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Conserved domains on  [gi|1351847013|ref|NP_001348053|]
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DNA excision repair protein ERCC-6-like 2 isoform 3 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13208550)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to Hamiltonella virus protein p41

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
41-254 1.22e-123

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18005:

Pssm-ID: 452890 [Multi-domain]  Cd Length: 245  Bit Score: 359.77  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKGTREDIENNMPEFllksMKKKPPSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNEL- 119
Cdd:cd18005    35 QVIAFLAAVLGKTGTRRDRENNRPRF----KKKPPASSAKKPVLIVAPLSVLYNWKDELDTWGHFEVGVYHGSRKDDELe 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 120 LRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMD 199
Cdd:cd18005   111 GRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLD 190
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1351847013 200 WAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18005   191 WAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and ...
81-466 8.54e-51

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair];


:

Pssm-ID: 223627 [Multi-domain]  Cd Length: 866  Bit Score: 184.94  E-value: 8.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  81 KMFLIVAPLSVLYNWKDELDTW--GYFRVTVLHGSKKDNELLRLKQRK---------CEIALTTYETLR---LCLEELNS 146
Cdd:COG0553   391 GPALIVVPASLLSNWKREFEKFapDLRLVLVYHGEKSELDKKREALRDllklhlviiFDVVITTYELLRrflVDHGGLKK 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 147 LEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAV-PGLLGSR-IHFKKQFSDPVEHGq 224
Cdd:COG0553   471 IEWDRVVLDEAHRIKNDQSSEGKALQFLKALNRLDLTGTPLENRLGELWSLLQEFLnPGLLGTSfAIFTRLFEKPIQAE- 549
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 225 RHTATKRELATgrkAMHRLAKKMSGWFLRRTKT--LIKGQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVALiltssqpC 302
Cdd:COG0553   550 EDIGPLEAREL---GIELLRKLLSPFILRRTKEdvEVLKELPPKIEKVLECELSEEQRELYEALLEGAEKNQ-------Q 619
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 303 TCGSGQKRRKCCYKTNSRGDTVrtlcLSYLTVLQKVANHVALLQAASTSKHQETVIKRICDRVF-SRFPDFVQKSKdaaf 381
Cdd:COG0553   620 LLEDLEKADSDENRIGDSELNI----LALLTRLRQICNHPALVDEGLEATFDRIVLLLREDKDFdYLKKPLIQLSK---- 691
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 382 etlsdpkysGKMKVLQQLLNHFRKQ---RDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQD 458
Cdd:COG0553   692 ---------GKLQALDELLLDKLLEeghYHKVLIFSQFTPVLDLLEDYLKALGIKYVRLDGSTPAKRRQELIDRFNADEE 762

                  ....*...
gi 1351847013 459 VNICLVST 466
Cdd:COG0553   763 EKVFLLSL 770
 
Name Accession Description Interval E-value
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
41-254 1.22e-123

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 359.77  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKGTREDIENNMPEFllksMKKKPPSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNEL- 119
Cdd:cd18005    35 QVIAFLAAVLGKTGTRRDRENNRPRF----KKKPPASSAKKPVLIVAPLSVLYNWKDELDTWGHFEVGVYHGSRKDDELe 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 120 LRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMD 199
Cdd:cd18005   111 GRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLD 190
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1351847013 200 WAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18005   191 WAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
SNF2_N pfam00176
SNF2 family N-terminal domain; This domain is found in proteins involved in a variety of ...
42-345 1.00e-51

SNF2 family N-terminal domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 1.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  42 VISFLAAVLHkkgtrediennmpeflLKSMKKKPpstakkmFLIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDNE 118
Cdd:pfam00176  34 TISLLLYLKH----------------VDKNWGGP-------TLIVVPLSLLHNWMNEFERWvspPALRVVVLHGNKRPQE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 119 LLRLKQ---RKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELW 195
Cdd:pfam00176  91 RWKNDPnflADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELW 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 196 CVMDWAVPGLLGSRIHFKKQFSDPVehgQRHTATKRelatgrkaMHRLAKKMSGWFLRRTKTLIKGQLPKKEDRMVYCSL 275
Cdd:pfam00176 171 ALLNFLRPGPFGSLSTFRNWFDRPI---ERGGGKKG--------VSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRL 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 276 TDFQKAVYQTVLETEDVALILTSSQpctcgsgqkrrkccyktnsrGDTVRTLCLSYLTVLQKVANHVALL 345
Cdd:pfam00176 240 SKLQRKLYQTFLLKKDLNAIKTGEG--------------------GREIKASLLNILMRLRKICNHPGLI 289
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and ...
81-466 8.54e-51

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair];


Pssm-ID: 223627 [Multi-domain]  Cd Length: 866  Bit Score: 184.94  E-value: 8.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  81 KMFLIVAPLSVLYNWKDELDTW--GYFRVTVLHGSKKDNELLRLKQRK---------CEIALTTYETLR---LCLEELNS 146
Cdd:COG0553   391 GPALIVVPASLLSNWKREFEKFapDLRLVLVYHGEKSELDKKREALRDllklhlviiFDVVITTYELLRrflVDHGGLKK 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 147 LEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAV-PGLLGSR-IHFKKQFSDPVEHGq 224
Cdd:COG0553   471 IEWDRVVLDEAHRIKNDQSSEGKALQFLKALNRLDLTGTPLENRLGELWSLLQEFLnPGLLGTSfAIFTRLFEKPIQAE- 549
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 225 RHTATKRELATgrkAMHRLAKKMSGWFLRRTKT--LIKGQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVALiltssqpC 302
Cdd:COG0553   550 EDIGPLEAREL---GIELLRKLLSPFILRRTKEdvEVLKELPPKIEKVLECELSEEQRELYEALLEGAEKNQ-------Q 619
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 303 TCGSGQKRRKCCYKTNSRGDTVrtlcLSYLTVLQKVANHVALLQAASTSKHQETVIKRICDRVF-SRFPDFVQKSKdaaf 381
Cdd:COG0553   620 LLEDLEKADSDENRIGDSELNI----LALLTRLRQICNHPALVDEGLEATFDRIVLLLREDKDFdYLKKPLIQLSK---- 691
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 382 etlsdpkysGKMKVLQQLLNHFRKQ---RDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQD 458
Cdd:COG0553   692 ---------GKLQALDELLLDKLLEeghYHKVLIFSQFTPVLDLLEDYLKALGIKYVRLDGSTPAKRRQELIDRFNADEE 762

