|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
496-990 |
3.09e-140 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 436.19 E-value: 3.09e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 496 SLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:COG0553 241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRfnihsRYEDYNVIVTT----SDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:COG0553 321 LDGTRERAKGAN-----PFEDADLVITSygllRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGT 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQsiYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRI 731
Cdd:COG0553 396 PVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEK--GDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEET 468
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 732 ELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNV---MMQLRKMANHPllhrqyytaeklkemsQLMLKEPThceanp 808
Cdd:COG0553 469 LYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGLIlaaLTRLRQICSHP----------------ALLLEEGA------ 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 809 dlifedmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQH 888
Cdd:COG0553 527 --------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGI 574
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 889 RYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVI 968
Cdd:COG0553 575 EYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVY 654
|
490 500
....*....|....*....|..
gi 1772790412 969 KLISQGTIEESMLKINQQKLKL 990
Cdd:COG0553 655 KLVAEGTIEEKILELLEEKRAL 676
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
497-672 |
7.06e-117 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 356.70 E-value: 7.06e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQIRFNIHSRYEDYNVIVTT-------SDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 649
Cdd:cd17998 81 YGSQEERKHLRYDILKGLEDFDVIVTTynlatsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|...
gi 1772790412 650 GTPVQNNLLELMSLLNFVMPHMF 672
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
476-991 |
1.18e-112 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 372.98 E-value: 1.18e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 476 LTGNGGGWNIEQPSILNQSLslKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPA 554
Cdd:PLN03142 151 LGGSGGTRLLVQPSCIKGKM--RDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPK 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 555 STIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMG 630
Cdd:PLN03142 229 STLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVA-GKFDVCVTSFEmaikEKTALKRFSWRYIIIDEAHRIKNEN 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 631 SIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKsADEQsiyekERIAHAKQIIKP 710
Cdd:PLN03142 308 SLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGE-NDQQ-----EVVQQLHKVLRP 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 711 FILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQyytaekl 790
Cdd:PLN03142 381 FLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFQG------- 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 791 kemsqlmlkepthCEANPDLIFEDmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFS 870
Cdd:PLN03142 454 -------------AEPGPPYTTGE--------------------------HLVENSGKMVLLDKLLPKLKERDSRVLIFS 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 871 QFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTD-MDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYND 949
Cdd:PLN03142 495 QMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVD 574
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1772790412 950 KQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE 991
Cdd:PLN03142 575 LQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
497-672 |
3.18e-80 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 258.65 E-value: 3.18e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKErGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRfnIHSRYEDYNVIVTT----SDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:cd17919 81 YHGSQRERAQIR--AKEKLDKFDVVLTTyetlRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGT 158
|
170 180
....*....|....*....|.
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMF 672
Cdd:cd17919 159 PLQNNLEELWALLDFLDPPFL 179
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
497-715 |
4.43e-77 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 251.89 E-value: 4.43e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNiHSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:cd18003 81 YYGSAKERKLKRQG-WMKPNSFHVCITSYQlvvqDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSSKTKSADEQS-IYEKERIAHAKQIIKPFILRR 715
Cdd:cd18003 160 PLQNSLMELWSLMHFLMPHIFQSHQ-EFKEWFSNPLTAMSEGSqEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
500-778 |
6.44e-76 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 251.06 E-value: 6.44e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 500 YQKVGLNWL-ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN--GPHLIVVPASTIDNWLREVNLWC--PTLKVL 574
Cdd:pfam00176 1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 575 CYYGSQEERKQIrFNIHSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTG 650
Cdd:pfam00176 81 VLHGNKRPQERW-KNDPNFLADFDVVITTYEtlrkHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 651 TPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSktksaDEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDR 730
Cdd:pfam00176 160 TPLQNNLEELWALLNFLRPGPFGSL-STFRNWFDR-----PIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEY 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1772790412 731 IELCAMSEKQEQLYLGL-----FNRLKKSINNLEKNTEMCNVMMQLRKMANHP 778
Cdd:pfam00176 234 ILFCRLSKLQRKLYQTFllkkdLNAIKTGEGGREIKASLLNILMRLRKICNHP 286
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
497-717 |
1.62e-73 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 242.68 E-value: 1.62e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQIRFNIHSRYE--DYNVIVTTS-----DDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 649
