEV------LQMYRQLdireHKGKTPLLVAAAANQPLIVEDLLSLGAE---PNATD---- 129
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAapelvnEPMTSDL----YQGETALHIAVVNQNLNLVRELIARGADvvsPRATGtffr 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 130 -------HQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAamlpASVCpRMQN----SQARD 198
Cdd:cd22192   127 pgpknliYYGEHPLSFAACVGNEEIVRLLIEHG--ADIRAQDSLGNTVLHILVLQPNK----TFAC-QMYDlilsYDKED 199
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1344538211 199 RLTCVQMLL-QMGAshtsqeiksnkTILHLAVQAANPTLVQLLL 241
Cdd:cd22192   200 DLQPLDLVPnNQGL-----------TPFKLAAKEGNIVMFQHLV 232
 
Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-292 1.94e-09

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 200 LTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGlprgdlRAFVNMKAHGNTALHMAAALppGppQEAIVR 279
Cdd:pfam12796  10 LELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE------HADVNLKDNGRTALHYAARS--G--HLEIVK 78
                          90
                  ....*....|...
gi 1344538211 280 HLLAAGADPTLRN 292
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
60-301 6.09e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  60 DEEGDTLLHLFaargLRWAAYAAAEVLQMYRQ----LDIREHKGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA03095   44 GEYGKTPLHLY----LHYSSEKVKDIVRLLLEagadVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 135 VLHVAATyGL---PGVLSAVFKSGIqvDLEARDFEGLTPLHtaVLalnaamlpasvcprMQNSQARDRLtcVQMLLQMGA 211
Cdd:PHA03095  120 PLHVYLS-GFninPKVIRLLLRKGA--DVNALDLYGMTPLA--VL--------------LKSRNANVEL--LRLLIDAGA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 212 SHTSQEIkSNKTILHLAVQA--ANPTLVQLLLGlpRGDLRAFVNMkaHGNTALHMAAALppGPPQEAIVRHLLAAGADPT 289
Cdd:PHA03095  179 DVYAVDD-RFRSLLHHHLQSfkPRARIVRELIR--AGCDPAATDM--LGNTPLHSMATG--SSCKRSLVLPLLIAGISIN 251
                         250
                  ....*....|..
gi 1344538211 290 LRNLENEQPVHL 301
Cdd:PHA03095  252 ARNRYGQTPLHY 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-216 4.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 50.12  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 103 LLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKsgiQVDLEARDfEGLTPLHTAVLAlnaam 182
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKD-NGRTALHYAARS----- 71
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1344538211 183 lpasvcprmqnsqarDRLTCVQMLLQMGASHTSQ 216
Cdd:pfam12796  72 ---------------GHLEIVKLLLEKGADINVK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
90-241 1.03e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 52.13  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  90 RQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPG-----VLSAVFKSGIQVD-LEAR 163
Cdd:COG0666    64 RHLAARDLDGRLPLHSAASKGDDKIVKLLLASGADVNAKDADGDTPLHLAALNGNPPegnieVAKLLLEAGADLDvNNLR 143
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211 164 DFEGLTPLHTAVLALNAAMlpasvcprmqnsqardrltcVQMLLQMGASHTSQEIKSNkTILHLAVQAANPTLVQLLL 241
Cdd:COG0666   144 DEDGNTPLHWAALNGDADI--------------------VELLLEAGADPNSRNSYGV-TALDPAAKNGRIELVKLLL 200
PHA02876 PHA02876
ankyrin repeat protein; Provisional
98-299 1.05e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  98 KGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYG-LPGVLSAVFKSGIQVDleARDFEGLTPLHTAV 175
Cdd:PHA02876  306 KGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN--ARDYCDKTPIHYAA 383
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 176 LalnaamlpasvcprmqnsqaRDRLTCVQMLLQMGA--SHTSQEIksnKTILHLAVQAANP-TLVQLLLglprgDLRAFV 252
