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Conserved domains on  [gi|1802446937|ref|NP_001364997|]
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ankyrin and armadillo repeat-containing protein [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 4.04e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 4.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  606 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 685
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                          170
                   ....*....|.
gi 1802446937  686 EVLKYIIKLNI 696
Cdd:COG0666    233 EIVKLLLEAGA 243
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 705-947 1.47e-08

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 59.73  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  705 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQ---CKTVGLLsnISTHKSAVhalve 781
Cdd:PLN03200   493 LVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGPKGQeiaAKTLTKL--VRTADAAT----- 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  782 aggIPSLINLLVCDEPEvhSRCAVIlyDIAQC-----ENKDVI----AKYNGIPSLINLLNLNIE-------NVLVNVMN 845
Cdd:PLN03200   566 ---ISQLTALLLGDLPE--SKVHVL--DVLGHvlsvaSLEDLVregsAANDALRTLIQLLSSSKEetqekaaSVLADIFS 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  846 CIRVLCigneNNQRAVrehKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQD-AIAMEGAIPPLVALFKGKQISVQ 924
Cdd:PLN03200   639 SRQDLC----ESLATD---EIINPCIKLLTNNTEAVATQSARALAALSRSIKENRKvSYAAEDAIKPLIKLAKSSSIEVA 711

                          250       260
                   ....*....|....*....|...
gi 1802446937  925 MKGAMAVESLASHNALIQKAFLE 947
Cdd:PLN03200   712 EQAVCALANLLSDPEVAAEALAE 734
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 4.04e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 4.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  606 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 685
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                          170
                   ....*....|.
gi 1802446937  686 EVLKYIIKLNI 696
Cdd:COG0666    233 EIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
574-669 2.35e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  574 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 653
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 1802446937  654 TIQYLFSIGANWRKTD 669
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 705-947 1.47e-08

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 59.73  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  705 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQ---CKTVGLLsnISTHKSAVhalve 781
Cdd:PLN03200   493 LVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGPKGQeiaAKTLTKL--VRTADAAT----- 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  782 aggIPSLINLLVCDEPEvhSRCAVIlyDIAQC-----ENKDVI----AKYNGIPSLINLLNLNIE-------NVLVNVMN 845
Cdd:PLN03200   566 ---ISQLTALLLGDLPE--SKVHVL--DVLGHvlsvaSLEDLVregsAANDALRTLIQLLSSSKEetqekaaSVLADIFS 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  846 CIRVLCigneNNQRAVrehKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQD-AIAMEGAIPPLVALFKGKQISVQ 924
Cdd:PLN03200   639 SRQDLC----ESLATD---EIINPCIKLLTNNTEAVATQSARALAALSRSIKENRKvSYAAEDAIKPLIKLAKSSSIEVA 711

                          250       260
                   ....*....|....*....|...
gi 1802446937  925 MKGAMAVESLASHNALIQKAFLE 947
Cdd:PLN03200   712 EQAVCALANLLSDPEVAAEALAE 734
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 731-771 2.41e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 2.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1802446937  731 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 771
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
686-848 2.76e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.35  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  686 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 765
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  766 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 839
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                   ....*....
gi 1802446937  840 LVNVMNCIR 848
Cdd:COG5064    431 IEVALDAIE 439
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 738-770 1.51e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.49  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1802446937   738 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 770
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 537-664 3.22e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  537 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 616
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1802446937  617 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 664
Cdd:PHA02875   149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 4.04e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 4.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  606 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 685
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL 232

                          170
                   ....*....|.
gi 1802446937  686 EVLKYIIKLNI 696
Cdd:COG0666    233 EIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 2.45e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 2.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRfvtfSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD----NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  606 PIHFAAFYDNVCIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 685
Cdd:COG0666    189 PLHLAAENGHLEIVKLLLEAGADV---NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265

                          170
                   ....*....|.
gi 1802446937  686 EVLKYIIKLNI 696
Cdd:COG0666    266 LIVKLLLLALL 276
Ank_2 pfam12796
Ankyrin repeats (3 copies);
574-669 2.35e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  574 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 653
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 1802446937  654 TIQYLFSIGANWRKTD 669
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 705-947 1.47e-08

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 59.73  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  705 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQ---CKTVGLLsnISTHKSAVhalve 781
Cdd:PLN03200   493 LVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGPKGQeiaAKTLTKL--VRTADAAT----- 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  782 aggIPSLINLLVCDEPEvhSRCAVIlyDIAQC-----ENKDVI----AKYNGIPSLINLLNLNIE-------NVLVNVMN 845
Cdd:PLN03200   566 ---ISQLTALLLGDLPE--SKVHVL--DVLGHvlsvaSLEDLVregsAANDALRTLIQLLSSSKEetqekaaSVLADIFS 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  846 CIRVLCigneNNQRAVrehKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQD-AIAMEGAIPPLVALFKGKQISVQ 924
Cdd:PLN03200   639 SRQDLC----ESLATD---EIINPCIKLLTNNTEAVATQSARALAALSRSIKENRKvSYAAEDAIKPLIKLAKSSSIEVA 711