Cdd:cd18009 84 HGTKEERERLRKKIMKREGtlQDFPVVVTSyeiamRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLT 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790412 650 GTPVQNNLLELMSLLNFVMPHMFSS-STSEIRRMFSSKTKSADEQSIYEKERIAHA----KQIIKPFILRRVK 717
Cdd:cd18009 164 GTPLQNNLSELWSLLNFLLPDVFDDlSSFESWFDFSSLSDNAADISNLSEEREQNIvhmlHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
497-717 |
2.38e-69 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 230.67 E-value: 2.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIhSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:cd17997 84 LIGDKEERADIIRDV-LLPGKFDVCITSYEmvikEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGT 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQsiyekERIAHAKQIIKPFILRRVK 717
Cdd:cd17997 163 PLQNNLHELWALLNFLLPDVFTSS-EDFDEWFNVNNCDDDNQ-----EVVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
497-717 |
1.02e-68 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 228.60 E-value: 1.02e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQIRfnihsRYEDYNVIVTTSddrSLFRRL-------KLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 649
Cdd:cd18012 85 HGTKRKREKLR-----ALEDYDLVITSY---GLLRRDiellkevKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALT 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790412 650 GTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSiYEKERIAHAKQIIKPFILRRVK 717
Cdd:cd18012 157 GTPIENHLGELWSIFDFLNPGLLGSYKR-----FKKRFAKPIEKD-GDEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
497-717 |
9.73e-64 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 215.31 E-value: 9.73e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKIV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIhsRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT-INANNRLLLTG 650
Cdd:cd17996 84 YKGTPDVRKKLQSQI--RAGKFNVLLTTYEyiikDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLTG 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790412 651 TPVQNNLLELMSLLNFVMPHMFSSSTSeIRRMFS---SKTKSADEQSIYEKER---IAHAKQIIKPFILRRVK 717
Cdd:cd17996 162 TPLQNNLPELWALLNFLLPKIFKSCKT-FEQWFNtpfANTGEQVKIELNEEETlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
497-715 |
2.00e-61 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 208.90 E-value: 2.00e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNI---HSRYED--YNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRL 646
Cdd:cd18002 81 YWGNPKDRKVLRKFWdrkNLYTRDapFHVVITSYQlvvqDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 647 LLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKS-ADEQSIYEKERIAHAKQIIKPFILRR 715
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSH-DEFNEWFSKDIEShAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
497-715 |
2.37e-61 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 208.36 E-value: 2.37e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQqYGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIR----FNIHSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLL 647
Cdd:cd17993 82 YLGDIKSRDTIReyefYFSQTKKLKFNVLLTTYEiilkDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLL 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790412 648 LTGTPVQNNLLELMSLLNFVMPHMFssstsEIRRMFSsktksaDEQSIYEKERIAHAKQIIKPFILRR 715
Cdd:cd17993 162 ITGTPLQNSLKELWALLHFLMPGKF-----DIWEEFE------EEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
497-715 |
2.77e-56 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 194.00 E-value: 2.77e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCpTLKVLC 575
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGiRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFnihsrYEDY---------------NVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 636
Cdd:cd17995 80 YHGSGESRQIIQQ-----YEMYfkdaqgrkkkgvykfDVLITTYEmviaDAEELRKIPWRVVVVDEAHRLKNRNSKLLQG 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1772790412 637 LMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSIYEKERiahakQIIKPFILRR 715
Cdd:cd17995 155 LKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEE-----FLEEFGDLKTAEQVEKLQ-----ALLKPYMLRR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
846-971 |
4.30e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 190.00 E-value: 4.30e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 846 SGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAG 925
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1772790412 926 GLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLI 971
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
497-715 |
2.06e-53 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 185.72 E-value: 2.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLaGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIHSrYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:cd18006 81 YMGDKEKRLDLQQDIKS-TNRFHVLLTTYEiclkDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMFSSSTSEirRMFSSKTKSADEQSIYEKeriahAKQIIKPFILRR 715
Cdd:cd18006 160 PIQNSLQELYALLSFIEPNVFPKDKLD--DFIKAYSETDDESETVEE-----LHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
497-728 |
8.74e-51 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 179.48 E-value: 8.74e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIHSRYEdYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGT 651
Cdd:cd18064 96 LIGDKDQRAAFVRDVLLPGE-WDVCVTSYEmlikEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGT 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1772790412 652 PVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIahaKQIIKPFILRRVKEEVLKQLPPKK 728
Cdd:cd18064 175 PLQNNLHELWALLNFLLPDVFNSA-EDFDSWFDTNNCLGDQKLV---ERL---HMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
497-715 |
8.42e-50 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 176.02 E-value: 8.42e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 576