                  ....*...
gi 1351847013 459 VNICLVST 466
Cdd:COG0553   763 EKVFLLSL 770
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
84-466 6.59e-39

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 150.34  E-value: 6.59e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013   84 LIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELLR---LKQRKCEIALTTYEtlrLCLEELNSLE---WSAIIVDE 156
Cdd:PLN03142   223 MVVAPKSTLGNWMNEIRRFcPVLRAVKFHGNPEERAHQReelLVAGKFDVCVTSFE---MAIKEKTALKrfsWRYIIIDE 299
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  157 AHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQrhtatkrelatg 236
Cdd:PLN03142   300 AHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQ------------ 367
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  237 RKAMHRLAKKMSGWFLRRTKTLIKGQLPKKEDRMVYCSLTDFQKAVYQTVLEtEDVALIltssqpctcgsgqkrrkccyk 316
Cdd:PLN03142   368 QEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQ-KDLDVV--------------------- 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  317 tNSRGDtvRTLCLSYLTVLQKVANHVALLQAASTSkhqetvikricdrvfsrfPDFVqkSKDAAFETlsdpkySGKMKVL 396
Cdd:PLN03142   426 -NAGGE--RKRLLNIAMQLRKCCNHPYLFQGAEPG------------------PPYT--TGEHLVEN------SGKMVLL 476
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1351847013  397 QQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQDVNIC-LVST 466
Cdd:PLN03142   477 DKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVfLLST 547
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
389-466 4.35e-23

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 94.47  E-value: 4.35e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1351847013 389 YSGKMKVLQQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQDVNICLVST 466
Cdd:cd18793     9 VSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLST 86
DEXDc smart00487
DEAD-like helicases superfamily;
63-195 8.92e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 78.69  E-value: 8.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013   63 MPEFLLKSMKKKPpstaKKMFLIVAPLSVL-YNWKDELDTWGYF----RVTVLHGSKKDNELLRLKQRKCEIALTTYETL 137
Cdd:smart00487  41 ALLPALEALKRGK----GGRVLVLVPTRELaEQWAEELKKLGPSlglkVVGLYGGDSKREQLRKLESGKTDILVTTPGRL 116
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1351847013  138 RLCLEE--LNSLEWSAIIVDEAHRIKNPKAR--VTEVMKAV-KCKVRIGLTGTVLQNNMKELW 195
Cdd:smart00487 117 LDLLENdkLSLSNVDLVILDEAHRLLDGGFGdqLEKLLKLLpKNVQLLLLSATPPEEIENLLE 179
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
391-466 3.73e-09

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 425571 [Multi-domain]  Cd Length: 109  Bit Score: 54.14  E-value: 3.73e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1351847013 391 GKMKVLQQLLNhfRKQRDKVLLFSFSTKLLDvLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSqDVNIcLVST 466
Cdd:pfam00271   1 EKLEALLELLK--KERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVAT 71
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair];
78-185 5.14e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair];


Pssm-ID: 223989 [Multi-domain]  Cd Length: 442  Bit Score: 54.75  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  78 TAKKMFLIVAPLSVL-YNWKDELDTWGYFR--VTVLHGSKKDNellrlkqRKCEIALTTYETL--RLCLEELNSLEWSAI 152
Cdd:COG1061    78 ELKRSTLVLVPTKELlDQWAEALKKFLLLNdeIGIYGGGEKEL-------EPAKVTVATVQTLarRQLLDEFLGNEFGLI 150
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1351847013 153 IVDEAHRIKNPKAR-VTEVMKAVkcKVRIGLTGT 185
Cdd:COG1061   151 IFDEVHHLPAPSYRrILELLSAA--YPRLGLTAT 182
HELICc smart00490
helicase superfamily c-terminal domain;
421-466 1.47e-04

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 40.27  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1351847013  421 DVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSsqDVNICLVST 466
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNN--GKIKVLVAT 44
SWIM_PBPRA1643 TIGR04102
SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have ...
301-314 6.59e-03

SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.


Pssm-ID: 200353 [Multi-domain]  Cd Length: 108  Bit Score: 36.13  E-value: 6.59e-03
                          10
                  ....*....|....
gi 1351847013 301 PCTCGSGQKRRKCC 314
Cdd:TIGR04102  94 PCPCGSGKKYKKCC 107
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
127-192 9.97e-03

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 38.24  E-value: 9.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1351847013 127 CEIALTTY-----------ETLRLcLEELNSLEWSAIIVDEAHRIknPKARVTEVMKAVKCKVRIGLTGTVLQNNMK 192
Cdd:TIGR00603 344 AGVVVSTYsmvahtgkrsyESEKV-MEWLTNREWGLILLDEVHVV--PAAMFRRVLTIVQAHCKLGLTATLVREDDK 417
 
Name Accession Description Interval E-value
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
41-254 1.22e-123

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 359.77  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKGTREDIENNMPEFllksMKKKPPSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNEL- 119
Cdd:cd18005    35 QVIAFLAAVLGKTGTRRDRENNRPRF----KKKPPASSAKKPVLIVAPLSVLYNWKDELDTWGHFEVGVYHGSRKDDELe 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 120 LRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMD 199
Cdd:cd18005   111 GRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLD 190
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1351847013 200 WAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18005   191 WAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
SNF2_N pfam00176
SNF2 family N-terminal domain; This domain is found in proteins involved in a variety of ...
42-345 1.00e-51

SNF2 family N-terminal domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 1.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  42 VISFLAAVLHkkgtrediennmpeflLKSMKKKPpstakkmFLIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDNE 118
Cdd:pfam00176  34 TISLLLYLKH----------------VDKNWGGP-------TLIVVPLSLLHNWMNEFERWvspPALRVVVLHGNKRPQE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 119 LLRLKQ---RKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELW 195
Cdd:pfam00176  91 RWKNDPnflADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELW 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 196 CVMDWAVPGLLGSRIHFKKQFSDPVehgQRHTATKRelatgrkaMHRLAKKMSGWFLRRTKTLIKGQLPKKEDRMVYCSL 275
Cdd:pfam00176 171 ALLNFLRPGPFGSLSTFRNWFDRPI---ERGGGKKG--------VSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRL 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 276 TDFQKAVYQTVLETEDVALILTSSQpctcgsgqkrrkccyktnsrGDTVRTLCLSYLTVLQKVANHVALL 345
Cdd:pfam00176 240 SKLQRKLYQTFLLKKDLNAIKTGEG--------------------GREIKASLLNILMRLRKICNHPGLI 289
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and ...
81-466 8.54e-51

