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Conserved domains on  [gi|1393169456|ref|NP_001350609|]
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zinc finger protein 584 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-329 4.41e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 144 CPTGRSAFKKSAHINPRKIHTGETAH-------VCNECGKAFSYPSKLRKHQ--KVHTG--IKPFKC--SDCGKTFNRKD 210
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEkgfslpiKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 211 ALVLHQRIHTGERPYEC--SKCGKTFSVLST-----LIRHRKVHIGERPYECT--ECGKFFKYNNSFILHQRVHTGERP- 280
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1393169456 281 -FECKQCGKGYVTRSGLYQHWKVHTGERPYECSLCGKTFTTRSYRNRHQQ 329
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-329 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 144 CPTGRSAFKKSAHINPRKIHTGETAH-------VCNECGKAFSYPSKLRKHQ--KVHTG--IKPFKC--SDCGKTFNRKD 210
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEkgfslpiKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 211 ALVLHQRIHTGERPYEC--SKCGKTFSVLST-----LIRHRKVHIGERPYECT--ECGKFFKYNNSFILHQRVHTGERP- 280
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1393169456 281 -FECKQCGKGYVTRSGLYQHWKVHTGERPYECSLCGKTFTTRSYRNRHQQ 329
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 1393169456 184 LRKHQKVHTGIKPFKCSDCGKTFNR 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-329 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 144 CPTGRSAFKKSAHINPRKIHTGETAH-------VCNECGKAFSYPSKLRKHQ--KVHTG--IKPFKC--SDCGKTFNRKD 210
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEkgfslpiKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 211 ALVLHQRIHTGERPYEC--SKCGKTFSVLST-----LIRHRKVHIGERPYECT--ECGKFFKYNNSFILHQRVHTGERP- 280
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1393169456 281 -FECKQCGKGYVTRSGLYQHWKVHTGERPYECSLCGKTFTTRSYRNRHQQ 329
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-360 1.96e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 176 KAFSYPSKLRKHQKVHTGI-KPFKCSDCGKTFNRKDALVLHQR--IHTGE--RPYEC--SKCGKTFSVLSTLIRHRKVHI 248
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 249 GERPYECTECGKFFKYNNSFIlhqrvhtgERPFECkqcgkgyvtrsgLYQHWKVHTgERPYECSL--CGKTFTTRSYRNR 326
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLLN--------NEPPQS------------LQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSL 406

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1393169456 327 HQQFHTEERSYEC--TECGKAFKHSSTLLQHKKVHT 360
Cdd:COG5048   407 HIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-243 2.33e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 117 SDCGKVFLKAFALLDHLITHSEERPFRCPTGRSAFKKS--------AHINPRKIHTGETAHVC--NECGKAFSYPSKLRK 186
Cdd:COG5048   327 SLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1393169456 187 HQKVHT--GIKPFKCSDCGKTFNRKDALVLHQRIHTGERPYECSKCGKtFSVLSTLIRH 243
Cdd:COG5048   407 HIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 1393169456 184 LRKHQKVHTGIKPFKCSDCGKTFNR 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 277-357 1.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393169456 277 GERPFECK--QCGKGYVTRSGLYQHwKVHtgerpyecSLCGKTFTTRSYRNRHQQFHTEERSYECTECGKAFKHSSTLLQ 354
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1393169456 355 HKK 357
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-235 2.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*
gi 1393169456 211 ALVLHQRIHTGERPYECSKCGKTFS 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 4.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.21e-03
                          10        20
                  ....*....|....*....|....*
gi 1393169456 240 LIRHRKVHIGERPYECTECGKFFKY 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 197-219 4.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|...
gi 1393169456 197 FKCSDCGKTFNRKDALVLHQRIH 219
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 192-252 5.44e-03

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 38.63  E-value: 5.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393169456 192 TGIKP------FKCSDCGKTFnrkdalVLHQRIHTGERPYECSKCGKT--FSVL---STLIRHRKVHIGERP 252
Cdd:COG1241   118 TEVKPkiteaaFECPRCGTET------YVPQTGEKLQEPHECPGCGRQgpFKLLpekSEFIDAQKIRIQEPP 183
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 169-191 7.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.13e-03
                          10        20
                  ....*....|....*....|...
gi 1393169456 169 HVCNECGKAFSYPSKLRKHQKVH 191
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-233 8.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393169456 169 HVCNECGKAFSYPSKLRKHQKVHTGIKPFKCSD--CGKTFNRKDALVLHQRIHTGERPYECSKCGKT 233
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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