low-density lipoprotein receptor-related protein 11 isoform 5 precursor [Mus musculus]
MANEC and LDLa domain-containing protein( domain architecture ID 11275466)
protein containing domains MANEC, PKD, and LDLa
List of domain hits
Name | Accession | Description | Interval | E-value | |||
MANEC | smart00765 | The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ... |
69-172 | 5.29e-36 | |||
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase. : Pssm-ID: 129004 Cd Length: 93 Bit Score: 128.72 E-value: 5.29e-36
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
299-333 | 3.89e-10 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 54.91 E-value: 3.89e-10
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PKD | smart00089 | Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
191-285 | 5.46e-06 | |||
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases. : Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 44.36 E-value: 5.46e-06
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Name | Accession | Description | Interval | E-value | |||
MANEC | smart00765 | The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ... |
69-172 | 5.29e-36 | |||
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase. Pssm-ID: 129004 Cd Length: 93 Bit Score: 128.72 E-value: 5.29e-36
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MANEC | pfam07502 | MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ... |
72-171 | 3.15e-33 | |||
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. Pssm-ID: 462186 Cd Length: 90 Bit Score: 120.88 E-value: 3.15e-33
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
299-333 | 3.89e-10 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 54.91 E-value: 3.89e-10
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
299-330 | 1.96e-09 | |||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.64 E-value: 1.96e-09
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
297-333 | 1.55e-06 | |||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 44.55 E-value: 1.55e-06
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PKD | smart00089 | Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
191-285 | 5.46e-06 | |||
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases. Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 44.36 E-value: 5.46e-06
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myxo_dep_M36 | NF038112 | myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
193-298 | 2.28e-05 | |||
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes. Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 47.34 E-value: 2.28e-05
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PKD | cd00146 | polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
185-285 | 2.59e-05 | |||
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases. Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 42.48 E-value: 2.59e-05
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myxo_dep_M36 | NF038112 | myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
192-285 | 1.79e-03 | |||
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes. Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 41.18 E-value: 1.79e-03
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PKD_4 | pfam18911 | PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
192-285 | 4.03e-03 | |||
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 36.48 E-value: 4.03e-03
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Name | Accession | Description | Interval | E-value | |||
MANEC | smart00765 | The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ... |
69-172 | 5.29e-36 | |||
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase. Pssm-ID: 129004 Cd Length: 93 Bit Score: 128.72 E-value: 5.29e-36
|
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MANEC | pfam07502 | MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ... |
72-171 | 3.15e-33 | |||
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. Pssm-ID: 462186 Cd Length: 90 Bit Score: 120.88 E-value: 3.15e-33
|
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
299-333 | 3.89e-10 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 54.91 E-value: 3.89e-10
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
299-330 | 1.96e-09 | |||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.64 E-value: 1.96e-09
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
297-333 | 1.55e-06 | |||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 44.55 E-value: 1.55e-06
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PKD | smart00089 | Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ... |
191-285 | 5.46e-06 | |||
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases. Pssm-ID: 214510 [Multi-domain] Cd Length: 79 Bit Score: 44.36 E-value: 5.46e-06
|
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myxo_dep_M36 | NF038112 | myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
193-298 | 2.28e-05 | |||
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes. Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 47.34 E-value: 2.28e-05
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PKD | cd00146 | polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ... |
185-285 | 2.59e-05 | |||
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases. Pssm-ID: 238084 [Multi-domain] Cd Length: 81 Bit Score: 42.48 E-value: 2.59e-05
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myxo_dep_M36 | NF038112 | myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
192-285 | 1.79e-03 | |||
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes. Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 41.18 E-value: 1.79e-03
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PKD_4 | pfam18911 | PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. |
192-285 | 4.03e-03 | |||
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins. Pssm-ID: 436824 [Multi-domain] Cd Length: 85 Bit Score: 36.48 E-value: 4.03e-03
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Blast search parameters | ||||
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