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair];


Pssm-ID: 223627 [Multi-domain]  Cd Length: 866  Bit Score: 184.94  E-value: 8.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  81 KMFLIVAPLSVLYNWKDELDTW--GYFRVTVLHGSKKDNELLRLKQRK---------CEIALTTYETLR---LCLEELNS 146
Cdd:COG0553   391 GPALIVVPASLLSNWKREFEKFapDLRLVLVYHGEKSELDKKREALRDllklhlviiFDVVITTYELLRrflVDHGGLKK 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 147 LEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAV-PGLLGSR-IHFKKQFSDPVEHGq 224
Cdd:COG0553   471 IEWDRVVLDEAHRIKNDQSSEGKALQFLKALNRLDLTGTPLENRLGELWSLLQEFLnPGLLGTSfAIFTRLFEKPIQAE- 549
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 225 RHTATKRELATgrkAMHRLAKKMSGWFLRRTKT--LIKGQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVALiltssqpC 302
Cdd:COG0553   550 EDIGPLEAREL---GIELLRKLLSPFILRRTKEdvEVLKELPPKIEKVLECELSEEQRELYEALLEGAEKNQ-------Q 619
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 303 TCGSGQKRRKCCYKTNSRGDTVrtlcLSYLTVLQKVANHVALLQAASTSKHQETVIKRICDRVF-SRFPDFVQKSKdaaf 381
Cdd:COG0553   620 LLEDLEKADSDENRIGDSELNI----LALLTRLRQICNHPALVDEGLEATFDRIVLLLREDKDFdYLKKPLIQLSK---- 691
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 382 etlsdpkysGKMKVLQQLLNHFRKQ---RDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQD 458
Cdd:COG0553   692 ---------GKLQALDELLLDKLLEeghYHKVLIFSQFTPVLDLLEDYLKALGIKYVRLDGSTPAKRRQELIDRFNADEE 762

                  ....*...
gi 1351847013 459 VNICLVST 466
Cdd:COG0553   763 EKVFLLSL 770
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
42-203 3.97e-47

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 160.81  E-value: 3.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  42 VISFLAAVLHKKGTRediennmpefllksmkkkppstakKMFLIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELL 120
Cdd:cd17919    36 AIAFLAYLLKEGKER------------------------GPVLVVCPLSVLENWEREFEKWtPDLRVVVYHGSQRERAQI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 121 R--LKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVM 198
Cdd:cd17919    92 RakEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALL 171

                  ....*
gi 1351847013 199 DWAVP 203
Cdd:cd17919   172 DFLDP 176
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
41-254 1.74e-40

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 144.82  E-value: 1.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKgtrediennmpefLLKSMkkkppstakkmfLIVAPLSVLYNWKDELDTWGY-FRVTVLHGSKKD--N 117
Cdd:cd18001    35 QICAFLSGMFDSG-------------LIKSV------------LVVMPTSLIPHWVKEFAKWTPgLRVKVFHGTSKKerE 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 118 ELLRLKQRKCEIALTTYETLRLCLEELNSLE-----WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMK 192
Cdd:cd18001    90 RNLERIQRGGGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLK 169
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1351847013 193 ELWCVMDWAVPG-LLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18001   170 ELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
67-256 1.04e-39

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 142.32  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPSTAkkmFLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSK-KDNELLRLKQRkcEIALTTYETLRLCLEEL 144
Cdd:cd18012    43 LLLSRKEEGRKGP---SLVVAPTSLIYNWEEEAAKFApELKVLVIHGTKrKREKLRALEDY--DLVITSYGLLRRDIELL 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 145 NSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQ 224
Cdd:cd18012   118 KEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDG 197
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1351847013 225 RhtatkrelatgRKAMHRLAKKMSGWFLRRTK 256
Cdd:cd18012   198 D-----------EEALEELKKLISPFILRRLK 218
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
84-466 6.59e-39

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 150.34  E-value: 6.59e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013   84 LIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELLR---LKQRKCEIALTTYEtlrLCLEELNSLE---WSAIIVDE 156
Cdd:PLN03142   223 MVVAPKSTLGNWMNEIRRFcPVLRAVKFHGNPEERAHQReelLVAGKFDVCVTSFE---MAIKEKTALKrfsWRYIIIDE 299
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  157 AHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQrhtatkrelatg 236
Cdd:PLN03142   300 AHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQ------------ 367
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  237 RKAMHRLAKKMSGWFLRRTKTLIKGQLPKKEDRMVYCSLTDFQKAVYQTVLEtEDVALIltssqpctcgsgqkrrkccyk 316
Cdd:PLN03142   368 QEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQ-KDLDVV--------------------- 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  317 tNSRGDtvRTLCLSYLTVLQKVANHVALLQAASTSkhqetvikricdrvfsrfPDFVqkSKDAAFETlsdpkySGKMKVL 396
Cdd:PLN03142   426 -NAGGE--RKRLLNIAMQLRKCCNHPYLFQGAEPG------------------PPYT--TGEHLVEN------SGKMVLL 476
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1351847013  397 QQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQDVNIC-LVST 466
Cdd:PLN03142   477 DKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVfLLST 547
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
67-254 2.82e-37

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 136.65  E-value: 2.82e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPsTAKKmFLIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDNELLRLKQ---RKCEIALTTYETLRLC 140
Cdd:cd18004    48 LLKQGPYGKP-TAKK-ALIVCPSSLVGNWKAEFDKWlglRRIKVVTADGNAKDVKASLDFFssaSTYPVLIISYETLRRH 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 141 LEELNSLEWSAIIV-DEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDP 219
Cdd:cd18004   126 AEKLSKKISIDLLIcDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEP 205
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1351847013 220 VEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18004   206 ILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
84-254 8.62e-36

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 132.47  E-value: 8.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDNELLRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRI 160
Cdd:cd17999    59 LVVCPPTLVGHWVAEIKKYfpnAFLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHII 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 161 KNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAM 240
Cdd:cd17999   139 KNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALAL 218
                         170
                  ....*....|....
gi 1351847013 241 HRLAKKMSGWFLRR 254
Cdd:cd17999   219 EALHKQVLPFLLRR 232
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
83-224 1.48e-33

