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Conserved domains on  [gi|1839337248|ref|NP_001369384|]
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zinc finger protein 454 isoform 5 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-468 3.35e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 133 GKAFSKSSTLKKHQKLHTEKLNPSQKSPmkekrYKCRECGKAFHQSTHLIHHQRVHTGEKPYQCKD--CGKAFSVSSSLS 210
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRP-----DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 211 YHQKIHTGEKPFEC----------------NVCGKAFIRNIHLSHHHRMHTGEKPFQCNLcdkafvcrahltkHQHIHSG 274
Cdd:COG5048    81 RHLRTHHNNPSDLNskslplsnskasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDL-------------LSISNLR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 275 KKPYK-CNECGKAFNQSTSFLQ-------------------HQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPY 334
Cdd:COG5048   148 NNPLPgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 335 QCIECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFR--DQSALAQHQRTHTGE-----KPYTCNICEKAFSDHSALTQ 407
Cdd:COG5048   228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTR 307

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839337248 408 HKR--IHTRE--KPYKC--KTCGKAFIRSTHLIQHQRIHTGEKPYKC--NTCGKAFNQTANLAQHQRHH 468
Cdd:COG5048   308 HLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-468 3.35e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 133 GKAFSKSSTLKKHQKLHTEKLNPSQKSPmkekrYKCRECGKAFHQSTHLIHHQRVHTGEKPYQCKD--CGKAFSVSSSLS 210
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRP-----DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 211 YHQKIHTGEKPFEC----------------NVCGKAFIRNIHLSHHHRMHTGEKPFQCNLcdkafvcrahltkHQHIHSG 274
Cdd:COG5048    81 RHLRTHHNNPSDLNskslplsnskasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDL-------------LSISNLR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 275 KKPYK-CNECGKAFNQSTSFLQ-------------------HQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPY 334
Cdd:COG5048   148 NNPLPgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 335 QCIECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFR--DQSALAQHQRTHTGE-----KPYTCNICEKAFSDHSALTQ 407
Cdd:COG5048   228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTR 307

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839337248 408 HKR--IHTRE--KPYKC--KTCGKAFIRSTHLIQHQRIHTGEKPYKC--NTCGKAFNQTANLAQHQRHH 468
Cdd:COG5048   308 HLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-457 2.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1839337248 432 HLIQHQRIHTGEKPYKCNTCGKAFNQ 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 416-469 6.81e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 6.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1839337248 416 KPYkCKTCGKAFIRSTHLIQHQRIHTgekpYKCNTCGKAFNQTANLAQH--QRHHT 469
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHclQVHKE 51
PHA00733 PHA00733
hypothetical protein
 389-436 6.14e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1839337248 389 PYTCNICEKAFSDHSALTQHKRIHTREKpyKCKTCGKAFIRSTHLIQH 436
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-468 3.35e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 133 GKAFSKSSTLKKHQKLHTEKLNPSQKSPmkekrYKCRECGKAFHQSTHLIHHQRVHTGEKPYQCKD--CGKAFSVSSSLS 210
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRP-----DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 211 YHQKIHTGEKPFEC----------------NVCGKAFIRNIHLSHHHRMHTGEKPFQCNLcdkafvcrahltkHQHIHSG 274
Cdd:COG5048    81 RHLRTHHNNPSDLNskslplsnskasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDL-------------LSISNLR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 275 KKPYK-CNECGKAFNQSTSFLQ-------------------HQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPY 334
Cdd:COG5048   148 NNPLPgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 335 QCIECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFR--DQSALAQHQRTHTGE-----KPYTCNICEKAFSDHSALTQ 407
Cdd:COG5048   228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTR 307

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1839337248 408 HKR--IHTRE--KPYKC--KTCGKAFIRSTHLIQHQRIHTGEKPYKC--NTCGKAFNQTANLAQHQRHH 468
Cdd:COG5048   308 HLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
92-353 2.00e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248  92 VLTQQNTPSKLSEQRVRAESSSPIQSQRSQASKTAfecSECGKAFSKSSTLKKHQKLHTEKLNPSQKSPMKEKRYKCREC 171
Cdd:COG5048   219 NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS---SSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 172 GKAFHQSTHLIHHQR--VHTGE--KPYQC--KDCGKAFSVSSSLSYHQKIHTGEKPFEC--NVCGKAFIRNIH-----LS 238
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 239 HHHRMHTGEKPFQC--NLCDKAFVCRAHLTKHQHIHSGKKPYKCNecgkafnqstsflqhqrihtgekpfeCNECGKAFR 316
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK--------------------------NPPCSKSFN 429

