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Conserved domains on  [gi|1376477400|ref|NP_001349274|]
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sodium/potassium/calcium exchanger 4 isoform 2 [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 5.49e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 5.49e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSN---------------------------------------------- 270
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKvmalgdlskgdvaeaehtgertgeegerpteaegengeesggeaeq 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  271 --ELEDVKEKPPYGKTPVVMVDE-------------------ILSSSPPKFTFPE------------------------- 304
Cdd:TIGR00927  670 egETETKGENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegea 749

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  305 -AGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPPP 378
Cdd:TIGR00927  750 eGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVK 829

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  379 QPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKWV 409
Cdd:TIGR00927  830 DETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYL 909

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  410 FTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLI 489
Cdd:TIGR00927  910 FLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI 989

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  490 VARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLG 569
Cdd:TIGR00927  990 VARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650
                   ....*....|....*...
gi 1376477400  570 IYVLVLYAVFLCFSIMIE 587
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 5.49e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 5.49e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSN---------------------------------------------- 270
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKvmalgdlskgdvaeaehtgertgeegerpteaegengeesggeaeq 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  271 --ELEDVKEKPPYGKTPVVMVDE-------------------ILSSSPPKFTFPE------------------------- 304
Cdd:TIGR00927  670 egETETKGENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegea 749

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  305 -AGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPPP 378
Cdd:TIGR00927  750 eGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVK 829

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  379 QPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKWV 409
Cdd:TIGR00927  830 DETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYL 909

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  410 FTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLI 489
Cdd:TIGR00927  910 FLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI 989

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  490 VARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLG 569
Cdd:TIGR00927  990 VARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650
                   ....*....|....*...
gi 1376477400  570 IYVLVLYAVFLCFSIMIE 587
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-582 2.25e-37

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 140.27  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 120 DFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 200 WWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMKYNMKMQtffttkqksiANGNPVSNELEDVKEKP 279
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKE----------PAWEEVEEELEEKPKMS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 280 pygktpvvmvdeilsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvnskplqngrhenmengn 359
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 360 vpvenpedpqqgqeqqpppqppppepesvetvflspfsmpeakgdkakwvftWPLIFLLcvtipncskprwekffmvtFI 439
Cdd:COG0530   150 ----------------------------------------------------LWKALLL-------------------LV 158

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 440 TATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPw 519
Cdd:COG0530   159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG- 237

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376477400 520 glqtMVInygSTVKINSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCF 582
Cdd:COG0530   238 ----ALI---TPIPVDPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 433-585 9.05e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.07  E-value: 9.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 433 FFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 512
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376477400 513 VGLGIPWGLqTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGIYVLVLYAVFLCFSIM 585
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 457-580 2.20e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 62.36  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 457 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKins 536
Cdd:PRK10734  198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLAFSR--- 274

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1376477400 537 rglVYSVVLLLgSVALTVLGIhLNKWRLDRKLGIYVLVLYAVFL 580
Cdd:PRK10734  275 ---DYWVMLLV-SVIFALLCW-RRKRRIGRGAGALLLGGFIVWL 313
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 5.49e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 5.49e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSN---------------------------------------------- 270
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKvmalgdlskgdvaeaehtgertgeegerpteaegengeesggeaeq 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  271 --ELEDVKEKPPYGKTPVVMVDE-------------------ILSSSPPKFTFPE------------------------- 304
Cdd:TIGR00927  670 egETETKGENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegea 749

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  305 -AGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPPP 378
Cdd:TIGR00927  750 eGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVK 829

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  379 QPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKWV 409
Cdd:TIGR00927  830 DETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYL 909

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  410 FTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLI 489
Cdd:TIGR00927  910 FLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI 989

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  490 VARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLG 569
Cdd:TIGR00927  990 VARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650
                   ....*....|....*...
gi 1376477400  570 IYVLVLYAVFLCFSIMIE 587
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 102-579 8.92e-45