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 125.82  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQR--------------KCEIALTTYETLRLCLEELNSLE 148
Cdd:cd17995    53 FLVIAPLSTIPNWQREFETWTDMNVVVYHGSGESRQIIQQYEMyfkdaqgrkkkgvyKFDVLITTYEMVIADAEELRKIP 132
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQ 224
Cdd:cd17995   133 WRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLKTAEQ 208
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
67-238 4.55e-30

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 117.01  E-value: 4.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPSTAKkmFLIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDN-ELLRLK-----QRKCEIALTTYETL 137
Cdd:cd18007    46 FLHTYLAAAPRRSR--PLVLCPASTLYNWEDEFKKWlppDLRPLLVLVSLSASKrADARLRkinkwHKEGGVLLIGYELF 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 138 RLCLEELNSLEWSA--------------IIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVP 203
Cdd:cd18007   124 RNLASNATTDPRLKqefiaalldpgpdlLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARP 203
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1351847013 204 GLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRK 238
Cdd:cd18007   204 KYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLK 238
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
83-256 2.96e-29

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 114.34  E-value: 2.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKK-DNELLR--LKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAH 158
Cdd:cd17997    56 HLIIVPKSTLDNWMREFKRWcPSLRVVVLIGDKEeRADIIRdvLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAH 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 159 RIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKrelatgrk 238
Cdd:cd17997   136 RIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEVVQ-------- 207
                         170
                  ....*....|....*...
gi 1351847013 239 amhRLAKKMSGWFLRRTK 256
Cdd:cd17997   208 ---RLHKVLRPFLLRRIK 222
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
84-206 8.16e-29

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 112.03  E-value: 8.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTW-GYFRVTVLH--------GSKKDNELLRLKQRKCE-----IALTTYETLRLCLEELNSLEW 149
Cdd:cd18000    54 LIVCPATVLKQWVKEFHRWwPPFRVVVLHssgsgtgsEEKLGSIERKSQLIRKVvgdggILITTYEGFRKHKDLLLNHNW 133
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351847013 150 SAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLL 206
Cdd:cd18000   134 QYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
83-256 2.98e-27

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 109.01  E-value: 2.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLRLKQRK-------CEIALTTYETLRLCLEELNSLEWSAIIV 154
Cdd:cd18009    55 FLVIAPLSTLPNWVNEFARFTpSVPVLLYHGTKEERERLRKKIMKregtlqdFPVVVTSYEIAMRDRKALQHYAWKYLIV 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 155 DEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFsDPVEHGQRhTATKRELA 234
Cdd:cd18009   135 DEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWF-DFSSLSDN-AADISNLS 212
                         170       180
                  ....*....|....*....|....
gi 1351847013 235 TGRKA--MHRLAKKMSGWFLRRTK 256
Cdd:cd18009   213 EEREQniVHMLHAILKPFLLRRLK 236
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
67-254 1.80e-26

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 107.17  E-value: 1.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPSTAKKMflIVAPLSVLYNWKDELDTWGYFRVTVL--HGSKKDNELLRLKQRKCE--------IALTTYET 136
Cdd:cd18067    48 LLRQSPQCKPEIDKAI--VVSPSSLVKNWANELGKWLGGRLQPLaiDGGSKKEIDRKLVQWASQqgrrvstpVLIISYET 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 137 LRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQF 216
Cdd:cd18067   126 FRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNF 205
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1351847013 217 SDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRR 254
Cdd:cd18067   206 ELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
66-254 2.47e-26

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 105.90  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  66 FLLKSMKKKPPstakkmFLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLR--------LKQRKCEIALTTYET 136
Cdd:cd17993    43 YLFHSQQQYGP------FLVVVPLSTMPAWQREFAKWApDMNVIVYLGDIKSRDTIReyefyfsqTKKLKFNVLLTTYEI 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 137 LRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGllgsRIHFKKQF 216
Cdd:cd17993   117 ILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPG----KFDIWEEF 192
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1351847013 217 SDpvEHGQrhtatKRElatgrKAMHRLAKKMSGWFLRR 254
Cdd:cd17993   193 EE--EHDE-----EQE-----KGIADLHKELEPFILRR 218
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
81-254 9.68e-26

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 104.93  E-value: 9.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  81 KMFLIVAPLSVLYNWKDELDTW---GYFRVTVLHGSKKDNELLrlKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEA 157
Cdd:cd18066    61 KRALIVTPGSLVKNWKKEFQKWlgsERIKVFTVDQDHKVEEFI--ASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEG 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 158 HRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGR 237
Cdd:cd18066   139 HRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGE 218
                         170
                  ....*....|....*..
gi 1351847013 238 KAMHRLAKKMSGWFLRR 254
Cdd:cd18066   219 ARAAELTRLTGLFILRR 235
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
83-256 2.17e-25

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 103.99  E-value: 2.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLH-GSKKDNELLRLKQRKCE--IALTTYETLRLCLEELNSLEWSAIIVDEAHR 159
Cdd:cd17996    56 YLVIVPLSTLSNWVSEFEKWAPSVSKIVYkGTPDVRKKLQSQIRAGKfnVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHR 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 160 IKNPKARVTEVMKAVKC-KVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEH-GQRHtatKRELATGR 237
Cdd:cd17996   136 MKNAQSKLTQTLNTYYHaRYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANtGEQV---KIELNEEE 212
                         170       180
                  ....*....|....*....|.
gi 1351847013 238 KAM--HRLAKKMSGWFLRRTK 256
Cdd:cd17996   213 TLLiiRRLHKVLRPFLLRRLK 233
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
78-224 2.35e-24

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 100.66  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  78 TAKKMFLIVAPLSVLYNWKDELDTW------------GYFRVTVLHGSKKD----NELLRLKQRKCEIALTTYETLRLcl 141
Cdd:cd18069    56 TGAKTVLAIVPVNTLQNWLSEFNKWlpppealpnvrpRPFKVFILNDEHKTtaarAKVIEDWVKDGGVLLMGYEMFRL-- 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 142 EELNSLewsaIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVE 221
Cdd:cd18069   134 RPGPDV----VICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPIL 209

                  ...
gi 1351847013 222 HGQ 224
Cdd:cd18069   210 NGQ 212
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
389-466 4.35e-23