                          250       260
                   ....*....|....*....|...
gi 1802446937  925 MKGAMAVESLASHNALIQKAFLE 947
Cdd:PLN03200   712 EQAVCALANLLSDPEVAAEALAE 734
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 710-934 2.88e-08

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 58.96  E-value: 2.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  710 QCESYKRRMMAVMSLEViclaNDQYWrCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVE-AGGIPSL 788
Cdd:PLN03200   461 QQQEYAVALLAILTDEV----DESKW-AITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAGAVPAL 535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  789 INLLVCDEPEVHSRCAVILYDIAQCENKDVIAKyngipsLINLLNLNIENVLVNVMNCIR-VLCIGNENN--QRAVREHK 865
Cdd:PLN03200   536 LWLLKNGGPKGQEIAAKTLTKLVRTADAATISQ------LTALLLGDLPESKVHVLDVLGhVLSVASLEDlvREGSAAND 609

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1802446937  866 GLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESL 934
Cdd:PLN03200   610 ALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAAL 678
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 744-938 2.09e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 55.88  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  744 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 818
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  819 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRD 895
Cdd:PLN03200   140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMA 219

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1802446937  896 NKEIQDAIAMEGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 938
Cdd:PLN03200   220 FESSISKVLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
Ank_4 pfam13637
Ankyrin repeats (many copies);
641-692 1.83e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 1.83e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1802446937  641 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 692
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 731-771 2.41e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 2.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1802446937  731 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 771
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
686-848 2.76e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.35  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  686 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 765
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  766 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 839
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                   ....*....
gi 1802446937  840 LVNVMNCIR 848
Cdd:COG5064    431 IEVALDAIE 439
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 738-770 1.51e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.49  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1802446937   738 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 770
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
571-693 1.69e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.33  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  571 PTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDpslLEAEATAENQCTPLLLAATSG 650
Cdd:COG0666     22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1802446937  651 ALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 693
Cdd:COG0666     99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141
Ank_2 pfam12796
Ankyrin repeats (3 copies);
643-693 2.97e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 2.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1802446937  643 LLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 693
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 537-664 3.22e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  537 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 616
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1802446937  617 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 664
Cdd:PHA02875   149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 521-636 3.23e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  521 TSSSTINVSDEAGYTIFHHAALHNRvSIICQLCNaNFKVNqrrfVTFSQGPTPLHLAAQ-ACSLETTVCLLCSKADYTLS 599
Cdd:PHA02874   211 DHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASIN----DQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIK 284

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1802446937  600 EKRGWMPIHFAAFYDNvciiialcrKDPSLLEAEATA 636
Cdd:PHA02874   285 DNKGENPIDTAFKYIN---------KDPVIKDIIANA 312
Ank_4 pfam13637
Ankyrin repeats (many copies);
572-622 3.82e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1802446937  572 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIAL 622
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-598 4.83e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 4.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNanfKVNQRRfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTL 598
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 723-1042 3.68e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  723 SLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSN-ISTHKSAVHALVEAGGIPSLINLLVC-DEPEVH 800
Cdd:PLN03200   170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVR 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  801 SRCAVILYDI-AQC-ENKDVIAKYNGIPSLINllnlnieNVLVNVMNCIRvlcignENNQRAVREHK---------GLPY 869
Cdd:PLN03200   250 AEAAGALEALsSQSkEAKQAIADAGGIPALIN-------ATVAPSKEFMQ------GEFAQALQENAmgalanicgGMSA 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  870 LIRFL--SSDS--------DVLKAVSSA-AIAEVGRDNKEIQDAIAMEGAippLVALFKGKQIS-VQMKgamAVESLASh 937
Cdd:PLN03200   317 LILYLgeLSESprspapiaDTLGALAYAlMVFDSSAESTRAFDPTVIEQI---LVKLLKPRDTKlVQER---IIEALAS- 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  938 naLIQKAFLEKSLTKYLLKLLKAFQI-----DVKEQ----------GAVALW-ALAGQTlkqqkymaeqiGYSFIINMLL 1001
Cdd:PLN03200   390 --LYGNAYLSRKLNHAEAKKVLVGLItmataDVQEEliralsslccGKGGLWeALGGRE-----------GVQLLISLLG 456

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1802446937 1002 SPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLL 1042
Cdd:PLN03200   457 LSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLL 497
Ank_5 pfam13857
Ankyrin repeats (many copies);
526-577 7.49e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 7.49e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1802446937  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFvtfsQGPTPLHLA 577
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE----EGLTALDLA 56
HEAT COG1413
HEAT repeat [General function prediction only];
701-811 8.15e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.07  E-value: 8.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446937  701 VWKTLVEMLQCESYKRRMMAVMSLEVIClandqywrcilDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKS------ 774
Cdd:COG1413     17 AVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAvpalia 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1802446937  775 ------------AVHALVEAGG---IPSLINLLVCDEPEVHSRCAVILYDIA 811
Cdd:COG1413     86 alkdedpevrraAAEALGRLGDpaaVPALLEALKDPDWEVRRAAARALGRLG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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