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Conserved domains on  [gi|1358101719|ref|NP_001348212|]
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galactose-3-O-sulfotransferase 4 isoform 1 [Mus musculus]

Protein Classification

sulfotransferase family protein( domain architecture ID 366236)

sulfotransferase family protein may catalyze the transfer of sulfate from a donor such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor substrate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sulfotransfer_2 super family cl22970
Sulfotransferase family; This family includes a variety of sulfotransferase enzymes. ...
1-463 4.24e-109

Sulfotransferase family; This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.


The actual alignment was detected with superfamily member pfam06990:

Pssm-ID: 451469  Cd Length: 400  Bit Score: 329.19  E-value: 4.24e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719   1 MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQFLGGSFQRRLPGLQLRQSWVPSLGSTVKSCLPRQRLVFLKTHKSGSS 80
Cdd:pfam06990   1 MLPILQRLQKKPWESMAKGLVLGALGFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPAECPPRRNIVFLKTHKTASS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719  81 SVLNLLHRYGDQQGLRFALPA--HYQFGYPKLFQASKVKGYhpqsadtQKPFHILCHHMRFNLKEVLQVMPSDSFFFSIV 158
Cdd:pfam06990  81 TVLNILFRFAEKHNLKVALPNgcRNDFDYPTFFAASLVQDY-------RACFNIICNHLRFHYDEVRGLMPTNTIYITIL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 159 RDPAALARSAFSYYKSVSSAFRKAPS--LAAFLSNPQAFYRPGARGNHYARNLLWFDFGLPSPPEtktmkvspqlPRDPK 236
Cdd:pfam06990 154 RDPARLFESSFHYYGPYVPAFRKLPAgdLTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLD----------PSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 237 slqlhivpsgaspgtlfrpvttaadsykqpaslvssdfrpsSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWSLD 316
Cdd:pfam06990 224 -----------------------------------------AYVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELD 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 317 DVVGFMHNAQAGKKQSLIRTanktvvtgedqQLTKQARAWNNLDWALYIHFNRSLWARIEQYGRSRLQRAVAELRARREA 396
Cdd:pfam06990 263 DVLYFKLNARRASPVPRLSG-----------ELYGRARAWNALDSHLYRHFNATFWRKVAAFGRERMAREVAALRHARER 331
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1358101719 397 LAKRCLVGGEALDP-KYIADAKLRPLQ-FGSAKVLGYVLQSGLNQKDKEECERLATPELQYKDKLDAKQ 463
Cdd:pfam06990 332 LRTICIDDGHALVDaAQIRDEALQPWQpSGKKDILGYNLKKGIGQRHAQLCRRLLMPEIQYLMDLGANQ 400
 
Name Accession Description Interval E-value
Gal-3-0_sulfotr pfam06990
Galactose-3-O-sulfotransferase; This family consists of several mammalian ...
1-463 4.24e-109

Galactose-3-O-sulfotransferase; This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.


Pssm-ID: 254007  Cd Length: 400  Bit Score: 329.19  E-value: 4.24e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719   1 MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQFLGGSFQRRLPGLQLRQSWVPSLGSTVKSCLPRQRLVFLKTHKSGSS 80
Cdd:pfam06990   1 MLPILQRLQKKPWESMAKGLVLGALGFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPAECPPRRNIVFLKTHKTASS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719  81 SVLNLLHRYGDQQGLRFALPA--HYQFGYPKLFQASKVKGYhpqsadtQKPFHILCHHMRFNLKEVLQVMPSDSFFFSIV 158
Cdd:pfam06990  81 TVLNILFRFAEKHNLKVALPNgcRNDFDYPTFFAASLVQDY-------RACFNIICNHLRFHYDEVRGLMPTNTIYITIL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 159 RDPAALARSAFSYYKSVSSAFRKAPS--LAAFLSNPQAFYRPGARGNHYARNLLWFDFGLPSPPEtktmkvspqlPRDPK 236
Cdd:pfam06990 154 RDPARLFESSFHYYGPYVPAFRKLPAgdLTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLD----------PSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 237 slqlhivpsgaspgtlfrpvttaadsykqpaslvssdfrpsSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWSLD 316
Cdd:pfam06990 224 -----------------------------------------AYVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELD 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 317 DVVGFMHNAQAGKKQSLIRTanktvvtgedqQLTKQARAWNNLDWALYIHFNRSLWARIEQYGRSRLQRAVAELRARREA 396
Cdd:pfam06990 263 DVLYFKLNARRASPVPRLSG-----------ELYGRARAWNALDSHLYRHFNATFWRKVAAFGRERMAREVAALRHARER 331
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1358101719 397 LAKRCLVGGEALDP-KYIADAKLRPLQ-FGSAKVLGYVLQSGLNQKDKEECERLATPELQYKDKLDAKQ 463
Cdd:pfam06990 332 LRTICIDDGHALVDaAQIRDEALQPWQpSGKKDILGYNLKKGIGQRHAQLCRRLLMPEIQYLMDLGANQ 400
 
Name Accession Description Interval E-value
Gal-3-0_sulfotr pfam06990
Galactose-3-O-sulfotransferase; This family consists of several mammalian ...
1-463 4.24e-109

Galactose-3-O-sulfotransferase; This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.


Pssm-ID: 254007  Cd Length: 400  Bit Score: 329.19  E-value: 4.24e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719   1 MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQFLGGSFQRRLPGLQLRQSWVPSLGSTVKSCLPRQRLVFLKTHKSGSS 80
Cdd:pfam06990   1 MLPILQRLQKKPWESMAKGLVLGALGFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPAECPPRRNIVFLKTHKTASS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719  81 SVLNLLHRYGDQQGLRFALPA--HYQFGYPKLFQASKVKGYhpqsadtQKPFHILCHHMRFNLKEVLQVMPSDSFFFSIV 158
Cdd:pfam06990  81 TVLNILFRFAEKHNLKVALPNgcRNDFDYPTFFAASLVQDY-------RACFNIICNHLRFHYDEVRGLMPTNTIYITIL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 159 RDPAALARSAFSYYKSVSSAFRKAPS--LAAFLSNPQAFYRPGARGNHYARNLLWFDFGLPSPPEtktmkvspqlPRDPK 236
Cdd:pfam06990 154 RDPARLFESSFHYYGPYVPAFRKLPAgdLTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLD----------PSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 237 slqlhivpsgaspgtlfrpvttaadsykqpaslvssdfrpsSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWSLD 316
Cdd:pfam06990 224 -----------------------------------------AYVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELD 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1358101719 317 DVVGFMHNAQAGKKQSLIRTanktvvtgedqQLTKQARAWNNLDWALYIHFNRSLWARIEQYGRSRLQRAVAELRARREA 396
Cdd:pfam06990 263 DVLYFKLNARRASPVPRLSG-----------ELYGRARAWNALDSHLYRHFNATFWRKVAAFGRERMAREVAALRHARER 331
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1358101719 397 LAKRCLVGGEALDP-KYIADAKLRPLQ-FGSAKVLGYVLQSGLNQKDKEECERLATPELQYKDKLDAKQ 463
Cdd:pfam06990 332 LRTICIDDGHALVDaAQIRDEALQPWQpSGKKDILGYNLKKGIGQRHAQLCRRLLMPEIQYLMDLGANQ 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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