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 94.47  E-value: 4.35e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1351847013 389 YSGKMKVLQQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQDVNICLVST 466
Cdd:cd18793     9 VSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLST 86
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
83-218 1.51e-22

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 95.49  E-value: 1.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQR--------------KCEIALTTYETLRLCLEELNSLE 148
Cdd:cd18058    52 FLIIAPLSTITNWEREFRTWTEMNAIVYHGSQISRQMIQQYEMyyrdeqgnplsgifKFQVVITTFEMILADCPELKKIN 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSD 218
Cdd:cd18058   132 WSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGD 201
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
83-218 1.55e-21

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 92.81  E-value: 1.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQRKC--------------EIALTTYETLRLCLEELNSLE 148
Cdd:cd18060    52 FLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCkdsrgrlipgaykfDALITTFEMILSDCPELREIE 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSD 218
Cdd:cd18060   132 WRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGD 201
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
41-195 1.98e-21

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 92.74  E-value: 1.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKGTREDIENNMPEFLLKSMKKKPPSTakkmFLIVAPLSVLYNWKDELDT---WGYFRVTVLHGSKKDN 117
Cdd:cd18008    27 KTIQALALILATRPQDPKIPEELEENSSDPKKLYLSKT----TLIVVPLSLLSQWKDEIEKhtkPGSLKVYVYHGSKRIK 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 118 ELLRLKQrkCEIALTTYETLR------------LCLEE----LNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIG 181
Cdd:cd18008   103 SIEELSD--YDIVITTYGTLAsefpknkkgggrDSKEKeaspLHRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWC 180
                         170
                  ....*....|....
gi 1351847013 182 LTGTVLQNNMKELW 195
Cdd:cd18008   181 LTGTPIQNSLDDLY 194
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
84-254 3.92e-21

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 91.64  E-value: 3.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELLR---LKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHR 159
Cdd:cd18003    54 LIVVPTSVMLNWEMEFKRWcPGFKILTYYGSAKERKLKRqgwMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHN 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 160 IKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDP----VEHGQRHTatkrelat 235
Cdd:cd18003   134 IKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPltamSEGSQEEN-------- 205
                         170
                  ....*....|....*....
gi 1351847013 236 gRKAMHRLAKKMSGWFLRR 254
Cdd:cd18003   206 -EELVRRLHKVLRPFLLRR 223
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
83-218 4.37e-21

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 91.61  E-value: 4.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQRKC--------------EIALTTYETLRLCLEELNSLE 148
Cdd:cd18061    52 FLIIAPLSTIANWEREFRTWTDLNVVVYHGSLISRQMIQQYEMYFrdsqgriirgayrfQAIITTFEMILGGCPELNAID 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSD 218
Cdd:cd18061   132 WRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGD 201
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
83-218 6.79e-21

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 90.86  E-value: 6.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQR--------------KCEIALTTYETLRLCLEELNSLE 148
Cdd:cd18059    52 FLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMyfkdpqgrvikgsyKFHAIITTFEMILTDCPELRNIP 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSD 218
Cdd:cd18059   132 WRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGD 201
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
83-254 3.53e-20

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 89.10  E-value: 3.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELLR---------LKQRKCEIALTTYETLRLCLEELNSLEWSAI 152
Cdd:cd18002    53 FLVIAPASTLHNWQQEISRFvPQFKVLPYWGNPKDRKVLRkfwdrknlyTRDAPFHVVITSYQLVVQDEKYFQRVKWQYM 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 153 IVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVE-HGQRHTATKR 231
Cdd:cd18002   133 VLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEsHAENKTGLNE 212
                         170       180
                  ....*....|....*....|...
gi 1351847013 232 ElatgrkAMHRLAKKMSGWFLRR 254
Cdd:cd18002   213 H------QLKRLHMILKPFMLRR 229
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
83-218 4.03e-20

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 87.88  E-value: 4.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-YFRVTVLHGskkDNELLrlkqrkceialTTYETLRLCLEELNSLEWSAIIVDEAHRIK 161
Cdd:cd17994    53 FLVSAPLSTIINWEREFEMWApDFYVVTYVG---DHVLL-----------TSYELISIDQAILGSIDWAVLVVDEAHRLK 118
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351847013 162 NPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSD 218
Cdd:cd17994   119 NNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD 175
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
83-254 5.66e-20

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 88.52  E-value: 5.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLR--------LKQRKCEIALTTYETLRLCLEELNSLEWSAII 153
Cdd:cd18054    73 FLLVVPLSTLTSWQREFEIWApEINVVVYIGDLMSRNTIReyewihsqTKRLKFNALITTYEILLKDKTVLGSINWAFLG 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 154 VDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPgllgSRIHFKKQFSDpvEHGQrhtatKREl 233
Cdd:cd18054   153 VDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP----EKFEFWEDFEE--DHGK-----GRE- 220
                         170       180
                  ....*....|....*....|.
gi 1351847013 234 aTGRKAMHRLakkMSGWFLRR 254
Cdd:cd18054   221 -NGYQSLHKV---LEPFLLRR 237
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
84-254 1.04e-19

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 87.91  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELD---TWGYFRVTVLHGSKKDNELLRLKqrKCEIALTTYETLrlCLEE-------LNSLEWSAII 153
Cdd:cd18071    75 LIVCPLSVLSNWETQFEehvKPGQLKVYTYHGGERNRDPKLLS--KYDIVLTTYNTL--ASDFgakgdspLHTINWLRVV 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 154 VDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMdwavpgllgSRIHFKKqFSDPvEHGQRhtATKREL 233
Cdd:cd18071   151 LDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLL---------SFLHLKP-FSNP-EYWRR--LIQRPL 217
                         170       180
                  ....*....|....*....|..
gi 1351847013 234 ATG-RKAMHRLAKKMSGWFLRR 254
Cdd:cd18071   218 TMGdPTGLKRLQVLMKQITLRR 239
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
79-224 1.63e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 87.43  E-value: 1.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  79 AKKMFLIVAPLSVLYNWKDELDTWGY-FRVTVLHGSK------KDNE-------------LLRLK---QRKCEIALTTYE 135
Cdd:cd18057    49 SKGPYLVSAPLSTIINWEREFEMWAPdFYVVTYTGDKesrsviRENEfsfednairsgkkVFRMKkeaQIKFHVLLTSYE 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 136 TLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQ 215
Cdd:cd18057   129 LITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEE 208