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YG-SQEERKQIRFNIHSRY----EDYNVIVTTSDDRSLFRR--LKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 649
Cdd:cd18001 81 HGtSKKERERNLERIQRGGgvllTTYGMVLSNTEQLSADDHdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1772790412 650 GTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKERI------AHAKQIIKPFILRR 715
Cdd:cd18001 161 GTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFENPITRGRDKDATQGEKAlgsevaENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
486-715 |
5.48e-49 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 174.04 E-value: 5.48e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 486 EQPSIL-NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLY-QEGNNGPHLIVVPASTIDNWLRE 563
Cdd:cd18054 9 KQPSYIgGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 564 VNLWCPTLKVLCYYGSQEERKQIRFN--IHSRYE--DYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQ 635
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRNTIREYewIHSQTKrlKFNALITTYEillkDKTVLGSINWAFLGVDEAHRLKNDDSLLYK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 636 HLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYekeriahakQIIKPFILRR 715
Cdd:cd18054 169 TLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEF--WEDFEEDHGKGRENGYQSLH---------KVLEPFLLRR 237
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
497-715 |
6.82e-48 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 170.61 E-value: 6.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA---YLYQEGNNG---PHLIVVPASTIDNWLREVNLWCPT 570
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 571 --LKVLCYYGSQEERKQIRfnihSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANN 644
Cdd:cd17999 81 afLKPLAYVGPPQERRRLR----EQGEKHNVIVASYDvlrnDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANH 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790412 645 RLLLTGTPVQNNLLELMSLLNFVMPHmFSSSTSEIRRMFSSK-TKSAD-EQSIYEKERIAHA-----KQIIkPFILRR 715
Cdd:cd17999 157 RLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPiLASRDsKASAKEQEAGALAlealhKQVL-PFLLRR 232
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
486-717 |
2.14e-46 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 166.35 E-value: 2.14e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 486 EQPSILNQSlSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREV 564
Cdd:cd18065 6 ESPSYVKGG-TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNiPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 565 NLWCPTLKVLCYYGSQEERKQIRFNIHSRYEdYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTI 640
Cdd:cd18065 85 KRWVPSLRAVCLIGDKDARAAFIRDVMMPGE-WDVCVTSYEmvikEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREF 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1772790412 641 NANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIaHAkqIIKPFILRRVK 717
Cdd:cd18065 164 KTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWFDTKNCLGDQKLV---ERL-HA--VLKPFLLRRIK 233
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
497-669 |
2.76e-44 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 158.64 E-value: 2.76e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVL- 574
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 575 ----CYYGSQEERKQIRFN----IHSRYEDYNVIVTTsddRSLFRRLKL-------NYAIFDEGHMLKNMG---SIRYQH 636
Cdd:cd18000 81 lhssGSGTGSEEKLGSIERksqlIRKVVGDGGILITT---YEGFRKHKDlllnhnwQYVILDEGHKIRNPDaeiTLACKQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 1772790412 637 LMTInanNRLLLTGTPVQNNLLELMSLLNFVMP 669
Cdd:cd18000 158 LRTP---HRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
485-717 |
3.13e-43 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 157.90 E-value: 3.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 485 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 563
Cdd:cd18062 12 VEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRiNGPFLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 564 VNLWCPTLKVLCYYGSQEERKQirFNIHSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 639
Cdd:cd18062 92 FDKWAPSVVKVSYKGSPAARRA--FVPQLRSGKFNVLLTTYEyiikDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 640 -INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFILRR 715
Cdd:cd18062 170 hYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETiliIRRLHKVLRPFLLRR 249
|
..
gi 1772790412 716 VK 717
Cdd:cd18062 250 LK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
485-717 |
8.57e-43 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 156.76 E-value: 8.57e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 485 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 563
Cdd:cd18063 12 VEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRlNGPYLIIVPLSTLSNWTYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 564 VNLWCPTLKVLCYYGSQEERKQIRFNIhsRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 639
Cdd:cd18063 92 FDKWAPSVVKISYKGTPAMRRSLVPQL--RSGKFNVLLTTYEyiikDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 640 -INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFILRR 715
Cdd:cd18063 170 hYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETiliIRRLHKVLRPFLLRR 249
|
..
gi 1772790412 716 VK 717
Cdd:cd18063 250 LK 251
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
486-715 |
5.38e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 153.67 E-value: 5.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 486 EQPSIL--NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLR 562
Cdd:cd18053 8 KQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQlYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 563 EVNLWCPTLKVLCYYGSQEERKQIR----FNIHSRYEDYNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRY 634
Cdd:cd18053 88 EIQTWAPQMNAVVYLGDINSRNMIRthewMHPQTKRLKFNILLTTYEillkDKSFLGGLNWAFIGVDEAHRLKNDDSLLY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 635 QHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYEKeriahakqiIKPFILR 714
Cdd:cd18053 168 KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSS--WEDFEEEHGKGREYGYASLHKE---------LEPFLLR 236
|
.
