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Conserved domains on  [gi|1579876428|ref|NP_001355677|]
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paired box protein Pax-2 isoform 6 [Mus musculus]

Protein Classification

PAX and Pax2_C domain-containing protein( domain architecture ID 10646823)

protein containing domains PAX, homeodomain, and Pax2_C

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
15-139 4.08e-89

Paired Box domain;


:

Pssm-ID: 128645  Cd Length: 125  Bit Score: 265.34  E-value: 4.08e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428   15 RHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 94
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1579876428   95 VDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR 139
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
281-366 3.77e-46

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


:

Pssm-ID: 432530  Cd Length: 113  Bit Score: 154.56  E-value: 3.77e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428 281 SSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAW 360
Cdd:pfam12403   2 SLPSFSAFAHLGSSYGQFQSYSLVPGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEAW 81

                  ....*.
gi 1579876428 361 RFSNPA 366
Cdd:pfam12403  82 RFPNPS 87
homeodomain super family cl00084
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
231-254 8.00e-03

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 444687  Cd Length: 54  Bit Score: 34.41  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|....
gi 1579876428 231 TFTQQQLEALDRVFERPSYPDVFQ 254
Cdd:pfam00046   4 TFTPEQLEELEKEFQENPYPSREE 27
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
15-139 4.08e-89

Paired Box domain;


Pssm-ID: 128645  Cd Length: 125  Bit Score: 265.34  E-value: 4.08e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428   15 RHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 94
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1579876428   95 VDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR 139
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
16-141 1.08e-83

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 251.57  E-value: 1.08e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  16 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVV 95
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEVV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1579876428  96 DKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTK 141
Cdd:cd00131    82 KKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
16-139 1.38e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 251.33  E-value: 1.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  16 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVV 95
Cdd:pfam00292   2 HGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEVV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1579876428  96 DKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR 139
Cdd:pfam00292  82 TKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
281-366 3.77e-46

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 432530  Cd Length: 113  Bit Score: 154.56  E-value: 3.77e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428 281 SSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAW 360
Cdd:pfam12403   2 SLPSFSAFAHLGSSYGQFQSYSLVPGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEAW 81

                  ....*.
gi 1579876428 361 RFSNPA 366
Cdd:pfam12403  82 RFPNPS 87
COG3415 COG3415
Transposase [Mobilome: prophages, transposons];
29-120 1.53e-03

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 225949 [Multi-domain]  Cd Length: 138  Bit Score: 38.52  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  29 GRPLPDVVRQRIVELAH-QGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNpT 107
Cdd:COG3415     2 AKPFSNDLRERVVDAVVgEGLSCREAAKRFGVSISTVYRWVRRYRETGLDLPPKPRKGRPRKLSEEQLEILLERLREK-D 80
                          90
                  ....*....|...
gi 1579876428 108 MFAWEIRDRLLAE 120
Cdd:COG3415    81 WTLKELVEELGLE 93
Homeobox pfam00046
Homeobox domain;
231-254 8.00e-03

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 34.41  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|....
gi 1579876428 231 TFTQQQLEALDRVFERPSYPDVFQ 254
Cdd:pfam00046   4 TFTPEQLEELEKEFQENPYPSREE 27
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
15-139 4.08e-89

Paired Box domain;


Pssm-ID: 128645  Cd Length: 125  Bit Score: 265.34  E-value: 4.08e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428   15 RHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 94
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1579876428   95 VDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR 139
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
16-141 1.08e-83

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 251.57  E-value: 1.08e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  16 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVV 95
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEVV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1579876428  96 DKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTK 141
Cdd:cd00131    82 KKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
16-139 1.38e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 251.33  E-value: 1.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  16 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVV 95
Cdd:pfam00292   2 HGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEVV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1579876428  96 DKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR 139
Cdd:pfam00292  82 TKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
281-366 3.77e-46

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 432530  Cd Length: 113  Bit Score: 154.56  E-value: 3.77e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428 281 SSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAW 360
Cdd:pfam12403   2 SLPSFSAFAHLGSSYGQFQSYSLVPGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEAW 81

                  ....*.
gi 1579876428 361 RFSNPA 366
Cdd:pfam12403  82 RFPNPS 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
29-78 1.02e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1579876428  29 GRPLPDVVRQRIVE-LAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIK 78
Cdd:cd00090     1 LKALSDPTRLRILRlLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVE 51
COG3415 COG3415
Transposase [Mobilome: prophages, transposons];
29-120 1.53e-03

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 225949 [Multi-domain]  Cd Length: 138  Bit Score: 38.52  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1579876428  29 GRPLPDVVRQRIVELAH-QGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNpT 107
Cdd:COG3415     2 AKPFSNDLRERVVDAVVgEGLSCREAAKRFGVSISTVYRWVRRYRETGLDLPPKPRKGRPRKLSEEQLEILLERLREK-D 80
                          90
                  ....*....|...
gi 1579876428 108 MFAWEIRDRLLAE 120
Cdd:COG3415    81 WTLKELVEELGLE 93
Homeobox pfam00046
Homeobox domain;
231-254 8.00e-03

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 34.41  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|....
gi 1579876428 231 TFTQQQLEALDRVFERPSYPDVFQ 254
Cdd:pfam00046   4 TFTPEQLEELEKEFQENPYPSREE 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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