                  ....*....
gi 1351847013 216 FSDPVEHGQ 224
Cdd:cd18057   209 FADISKEDQ 217
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
83-224 2.12e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 86.99  E-value: 2.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-----------------------YFRVTVLHGSKKDNELLRLKQRKCEIALTTYETLRL 139
Cdd:cd18055    53 FLVSAPLSTIINWEREFQMWApdfyvvtytgdkdsraiirenefSFDDNAVKGGKKAFKMKREAQVKFHVLLTSYELVTI 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 140 CLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDP 219
Cdd:cd18055   133 DQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI 212

                  ....*
gi 1351847013 220 VEHGQ 224
Cdd:cd18055   213 SKEDQ 217
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
79-224 3.50e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 86.27  E-value: 3.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  79 AKKMFLIVAPLSVLYNWKDELDTWG-----------------------YFRVTVLHGSKKDNELLRLKQRKCEIALTTYE 135
Cdd:cd18056    49 SKGPFLVSAPLSTIINWEREFEMWApdmyvvtyvgdkdsraiirenefSFEDNAIRGGKKASRMKKEASVKFHVLLTSYE 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 136 TLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQ 215
Cdd:cd18056   129 LITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEE 208

                  ....*....
gi 1351847013 216 FSDPVEHGQ 224
Cdd:cd18056   209 FADIAKEDQ 217
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
84-267 1.07e-18

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 85.10  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELLR---LKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHR 159
Cdd:cd18064    69 MVLVPKSTLHNWMAEFKRWvPTLRAVCLIGDKDQRAAFVrdvLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHR 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 160 IKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSdpvehgqrhtatKRELATGRKA 239
Cdd:cd18064   149 IKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD------------TNNCLGDQKL 216
                         170       180
                  ....*....|....*....|....*...
gi 1351847013 240 MHRLAKKMSGWFLRRTKTLIKGQLPKKE 267
Cdd:cd18064   217 VERLHMVLRPFLLRRIKADVEKSLPPKK 244
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
83-256 2.07e-18

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 84.34  E-value: 2.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGyfrVTVLHGSKKDNELLR------LKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDE 156
Cdd:cd18063    76 YLIIVPLSTLSNWTYEFDKWA---PSVVKISYKGTPAMRrslvpqLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDE 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 157 AHRIKNPKARVTEVMKA-VKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEH-GQRHTATKRELA 234
Cdd:cd18063   153 GHRMKNHHCKLTQVLNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMtGERVDLNEEETI 232
                         170       180
                  ....*....|....*....|..
gi 1351847013 235 TgrkAMHRLAKKMSGWFLRRTK 256
Cdd:cd18063   233 L---IIRRLHKVLRPFLLRRLK 251
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
83-233 5.38e-18

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 83.18  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLRL--------KQRKCEIALTTYETLRLCLEELNSLEWSAII 153
Cdd:cd18053    73 FLLVVPLSTLTSWQREIQTWApQMNAVVYLGDINSRNMIRThewmhpqtKRLKFNILLTTYEILLKDKSFLGGLNWAFIG 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 154 VDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGqrHTATKREL 233
Cdd:cd18053   153 VDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYG--YASLHKEL 230
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
83-256 7.13e-18

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 82.78  E-value: 7.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLH-GSKKDNE--LLRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHR 159
Cdd:cd18062    76 FLIIVPLSTLSNWVYEFDKWAPSVVKVSYkGSPAARRafVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHR 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 160 IKNPKARVTEVMKA-VKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEH-GQRHTATKRELATgr 237
Cdd:cd18062   156 MKNHHCKLTQVLNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMtGEKVDLNEEETIL-- 233
                         170
                  ....*....|....*....
gi 1351847013 238 kAMHRLAKKMSGWFLRRTK 256
Cdd:cd18062   234 -IIRRLHKVLRPFLLRRLK 251
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
83-207 1.23e-17

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 81.33  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLRlKQRKCE----IALTTYEtlrLCLEE---LNSLEWSAIIV 154
Cdd:cd18006    53 FLVLCPLSVLDNWKEELNRFApDLSVITYMGDKEKRLDLQ-QDIKSTnrfhVLLTTYE---ICLKDasfLKSFPWASLVV 128
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351847013 155 DEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLG 207
Cdd:cd18006   129 DEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFP 181
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
84-233 2.23e-17

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 81.47  E-value: 2.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTWGYF-------RVTVLhGSKKDNELLRLK----QRKCEIALTTYETLRLCLEELN-SLEWSA 151
Cdd:cd18068    65 LVVCPLNTVLNWLNEFEKWQEGlkdeekiEVNEL-ATYKRPQERSYKlqrwQEEGGVMIIGYDMYRILAQERNvKSREKL 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 152 ---------------IIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQF 216
Cdd:cd18068   144 keifnkalvdpgpdfVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRF 223
                         170
                  ....*....|....*..
gi 1351847013 217 SDPVEHGQRHTATKREL 233
Cdd:cd18068   224 VNPIQNGQCADSTLVDV 240
DEXDc smart00487
DEAD-like helicases superfamily;
63-195 8.92e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 78.69  E-value: 8.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013   63 MPEFLLKSMKKKPpstaKKMFLIVAPLSVL-YNWKDELDTWGYF----RVTVLHGSKKDNELLRLKQRKCEIALTTYETL 137
Cdd:smart00487  41 ALLPALEALKRGK----GGRVLVLVPTRELaEQWAEELKKLGPSlglkVVGLYGGDSKREQLRKLESGKTDILVTTPGRL 116
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1351847013  138 RLCLEE--LNSLEWSAIIVDEAHRIKNPKAR--VTEVMKAV-KCKVRIGLTGTVLQNNMKELW 195
Cdd:smart00487 117 LDLLENdkLSLSNVDLVILDEAHRLLDGGFGdqLEKLLKLLpKNVQLLLLSATPPEEIENLLE 179
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
84-256 1.10e-16

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 78.91  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKDNELL---RLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHR 159
Cdd:cd18065    69 MVLVPKSTLHNWMNEFKRWvPSLRAVCLIGDKDARAAFirdVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHR 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 160 IKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSdpvehgqrhtaTKRELATgRKA 239
Cdd:cd18065   149 IKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD-----------TKNCLGD-QKL 216
                         170
                  ....*....|....*..
gi 1351847013 240 MHRLAKKMSGWFLRRTK 256
Cdd:cd18065   217 VERLHAVLKPFLLRRIK 233
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
83-219 3.48e-16