gi 1772790412 715 R 715
Cdd:cd18053 237 R 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
497-715 |
3.41e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 149.90 E-value: 3.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHsKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSqeerkqirfniHSRYEDYNVIvttSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQN 655
Cdd:cd17994 81 YVGD-----------HVLLTSYELI---SIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQN 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 656 NLLELMSLLNFVMPHMFSSSTSeirrmFssktkSADEQSIYEKERIAHAKQIIKPFILRR 715
Cdd:cd17994 147 NLEELFHLLNFLTPERFNNLQG-----F-----LEEFADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
497-715 |
3.15e-40 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 148.97 E-value: 3.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWL--ALVHKHGLNG---ILADEMGLGKTIQAIAFLAYLYQEGNNGPH-----LIVVPASTIDNWLREVNL 566
Cdd:cd18004 1 LRPHQREGVQFLydCLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 567 WCP--TLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTSDdrsLFRRL--------KLNYAIFDEGHMLKNMGSIRYQH 636
Cdd:cd18004 81 WLGlrRIKVVTADGNAKDVKASLDFFSSA-STYPVLIISYE---TLRRHaeklskkiSIDLLICDEGHRLKNSESKTTKA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 637 LMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKP 710
Cdd:cd18004 157 LNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSL-ASFRKVFeepilrSRDPDASEEDKELGAERSQELSELTSR 235
|
....*
gi 1772790412 711 FILRR 715
Cdd:cd18004 236 FILRR 240
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
497-715 |
5.24e-40 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 148.20 E-value: 5.24e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLaLVHkhGlnGILADEMGLGKTIQAIA----------FLAYLYQEGNNGPH--------LIVVPASTID 558
Cdd:cd18008 1 LLPYQKQGLAWM-LPR--G--GILADEMGLGKTIQALAlilatrpqdpKIPEELEENSSDPKklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 559 NWLREVN--LWCPTLKVLCYYGSQEERkqirfNIHSrYEDYNVIVTT--------SDDRSLFRRLKLNYA---------- 618
Cdd:cd18008 76 QWKDEIEkhTKPGSLKVYVYHGSKRIK-----SIEE-LSDYDIVITTygtlasefPKNKKGGGRDSKEKEasplhrirwy 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 619 --IFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNF--VMP-HMFSSSTSEIRRMFSSktksadeq 693
Cdd:cd18008 150 rvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFlrVEPfGDYPWFNSDISKPFSK-------- 221
|
250 260
....*....|....*....|..
gi 1772790412 694 siYEKERIAHAKQIIKPFILRR 715
Cdd:cd18008 222 --NDRKALERLQALLKPILLRR 241
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
497-715 |
9.53e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 140.95 E-value: 9.53e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQI-RFNIHSRYED---------YNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINA 642
Cdd:cd18058 80 HGSQISRQMIqQYEMYYRDEQgnplsgifkFQVVITTFEmilaDCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790412 643 NNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 715
Cdd:cd18058 160 EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
497-715 |
4.07e-37 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 140.21 E-value: 4.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-------------EGNNGPH--------LIVVPAS 555
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrennrpRFKKKPPassakkpvLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 556 TIDNWLREVNLWcPTLKVLCYYGSQEERKQIRFNIHSRYEdynVIVTTSDdrsLFRR-------LKLNYAIFDEGHMLKN 628
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDELEGRLKAGRLE---VVVTTYD---TLRRcidslnsINWSAVIADEAHRIKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 629 MGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFS-------SKTKSADEQSIYEKeRI 701
Cdd:cd18005 154 PKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSepikrgqRHTATARELRLGRK-RK 231
|
250
....*....|....
gi 1772790412 702 AHAKQIIKPFILRR 715
Cdd:cd18005 232 QELAVKLSKFFLRR 245
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
497-715 |
6.82e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 139.04 E-value: 6.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSkGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSI 632
Cdd:cd18057 81 YTGDKESRSVIRENEFS-FEDnairsgkkvfrmkkeaqikFHVLLTSYElitiDQAILGSIEWACLVVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 633 RYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIKPFI 712
Cdd:cd18057 160 FFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLGPHM 229
|
...
