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Conserved domains on  [gi|1402624250|ref|NP_001351358|]
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pro-neuregulin-1, membrane-bound isoform isoform 10 precursor [Mus musculus]

Protein Classification

EGF_CA and Neuregulin domain-containing protein( domain architecture ID 11076467)

EGF_CA and Neuregulin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neuregulin super family cl20026
Neuregulin intracellular region;
155-311 1.62e-84

Neuregulin intracellular region;


The actual alignment was detected with superfamily member pfam02158:

Pssm-ID: 426627  Cd Length: 360  Bit Score: 258.61  E-value: 1.62e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 155 TKKQRQKLHDRLRQSLRSERNNMvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 234
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 235 VTQTPSH---SWSNGHTESIISESHSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRECNSFLRHARETPDSYRDSPHSE 310
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  .
gi 1402624250 311 R 311
Cdd:pfam02158 159 R 159
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 78-108 2.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1402624250  78 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 108
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
155-311 1.62e-84

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 258.61  E-value: 1.62e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 155 TKKQRQKLHDRLRQSLRSERNNMvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 234
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 235 VTQTPSH---SWSNGHTESIISESHSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRECNSFLRHARETPDSYRDSPHSE 310
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  .
gi 1402624250 311 R 311
Cdd:pfam02158 159 R 159
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 78-108 2.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1402624250  78 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 108
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 78-110 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1402624250  78 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 110
Cdd:cd00054    11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
PHA02887 PHA02887
EGF-like protein; Provisional
 69-111 7.28e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 36.06  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1402624250  69 KCAEKEKTFCVNGgECFMVKDLSnpsRYLCKCQPGFTGARCTE 111
Cdd:PHA02887   85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
155-311 1.62e-84

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 258.61  E-value: 1.62e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 155 TKKQRQKLHDRLRQSLRSERNNMvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 234
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402624250 235 VTQTPSH---SWSNGHTESIISESHSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRECNSFLRHARETPDSYRDSPHSE 310
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  .
gi 1402624250 311 R 311
Cdd:pfam02158 159 R 159
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 78-108 2.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1402624250  78 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 108
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 78-110 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1402624250  78 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 110
Cdd:cd00054    11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
PHA02887 PHA02887
EGF-like protein; Provisional
 69-111 7.28e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 36.06  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1402624250  69 KCAEKEKTFCVNGgECFMVKDLSnpsRYLCKCQPGFTGARCTE 111
Cdd:PHA02887   85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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