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Conserved domains on  [gi|1781308753|ref|NP_001363868|]
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HEAT repeat-containing protein 4 [Mus musculus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein similar to Homo sapiens deoxyhypusine hydroxylase (DOHH), which catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  10378263
SCOP:  4001283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
692-837 2.49e-11

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  692 VRQSAAKALGRMNlGKEIHDMIRVKLCQGNSQERIKALSLIRVLKLMTAklLPSFLTCFSDEFTGIRQAACLAAGalQIR 771
Cdd:COG1413      1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA--VPALLEALKDPDPEVRAAAAEALG--RIG 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1781308753  772 DRMVLERLMNLMHtDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHYEDsPGVRLEACRSILALK 837
Cdd:COG1413     76 DPEAVPALIAALK-DEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPD-WEVRRAAARALGRLG 137
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
692-837 2.49e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  692 VRQSAAKALGRMNlGKEIHDMIRVKLCQGNSQERIKALSLIRVLKLMTAklLPSFLTCFSDEFTGIRQAACLAAGalQIR 771
Cdd:COG1413      1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA--VPALLEALKDPDPEVRAAAAEALG--RIG 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1781308753  772 DRMVLERLMNLMHtDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHYEDsPGVRLEACRSILALK 837
Cdd:COG1413     76 DPEAVPALIAALK-DEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPD-WEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 776-841 4.66e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.79  E-value: 4.66e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1781308753  776 LERLMNLMHTDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHYEDsPGVRLEACRSILALKLHGA 841
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALGRIG--DPEAVPALLELLKDED-PAVRRAAAEALGKIGDPEA 63
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
692-837 2.49e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 62.34  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  692 VRQSAAKALGRMNlGKEIHDMIRVKLCQGNSQERIKALSLIRVLKLMTAklLPSFLTCFSDEFTGIRQAACLAAGalQIR 771
Cdd:COG1413      1 VRRAAARALGRLG-DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA--VPALLEALKDPDPEVRAAAAEALG--RIG 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1781308753  772 DRMVLERLMNLMHtDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHYEDsPGVRLEACRSILALK 837
Cdd:COG1413     76 DPEAVPALIAALK-DEDPEVRRAAAEALGRLG--DPAAVPALLEALKDPD-WEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 776-841 4.66e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.79  E-value: 4.66e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1781308753  776 LERLMNLMHTDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHYEDsPGVRLEACRSILALKLHGA 841
Cdd:pfam13646    1 LPALLQALLRDPDPEVRAAAIRALGRIG--DPEAVPALLELLKDED-PAVRRAAAEALGKIGDPEA 63
HEAT COG1413
HEAT repeat [General function prediction only];
650-803 5.39e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 5.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  650 LNSRQWKDRIVACRAFSQITGKVCIDMkqkIIQLMwNDWNKEVRQSAAKALGRMnlgkeihdmirvklcqgNSQERIKAl 729
Cdd:COG1413     25 LADEDPDVRAAAARALGRLGDPRAVPA---LLEAL-KDPDPEVRAAAAEALGRI-----------------GDPEAVPA- 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1781308753  730 sLIRVLKlmtakllpsfltcfsDEFTGIRQAACLAAGalQIRDRMVLERLMNLMHtDPYWKIKAFAIRALGQIG 803
Cdd:COG1413     83 -LIAALK---------------DEDPEVRRAAAEALG--RLGDPAAVPALLEALK-DPDWEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 678-800 7.24e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.41  E-value: 7.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  678 QKIIQLMWNDWNKEVRQSAAKALGRMNlgkeihdmirvklcqgnsqerikalslirvlklmTAKLLPSFLTCFSDEFTGI 757
Cdd:pfam13646    2 PALLQALLRDPDPEVRAAAIRALGRIG----------------------------------DPEAVPALLELLKDEDPAV 47

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1781308753  758 RQAACLAAGalQIRDRMVLERLMNLMHTDPYWKIKAFAIRALG 800
Cdd:pfam13646   48 RRAAAEALG--KIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
757-851 9.25e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 9.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781308753  757 IRQAACLAAGalQIRDRMVLERLMNLMHtDPYWKIKAFAIRALGQIGlvSPQLTNKLLWAIHyEDSPGVRLEAcrsILAL 836
Cdd:COG1413      1 VRRAAARALG--RLGDPAAVPALIAALA-DEDPDVRAAAARALGRLG--DPRAVPALLEALK-DPDPEVRAAA---AEAL 71

                           90
                   ....*....|....*.
gi 1781308753  837 -KLHGAQVRDTFLDVL 851
Cdd:COG1413     72 gRIGDPEAVPALIAAL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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