gi 1772790412 713 LRR 715
Cdd:cd18057 230 LRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
497-715 |
5.13e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 135.93 E-value: 5.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQIR-----------------FNIHSRYEDYNVIVTtsdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 639
Cdd:cd18059 80 HGSQASRRTIQlyemyfkdpqgrvikgsYKFHAIITTFEMILT---DCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKM 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1772790412 640 INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 715
Cdd:cd18059 157 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
497-715 |
3.45e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 133.98 E-value: 3.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTkGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSI 632
Cdd:cd18055 81 YTGDKDSRAIIRENEFS-FDDnavkggkkafkmkreaqvkFHVLLTSYElvtiDQAALGSIRWACLVVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 633 RYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIKPFI 712
Cdd:cd18055 160 FFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLGPHM 229
|
...
gi 1772790412 713 LRR 715
Cdd:cd18055 230 LRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
497-715 |
6.27e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 133.27 E-value: 6.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 575
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSkGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSI 632
Cdd:cd18056 81 YVGDKDSRAIIRENEFS-FEDnairggkkasrmkkeasvkFHVLLTSYElitiDMAILGSIDWACLIVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 633 RYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIKPFI 712
Cdd:cd18056 160 FFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEF-------AD---IAKEDQIKKLHDMLGPHM 229
|
...
gi 1772790412 713 LRR 715
Cdd:cd18056 230 LRR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
497-715 |
1.13e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 132.10 E-value: 1.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQIRfnihsRYEDY---------------NVIVTTSD----DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 637
Cdd:cd18060 80 HGSLASRQMIQ-----QYEMYckdsrgrlipgaykfDALITTFEmilsDCPELREIEWRCVIIDEAHRLKNRNCKLLDSL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790412 638 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 715
Cdd:cd18060 155 KHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
497-685 |
1.92e-33 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 129.33 E-value: 1.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLN--WLALVHKHGLNG-----ILADEMGLGKTIQAIAFL-AYLYQEGNNGPHLIVVPASTIDNWLREVNLWC 568
Cdd:cd18007 1 LKPHQVEGVRflWSNLVGTDVGSDegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 569 P----TLKVLCYYGSQEERKQIRFNI---HSR-------YEDY-----NVIVTTSDDRSLFRRLKLNYA---IFDEGHML 626
Cdd:cd18007 81 PpdlrPLLVLVSLSASKRADARLRKInkwHKEggvlligYELFrnlasNATTDPRLKQEFIAALLDPGPdllVLDEGHRL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1772790412 627 KNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSS 685
Cdd:cd18007 161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLK-EFKKKFVK 218
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
497-715 |
1.62e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 123.19 E-value: 1.62e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 576
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 577 YGSQEERKQI-RFNIHSRYEDYNVI--------VTTSDDRSLFRRLKLNY-----AIFDEGHMLKNMGSIRYQHLMTINA 642
Cdd:cd18061 80 HGSLISRQMIqQYEMYFRDSQGRIIrgayrfqaIITTFEMILGGCPELNAidwrcVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790412 643 NNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 715
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
497-681 |
8.36e-31 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 120.77 E-value: 8.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWlALvhKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnnGPHLIVVPASTIDNWLREVNLWCPTLK---V 573
Cdd:cd18010 1 LLPFQREGVCF-AL--RRGGRVLIADEMGLGKTVQAIAIAAYYREE---WPLLIVCPSSLRLTWADEIERWLPSLPpddI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 574 LCYYGSQE--ERKQIRFNIHSrYEdynvIVTTSDDRSLFRRLKLnyAIFDEGHMLKNMGSIRYQHLMTI--NANNRLLLT 649
Cdd:cd18010 75 QVIVKSKDglRDGDAKVVIVS-YD----LLRRLEKQLLARKFKV--VICDESHYLKNSKAKRTKAALPLlkRAKRVILLS 147
|
170 180 190
....*....|....*....|....*....|..