Cdd:PHA02876  384 V--------------------RNNVVIINTLLDYGAdiEALSQKI---GTALHFALCGTNPyMSVKTLI-----DRGANV 435
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1344538211 253 NMK-AHGNTALHMAAALPPGPpqeAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA02876  436 NSKnKDLSTPLHYACKKNCKL---DVIEMLLDNGADVNAINIQNQYPL 480
PHA02878 PHA02878
ankyrin repeat protein; Provisional
96-241 1.05e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  96 EHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDleARDFEGLTPLHTAV 175
Cdd:PHA02878  165 RHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD--ARDKCGNTPLHISV 242
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1344538211 176 lalnAAMLPASVcprmqnsqardrltcVQMLLQMGASHTSQEIKSNKTILHLAVQaaNPTLVQLLL 241
Cdd:PHA02878  243 ----GYCKDYDI---------------LKLLLEHGVDVNAKSYILGLTALHSSIK--SERKLKLLL 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
99-299 2.61e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  99 GKTPL---LVAAAANqPLIVEDLLSLGAEPNATDHQGRSVLHV-----AATyglPGVLSAVFKSGiqVDLEARDFEGLTP 170
Cdd:PHA03095  117 GRTPLhvyLSGFNIN-PKVIRLLLRKGADVNALDLYGMTPLAVllksrNAN---VELLRLLIDAG--ADVYAVDDRFRSL 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 171 LHtaVLALNaamlpasvcprmqnsqARDRLTCVQMLLQMGASHTSQEIKSNkTILHLAV---QAANPTLVQLLLGlprgd 247
Cdd:PHA03095  191 LH--HHLQS----------------FKPRARIVRELIRAGCDPAATDMLGN-TPLHSMAtgsSCKRSLVLPLLIA----- 246
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1344538211 248 lRAFVN-MKAHGNTALHMAAALppgpPQEAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA03095  247 -GISINaRNRYGQTPLHYAAVF----NNPRACRRLIALGADINAVSSDGNTPL 294
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
58-174 2.70e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 50.59  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  58 AQDEEGDTLLHLFAARG--LRWAAYAAAEVLQMYRQLDI---REHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQG 132
Cdd:COG0666   101 AKDADGDTPLHLAALNGnpPEGNIEVAKLLLEAGADLDVnnlRDEDGNTPLHWAALNGDADIVELLLEAGADPNSRNSYG 180
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1344538211 133 RSVLHVAATYGLPGVLSAVFKSGI-------------QVDLEARDFEGLTPLHTA 174
Cdd:COG0666   181 VTALDPAAKNGRIELVKLLLDKGLhlsllkfnlegvaNANVSKRNILNLTSLIIA 235
PHA03095 PHA03095
ankyrin-like protein; Provisional
114-302 1.14e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 114 IVEDLLSLGAEPNATDHQGRSVLHVAATYGLP---GVLSAVFKSGIQVDleARDFEGLTPLHTavLALNAAMLPAsvcpr 190
Cdd:PHA03095   29 EVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVN--APERCGFTPLHL--YLYNATTLDV----- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 191 mqnsqardrltcVQMLLQMGAShTSQEIKSNKTILH--LAVQAANPTLVQLLL--GLPRGDLRAF--------------- 251
Cdd:PHA03095  100 ------------IKLLIKAGAD-VNAKDKVGRTPLHvyLSGFNINPKVIRLLLrkGADVNALDLYgmtplavllksrnan 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1344538211 252 ---VNM-----------KAHGNTALHMAAALPPgpPQEAIVRHLLAAGADPTLRNLENEQPVHLL 302
Cdd:PHA03095  167 velLRLlidagadvyavDDRFRSLLHHHLQSFK--PRARIVRELIRAGCDPAATDMLGNTPLHSM 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-129 3.30e-06

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 44.73  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  46 AHILALGPQQLLAQDEEGDTLLHLFAARGLrwaaYAAAEVLQMYRQLDIREHkGKTPLLVAAAANQPLIVEDLLSLGAEP 125
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLAAKNGH----LEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADI 87

                  ....
