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Conserved domains on  [gi|1591647145|ref|NP_001355988|]
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zinc finger protein 64 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-553 3.92e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 248 LRSHTASVLENDVQKPaGLPAEESDAQQAPAVTLSLEakertatlgertFNCRYPGCHFKTVHGMKDLDRHLRIHTGDKP 327
Cdd:COG5048   111 SSSSSNSNDNNLLSSH-SLPPSSRDPQLPDLLSISNL------------RNNPLPGNNSSSVNTPQSNSLHPPLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 328 HKCEFCDKCFSRKDNLTM---------------------HMRCHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKC 386
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSipsssensplsssysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 387 QLCPYASR------NSSQLTVHLRSHTG-DTPFQCWLCSAKFKISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKA 453
Cdd:COG5048   258 SESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 454 NLKSHIRIkHTFKCLHCA--------FQGRDRADLLEHSRLHQADHPEKCPECSYSCSNPAALR-----VHSRVHCTDRP 520
Cdd:COG5048   338 ALKRHILL-HTSISPAKEkllnssskFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRP 416

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1591647145 521 --FKCDFCSFDTKRPSSLakhidKVHREGAKTENR 553
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNL-----IPHKKIHTNHAP 446
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-553 3.92e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 248 LRSHTASVLENDVQKPaGLPAEESDAQQAPAVTLSLEakertatlgertFNCRYPGCHFKTVHGMKDLDRHLRIHTGDKP 327
Cdd:COG5048   111 SSSSSNSNDNNLLSSH-SLPPSSRDPQLPDLLSISNL------------RNNPLPGNNSSSVNTPQSNSLHPPLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 328 HKCEFCDKCFSRKDNLTM---------------------HMRCHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKC 386
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSipsssensplsssysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 387 QLCPYASR------NSSQLTVHLRSHTG-DTPFQCWLCSAKFKISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKA 453
Cdd:COG5048   258 SESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 454 NLKSHIRIkHTFKCLHCA--------FQGRDRADLLEHSRLHQADHPEKCPECSYSCSNPAALR-----VHSRVHCTDRP 520
Cdd:COG5048   338 ALKRHILL-HTSISPAKEkllnssskFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRP 416

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1591647145 521 --FKCDFCSFDTKRPSSLakhidKVHREGAKTENR 553
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNL-----IPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 3.66e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.66e-05
                          10        20
                  ....*....|....*....|....*.
gi 1591647145 314 DLDRHLRIHTGDKPHKCEFCDKCFSR 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-553 3.92e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 170 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVH 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 248 LRSHTASVLENDVQKPaGLPAEESDAQQAPAVTLSLEakertatlgertFNCRYPGCHFKTVHGMKDLDRHLRIHTGDKP 327
Cdd:COG5048   111 SSSSSNSNDNNLLSSH-SLPPSSRDPQLPDLLSISNL------------RNNPLPGNNSSSVNTPQSNSLHPPLPANSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 328 HKCEFCDKCFSRKDNLTM---------------------HMRCHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKC 386
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSipsssensplsssysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 387 QLCPYASR------NSSQLTVHLRSHTG-DTPFQCWLCSAKFKISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKA 453
Cdd:COG5048   258 SESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 454 NLKSHIRIkHTFKCLHCA--------FQGRDRADLLEHSRLHQADHPEKCPECSYSCSNPAALR-----VHSRVHCTDRP 520
Cdd:COG5048   338 ALKRHILL-HTSISPAKEkllnssskFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRP 416

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1591647145 521 --FKCDFCSFDTKRPSSLakhidKVHREGAKTENR 553
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNL-----IPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 3.66e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.66e-05
                          10        20
                  ....*....|....*....|....*.
gi 1591647145 314 DLDRHLRIHTGDKPHKCEFCDKCFSR 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-443 8.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 312 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 381
Cdd:COG5048   302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1591647145 382 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 443
Cdd:COG5048   382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 2.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 1591647145 159 DMERHLKIHTGDKPHKCEVCGKCFSR 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-463 3.47e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 380 DERPYKCQL--CPYASRNSSQLTVH-LRSHtgdtpfqcwlCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLK 456
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1591647145 457 SHIRIKH 463
Cdd:COG5189   416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-209 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|..
gi 1591647145 188 LKTHMRCHTGVKPYKCKTCDYA 209
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-369 1.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 170 DKPHKCEVCGKCFSRKDKLKTHMRC--HTG--VKPYKC--KTCDYAAADSSSLNKHLRIHSDERPFKCQICPyASRNSSQ 243
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLN-SSSKFSP 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 244 LTVHLrsHTASVLENDVQKPAGLPAEESDAQQAPAVTLSLEAKERTATLGERTFNCRYPGCHfktvhgmkdldrhlriht 323
Cdd:COG5048   366 LLNNE--PPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS------------------ 425

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1591647145 324 gdkphkcefcdKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSS 369
Cdd:COG5048   426 -----------KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-606 1.42e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 325 DKPHKCEFCDKCFSRKDNLTMHMRCHTSVKPHKCHL--CDYAAVDSSSLKKHLRIH----SDERPYKCQLCPYASRNSSQ 398
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHhnnpSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 399 LTVHLRSHTGDTPFQCWLCSAKFKISSDLkRHMIVHSGEKPFKCEFCDVRCTMKANLKSHIRIKHTFKCLHcafqGRDRA 478
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPD-LLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP----SSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591647145 479 DLLEHSRLHQADHPEKCPECSYSCSNPAALRVHSRVH---CTDRPFKCDFC--SFDTKRPSSLAKHIDKVHregAKTENR 553
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssSLPLTTNSQLSpkSLLSQSPSSLSSSDSSSS---ASESPR 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1591647145 554 APPGKDGPGESGPNHVPNVSTQRAFG---CDKCGASFVRDDSLRCHRKQHSDWGEN 606
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGFSLpikSKQCNISFSRSSPLTRHLRSVNHSGES 318
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1591647145 426 DLKRHMIVHSGEKPFKCEFCDVRCT 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-364 4.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.76e-03
                          10        20
                  ....*....|....*....|...
gi 1591647145 342 NLTMHMRCHTSVKPHKCHLCDYA 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
201-224 6.28e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.45  E-value: 6.28e-03
                          10        20
                  ....*....|....*....|....
gi 1591647145 201 YKCKTCDYAAADSSSLNKHLRIHS 224
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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