|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
20-476 |
0e+00 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 655.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 20 HLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGL 99
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 180 GLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaen 259
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 260 eddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGG 339
Cdd:cd17342 213 ------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 340 IIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGN 419
Cdd:cd17342 263 IIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGS 342
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981438 420 SEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17342 343 SEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
22-479 |
4.36e-100 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 306.55 E-value: 4.36e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 22 AVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLfLGTLDTVFLFSYAVGLFI 101
Cdd:cd17344 3 FILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNIVLNNTTWCGWAPFDGKNGTEL-LGALDSAFLFAYAIGMFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 102 SGIIGDRLNLRWVLSFGMCSSAFVVFVFGtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGL 181
Cdd:cd17344 82 SGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 182 WSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaened 261
Cdd:cd17344 161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 262 dyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGII 341
Cdd:cd17344 211 ----------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIV 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 342 GGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSR-SPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGNS 420
Cdd:cd17344 263 GGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYfGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNA 342
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981438 421 EALATVTGIVDGTGSIGAAVGQYLVSLIQDnLGWMWVFYFFILMTSCTILFILPLIVRE 479
Cdd:cd17344 343 RALATVTAIIDGTGSIGAALGPLLAGLISS-RGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
23-476 |
2.59e-98 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 300.73 E-value: 2.59e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 23 VFLLTFFSYSLLHASRKTFSNVKVSISKQWtpnafntsldlpaeiwssnhlfpstEEATLFLGTLDTVFLFSYAVGLFIS 102
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEI-------------------------GLSKDDLGIIGSAFLIAYAVGKFIS 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 103 GIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEwlhfynKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLW 182
Cdd:cd17312 59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTS------LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIW 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 183 SACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaened 261
Cdd:cd17312 133 STSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 262 dyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGII 341
Cdd:cd17312 183 ----------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 342 GGTLLGFISDVL--QKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQeliqgn 419
Cdd:cd17312 235 GTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRK------ 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981438 420 sEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17312 309 -EAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
84-475 |
1.27e-31 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 125.82 E-value: 1.27e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhFYNKWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA--TSSVGLMFILLFLNGWFQGMGWPPSG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGN----ILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSI 239
Cdd:cd17345 118 RTMVHWFSKKERGTWTSIWNISHNVGGglvgPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 240 gAEESSEEDSQrplidgaENEDDYEPNYSIQEdravvqvkaISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSN 319
Cdd:cd17345 198 -EEYKGDYPEE-------ADGEEEEQELSAWE---------IFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 320 NFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQK--RAPVLALSLFLAVGSLVGYSRSPNNKSINALLmTITGFFIGG 397
Cdd:cd17345 261 VKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYWLAPNVLVDLIAL-IALGFLIYG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 398 PSNMVS-SAIsadlgrqELIQGNseALATVTGIVDGTGSI-GAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPL 475
Cdd:cd17345 340 PVMLIGlQAL-------ELVPKK--AAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALV 410
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
84-478 |
8.90e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 119.59 E-value: 8.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsigae 242
Cdd:COG2271 121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALLRFWLL--------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2271 186 -----------------------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKR-APVLALSLFLAVGSLVGYSRSPNNkSINALLMTITGFFIGGPSNM 401
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981438 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLIVR 478
Cdd:COG2271 292 LWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
84-454 |
8.27e-22 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 97.06 E-value: 8.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGA--FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGA 241
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 242 EESSEEDSQRPLidgAENEddyepnysiqedravVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNF 321
Cdd:TIGR00881 186 MPNEEPDGDAEK---KEEE---------------LTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 322 GWKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAPVLALSLFLAVGSLVGYSRSP-NNKSINALLMTITGFFIGGP 398
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPaANPLMDLICLFALGFLVYGP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981438 399 SNMVSSAISadlgrqELiqGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGW 454