gi 1344538211 126 NATD 129
Cdd:pfam12796  88 NVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
59-208 7.62e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 7.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  59 QDEEGDTLLHLFAARGlrwaayaAAEVLQM---YR-QLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA02874  120 KDAELKTFLHYAIKKG-------DLESIKMlfeYGaDVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGES 192
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1344538211 135 VLHVAATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVLAlNAAMLPASVCPRMQNSQARDRLTCVQMLLQ 208
Cdd:PHA02874  193 PLHNAAEYGDYACIKLLIDHGNHIMNKCKN--GFTPLHNAIIH-NRSAIELLINNASINDQDIDGSTPLHHAIN 263
PHA02876 PHA02876
ankyrin repeat protein; Provisional
113-300 1.38e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 113 LIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVLALNAAMLPASVCPR-- 190
Cdd:PHA02876  159 LIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD--DLSVLECAVDSKNIDTIKAIIDNRsn 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 191 -------MQNSQARDRLTCVQMLLQMGASHTSQEIKSNkTILHLAVQAanPTLVQLLLG-LPRGdlrAFVNMK-AHGNTA 261
Cdd:PHA02876  237 inkndlsLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN-TPLHHASQA--PSLSRLVPKlLERG---ADVNAKnIKGETP 310
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1344538211 262 LHMAAAlpPGPPQEAIvRHLLAAGADPTLRNLENEQPVH 300
Cdd:PHA02876  311 LYLMAK--NGYDTENI-RTLIMLGADVNAADRLYITPLH 346
PHA03100 PHA03100
ankyrin repeat protein; Provisional
101-301 2.47e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 101 TPLLVAAAANQPLIVEDLLSLGAEPN--ATDHQGRSVLHVAATYGLPGVLSAV---FKSGiqVDLEARDFEGLTPLHTAV 175
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIVkllLEYG--ANVNAPDNNGITPLLYAI 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 176 lalnaamlpasvCPRMQNsqardrLTCVQMLLQMGA---SHTSqeikSNKTILHLAVQAANPTL--VQLLLglprgDLRA 250
Cdd:PHA03100  115 ------------SKKSNS------YSIVEYLLDNGAnvnIKNS----DGENLLHLYLESNKIDLkiLKLLI-----DKGV 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211 251 FVNMK-----------------AHGNTALHMAAALPpgppQEAIVRHLLAAGADPTLRNLENEQPVHL 301
Cdd:PHA03100  168 DINAKnrvnyllsygvpinikdVYGFTPLHYAVYNN----NPEFVKYLLDLGANPNLVNKYGDTPLHI 231
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
103-177 6.23e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 6.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1344538211 103 LLVAAAANQPLIvEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLeaRDFEGLTPLHTAVLA 177
Cdd:PLN03192  530 LTVASTGNAALL-EELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI--RDANGNTALWNAISA 601
PHA03095 PHA03095
ankyrin-like protein; Provisional
114-284 8.45e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 114 IVEDLLSLGAEPNATDHQGRSVLHVAATYG--LPGVLSAVFKSGIQVDleARDFEGLTPLHTAVLALNAAmlpasVCPRm 191
Cdd:PHA03095  204 IVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPR-----ACRR- 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 192 qnsqardrltcvqmLLQMGASHTsqeiksnktilhlAVQAANPTlvqlllglprgdlrAFVNMKAHGNTALhMAAALPPG 271
Cdd:PHA03095  276 --------------LIALGADIN-------------AVSSDGNT--------------PLSLMVRNNNGRA-VRAALAKN 313
                         170
                  ....*....|...
gi 1344538211 272 PPQEAIVRHLLAA 284
Cdd:PHA03095  314 PSAETVAATLNTA 326
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-143 1.75e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1344538211 101 TPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYG 143
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG 45
PHA03095 PHA03095
ankyrin-like protein; Provisional
58-134 1.82e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  58 AQDEEGDTLLHLFAARGLRWAA----YAAAEVlqmyrQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGR 133
Cdd:PHA03095  217 ATDMLGNTPLHSMATGSSCKRSlvlpLLIAGI-----SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                  .
