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Conserved domains on  [gi|1371542595|ref|NP_001348288|]
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microfibril-associated glycoprotein 4 isoform 3 [Mus musculus]

Protein Classification

fibrinogen-related domain-containing protein (domain architecture ID 10053370)

fibrinogen-related domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
29-247 2.43e-117

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040  Cd Length: 215  Bit Score: 333.82  E-value: 2.43e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  29 QQPLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADGEYWLGLQ 108
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 109 NLHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISPnaisaEEDGYTLYVAGFEdGGAGDSLSYHSGQKFSTFDRDQDLF 188
Cdd:cd00087    81 KIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGS-----ESEGYRLTLGGYS-GTAGDALSYHNGMKFSTFDRDNDGA 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 189 VQNCAALSSGAFWFRSCHFANLNGFYLGGSH-LSYANGINWAQWKGFYYSLKRTEMKIRR 247
Cdd:cd00087   155 SGNCAESYSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIRP 214
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
29-247 2.43e-117

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 333.82  E-value: 2.43e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  29 QQPLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADGEYWLGLQ 108
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 109 NLHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISPnaisaEEDGYTLYVAGFEdGGAGDSLSYHSGQKFSTFDRDQDLF 188
Cdd:cd00087    81 KIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGS-----ESEGYRLTLGGYS-GTAGDALSYHNGMKFSTFDRDNDGA 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 189 VQNCAALSSGAFWFRSCHFANLNGFYLGGSH-LSYANGINWAQWKGFYYSLKRTEMKIRR 247
Cdd:cd00087   155 SGNCAESYSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
30-248 7.36e-113

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548  Cd Length: 212  Bit Score: 322.69  E-value: 7.36e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595   30 QPLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADGEYWLGLQN 109
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNEN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  110 LHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISPnaisaEEDGYTLYVAGFEdGGAGD-SLSYHSGQKFSTFDRDQDLF 188
Cdd:smart00186  81 IHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVAD-----EADGYRLHIGGYS-GTAGDaSLTYHNGMQFSTYDRDNDKY 154
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  189 VQNCAALSSGAFWFRSCHFANLNGFYlgGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA 248
Cdd:smart00186 155 SGNCAEEYGGGWWYNNCHAANLNGRY--YPNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
31-246 7.78e-79

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095  Cd Length: 221  Bit Score: 236.65  E-value: 7.78e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  31 PLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFG-RADGEYWLGLQN 109
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGnLSPGEFWLGNDK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 110 LHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISpnaisAEEDGYTLYVAGF------EDGGAGDSLSYHSGQKFSTFDR 183
Cdd:pfam00147  82 IHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVT-----NENDKYRLHVENYigdagdALDTAGRSMTYHNGMQFSTWDR 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371542595 184 DQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIR 246
Cdd:pfam00147 157 DNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQNGIIWATWKGRWYSMKKAEMKIR 219
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
29-247 2.43e-117

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 333.82  E-value: 2.43e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  29 QQPLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADGEYWLGLQ 108
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 109 NLHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISPnaisaEEDGYTLYVAGFEdGGAGDSLSYHSGQKFSTFDRDQDLF 188
Cdd:cd00087    81 KIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGS-----ESEGYRLTLGGYS-GTAGDALSYHNGMKFSTFDRDNDGA 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 189 VQNCAALSSGAFWFRSCHFANLNGFYLGGSH-LSYANGINWAQWKGFYYSLKRTEMKIRR 247
Cdd:cd00087   155 SGNCAESYSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
30-248 7.36e-113

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548  Cd Length: 212  Bit Score: 322.69  E-value: 7.36e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595   30 QPLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFGRADGEYWLGLQN 109
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNEN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  110 LHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISPnaisaEEDGYTLYVAGFEdGGAGD-SLSYHSGQKFSTFDRDQDLF 188
Cdd:smart00186  81 IHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVAD-----EADGYRLHIGGYS-GTAGDaSLTYHNGMQFSTYDRDNDKY 154
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  189 VQNCAALSSGAFWFRSCHFANLNGFYlgGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA 248
Cdd:smart00186 155 SGNCAEEYGGGWWYNNCHAANLNGRY--YPNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
31-246 7.78e-79

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095  Cd Length: 221  Bit Score: 236.65  E-value: 7.78e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595  31 PLDCDDIYAQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWSDYKLGFG-RADGEYWLGLQN 109
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGnLSPGEFWLGNDK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371542595 110 LHLLTLKQKYELRVDLEDFENNTAYAKYIDFSISpnaisAEEDGYTLYVAGF------EDGGAGDSLSYHSGQKFSTFDR 183
Cdd:pfam00147  82 IHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVT-----NENDKYRLHVENYigdagdALDTAGRSMTYHNGMQFSTWDR 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371542595 184 DQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIR 246
Cdd:pfam00147 157 DNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQNGIIWATWKGRWYSMKKAEMKIR 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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