gi 1772790412 650 GTPVQNNLLELMSLLNFVMPHMFSSSTSEIRR 681
Cdd:cd18010 148 GTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
497-669 |
8.71e-29 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 114.51 E-value: 8.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLalvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVP-ASTIDNWLREVNLWCP--TLKV 573
Cdd:smart00487 9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPslGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 574 LCYYGSQEERKQIRFNIHSryeDYNVIVTTSD------DRSLFRRLKLNYAIFDEGHMLKNMGsiRYQHLMTI-----NA 642
Cdd:smart00487 86 VGLYGGDSKREQLRKLESG---KTDILVTTPGrlldllENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKLlkllpKN 160
|
170 180 190
....*....|....*....|....*....|
gi 1772790412 643 NNRLLLTGTP---VQNNLLELMSLLNFVMP 669
Cdd:smart00487 161 VQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
497-715 |
2.39e-27 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 111.48 E-value: 2.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWL-----ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPH------LIVVPASTIDNWLREVN 565
Cdd:cd18066 1 LRPHQREGIEFLyecvmGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 566 LWCPTLKVLCYYGSQEerKQIRFNIHSRYedYNVIVTTSDD--RSL--FRRLKLNYAIFDEGHMLKNMGSIRYQHLMTIN 641
Cdd:cd18066 81 KWLGSERIKVFTVDQD--HKVEEFIASPL--YSVLIISYEMllRSLdqISKLNFDLVICDEGHRLKNTSIKTTTALTSLS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 642 ANNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKPFILRR 715
Cdd:cd18066 157 CERRIILTGTPIQNDLQEFFALIDFVNPGIL-GSLSTYRKVYeepivrSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
497-715 |
1.93e-26 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 109.10 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWL----ALVHKHGLNG-ILADEMGLGKTIQAIAFLAYLYQEGNNGPHLI-----VVPASTIDNWLREVNL 566
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 567 WC-PTLKVLCYYGSQEE---RKQIRF-NIHSRYEDYNVIVTTSDDRSLFRRLKLNYA----IFDEGHMLKNMGSIRYQHL 637
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKeidRKLVQWaSQQGRRVSTPVLIISYETFRLHVEVLQKGEvglvICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 638 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSS------KTKSADEQSIYEKERIAHAKQIIKPF 711
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTA-AEFKKNFELpilkgrDADASEKERQLGEEKLQELISIVNRC 239
|
....
gi 1772790412 712 ILRR 715
Cdd:cd18067 240 IIRR 243
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
847-960 |
2.42e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 101.52 E-value: 2.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 847 GKFRVLGCILSelKQKGDRVVLFSQFTMMLDIlEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDmDIFVfLLSTKAGG 926
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1772790412 927 LGINLTSANVVILHDIDCNPYNDKQAEDRCHRVG 960
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
515-683 |
2.21e-23 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 99.89 E-value: 2.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 515 GLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCP-----------TLKVLCYYGSQEER 583
Cdd:cd18069 28 GFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPppealpnvrprPFKVFILNDEHKTT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 584 KQIRFNIHSRYEDYNVIVTTSDdrsLFR-RLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMS 662
Cdd:cd18069 108 AARAKVIEDWVKDGGVLLMGYE---MFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWC 184
|
170 180
....*....|....*....|.
gi 1772790412 663 LLNFVMPHMFSSSTsEIRRMF 683
Cdd:cd18069 185 MVDFVRPDFLGTRQ-EFSNMF 204
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
497-714 |
7.01e-23 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 99.34 E-value: 7.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLaLVHKhglnGILADEMGLGKTIQAIAFLA----------------------YLYQEGNN----GPHLI 550
Cdd:cd18070 1 LLPYQRRAVNWM-LVPG----GILADEMGLGKTVEVLALILlhprpdndldaadddsdemvccPDCLVAETpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 551 VVPASTIDNWLREVNLWCPT-LKVLCYYGsQEERKQIRFNIHSRYEDYNVIVTTSDD------------RSLFRRLKLNY 617
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQG-VKKDGALASPAPEILAEYDIVVTTYDVlrtelhyaeanrSNRRRRRQKRY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 618 --------------AIFDEGHMLKnmGSIRYQHLMT--INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRR 681
Cdd:cd18070 155 eappsplvlvewwrVCLDEAQMVE--SSTSKAAEMArrLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWARV 232
|
250 260 270
....*....|....*....|....*....|...