gi 1344538211 134 S 134
Cdd:PHA03095  292 T 292
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
107-175 2.18e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 2.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1344538211 107 AAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAV 175
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG--ADPTLLDKDGKTPLELAE 156
PHA02875 PHA02875
ankyrin repeat protein; Provisional
139-301 2.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 139 AATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVlalnaamlpasvcpRMQNSQArdrltcVQMLLQMGA--SHTSQ 216
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYD--GISPIKLAM--------------KFRDSEA------IKLLMKHGAipDVKYP 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 217 EIKSNktiLHLAVQAANPTLVQLLLglprgDLRAFVN--MKAHGNTALHMAAALPpgppQEAIVRHLLAAGADPTLRNLE 294
Cdd:PHA02875   67 DIESE---LHDAVEEGDVKAVEELL-----DLGKFADdvFYKDGMTPLHLATILK----KLDIMKLLIARGADPDIPNTD 134

                  ....*..
gi 1344538211 295 NEQPVHL 301
Cdd:PHA02875  135 KFSPLHL 141
Ank_5 pfam13857
Ankyrin repeats (many copies);
123-174 5.11e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 5.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1344538211 123 AEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTA 174
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG--VDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
114-299 6.26e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 114 IVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEarDFEGLTPLHTA----------VLALNAAML 183
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE--DDNGCYPIHIAikhnffdiikLLLEKGAYA 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 184 PAS---VCPRMQNSQARDRLTCVQMLLQMGaSHTSQEIKSNKTILHLAVqAANPTLVQLLLglprgDLRAFVNMKAHGNT 260
Cdd:PHA02874  184 NVKdnnGESPLHNAAEYGDYACIKLLIDHG-NHIMNKCKNGFTPLHNAI-IHNRSAIELLI-----NNASINDQDIDGST 256
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1344538211 261 ALHMaaALPPgPPQEAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA02874  257 PLHH--AINP-PCDIDIIDILLYHKADISIKDNKGENPI 292
PHA02875 PHA02875
ankyrin repeat protein; Provisional
93-277 8.03e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  93 DIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEarDFEGLTPLH 172
Cdd:PHA02875   96 DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE--DCCGCTPLI 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 173 TAVLALNAAmlpasVCprmqnsqardrltcvQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGlpRG-DLRAF 251
Cdd:PHA02875  174 IAMAKGDIA-----IC---------------KMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIK--RGaDCNIM 231
                         170       180
                  ....*....|....*....|....*.
gi 1344538211 252 VNMKAHGNTALHMAAALPPGPPQEAI 277
Cdd:PHA02875  232 FMIEGEECTILDMICNMCTNLESEAI 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
92-159 1.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.42  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211  92 LDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVD 159
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03095 PHA03095
ankyrin-like protein; Provisional
56-185 1.26e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  56 LLAQDEEGDTLLHLFA------ARGLRwaayaaaEVLQMYRQLDIREHKGKTPLLVAAAAN--QPLIVEDLLSLGAEPNA 127
Cdd:PHA03095  180 VYAVDDRFRSLLHHHLqsfkprARIVR-------ELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINA 252
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1344538211 128 TDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAAMLPA 185
Cdd:PHA03095  253 RNRYGQTPLHYAAVFNNPRACRRLIALG--ADINAVSSDGNTPLSLMVRNNNGRAVRA 308
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
63-241 1.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  63 GDTLLHLFAARGLRWAAYAAAEV------LQMYRQLdireHKGKTPLLVAAAANQPLIVEDLLSLGAE---PNATD---- 129
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAapelvnEPMTSDL----YQGETALHIAVVNQNLNLVRELIARGADvvsPRATGtffr 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 130 -------HQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAamlpASVCpRMQN----SQARD 198
