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Conserved domains on  [gi|1796386946|ref|NP_001364392|]
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chloride channel CLIC-like protein 1 isoform 1 precursor [Homo sapiens]

Protein Classification

MCLC domain-containing protein( domain architecture ID 10531842)

MCLC domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MCLC pfam05934
Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride ...
14-551 0e+00

Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer.


:

Pssm-ID: 461783  Cd Length: 549  Bit Score: 1091.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  14 VAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQS 93
Cdd:pfam05934  12 IAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSERKEVSPDLSYADELSDCYSKLDSLTHKVDECEKKKRKDYESQS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  94 NPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWR 173
Cdd:pfam05934  92 NPVFRRYLNKILIEAGKLGLPDENRGDMHYDAEIILKRQTLLEIEKFLNGEDWKPGALDDALSDILINFKFHDFEAWKWR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 174 FEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNV 253
Cdd:pfam05934 172 FEDSFGVDPYNVFMVLLCLLCIVMLVATELWTYVRWYTQLRRILIISFLFSLGWNWMYLYKVAFAQHQAEVAKMEPLNNV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 254 CAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPAL 333
Cdd:pfam05934 252 CAEKMDWTGSLWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGEFIKALMKEIPVL 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 334 LHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYA 413
Cdd:pfam05934 332 LHIPVLIIMALAVLSFCYGAGQSVPMLRHFGGPEREPPRALEPGDRRRQKEIDYRPRGGAGDADFSYRGQAGSIEQGPYD 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 414 KTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQS 493
Cdd:pfam05934 412 KTHECRRDVLRERDVDVRFQTGNKSPEVLRAFDLPDAEAREHPEVVPSHKSSGANTAPKETGELPGEGTPAEGSTESSQS 491
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796386946 494 AKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG 551
Cdd:pfam05934 492 AKPGSGQGAPGTAEGSPAAEKAPLKIDSEGSPEEGSTPSPASAVAAARGTDPVSSPCG 549
 
Name Accession Description Interval E-value
MCLC pfam05934
Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride ...
14-551 0e+00

Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer.


Pssm-ID: 461783  Cd Length: 549  Bit Score: 1091.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  14 VAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQS 93
Cdd:pfam05934  12 IAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSERKEVSPDLSYADELSDCYSKLDSLTHKVDECEKKKRKDYESQS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  94 NPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWR 173
Cdd:pfam05934  92 NPVFRRYLNKILIEAGKLGLPDENRGDMHYDAEIILKRQTLLEIEKFLNGEDWKPGALDDALSDILINFKFHDFEAWKWR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 174 FEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNV 253
Cdd:pfam05934 172 FEDSFGVDPYNVFMVLLCLLCIVMLVATELWTYVRWYTQLRRILIISFLFSLGWNWMYLYKVAFAQHQAEVAKMEPLNNV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 254 CAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPAL 333
Cdd:pfam05934 252 CAEKMDWTGSLWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGEFIKALMKEIPVL 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 334 LHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYA 413
Cdd:pfam05934 332 LHIPVLIIMALAVLSFCYGAGQSVPMLRHFGGPEREPPRALEPGDRRRQKEIDYRPRGGAGDADFSYRGQAGSIEQGPYD 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 414 KTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQS 493
Cdd:pfam05934 412 KTHECRRDVLRERDVDVRFQTGNKSPEVLRAFDLPDAEAREHPEVVPSHKSSGANTAPKETGELPGEGTPAEGSTESSQS 491
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796386946 494 AKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG 551
Cdd:pfam05934 492 AKPGSGQGAPGTAEGSPAAEKAPLKIDSEGSPEEGSTPSPASAVAAARGTDPVSSPCG 549
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
366-549 2.07e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  366 PESEPPQALRPRDRRRQEEI-DYRPDGGAGDAdfhyrgqmgpteqgpyaktyegrreilRERDVDLRFQTGNKSPEVLRA 444
Cdd:PHA03307   194 PPSTPPAAASPRPPRRSSPIsASASSPAPAPG---------------------------RSAADDAGASSSDSSSSESSG 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  445 FDvpdaEAREHPTVVPSHKSPVLDTKPKEtgGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGS 524
Cdd:PHA03307   247 CG----WGPENECPLPRPAPITLPTRIWE--ASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSS 320
                          170       180
                   ....*....|....*....|....*
gi 1796386946  525 PDQGSTYSPARGVAGPRGQDPVSSP 549
Cdd:PHA03307   321 SRESSSSSTSSSSESSRGAAVSPGP 345
 
Name Accession Description Interval E-value
MCLC pfam05934
Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride ...
14-551 0e+00

Mid-1-related chloride channel (MCLC); This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer.


Pssm-ID: 461783  Cd Length: 549  Bit Score: 1091.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  14 VAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQS 93
Cdd:pfam05934  12 IAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSERKEVSPDLSYADELSDCYSKLDSLTHKVDECEKKKRKDYESQS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  94 NPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWR 173
Cdd:pfam05934  92 NPVFRRYLNKILIEAGKLGLPDENRGDMHYDAEIILKRQTLLEIEKFLNGEDWKPGALDDALSDILINFKFHDFEAWKWR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 174 FEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNV 253
Cdd:pfam05934 172 FEDSFGVDPYNVFMVLLCLLCIVMLVATELWTYVRWYTQLRRILIISFLFSLGWNWMYLYKVAFAQHQAEVAKMEPLNNV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 254 CAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPAL 333
Cdd:pfam05934 252 CAEKMDWTGSLWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGEFIKALMKEIPVL 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 334 LHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYA 413
Cdd:pfam05934 332 LHIPVLIIMALAVLSFCYGAGQSVPMLRHFGGPEREPPRALEPGDRRRQKEIDYRPRGGAGDADFSYRGQAGSIEQGPYD 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946 414 KTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQS 493
Cdd:pfam05934 412 KTHECRRDVLRERDVDVRFQTGNKSPEVLRAFDLPDAEAREHPEVVPSHKSSGANTAPKETGELPGEGTPAEGSTESSQS 491
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796386946 494 AKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG 551
Cdd:pfam05934 492 AKPGSGQGAPGTAEGSPAAEKAPLKIDSEGSPEEGSTPSPASAVAAARGTDPVSSPCG 549
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
366-549 2.07e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  366 PESEPPQALRPRDRRRQEEI-DYRPDGGAGDAdfhyrgqmgpteqgpyaktyegrreilRERDVDLRFQTGNKSPEVLRA 444
Cdd:PHA03307   194 PPSTPPAAASPRPPRRSSPIsASASSPAPAPG---------------------------RSAADDAGASSSDSSSSESSG 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386946  445 FDvpdaEAREHPTVVPSHKSPVLDTKPKEtgGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGS 524
Cdd:PHA03307   247 CG----WGPENECPLPRPAPITLPTRIWE--ASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSS 320
                          170       180
                   ....*....|....*....|....*
gi 1796386946  525 PDQGSTYSPARGVAGPRGQDPVSSP 549
Cdd:PHA03307   321 SRESSSSSTSSSSESSRGAAVSPGP 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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