Cdd:TIGR00881 328 QMLIGVIAS------EL--APKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGW 375
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
84-476 |
1.70e-21 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 96.70 E-value: 1.70e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTewlhfyNKWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGae 242
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVG-- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseEDSQRPLIDGAENEDDYEPNYSIQEdRAVVQVKAIsFHQACClpgvipYSLAYACLKLVNYsfffWLPFYLSNNFG 322
Cdd:PRK11663 212 ----EWRHDALELAQQQEGAGLSRKEILT-KYVLLNPYI-WLLSFS------YVLVYVVRAAIND----WGNLYMSETLG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAP---VLALSLFLAVGSLvgYSRSPNNKSINALLMTITGFFIGG 397
Cdd:PRK11663 276 VDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPmnlIFAAGILLSVGSL--WLMPFASYVMQAACFFTIGFFVFG 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 398 PSNMVSSAiSADLGRQeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWvFYFFILMTSCTI-LFILPLI 476
Cdd:PRK11663 354 PQMLIGMA-AAECSHK-------EAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTG-FFVVISIAAGISaLLLLPFL 424
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
21-245 |
2.41e-18 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 87.00 E-value: 2.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 21 LAVFLLTFFSYSLLHASRKTFSNVKVSISKqwtpnafNTSLDLPAeiwssnhlfpsteeatlfLGTLDTVFLFSYAVGLF 100
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMN-------ELGLDKSD------------------LGLITSSQSLAYAISKF 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 101 ISGIIGDRLNLRWVLSFGMCSSAFVVFVFGtltewlHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFG 180
Cdd:cd17343 57 IGGVLSDQISARWLFSSGLVLSGLTTVAFS------GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWS 130
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981438 181 LWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESS 245
Cdd:cd17343 131 VLSTSMNLAGSLGPILATLLaLSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESK 196
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
84-476 |
8.54e-18 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 84.76 E-value: 8.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNkwfycgLWIVNGLLQSTGWPCVV 163
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAV------LWTLNAFFQGWGWPPCA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGae 242
Cdd:cd17488 114 RLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAaLTYGWRAGMYVPGIIAILMGIVLCWRLRDRPPYIWLLAFC-- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclpgvipYSLAYACLKLVNYsfffWLPFYLSNNFG 322
Cdd:cd17488 192 ----------------------------------------------------YVLVYVVRTAIND----WGNLYLSETHG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQK--RAP---VLALSLFLAVGSLvgYSRSPNNKSINALLMTITGFFIGG 397
Cdd:cd17488 216 YSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKgnRGPmnlIFALGLLVSVGAL--WLVPVHSYWLLATCFFTIGFFVFG 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981438 398 PSNMVSSAiSADLGRQeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17488 294 PQMLIGMA-AAECSHK-------DAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPLL 364
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
84-475 |
2.57e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 80.31 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:cd17319 40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY------VLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsigae 242
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAFIIEGLLGLLLAVLWWFYL--------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:cd17319 179 -----------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISD--VLQKRAPVLALSLFLAVGSLVGYSRSPnNKSINALLMTITGFFIGGPSn 400
Cdd:cd17319 212 FSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAAS- 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981438 401 MVSSAISADLGRqeliqgnSEALATVTGIVDGTGSIGAAVGQYLVS-LIQDNLGWMWVFYFFILMTSCTILFILPL 475
Cdd:cd17319 290 PVFWSLPADLLP-------GEAAATAGGLINSGGNLGGFVAPLLIGyLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
84-441 |
9.08e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.61 E-value: 9.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVL-QYGYEYAFLVTASVQFAGGIIIFFGllvspeeiglpsigae 242
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLP---------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseedsqrplidgaenedDYEPNYSIQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLsNNFG 322
Cdd:pfam07690 172 -------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSL-VGYSRSPNNKSINALLMTITGFFIGGPSNM 401
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1371981438 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVG 441
Cdd:pfam07690 312 LNALVSDLAPK--------EERGTASGLYNTAGSLGGALG 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
84-479 |
1.03e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.77 E-value: 1.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFynkwFYCGLWIvnGLLQSTGWPCVV 163
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL----LLLGLLL--GIGGGGSFAVGI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEeiglpsigae 242
Cdd:COG2223 116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPA---------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 esseedsqrplidgaeneddyepnysiqEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2223 186 ----------------------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLqKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMV 402
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371981438 403 SSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYFFILMTSCTILFILPLIVRE 479
Cdd:COG2223 317 FALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
89-444 |
2.19e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 78.06 E-value: 2.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHfyNKWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL----LTAAVK--NFGGLIALRFFLGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 169 WFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-------YGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSiga 241
