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Conserved domains on  [gi|1770967196|ref|NP_001362516|]
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fetuin-B isoform 1 precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 150-255 1.41e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.08  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196  150 TCPDCPSSIPTDSSnhQVLEAATESLAKYNNENTSKQYSLF-KVTRASSQWVVGPSYFVEYLIKESPCTKSQaSSCSLQS 228
Cdd:smart00043   1 LCLGGPSDVPPNDP--EVQEAADFAVAEYNKKSNDKYELRViKVVSAKSQVVAGTNYYLKVEVGETNCKKLS-VDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1770967196  229 SDSVPVGLCKGSLTRTHWEKF---VSVTCD 255
Cdd:smart00043  78 FLDQGEKFCTAKVWEKPWENKiklVEFKCT 107
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-122 6.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.98  E-value: 6.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196   36 CNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQeyRRGGLGSLFYLTLDVLETDCHVLRKKaWQDCgmrIFFESVYG 115
Cdd:smart00043  11 PNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK--SQVVAGTNYYLKVEVGETNCKKLSVD-LENC---PFLDQGEK 84


                   ....*..
gi 1770967196  116 QCKAIFY 122
Cdd:smart00043  85 FCTAKVW 91
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 150-255 1.41e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.08  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196  150 TCPDCPSSIPTDSSnhQVLEAATESLAKYNNENTSKQYSLF-KVTRASSQWVVGPSYFVEYLIKESPCTKSQaSSCSLQS 228
Cdd:smart00043   1 LCLGGPSDVPPNDP--EVQEAADFAVAEYNKKSNDKYELRViKVVSAKSQVVAGTNYYLKVEVGETNCKKLS-VDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1770967196  229 SDSVPVGLCKGSLTRTHWEKF---VSVTCD 255
Cdd:smart00043  78 FLDQGEKFCTAKVWEKPWENKiklVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 154-246 7.59e-12

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 60.81  E-value: 7.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196 154 CPSSIPTDSSNhqVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVP 233
Cdd:pfam00031   2 GLSPIPDNSPE--LQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKW 79

                          90
                  ....*....|...
gi 1770967196 234 VGLCKGSLTRTHW 246
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-122 6.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.98  E-value: 6.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196   36 CNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQeyRRGGLGSLFYLTLDVLETDCHVLRKKaWQDCgmrIFFESVYG 115
Cdd:smart00043  11 PNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK--SQVVAGTNYYLKVEVGETNCKKLSVD-LENC---PFLDQGEK 84


                   ....*..
gi 1770967196  116 QCKAIFY 122
Cdd:smart00043  85 FCTAKVW 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 153-254 6.89e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 58.64  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196 153 DCPSSIPTDSSnhQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSV 232
Cdd:cd00042     1 GGPSDIPANDP--EVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLE 78

                          90       100
                  ....*....|....*....|....*..
gi 1770967196 233 --PVGLCKGSLTRTHWEKF---VSVTC 254
Cdd:cd00042    79 egKKKFCTAKVWEKPWENFkelLSFKC 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-137 1.10e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 40.92  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196  31 LLSRGCNDSDVLAVAGFALRDINKDRKDGYvLRLNRVNDAQEYRRGGLgsLFYLTLDVLETDCHVLRKKAWQdCGMRIFF 110
Cdd:cd00042     3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGT--NYYITVEAGDTNCKKSSVPLDC-PDCKLLE 78

                          90       100
                  ....*....|....*....|....*..
gi 1770967196 111 ESVYGQCKAIFYMNNPSRVLYLAAYNC 137
Cdd:cd00042    79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 150-255 1.41e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.08  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196  150 TCPDCPSSIPTDSSnhQVLEAATESLAKYNNENTSKQYSLF-KVTRASSQWVVGPSYFVEYLIKESPCTKSQaSSCSLQS 228
Cdd:smart00043   1 LCLGGPSDVPPNDP--EVQEAADFAVAEYNKKSNDKYELRViKVVSAKSQVVAGTNYYLKVEVGETNCKKLS-VDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1770967196  229 SDSVPVGLCKGSLTRTHWEKF---VSVTCD 255
Cdd:smart00043  78 FLDQGEKFCTAKVWEKPWENKiklVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 154-246 7.59e-12

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 60.81  E-value: 7.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196 154 CPSSIPTDSSNhqVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVP 233
Cdd:pfam00031   2 GLSPIPDNSPE--LQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKW 79

                          90
                  ....*....|...
gi 1770967196 234 VGLCKGSLTRTHW 246
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-122 6.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.98  E-value: 6.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196   36 CNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQeyRRGGLGSLFYLTLDVLETDCHVLRKKaWQDCgmrIFFESVYG 115
Cdd:smart00043  11 PNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAK--SQVVAGTNYYLKVEVGETNCKKLSVD-LENC---PFLDQGEK 84


                   ....*..
gi 1770967196  116 QCKAIFY 122
Cdd:smart00043  85 FCTAKVW 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 153-254 6.89e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 58.64  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196 153 DCPSSIPTDSSnhQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSV 232
Cdd:cd00042     1 GGPSDIPANDP--EVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLE 78

                          90       100
                  ....*....|....*....|....*..
gi 1770967196 233 --PVGLCKGSLTRTHWEKF---VSVTC 254
Cdd:cd00042    79 egKKKFCTAKVWEKPWENFkelLSFKC 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-137 1.10e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 40.92  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967196  31 LLSRGCNDSDVLAVAGFALRDINKDRKDGYvLRLNRVNDAQEYRRGGLgsLFYLTLDVLETDCHVLRKKAWQdCGMRIFF 110
Cdd:cd00042     3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGT--NYYITVEAGDTNCKKSSVPLDC-PDCKLLE 78

                          90       100
                  ....*....|....*....|....*..
gi 1770967196 111 ESVYGQCKAIFYMNNPSRVLYLAAYNC 137
Cdd:cd00042    79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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