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1839337248 317 VNSSLTEHQRIHTGEKPYQCIECGKAFRDNSSFARHR 353
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-464 2.81e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248  97 NTPSKLSEQRVRAESSSPIQSQRSQASKTAFECSECgKAFSKSSTLKKHQKLHTEKLNPSQKSPMKEKRYKCRECGKAFH 176
Cdd:COG5048    73 FSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS-SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 177 QSTHLIHHQRVHTGEKPYQC--KDCGKAFSVSSSLSYHQKIHTGEKPFECNVCGKAFIRNIHLSHHHRMHTGEKPFQCNL 254
Cdd:COG5048   152 PGNNSSSVNTPQSNSLHPPLpaNSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTT 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 255 CdkAFVCRAHLTKHQHIhSGKKPYKCNECGKAFNQSTSFLQHQRIH----------TGEKPFECNECGKAFRVNSSLTEH 324
Cdd:COG5048   232 N--SQLSPKSLLSQSPS-SLSSSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRH 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 325 QR--IHTGE--KPYQCIE--CGKAFRDNSSFARHRKIHTGEKPYRCGLC-------EKAFRDQSALAQHQRTHTGEKPYT 391
Cdd:COG5048   309 LRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSE 388

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1839337248 392 C--NICEKAFSDHSALTQHKRIHTREKPY--KCKTCGKAFIRSTHLIQHQRIHTGEKPYKCNTCGKaFNQTANLAQH 464
Cdd:COG5048   389 TlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-469 4.69e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 117 SQRSQASKTAFECS--ECGKAFSKSSTLKKHQKLHTEK---LNPSQKSPMKEKRYKCRECGKAFHQSTHLIHHQRVHTGE 191
Cdd:COG5048    52 HIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 192 KPYQCKDCGKAFSVSSSLSYHQKIHTG-------EKPFECNVCGKAFIRNIHLSH--HHRMHTGEKPFQCNLCDKAFVCR 262
Cdd:COG5048   132 SRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPSSSENSPLSSSYSI 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 263 AHLTKHQHIHSGKKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNECGKAFR--VNSSLTEHQRIHTGE-----KPYQ 335
Cdd:COG5048   212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQSSSPNESDSSSekgfsLPIK 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 336 CIECGKAFRDNSSFARHR--KIHTGE--KPYRCG--LCEKAFRDQSALAQHQRTHTGEKPYTCNIC-------EKAFSDH 402
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEP 371

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1839337248 403 SALTQHKRIHTREKPY------KCKTCGKAFIRSTHLIQH--QRIHtgekPYKCNTCGKAFNQTANLAQHQRHHT 469
Cdd:COG5048   372 PQSLQQYKDLKNDKKSetlsnsCIRNFKRDSNLSLHIITHlsFRPY----NCKNPPCSKSFNRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 386-469 1.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 386 GEKPYTCNI--CEKAFSDHSALTQHkRIHTREKPYKCKTCGKafirsthlIQHQRIHTGEKPYKCNTCGKAFNQTANLAQ 463
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1839337248 464 HQRHHT 469
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-457 2.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1839337248 432 HLIQHQRIHTGEKPYKCNTCGKAFNQ 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 416-469 6.81e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 6.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1839337248 416 KPYkCKTCGKAFIRSTHLIQHQRIHTgekpYKCNTCGKAFNQTANLAQH--QRHHT 469
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHclQVHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-343 7.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.23e-04
                          10        20
                  ....*....|....*....|....
gi 1839337248 320 SLTEHQRIHTGEKPYQCIECGKAF 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-429 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1839337248 404 ALTQHKRIHTREKPYKCKTCGKAFIR 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-233 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 1839337248 208 SLSYHQKIHTGEKPFECNVCGKAFIR 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*
gi 1839337248 376 ALAQHQRTHTGEKPYTCNICEKAFS 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-472 1.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1839337248 416 KPYKCKTCGKAFIRSTHLIQHQRIHTGEKPYKCN--TCGKAFNQTANLAQHQRHHTGGK 472
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNP 90
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-315 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|.
gi 1839337248 295 QHQRIHTGEKPFECNECGKAF 315
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 1839337248 264 HLTKHQHIHSGKKPYKCNECGKAFNQ 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 274-354 3.88e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1839337248 274 GKKPYKCN--ECGKAFNQSTSfLQHQRIHtgekpfecNECGKAFRVNSSLTEHQRIHTGEKPYQCIECGKAFRDNSSFAR 351
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNG-LKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1839337248 352 HRK 354
Cdd:COG5189   417 HRK 419
PHA00733 PHA00733
hypothetical protein
 389-436 6.14e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1839337248 389 PYTCNICEKAFSDHSALTQHKRIHTREKpyKCKTCGKAFIRSTHLIQH 436
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-204 6.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|.
gi 1839337248 184 HQRVHTGEKPYQCKDCGKAFS 204
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-261 6.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.79e-03
                          10        20
                  ....*....|....*....|..
gi 1839337248 240 HHRMHTGEKPFQCNLCDKAFVC 261
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 8.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.22e-03
                          10        20
                  ....*....|....*....|...
gi 1839337248 418 YKCKTCGKAFIRSTHLIQHQRIH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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