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Conserved domains on  [gi|1495458077|ref|NP_001353822|]
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DENN domain-containing protein 5B isoform 6 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655191)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  11563850|21330364

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 209-397 2.98e-82

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 255.96  E-value: 2.98e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 209 YVSKSICLITPLPFMQACKKFLIQLYKAVTSQqPPPLPLESYIHNILYEVPLPPPGRSLKFY--GVYEPVICQRPGPSEL 286
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTIS-PLPNPIERFIANLLYEVPFPPPGRTQKLKplGGTEPILLQRPEDSEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 287 PLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPY 366
Cdd:pfam02141  80 PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1495458077 367 LMGLQSKEGtdrsKLELPQEANLCFVDIDNH 397
Cdd:pfam02141 160 IIGVHSRYF----DLLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 19-142 8.43e-27

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 8.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077   19 CRFAHYFVLCGIDADSGlepdelavlyqwleadrhgksqgaanttsgenfdqsPLRRTFKSKVLAHYPQNIEWNPFDQDA 98
Cdd:smart00800   2 SRLFDYFVVVGLDSDTG------------------------------------PLGRSYKPEILQRYPEKDFEDFPLPDS 45

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1495458077   99 VNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY 142
Cdd:smart00800  46 IPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 209-397 2.98e-82

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 255.96  E-value: 2.98e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 209 YVSKSICLITPLPFMQACKKFLIQLYKAVTSQqPPPLPLESYIHNILYEVPLPPPGRSLKFY--GVYEPVICQRPGPSEL 286
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTIS-PLPNPIERFIANLLYEVPFPPPGRTQKLKplGGTEPILLQRPEDSEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 287 PLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPY 366
Cdd:pfam02141  80 PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1495458077 367 LMGLQSKEGtdrsKLELPQEANLCFVDIDNH 397
Cdd:pfam02141 160 IIGVHSRYF----DLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 210-397 1.28e-67

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 217.83  E-value: 1.28e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077  210 VSKSICLITPLPFMQACKKFLIQLYKavTSQQPPPLPLESYIHNILYevPLPPPGRSLKFY--GVYEPVICQRPGPSELP 287
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYR--LLPSSSNLPLELLISLLLY--PVPPPGGSLVLVslGPGDLIELQRPLDSSLP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077  288 LSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYL 367
Cdd:smart00799  77 LIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                          170       180       190
                   ....*....|....*....|....*....|
gi 1495458077  368 MGLQSKEGTDRSKLELPqeaNLCFVDIDNH 397
Cdd:smart00799 157 IGVHSSYFEEVKELPDE---DVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 19-142 8.43e-27

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 8.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077   19 CRFAHYFVLCGIDADSGlepdelavlyqwleadrhgksqgaanttsgenfdqsPLRRTFKSKVLAHYPQNIEWNPFDQDA 98
Cdd:smart00800   2 SRLFDYFVVVGLDSDTG------------------------------------PLGRSYKPEILQRYPEKDFEDFPLPDS 45

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1495458077   99 VNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY 142
Cdd:smart00800  46 IPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 79-140 3.22e-17

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 75.72  E-value: 3.22e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1495458077  79 SKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDnkdPQFHSFIITREDGSRTYGFVLT 140
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSRE---PTFFSFVLTDEDGSRLYGACLT 59
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 209-397 2.98e-82

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 255.96  E-value: 2.98e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 209 YVSKSICLITPLPFMQACKKFLIQLYKAVTSQqPPPLPLESYIHNILYEVPLPPPGRSLKFY--GVYEPVICQRPGPSEL 286
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTIS-PLPNPIERFIANLLYEVPFPPPGRTQKLKplGGTEPILLQRPEDSEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077 287 PLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPY 366
Cdd:pfam02141  80 PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1495458077 367 LMGLQSKEGtdrsKLELPQEANLCFVDIDNH 397
Cdd:pfam02141 160 IIGVHSRYF----DLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 210-397 1.28e-67

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 217.83  E-value: 1.28e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077  210 VSKSICLITPLPFMQACKKFLIQLYKavTSQQPPPLPLESYIHNILYevPLPPPGRSLKFY--GVYEPVICQRPGPSELP 287
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYR--LLPSSSNLPLELLISLLLY--PVPPPGGSLVLVslGPGDLIELQRPLDSSLP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077  288 LSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYL 367
Cdd:smart00799  77 LIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                          170       180       190
                   ....*....|....*....|....*....|
gi 1495458077  368 MGLQSKEGTDRSKLELPqeaNLCFVDIDNH 397
Cdd:smart00799 157 IGVHSSYFEEVKELPDE---DVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 19-142 8.43e-27

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 103.95  E-value: 8.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495458077   19 CRFAHYFVLCGIDADSGlepdelavlyqwleadrhgksqgaanttsgenfdqsPLRRTFKSKVLAHYPQNIEWNPFDQDA 98
Cdd:smart00800   2 SRLFDYFVVVGLDSDTG------------------------------------PLGRSYKPEILQRYPEKDFEDFPLPDS 45

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1495458077   99 VNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY 142
Cdd:smart00800  46 IPLFCFPEGLDFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 79-140 3.22e-17

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 75.72  E-value: 3.22e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1495458077  79 SKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDnkdPQFHSFIITREDGSRTYGFVLT 140
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSRE---PTFFSFVLTDEDGSRLYGACLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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