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 161.34  E-value: 8.92e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 102 LHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 181
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 182 LCIIGVCGLFAgQVVRLTWWaVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILimkynmkmqtFFTTKQKS 261
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLL----------FLVKNERW 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 262 IANGNpvsneledvkekppygktpvvMVDEILSssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsang 341
Cdd:TIGR00367 149 VKYDT---------------------YTEENLD----------------------------------------------- 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 342 vnskplqngrhenmengnvpvENPEDpqqgqeqqpppqppppepesvetvflspfsmpeakgdkakwvftwPLIFllcvt 421
Cdd:TIGR00367 161 ---------------------ENNRR---------------------------------------------PQIF----- 169

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 422 ipncskprwekFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 501
Cdd:TIGR00367 170 -----------FSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVG 238

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376477400 502 NTIGSNVFDILVGLGIPWGLQTMvinygsTVKINSRGLVYSVVLLlgsVALTVLGIHLNKWRLDRKLGIYVLVLYAVF 579
Cdd:TIGR00367 239 NVIGSNIFNILVGLGVPSLFMPI------PVEPLAYNLDAPVMVI---VTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-582 2.25e-37

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 140.27  E-value: 2.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 120 DFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 200 WWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMKYNMKMQtffttkqksiANGNPVSNELEDVKEKP 279
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKE----------PAWEEVEEELEEKPKMS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 280 pygktpvvmvdeilsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvnskplqngrhenmengn 359
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 360 vpvenpedpqqgqeqqpppqppppepesvetvflspfsmpeakgdkakwvftWPLIFLLcvtipncskprwekffmvtFI 439
Cdd:COG0530   150 ----------------------------------------------------LWKALLL-------------------LV 158

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 440 TATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPw 519
Cdd:COG0530   159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG- 237

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376477400 520 glqtMVInygSTVKINSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCF 582
Cdd:COG0530   238 ----ALI---TPIPVDPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 433-585 9.05e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.07  E-value: 9.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 433 FFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 512
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376477400 513 VGLGIPWGLqTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGIYVLVLYAVFLCFSIM 585
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 1.90e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 102.30  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 103 HILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376477400 183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-245 1.96e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 94.81  E-value: 1.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  79 DPAIHEFPTDLFSNKERQHGAVLLHILGALymfyALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASV 158
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 159 IGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG-----QVVRLTWWAVcrdsvyyTLSVIVLIAFIY-DEEIVWWEGL 232
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPipvdpAVLSFDLPVM-------LAATLLLLGLLRtGGRIGRWEGL 280

                         170
                  ....*....|...
gi 1376477400 233 VLIILYVFYILIM 245
Cdd:COG0530   281 LLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
463-587 4.71e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.86  E-value: 4.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 463 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIpwglqTMVInygSTVKINSRGLVYS 542
Cdd:COG0530    15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGL-----AALI---RPLAVDRRVLRRD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1376477400 543 VVLLLGSVALTVLGIHLNkwRLDRKLGIYVLVLYAVFLCFSIMIE 587
Cdd:COG0530    87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 108-238 2.43e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.21  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 108 LYMFYALAIVCDDFfVPSLEKICEK---------------LHL---SEDVAGATFMAAGSSTPELFASVIGVF---ITHG 166
Cdd:TIGR00845  83 VYMFLGVSIIADRF-MASIEVITSQekeitikkpngettvTTVriwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 167 DVGVGTIVGSAVFNILCIIGVCGLF--AGQVVRL----------TWwavcrdSVYYTLSVIVLIAFIYDEEIVWWEGLVL 234
Cdd:TIGR00845 162 DLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtaAW------SVFAYVWLYLILAVFSPGVVEVWEGLLT 235