Cdd:cd17327 122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT--- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 242 EESSEEDSQRplidgaeneddyepnysIQEDRAVVQVKAISFHQ---ACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLS 318
Cdd:cd17327 199 EEEKELAVER-----------------LRANQTGKGDQKFKWKQikeAFKDPRTWLLFLFFFCSQITNNGISNFLPLILK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 319 NNfGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAP-VLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGG 397
Cdd:cd17327 262 SL-GFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLfAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGF 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1371981438 398 PSNM--VSSAISADLGRqeliqgnsealATVTGIVDGTGSIGAAVGQYL 444
Cdd:cd17327 341 PILLswISSNCAGYTKR-----------ATVLAIMLIFYNVGNIVAPQI 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
81-473 |
1.00e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.54 E-value: 1.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWP 160
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------WLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIG 240
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 241 AEESSEEDSQRPLIDGAENeddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNN 320
Cdd:cd06174 184 NEEASSKSVLKLLKRVLKN------------------------------PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 321 FGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSInALLMTITGFFIGGPSN 400
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-LLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371981438 401 MVSSAISadlgrqelIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQD-NLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd06174 313 LSFALIA--------ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
84-440 |
1.57e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 74.63 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:COG2814 47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL------WLLLAARFLQGLGAGALFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAE 242
Cdd:COG2814 121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 ESSEEDsqrplidgaeneddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2814 201 RELLRR-----------------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPNNKSInALLMTITGFFIGGPSNMV 402
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALAGSLWLL-LLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 1371981438 403 SSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAV 440
Cdd:COG2814 318 QALVAELAPP--------EARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
82-473 |
3.21e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 3.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 82 LFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPC 161
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsig 240
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 241 aeesseedsqrplidgaenEDDYEPNYSIQEDRAVVQVKAISFHQAcclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNN 320
Cdd:cd17325 172 -------------------PEPRPPPNKRAVSAARLRSGLRLLLRD---RRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 321 FGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPnnksiNALLMTITGFFIGGPSN 400
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371981438 401 MVSSAISADLGRqeliQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFF-ILMTSCTILFIL 473
Cdd:cd17325 304 LVFPATLALLAD----IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAaALLLLAAVLFLL 373
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
94-477 |
4.31e-12 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 67.81 E-value: 4.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 94 SYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLtEW----------LHFYNKWFycglwivngllQSTGWPCVV 163
Cdd:PRK11273 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV-PWatssiavmfvLLFLCGWF-----------QGMGWPPCG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGA--FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIga 241
Cdd:PRK11273 143 RTMVHWWSQKERGGIVSVWNCAHNVGGGLPPllFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPI-- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 242 eesseedsqrplidgAENEDDYEPNYSiQEDRAVVQVKAISFHQAccLPGVIPYSLAYA--CLKLVNYSFFFWLPFYLSN 319
Cdd:PRK11273 221 ---------------EEYKNDYPDDYN-EKHEQELTAKQIFMQYV--LPNKLLWYIAIAnvFVYLLRYGILDWSPTYLKE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 320 NfgwKEAEADKLSiW----YDVGGIIGGTLLGFISDVLQK--RAPVLALSLFL-AVGSLVGYSRSPNNKSINALLMTITG 392
Cdd:PRK11273 283 V---KHFALDKSS-WayflYEYAGIPGTLLCGWMSDKVFRgnRGATGVFFMTLvTIATIVYWLNPAGNPTVDMACMIVIG 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 393 FFIGGPSNMVssaisadlGRQELIQGNSEALATVTGIVDGTGSIGAAV-GQYLVSLIQDNLGWMWVfyfFILMTSCTILF 471
Cdd:PRK11273 359 FLIYGPVMLI--------GLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGG---FMVMIGGSILA 427
|
....*.
gi 1371981438 472 ILPLIV 477
Cdd:PRK11273 428 VILLIV 433
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
81-398 |
3.21e-11 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 65.45 E-value: 3.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHfYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:PRK09556 63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGS-VSLGLMIALWALSGFFQSTGGP 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLA---SSVLQYGYEYAFLVTASVqfAGGIIIFFGLLV---SPEEI 234
Cdd:PRK09556 142 CSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVAlwgANYFFDGHVIGMFIFPSI--IALIIGFIGLRYgsdSPEEL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 235 GL---PSIGAEESSEEDsqrplidgAENEDDYEPNYSIQEdRAVVQVKAISFhqaCCLPGVIPYslayaclkLVNYSFFF 311
Cdd:PRK09556 220 GWgkaEEIFGEPISEED--------KETESTDMTKWQIFV-EYVLKNPVIWL---LCFANIFLY--------IVRIGIDN 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 312 WLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQ-KRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTI 390
Cdd:PRK09556 280 WSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALALIIFTLGVYQHATSEYMYLASLFAL 359
|
....*...