Cdd:cd22192   127 pgpknliYYGEHPLSFAACVGNEEIVRLLIEHG--ADIRAQDSLGNTVLHILVLQPNK----TFAC-QMYDlilsYDKED 199
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1344538211 199 RLTCVQMLL-QMGAshtsqeiksnkTILHLAVQAANPTLVQLLL 241
Cdd:cd22192   200 DLQPLDLVPnNQGL-----------TPFKLAAKEGNIVMFQHLV 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
82-288 1.52e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  82 AAEVLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDlE 161
Cdd:PHA02875   18 ARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD-D 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 162 ARDFEGLTPLHTAVLALNAAMLpasvcprmqnsqardrltcvQMLLQMGAShTSQEIKSNKTILHLAVQAANPTLVQLLL 241
Cdd:PHA02875   97 VFYKDGMTPLHLATILKKLDIM--------------------KLLIARGAD-PDIPNTDKFSPLHLAVMMGDIKGIELLI 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1344538211 242 glprgDLRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAAGADP 288
Cdd:PHA02875  156 -----DHKACLDIEdCCGCTPLIIAMAK----GDIAICKMLLDSGANI 194
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
257-292 1.65e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 425426 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1344538211 257 HGNTALHMAAALppgPPQEAIVRHLLAAGADPTLRN 292
Cdd:pfam00023   1 DGNTPLHLAAGR---RGNLEIVKLLLSKGADVNARD 33
PHA02743 PHA02743
Viral ankyrin protein; Provisional
203-265 2.06e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 38.26  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1344538211 203 VQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGLPRGDLRAfVNMKAHgnTALHMA 265
Cdd:PHA02743   76 IELLVNMGADINARELGTGNTLLHIAASTKNYELAEWLCRQLGVNLGA-INYQHE--TAYHIA 135
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
99-174 3.64e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 38.97  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  99 GKTPLLVAAAANQPLIVEDLLSLGAEPNAT-DHQGRSVLHVAATYG---------LPGVLSAVFKSGIQVDLEA-RDFEG 167
Cdd:cd22194   188 GETPLALAACTNQPEIVQLLMEKESTDITSqDSRGNTVLHALVTVAedsktqndfVKRMYDMILLKSENKNLETiRNNEG 267

                  ....*..
gi 1344538211 168 LTPLHTA 174
Cdd:cd22194   268 LTPLQLA 274
PHA02876 PHA02876
ankyrin repeat protein; Provisional
85-174 4.69e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  85 VLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVaATYGLPGVLS--AVFKSGIQVDLEA 162
Cdd:PHA02876  361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHF-ALCGTNPYMSvkTLIDRGANVNSKN 439
                          90
                  ....*....|..
gi 1344538211 163 RDFEglTPLHTA 174
Cdd:PHA02876  440 KDLS--TPLHYA 449
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
30-171 5.00e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211  30 SPQLPSPTGPSLETARAHILALGPQQLLAQdeeGDTLlhlfaarGLRWAAYAAAEVlqmyrqlDIREHKGKTPLLVAAAA 109
Cdd:PTZ00322   63 TPDHNLTTEEVIDPVVAHMLTVELCQLAAS---GDAV-------GARILLTGGADP-------NCRDYDGRTPLHIACAN 125
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1344538211 110 NQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQV-DLEAR----DFEGLTPL 171
Cdd:PTZ00322  126 GHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHfELGANakpdSFTGKPPS 192
PHA02876 PHA02876
ankyrin repeat protein; Provisional
100-300 7.99e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.74  E-value: 7.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 100 KTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVF--KSGI-QVDLEARDFEGLTPLHTAVL 176
Cdd:PHA02876  179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdnRSNInKNDLSLLKAIRNEDLETSLL 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344538211 177 ALNAAMLPASV-----CPRMQNSQARDRLTCVQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGLPrGDLRAF 251
Cdd:PHA02876  259 LYDAGFSVNSIddcknTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLG-ADVNAA 337
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1344538211 252 VNMKahgNTALHMAAALppgPPQEAIVRHLLAAGADPTLRNLENEQPVH 300
Cdd:PHA02876  338 DRLY---ITPLHQASTL---DRNKDIVITLLELGANVNARDYCDKTPIH 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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