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 77.25  E-value: 3.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTW----GYFRVTVLHGSKkdnELLRLKQRKceIALTTYETLRLCLEELNSLEWSAIIVDEAH 158
Cdd:cd18010    46 LLIVCPSSLRLTWADEIERWlpslPPDDIQVIVKSK---DGLRDGDAK--VVIVSYDLLRRLEKQLLARKFKVVICDESH 120
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1351847013 159 RIKNPKA-RVTEVMKAVK-CKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDP 219
Cdd:cd18010   121 YLKNSKAkRTKAALPLLKrAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAA 183
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
74-195 4.42e-13

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 68.15  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  74 KPPSTAKKMfLIVAPLSVLYN-WKDELDTWGYFR---VTVLHGSKKdnELLRLKQRKCEIALTTYETLR-LCLEELNSLE 148
Cdd:cd18013    40 QLDDFTRRV-LVIAPLRVARStWPDEVEKWNHLRnltVSVAVGTER--QRSKAANTPADLYVINRENLKwLVNKSGDPWP 116
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1351847013 149 WSAIIVDEAHRIKNPKARVTEVMKAVKCKVR--IGLTGTVLQNNMKELW 195
Cdd:cd18013   117 FDMVVIDELSSFKSPRSKRFKALRKVRPVIKrlIGLTGTPSPNGLMDLW 165
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
41-195 2.15e-12

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 66.73  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKKGTREDIENNMPEFLLKSMKKKPPS-TAKKMFLIVAPLSVLYNWKDELDT---WGYFRVTVLHGSKKD 116
Cdd:cd18072    33 KTLTMIALILAQKNTQNRKEEEKEKALTEWESKKDSTlVPSAGTLVVCPASLVHQWKNEVESrvaSNKLRVCLYHGPNRE 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 117 NELLRLkqRKCEIALTTYETL---------RLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVL 187
Cdd:cd18072   113 RIGEVL--RDYDIVITTYSLVakeiptykeESRSSPLFRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPI 190

                  ....*...
gi 1351847013 188 QNNMKELW 195
Cdd:cd18072   191 QNNLLDMY 198
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
84-203 5.04e-12

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 64.33  E-value: 5.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  84 LIVAPLSVLYNWKDELDTWG-YFRVTVLHGSKKDNELLR---LKQR-KCEIALTTYETLRLCLEE---LNSLEWSAIIVD 155
Cdd:cd17998    53 LVVVPSSTLDNWLREFKRWCpSLKVEPYYGSQEERKHLRydiLKGLeDFDVIVTTYNLATSNPDDrsfFKRLKLNYVVYD 132
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1351847013 156 EAHRIKNPKA-RVTEVMKaVKCKVRIGLTGTVLQNNMKELWCVMDWAVP 203
Cdd:cd17998   133 EGHMLKNMTSeRYRHLMT-INANFRLLLTGTPLQNNLLELMSLLNFIMP 180
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
83-185 3.64e-09

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 55.00  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAP-LSVLYNWKDELDTWGYFRVTVLHGSKKDNellrlKQRKCEIALTTYETLRLCLEELNSL--EWSAIIVDEAHR 159
Cdd:cd17926    47 TLIVVPtDALLDQWKERFEDFLGDSSIGLIGGGKKK-----DFDDANVVVATYQSLSNLAEEEKDLfdQFGLLIVDEAHH 121
                          90       100
                  ....*....|....*....|....*.
gi 1351847013 160 IKNPKARvtEVMKAVKCKVRIGLTGT 185
Cdd:cd17926   122 LPAKTFS--EILKELNAKYRLGLTAT 145
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
391-466 3.73e-09

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 425571 [Multi-domain]  Cd Length: 109  Bit Score: 54.14  E-value: 3.73e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1351847013 391 GKMKVLQQLLNhfRKQRDKVLLFSFSTKLLDvLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSqDVNIcLVST 466
Cdd:pfam00271   1 EKLEALLELLK--KERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVAT 71
ResIII pfam04851
Type III restriction enzyme, res subunit;
83-185 8.71e-09

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 54.60  E-value: 8.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAP-LSVLYNWKDELDtwGYFRVTVLHGSKKDNELLRLKQRKCEIALTTYETL----RLCLEELNSLEWSAIIVDEA 157
Cdd:pfam04851  56 VLFLVPrKDLLEQALEEFK--KFLPNYVEIGEIISGDKKDESVDDNKIVVTTIQSLykalELASLELLPDFFDVIIIDEA 133
                          90       100
                  ....*....|....*....|....*...
gi 1351847013 158 HRIKNPKARvtEVMKAVKCKVRIGLTGT 185
Cdd:pfam04851 134 HRSGASSYR--NILEYFKPAFLLGLTAT 159
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
83-226 3.15e-08

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 53.83  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  83 FLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQRKCE--IALTTYETLR---LCLEELNSLEWSAIIVDEA 157
Cdd:cd18011    50 VLILCPASLVEQWQDELQDKFGLPFLILDRETAAQLRRLIGNPFEEfpIVIVSLDLLKrseERRGLLLSEEWDLVVVDEA 129
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1351847013 158 HRIKN----PKARVTEVMKAVKCKVR--IGLTGTVLQNNMKELWCVMDWAVPGllgsRIHFKKQFSDPVEHGQRH 226
Cdd:cd18011   130 HKLRNsgggKETKRYKLGRLLAKRARhvLLLTATPHNGKEEDFRALLSLLDPG----RFAVLGRFLRLDGLREVL 200
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
77-187 3.45e-08

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 53.07  E-value: 3.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  77 STAKKMFLIVAPLSV-LYNWKDELDTWGYF---RVTVLHGSKKDnellrlKQRKCEIALTTYETLR----------LCLE 142
Cdd:cd18029    48 CTIKKSTLVLCTSAVsVEQWRRQFLDWTTIddeQIGRFTSDKKE------IFPEAGVTVSTYSMLAntrkrspeseKFME 121
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1351847013 143 ELNSLEWSAIIVDEAHRIKNPKARvtEVMKAVKCKVRIGLTGTVL 187
Cdd:cd18029   122 FITEREWGLIILDEVHVVPAPMFR--RVLTLQKAHCKLGLTATLV 164
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair];
78-185 5.14e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair];