gi 1371981438 391 tGFFIGGP 398
Cdd:PRK09556 360 -GFLVFGP 366
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
84-227 |
2.38e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF------WLLLLLLALLGLGLGLVFPATL 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17325 311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
84-473 |
5.61e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.94 E-value: 5.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLhfynkWFYCGLWIV---NGLLQSTGWP 160
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLglgLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 161 CVVAVmgnwfGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYE----YAFLVTASVQFAGGIIIFFgllvspeeIGL 236
Cdd:COG0738 120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLILAVLLLLLALLFLR--------SKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 237 PSIGAEESSEEDSQRplidgaeneddyepnysiqedravvqvkaiSFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFY 316
Cdd:COG0738 187 PEIEEEEEEAAGSAA------------------------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 317 LSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLqKRAPVLALSLFLAVGSLVGYSRSPNNkSINALLMTITGFFIg 396
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGP-WLALIGLALVGLGL- 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371981438 397 gpSNMVSSAISAdlgrqeLIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:COG0738 314 --SLMFPTIFSL------ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
84-473 |
1.81e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 53.11 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00893 31 YGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLY------ILRVLLGAAEAPFFPGII 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLpsigae 242
Cdd:TIGR00893 105 LIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIhFSWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKW------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 ESSEEDSqrpLIDGAENEDdyepnysiQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:TIGR00893 179 LTEEEKY---IVVGGLLAE--------QQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLA-----VGSLVGYSRSPNNKSINALLMTITGFFIGG 397
Cdd:TIGR00893 248 LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAiiaglVLSLLMFATNYVNIPYAALALVALGFFGLG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 398 PSNMVSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYF---FILMTSCTILFIL 473
Cdd:TIGR00893 328 AGAIGWALISDNAPG--------NIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVvaaLALIGALSYLLLV 399
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
84-453 |
7.77e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 7.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF------WQLLLFRALVGIGEASYSPIAP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV--LQYGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsiga 241
Cdd:cd17328 110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLFV-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 242 eesseEDSQRPLIDGAENEDDYEPNYsIQEDRAVVQVKAISFHqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNF 321
Cdd:cd17328 176 -----REPPRGAAEGGVMAKSTATSF-LADLKALAKNPSFILS-----------TLGFTAVSFVTGALAFWAPTFFLRAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 322 GWKEAEADKLSIWYDVGGIIG----GTLLGFISDVLQKRAP-----VLALSLFLAVGSLVGysrSPNNKSINALLMTITG 392
Cdd:cd17328 239 GVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFL---ALVLALSNLLLAWVLL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371981438 393 FFIGGPSNMVSSAISADLgrQELIQGNSEALATVTGIVdGTGSIGAAVGQYLVSLIQDNLG 453
Cdd:cd17328 316 FLGEFLLSLNWAPVFAIL--LYVVIPTRRSTASAIQIL-LSHLLGDAGSPYLIGLISDLLR 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
84-473 |
1.85e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL------AGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAgRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEeiglpsiGAE 242
Cdd:COG2807 129 GLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPA-------AAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 243 ESSEEDSQRPLIdgaeneddyepnysiqEDRAVVQVkaisfhqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNfG 322
Cdd:COG2807 201 AAPAAASLRSLW----------------RSPLAWLL-----------------TLFFGLQSLLYYAVVAWLPPILRDA-G 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNnkSINALLMTITGFFIGGPSNMV 402
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981438 403 SSAISadlgrqeLIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYFFILMTSCTILFIL 473
Cdd:COG2807 325 LTLIG-------LRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-227 |
1.94e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP------WLFAIALVLTGFGGGLFEPASEA 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981438 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17329 112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
81-224 |
2.55e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFgtltewLHFYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF------LLTPGIWSYILLVLAGFLLFASFPV 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371981438 161 CVVAVMGNWFGKAG--RGVVFGLwsaCASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIF 224
Cdd:cd17478 303 TVVLAQELLPGNVGlaSGLMMGL---SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
84-473 |
7.29e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 7.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLwiVNGLLQSTGWPCVV 163
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL--GAGILDTGANTFVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 AVMGNWFGKAgRGVVFGLWSACASVGNILGAFLASSVLqyGYEYAFLVTASVQFAGGIIIFFGLLvspeeiglpsigaee 243
Cdd:cd17333 111 ALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSEL--SWSWAYLIIGLIYLLLAILILLTLF--------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 244 sseedsqrplidgAENEDDYEPNYSIQEDRAVVQVKAISfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGW 323
Cdd:cd17333 173 -------------PELPSARNPQQSVGAFSASASRLLRN-------PSIILGALALFLYVGAETAFSSWVPSYLVEKKHV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 324 KEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRApVLALSLFLAVGSLVGYSRSPnNKSINALLMTITGFFIGGpsnMVS 403
