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Conserved domains on  [gi|1391723758|ref|NP_001350485|]
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proteasomal ATPase-associated factor 1 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
92-392 1.78e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.78e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 171
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 172 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 251
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 252 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 329
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723758 330 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 392
Cdd:COG2319   337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
92-392 1.78e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.78e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 171
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 172 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 251
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 252 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 329
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723758 330 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 392
Cdd:COG2319   337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-339 1.32e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 1.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  90 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 169
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 170 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 240
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 241 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 303
Cdd:cd00200   166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1391723758 304 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 339
Cdd:cd00200   243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-163 1.92e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1391723758  124 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 163
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
168-205 5.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1391723758 168 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 205
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 92-210 2.53e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 166
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1391723758 167 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 210
Cdd:PLN00181  650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
92-392 1.78e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.78e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 171
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 172 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 251
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 252 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 329
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723758 330 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 392
Cdd:COG2319   337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-339 1.32e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 1.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  90 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 169
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 170 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 240
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 241 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 303
Cdd:cd00200   166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1391723758 304 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 339
Cdd:cd00200   243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-205 1.82e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 171
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1391723758 172 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 205
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
90-392 5.97e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 5.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  90 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 169
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 170 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVA---------VGAADNSI---NLG 237
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfspdgkllaSGSDDGTVrlwDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 238 SPEQMPS----EREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQ 306
Cdd:COG2319   193 TGKLLRTltghTGAVRSVAfspdgKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPdGRLLASGSADGTVRL 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 307 LDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVA--TWEKQIYTCCR 381
Cdd:COG2319   273 WDLATGE-LLRTLTGHSGGVNSVAFSPDGkLLASGSdDGTVRLWDlATGKLLRTLTGHT-GAVRSVAfsPDGKTLASGSD 350

                         330
                  ....*....|.
gi 1391723758 382 DGLVRRYQLSD 392
Cdd:COG2319   351 DGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-347 8.23e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 8.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 127 LRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 206
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 207 GRSACLGVLADCGSSINGVAVgaadnsinlgspeqMPSERevgteakMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFN 285
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAF--------------SPDGR-------ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVN 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391723758 286 CCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG--FIASQGDGSCFI 347
Cdd:cd00200   140 SVAFSpDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
102-392 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 102 SSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 181
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 182 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSI---NLGSPEQMPSEREVG 249
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspdgktlasGSADGTVrlwDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 250 TEA---------KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQLDVRSPRaPVQV 318
Cdd:COG2319   163 GAVtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPdGKLLASGSADGTVRLWDLATGK-LLRT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758 319 IHRSGAPVLSLLSVRDG-FIAS-QGDGSCFIVQ-QDLDYVTELTGADcDPVYKVAtW---EKQIYTCCRDGLVRRYQLSD 392
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGrLLASgSADGTVRLWDlATGELLRTLTGHS-GGVNSVA-FspdGKLLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-163 1.54e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 1.54e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391723758  90 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 163
Cdd:cd00200   216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-163 1.92e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1391723758  124 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 163
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-205 2.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1391723758  168 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 205
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
168-205 5.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1391723758 168 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 205
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
125-163 1.36e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1391723758 125 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 163
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 92-210 2.53e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723758  92 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 166
Cdd:PLN00181  574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1391723758 167 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 210
Cdd:PLN00181  650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-120 5.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 1391723758   92 HTKSITCLDISSRGGLGVSSSTDGTMKIW 120
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
92-120 6.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.35e-04
                          10        20
                  ....*....|....*....|....*....
gi 1391723758  92 HTKSITCLDISSRGGLGVSSSTDGTMKIW 120
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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