gi 1772790412 682 MFssktksadeQSIYEKERIAHAKQIIKPFILR 714
Cdd:cd18070 233 LI---------RPQGRNKAREPLAALLKELLWR 256
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
497-715 |
4.26e-20 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 90.62 E-value: 4.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLALVHKHGLNG-ILADEMGLGKTIQAIAFLayLYQEGN-------------------------NGPHLI 550
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTqnrkeeekekalteweskkdstlvpSAGTLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 551 VVPASTIDNWLREVN--LWCPTLKVLCYYGSQEERKQirfnihSRYEDYNVIVTT-------------SDDRSLFRRLKL 615
Cdd:cd18072 79 VCPASLVHQWKNEVEsrVASNKLRVCLYHGPNRERIG------EVLRDYDIVITTyslvakeiptykeESRSSPLFRIAW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 616 NYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstseirrmFSSKTKSADEQSI 695
Cdd:cd18072 153 ARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDD--------LKVWKKQVDNKSR 224
|
250 260
....*....|....*....|
gi 1772790412 696 YEKERIAhakQIIKPFILRR 715
Cdd:cd18072 225 KGGERLN---ILTKSLLLRR 241
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
877-960 |
1.29e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 84.19 E-value: 1.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 877 DILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMdiFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRC 956
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1772790412 957 HRVG 960
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
497-683 |
1.38e-19 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 89.18 E-value: 1.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWL---------ALVHKHGLNGILADEMGLGKTIQAIAFLAYLY---QEGNNGPHLIVVPASTIDNWLREV 564
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 565 NLWCPTLK--------VLCYYGSQEERkqiRFNIHSRYEDYNV---------IVTTSDDRSLFRRLKL-----------N 616
Cdd:cd18068 81 EKWQEGLKdeekievnELATYKRPQER---SYKLQRWQEEGGVmiigydmyrILAQERNVKSREKLKEifnkalvdpgpD 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1772790412 617 YAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMF 683
Cdd:cd18068 158 FVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIK-EFRNRF 223
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
515-667 |
4.69e-19 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 87.52 E-value: 4.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 515 GLNGILADEMGLGKTIQAIAFLAYlyqegnnGPHLIVVPASTIDNWLREV--NLWCPTLKVLCYYGSQEERKQirfnihS 592
Cdd:cd18071 48 VRGGILADDMGLGKTLTTISLILA-------NFTLIVCPLSVLSNWETQFeeHVKPGQLKVYTYHGGERNRDP------K 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 593 RYEDYNVIVTTSD---------DRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSL 663
Cdd:cd18071 115 LLSKYDIVLTTYNtlasdfgakGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194
|
....
gi 1772790412 664 LNFV 667
Cdd:cd18071 195 LSFL 198
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
497-665 |
2.91e-18 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 84.26 E-value: 2.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNwLALVHKHgLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREvnLW-CPTLKVLC 575
Cdd:cd18011 1 PLPHQIDAVL-RALRKPP-VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDE--LQdKFGLPFLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 576 YYGsqEERKQIRFNIHSRYEDYNVIVTTSD--DRSLFRRLKLNYA-----IFDEGHMLKNMGSIRYQHLMTI------NA 642
Cdd:cd18011 77 LDR--ETAAQLRRLIGNPFEEFPIVIVSLDllKRSEERRGLLLSEewdlvVVDEAHKLRNSGGGKETKRYKLgrllakRA 154
|
170 180
....*....|....*....|....*.
gi 1772790412 643 NNRLLLTGTPVQNN---LLELMSLLN 665
Cdd:cd18011 155 RHVLLLTATPHNGKeedFRALLSLLD 180
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
497-660 |
7.15e-10 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 60.06 E-value: 7.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGLNWLAlvhKHGLNGILADeMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTI-DNWLREVNLW--CPTLKV 573
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVArSTWPDEVEKWnhLRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 574 LCYYGSQEER-----KQIRFNIHSRyEDYNVIVTTSDDRSLFRRLklnyaIFDEGHMLKNMGSIRYQHLMTIN--ANNRL 646
Cdd:cd18013 77 SVAVGTERQRskaanTPADLYVINR-ENLKWLVNKSGDPWPFDMV-----VIDELSSFKSPRSKRFKALRKVRpvIKRLI 150
|
170
....*....|....
gi 1772790412 647 LLTGTPVQNNLLEL 660
Cdd:cd18013 151 GLTGTPSPNGLMDL 164
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
495-652 |
2.21e-09 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 57.30 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 495 LSLKPYQKVGL-NWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDN-WLREVNLWCPTLK 572
Cdd:pfam04851 2 LELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEqALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 573 VLCYYGSQEERKQIrfnihsrYEDYNVIVTT--------SDDRSLFRRLKLNYAIFDEGHMLknmGSIRYQHLMTINANN 644
Cdd:pfam04851 82 EIGEIISGDKKDES-------VDDNKIVVTTiqslykalELASLELLPDFFDVIIIDEAHRS---GASSYRNILEYFKPA 151
|
....*....
gi 1772790412 645 RLL-LTGTP 652
Cdd:pfam04851 152 FLLgLTATP 160
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
497-652 |
6.18e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.77 E-value: 6.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 497 LKPYQKVGL-NWLAlvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnngPHLIVVP-ASTIDNWLREvnlwcptlkvL 574
Cdd:cd17926 1 LRPYQEEALeAWLA--HKNNRRGILVLPTGSGKTLTALALIAYLKEL----RTLIVVPtDALLDQWKER----------F 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 575 CYYGSQEERKQIRFNIHSRYEDYNVIVTTSDdrSLFRRLKLNYA--------IFDEGHmlkNMGSIRYQHLMTI-NANNR 645
Cdd:cd17926 65 EDFLGDSSIGLIGGGKKKDFDDANVVVATYQ--SLSNLAEEEKDlfdqfgllIVDEAH---HLPAKTFSEILKElNAKYR 139
|
....*..