Pssm-ID: 223989 [Multi-domain]  Cd Length: 442  Bit Score: 54.75  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  78 TAKKMFLIVAPLSVL-YNWKDELDTWGYFR--VTVLHGSKKDNellrlkqRKCEIALTTYETL--RLCLEELNSLEWSAI 152
Cdd:COG1061    78 ELKRSTLVLVPTKELlDQWAEALKKFLLLNdeIGIYGGGEKEL-------EPAKVTVATVQTLarRQLLDEFLGNEFGLI 150
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1351847013 153 IVDEAHRIKNPKAR-VTEVMKAVkcKVRIGLTGT 185
Cdd:COG1061   151 IFDEVHHLPAPSYRrILELLSAA--YPRLGLTAT 182
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
78-185 5.93e-07

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 48.94  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  78 TAKKMFLIVAPLSVL-YNWKDELDTWGYF--RVTVLHGSKKDNELLRLKQRKCEIALTTYETLRLCLEELNSL---EWSA 151
Cdd:cd00046    28 KKGKKVLVLVPTKALaLQTAERLRELFGPgiRVAVLVGGSSAEEREKNKLGDADIIIATPDMLLNLLLREDRLflkDLKL 107
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1351847013 152 IIVDEAHRIKnPKARVTEVMKAVKCKV------RIGLTGT 185
Cdd:cd00046   108 IIVDEAHALL-IDSRGALILDLAVRKAglknaqVILLSAT 146
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
41-194 7.19e-06

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 47.34  E-value: 7.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  41 KVISFLAAVLHKkgTREDIENNMPEFLLKSMK-------KKPPSTAKKMfLIVAPLSVLYNWKDELD--TWGYFRVTVLH 111
Cdd:cd18070    27 KTVEVLALILLH--PRPDNDLDAADDDSDEMVccpdclvAETPVSSKAT-LIVCPSAILAQWLDEINrhVPSSLKVLTYQ 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 112 GSKKDNELL-----RLKQrkCEIALTTYETLR--------------LCLEE--------LNSLEWSAIIVDEAHRIKNPK 164
Cdd:cd18070   104 GVKKDGALAspapeILAE--YDIVVTTYDVLRtelhyaeanrsnrrRRRQKryeappspLVLVEWWRVCLDEAQMVESST 181
                         170       180       190
                  ....*....|....*....|....*....|
gi 1351847013 165 ARVTEVMKAVKCKVRIGLTGTVLQNNMKEL 194
Cdd:cd18070   182 SKAAEMARRLPRVNRWCVSGTPIQRGLDDL 211
HELICc smart00490
helicase superfamily c-terminal domain;
421-466 1.47e-04

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 40.27  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1351847013  421 DVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSsqDVNICLVST 466
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNN--GKIKVLVAT 44
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
67-186 1.72e-04

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 41.84  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPstaKKMFLIVAPLSVL----Y-NWKDELDTWGYFRVTVLHGSKKDNELLRLKqrKCEIALTTYETLRLCL 141
Cdd:pfam00270  35 ALEALDKLDN---GPQALVLAPTRELaeqiYeELKKLGKGLGLKVASLLGGDSRKEQLEKLK--GPDILVGTPGRLLDLL 109
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351847013 142 EE---LNSLEWsaIIVDEAHRI--KNPKARVTEVMKAVKCKVRI-GLTGTV 186
Cdd:pfam00270 110 QErklLKNLKL--LVLDEAHRLldMGFGPDLEEILRRLPKKRQIlLLSATL 158
PRK02250 PRK02250
hypothetical protein; Provisional
210-314 5.24e-04

hypothetical protein; Provisional


Pssm-ID: 179393 [Multi-domain]  Cd Length: 166  Bit Score: 40.63  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 210 IHFKKQFSdpvEHGQRHTATKRElatgrkamhRLAKKMSGWFLrrtktlIKGQLPKKEdrmvycslTDFQKAVYQTVlet 289
Cdd:PRK02250   92 VEFKAYFD---EEGKRYCLEERS---------RFLKENGLWYY------IDGTFPEEE--------PEQDPRLNQSV--- 142
                          90       100
                  ....*....|....*....|....*
gi 1351847013 290 edVALILTSSQPCTCGSGQKRRKCC 314
Cdd:PRK02250  143 --SSLKQGRNDPCICGSGKKFKKCC 165
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
67-186 6.54e-03

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 224122 [Multi-domain]  Cd Length: 814  Bit Score: 39.17  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013  67 LLKSMKKKPPSTAKKmfLIVAPL-----SVLYNWKDELDTWGyFRVTVLHGSKKDNELLRLKQRKCEIALTTYETLRLCL 141
Cdd:COG1201    62 LLSLGKGKLEDGIYA--LYISPLkalnnDIRRRLEEPLRELG-IEVAVRHGDTPQSEKQKMLKNPPHILITTPESLAILL 138
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351847013 142 ------EELNSLEWsaIIVDEAHRIKNPK---------ARVTEVMKAVkckVRIGLTGTV 186
Cdd:COG1201   139 nspkfrELLRDVRY--VIVDEIHALAESKrgvqlalslERLRELAGDF---QRIGLSATV 193
SWIM_PBPRA1643 TIGR04102
SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have ...
301-314 6.59e-03

SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Members of this protein family have a SWIM, or SEC-C, domain (see pfam02810), a 21-amino acid putative Zn-binding domain that is shared with SecA, plant MuDR transposases, etc. This small protein family of unknown function occurs primarily in marine bacteria.


Pssm-ID: 200353 [Multi-domain]  Cd Length: 108  Bit Score: 36.13  E-value: 6.59e-03
                          10
                  ....*....|....
gi 1351847013 301 PCTCGSGQKRRKCC 314
Cdd:TIGR04102  94 PCPCGSGKKYKKCC 107
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
127-192 9.97e-03

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 38.24  E-value: 9.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1351847013 127 CEIALTTY-----------ETLRLcLEELNSLEWSAIIVDEAHRIknPKARVTEVMKAVKCKVRIGLTGTVLQNNMK 192
Cdd:TIGR00603 344 AGVVVSTYsmvahtgkrsyESEKV-MEWLTNREWGLILLDEVHVV--PAAMFRRVLTIVQAHCKLGLTATLVREDDK 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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