Cdd:cd17333 233 SDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT-LLVLSGSGALLGLLILLLAP-TLVVGLVATALLGLFMAA---LFP 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 404 SAISadlgrqELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMtsCTILFIL 473
Cdd:cd17333 308 TILS------LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITIL--YAIIFVL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-225 |
1.45e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 76 STEEATLFLGtldtVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGtlteWLHFYNKWFYCGLWIVNGLLQ 155
Cdd:COG2211 262 SAALVGLLLA----LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF----FLGPGNLWLLLVLAALAGIGL 333
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371981438 156 STGWPCVVAVM------GNW-FGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:COG2211 334 GAILVLPWAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAlFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
84-241 |
1.86e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.34 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMcssafVVFVFGTL-------TEWLhfynkwfyCGLWIVNGLLQS 156
Cdd:COG0477 51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL-----LLFGLASLlcglapsPELL--------IAARALQGIGAG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 157 TGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVqfagGIIIFFGLLVSPEEIG 235
Cdd:COG0477 118 GLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPL----GLLALVLRLRLPESRG 193
|
....*.
gi 1371981438 236 LPSIGA 241
Cdd:COG0477 194 LLLALL 199
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
25-215 |
2.19e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.84 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 25 LLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFP-STEEATLFLGTldtvFLFSYAVGLFISG 103
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDwSEKTQGIILSS----FFYGYILTQIPGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 104 IIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWS 183
Cdd:cd17318 78 YLAEKYGAKRVLGYSILITALLTL----LTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153
|
170 180 190
....*....|....*....|....*....|....
gi 1371981438 184 ACASVGNILgAFLASSVL--QYGYEYAFLVTASV 215
Cdd:cd17318 154 SGSQFGTVI-AMPLSGFLceSLGWPSIFYIFGGL 186
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-230 |
3.89e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 9 RGALLTSFSHHHLAVFLLTFFSYSLlhasrktfsnVKVSISkQWTPNAFNTSLDLPAEIwssnhlfpsteeATLFLgtld 88
Cdd:COG0738 200 AASLKSLLKNPRLLLGGLAIFLYVG----------AEGAIG-DWLPLYLKDVLGLSEAT------------AALGL---- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTewlhfyNKWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP------GPWLALIGLALVGLGLSLMFPTIFSLALD 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981438 169 WFGKAGrGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTAsvqFAGGIIIFFGLLVS 230
Cdd:COG0738 327 GLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADaFGLRAAFLVPL---VCYLLILLLALALK 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
89-453 |
7.65e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLF---ISGIIGDRLNLRW-----VLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:COG2211 50 LILLVARLWDAItdpLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 161 CVVAVMGNWFGKAG-RGVVFGLWSACASVGNILGAFLASSVLQY-------GYEYAFLVTASVQFAGGIIIFFGLlvspe 232
Cdd:COG2211 130 PYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGT----- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 233 eiglpsigAEESSEEDSQRPLIDGAeneddyepnysiqedRAVVQVKAISFHqacclpgvipySLAYACLKLVNYSFFFW 312
Cdd:COG2211 205 --------KERPVPEEEKVSLKESL---------------KALLKNRPFLLL-----------LLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 313 LPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITG 392
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371981438 393 FFIGGPsNMVSSAISADLGRQELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG 453
Cdd:COG2211 331 IGLGAI-LVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
85-473 |
8.63e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 8.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMcssafVVFVFGTLTEWLHfYNKWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLL-----LLFILGNLLAALA-PSFALLLLARALAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFgllvspeeiGLPSIGAEE 243
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWR---------LLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 244 SSEEDSQRPLIDGAENeddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGW 323
Cdd:cd17324 182 PGSLGLLSSLLLLLRN------------------------------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 324 KEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYsrSPNNKSINALLMTITGFFIGGPSNMVS 403
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL--LGPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 404 SAISadlgrqeliQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd17324 310 TRVL---------RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
84-225 |
2.09e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL------WLLLAALFLLGLAGGLFNVPLN 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371981438 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
84-246 |
2.21e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.38 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYnkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL----LMALVGSY--PVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 164 -AVMGnWFGKAGRGVVFGLWSACASVGNILGA-FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGA 241
Cdd:cd17475 107 rAIMR-WFPPRERGLAMGIRQTGVPLGGALAAaLLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAS 185
|
....*
gi 1371981438 242 EESSE 246
Cdd:cd17475 186 TLLRS 190
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
25-214 |
2.55e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 43.31 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 25 LLTFFSYSLLHASRKTFSNVKVSISKQwtpnaFNtsldlpaeiWSSNhlfpsteeatlFLGTLDTVFLFSYAVGLFISGI 104
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKE-----FG---------WSKT-----------DQGLVLSSFFWGYALTQVLGGY 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 105 IGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSA 184
Cdd:cd17380 57 LADRFGGKKVLLLAVALWSLATL----LTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTA 132
|
170 180 190
....*....|....*....|....*....|.