                  ....
gi 1376477400 235 IILY 238
Cdd:TIGR00845 236 FFFF 239
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 438-584 6.99e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.58  E-value: 6.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 438 FITATLWIAVFSY-LMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 516
Cdd:TIGR00367   6 YLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376477400 517 IPWGLqtmvinygSTVKINSRGLVYSVVLLLGSVALtvLGIHLNKWRLDRKLGIYVLVLYAVFLCFSI 584
Cdd:TIGR00367  86 LSAIF--------SPIIVDKDWLRRDILFYLLVSIL--LLFFGLDGQISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 436-554 1.36e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 67.51  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 436 VTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLG-DMAVSNTIGSNVFDILVG 514
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1376477400 515 LGIPWGLQTMV-INYGSTVKINSRGLVYSVVLLLGSVALTV 554
Cdd:TIGR00845 837 IGVAWSIAAIYhAANGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 457-580 2.20e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 62.36  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 457 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKins 536
Cdd:PRK10734  198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLAFSR--- 274

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1376477400 537 rglVYSVVLLLgSVALTVLGIhLNKWRLDRKLGIYVLVLYAVFL 580
Cdd:PRK10734  275 ---DYWVMLLV-SVIFALLCW-RRKRRIGRGAGALLLGGFIVWL 313
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 452-586 5.66e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.20  E-value: 5.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 452 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINygST 531
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH--SD 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376477400 532 VKINSRGLVYSVVLLLGSValtvlgihLNKWRLDRKLGIYVLVLYAVFLCFSIMI 586
Cdd:PRK10734  100 VLRRELPLMLLVSVLAGSV--------LYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 98-584 6.96e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 62.09  E-value: 6.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  98 GAVLLHI-LGALymFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASvIGVFI--THGDVGVGTIV 174
Cdd:PLN03151  139 GYAVLGVwLVAL--FYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 175 GSAVFNILCIIGVCGL-FAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMKYNMKMQT 253
Cdd:PLN03151  216 GGAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRK 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 254 F-FTTKQKSIANGNPV-----SNELEDvkEKPPYgkTPVVMVDE-----ILSSSPPKFTFpeaglrimitnkfgprtrlr 322
Cdd:PLN03151  296 HaRRLKLDVVTPLLPVqgsifSPSVEE--DESMY--SPLLESDTesdvpRLQTSLPQWMW-------------------- 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 323 mASRIIINERQRLINSANGvNSKPLQNGRHENMENGNVP---------VENPEDPQQGQEQQPPPQPPPPEPESVETVFL 393
Cdd:PLN03151  352 -ASNVAIYSNHFAKGSVHD-EERPPWGWTDEGAEVESSLfscsklfslLEMPLTIPRRLTIPIVEEDRWSKTYAVASASL 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 394 SP------FSMPEAKGDKAKWVFTWPLIFLLCV--------TIPNcSKPRWEKFFMVT--FITATLWIAVFSYLMVWLVT 457
Cdd:PLN03151  430 APvllaflWSSQDDVSLQARIAAYFIGVAIGSTlgflaykyTEPD-RPPRRFLIPWVLggFIMSIVWFYMIANELVALLV 508

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 458 IIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGlGD---MAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKI 534
Cdd:PLN03151  509 AFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLP 587

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1376477400 535 NSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFSI 584
Cdd:PLN03151  588 EDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 101-245 2.72e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.81  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400 101 LLHILGALYMFYALAIVCDDFFVPSLekiceklhlsedVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 180
Cdd:PRK10734   13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1376477400 181 ILCIIGVCGLFAGQVVRLtwwAVCRDSVYYTLSVIVLIAFI-YDEEIVWWEGLVLIILYVFYILIM 245
Cdd:PRK10734   81 ILLILGLAALIRPFTVHS---DVLRRELPLMLLVSVLAGSVlYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 99-192 1.43e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.33  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477400  99 AVLLHILGALYMFYALAIVCDDFFVpslekICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAV 178
Cdd:PRK10734  175 AFLWLGIALIIMPMATRMVIDNATV-----LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNI 249

                          90
                  ....*....|....
gi 1376477400 179 FNILCIIGVCGLFA 192
Cdd:PRK10734  250 FNIVIVLGLPALIS 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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