gi 1772790412 646 LLLTGTP 652
Cdd:cd17926 140 LGLTATP 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
494-653 |
1.06e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 55.80 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 494 SLSLKPYQKVGLN-WLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYqegNNGPHLIVVPASTI-DNWLREVnlwcptL 571
Cdd:COG1061 78 SFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTVLALALAAELL---RGKRVLVLVPRRELlEQWAEEL------R 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 572 KVLCYYGSQEERKQIrfnihsryeDYNVIVTTSDdrSLFRRLKLN-------YAIFDEGHmlkNMGSIRYQHLMT-INAN 643
Cdd:COG1061 149 RFLGDPLAGGGKKDS---------DAPITVATYQ--SLARRAHLDelgdrfgLVIIDEAH---HAGAPSYRRILEaFPAA 214
|
170
....*....|
gi 1772790412 644 NRLLLTGTPV 653
Cdd:COG1061 215 YRLGLTATPF 224
|
|
| DpdE |
NF041062 |
protein DpdE; |
520-725 |
6.76e-06 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 50.36 E-value: 6.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 520 LADEMGLGKTIQA-IAFLAYLYQEgnngPH---LIVVPASTIDNWLREvnlwcptLKVlcyygsqeerkqiRFNI-HSRY 594
Cdd:NF041062 175 LADEVGLGKTIEAgLVIRQHLLDN----PDarvLVLVPDALVRQWRRE-------LRD-------------KFFLdDFPG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 595 EDYNVIVTTSDDRSLFRRLKLNYAIFDEGHMLKNMG-------SIRYQHLMTI--NANNRLLLTGTPVQNNLLELMSLLN 665
Cdd:NF041062 231 ARVRVLSHEEPERWEPLLDAPDLLVVDEAHQLARLAwsgdppeRARYRELAALahAAPRLLLLSATPVLGNEETFLALLH 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1772790412 666 FVMPHMFSSSTSEirrmfssktksADEQSIYEKERIAHAKQIIKP----FILRRVKEEVLKQLP 725
Cdd:NF041062 311 LLDPDLYPLDDLE-----------AFRERLEEREELGRLVLGLDPdnpnFLLRQALDELRALFP 363
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
525-655 |
1.23e-04 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 43.77 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 525 GLGKTiqAIAFLAYLYQ--EGNNGPH-LIVVP--------ASTIDNWLREVNLwcptlKVLCYYGSQEERKQIRfnihsR 593
Cdd:pfam00270 24 GSGKT--LAFLLPALEAldKLDNGPQaLVLAPtrelaeqiYEELKKLGKGLGL-----KVASLLGGDSRKEQLE-----K 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1772790412 594 YEDYNVIVTT-------SDDRSLFRRLKlnYAIFDEGHMLKNMGSIR--YQHLMTINANNR-LLLTGTPVQN 655
Cdd:pfam00270 92 LKGPDILVGTpgrlldlLQERKLLKNLK--LLVLDEAHRLLDMGFGPdlEEILRRLPKKRQiLLLSATLPRN 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
517-651 |
1.81e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 42.78 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 517 NGILADEMGLGKTIQA--IAFLAYLYQEGNNgphLIVVPASTIDN----WLREvnLWCPTLKVLCYYG--SQEERKQIRF 588
Cdd:cd00046 3 NVLITAPTGSGKTLAAllAALLLLLKKGKKV---LVLVPTKALALqtaeRLRE--LFGPGIRVAVLVGgsSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1772790412 589 NihsryeDYNVIVTT---------SDDRSLFRRLKlnYAIFDEGHML----KNMGSIRYQHLMTINANNR-LLLTGT 651
Cdd:cd00046 78 G------DADIIIATpdmllnlllREDRLFLKDLK--LIIVDEAHALlidsRGALILDLAVRKAGLKNAQvILLSAT 146
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
847-938 |
2.96e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 39.54 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790412 847 GKFRVLGCILSELKQkGDRVVLFSQFTMMLD-ILEVLLKhhqhrYLrLDGKTQISERIHLIDEF-----NTdmdIFVfll 920
Cdd:cd18789 34 NKLRALEELLKRHEQ-GDKIIVFTDNVEALYrYAKRLLK-----PF-ITGETPQSEREEILQNFregeyNT---LVV--- 100
|
90
....*....|....*...
gi 1772790412 921 sTKAGGLGINLTSANVVI 938
Cdd:cd18789 101 -SKVGDEGIDLPEANVAI 117
|
|
| |