gi 1371981438 185 CASVGNILGAFLASSVL-QYGYEYAFLVTAS 214
Cdd:cd17380 133 GSYLGTLLGGLIGPLLLeYYGWPSVFYFFGL 163
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
89-251 |
3.68e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFG--MCSSAFVVFVFGTltewlhfYNKWFYCGLWIVNGLLQSTGWPCVVAVM 166
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGgiLFGLGFILSAFAI-------SLPLLFLGYGVLGGIGAGIGYITPVSTA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 167 GNWFgKAGRGVVFGLWSACASVGNILGAFLASSVL-QYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESS 245
Cdd:cd17353 118 VKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLInTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN 196
|
....*.
gi 1371981438 246 EEDSQR 251
Cdd:cd17353 197 AENSPR 202
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
89-224 |
7.33e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFynkWFYCGLW-IVNGLLQSTGwPCVVAVMG 167
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLL---LLGFILWgLYMGAQESIE-RAAVADLV 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1371981438 168 nwfGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIF 224
Cdd:cd17370 317 ---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDlISPSAAFLFSAVLALIALLLLL 371
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
349-473 |
1.03e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.58 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 349 ISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINAllMTITGFfIGGPSNmvssaiSADLGRQELIQGNSE--ALATV 426
Cdd:pfam06609 101 LTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAA--MTLLGV-AAGPAG------ASPLFIGELMSNKTKflGLLIV 171
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1371981438 427 TGIVDGTGSIGAAVGQYLVslIQDNlgWMWVFYFFILMTSCTILFIL 473
Cdd:pfam06609 172 SAPTIAMNGAGPYFGQRLA--IQGN--WRWIFYIYIIMSAIAVLLII 214
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
100-225 |
2.35e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL------LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1371981438 180 GLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
160-227 |
3.52e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 3.52e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981438 160 PCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17391 312 PAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
82-225 |
4.17e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 82 LFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTeWLHFYNKWFYCGLWIVNGLLQSTGWPC 161
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLA-LLGSLSLWLLLVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371981438 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLF 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
85-225 |
4.95e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV------ALLLVLRLIHGIGWGAFTTAAAT 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371981438 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd17489 108 LVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVLALLALLLVFL 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
80-473 |
8.50e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 80 ATLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGW 159
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP------ILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 160 PCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-----LQYGYEYAFLVtasvqfaGGIIIFFGLLVSpeei 234
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllsGDWGWRILFLI-------GALPALLALLLR---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 235 glpsigaeesseedsqrplidgaeneddyepnysiqedRAVVQVkaisfhqacclpgvipySLAYACLKLVNYSFFFWLP 314
Cdd:cd17316 177 --------------------------------------RRTLLL-----------------ILLWFFISFGYYGLTTFLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 315 FYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFF 394
Cdd:cd17316 202 TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371981438 395 IGGPSNMVSSAISADLGRqeliqgnSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd17316 281 FVGGVWGALYAYLAELFP-------TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
89-197 |
8.53e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.46 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371981438 89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFgmcsSAFVVFVFGTLTEWLHFYnkWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLL----STLVTAVSGVLTAFSPNY--TVFLVFRLLVGMGIGGIWVQAVVLNTE 207
|
90 100
....*....|....*....|....*....
gi 1371981438 169 WFGKAGRGVVFGLWSACASVGNILGAFLA 197
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLVA 236
|
|
| |
