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Conserved domains on  [gi|1845766250|ref|NP_001369767|]
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uncharacterized protein LOC668525 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 45-85 1.34e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 1.34e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845766250  45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLTVIG 85
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-408 3.68e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250  98 HSSRRNERYVSNHSGEKLYECNERSKAFSCPSHLQchkrrqigeKTHEHNQCGKAFPTPSHLQYHERTHTGEKPYECPQC 177
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH---------PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSP 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 178 GQAFKKCSHLQRYKRTRTGEKPYKCNQCGKAFTSHNGLQYHKTT------HTGEKPYECNQCGKAFAQFCSLQYHKRTHT 251
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 252 G-EKPYECNQCGKAFAQLRSLKCHNRT--HTGE--KPYEC--NQCGKAFALLSGLQCHKRTHTGEKPYKCH--QCGKAFT 322
Cdd:COG5048   285 GfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 323 S-----HNGLQYHKRTHTGEKPYEC--HQCGKAFAQLISLQYHKRKHTGEKPYECN--QCGKAFSQHSHLQYHKRTHTGE 393
Cdd:COG5048   365 PllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNH 444

                         330
                  ....*....|....*
gi 1845766250 394 KPYECNQCGKAFAQL 408
Cdd:COG5048   445 APLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-435 3.05e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|..
gi 1845766250 414 HKRTHTGEKPYECNQCGKAFAQ 435
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 45-85 1.34e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 1.34e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845766250  45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLTVIG 85
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 45-82 1.18e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.18e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845766250  45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLT 82
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
45-86 6.19e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 71.85  E-value: 6.19e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1845766250   45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLTVIGY 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-408 3.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250  98 HSSRRNERYVSNHSGEKLYECNERSKAFSCPSHLQchkrrqigeKTHEHNQCGKAFPTPSHLQYHERTHTGEKPYECPQC 177
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH---------PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSP 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 178 GQAFKKCSHLQRYKRTRTGEKPYKCNQCGKAFTSHNGLQYHKTT------HTGEKPYECNQCGKAFAQFCSLQYHKRTHT 251
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 252 G-EKPYECNQCGKAFAQLRSLKCHNRT--HTGE--KPYEC--NQCGKAFALLSGLQCHKRTHTGEKPYKCH--QCGKAFT 322
Cdd:COG5048   285 GfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 323 S-----HNGLQYHKRTHTGEKPYEC--HQCGKAFAQLISLQYHKRKHTGEKPYECN--QCGKAFSQHSHLQYHKRTHTGE 393
Cdd:COG5048   365 PllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNH 444

                         330
                  ....*....|....*
gi 1845766250 394 KPYECNQCGKAFAQL 408
Cdd:COG5048   445 APLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 2.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 1845766250 382 HLQYHKRTHTGEKPYECNQCGKAFAQ 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-435 3.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|..
gi 1845766250 414 HKRTHTGEKPYECNQCGKAFAQ 435
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 45-85 1.34e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 1.34e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845766250  45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLTVIG 85
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 45-82 1.18e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.18e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845766250  45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLT 82
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
45-86 6.19e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 71.85  E-value: 6.19e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1845766250   45 VTYDDVHVNFTGEEWNLLDPSQKSLYKDVMLETYWNLTVIGY 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-408 3.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250  98 HSSRRNERYVSNHSGEKLYECNERSKAFSCPSHLQchkrrqigeKTHEHNQCGKAFPTPSHLQYHERTHTGEKPYECPQC 177
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH---------PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSP 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 178 GQAFKKCSHLQRYKRTRTGEKPYKCNQCGKAFTSHNGLQYHKTT------HTGEKPYECNQCGKAFAQFCSLQYHKRTHT 251
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 252 G-EKPYECNQCGKAFAQLRSLKCHNRT--HTGE--KPYEC--NQCGKAFALLSGLQCHKRTHTGEKPYKCH--QCGKAFT 322
Cdd:COG5048   285 GfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 323 S-----HNGLQYHKRTHTGEKPYEC--HQCGKAFAQLISLQYHKRKHTGEKPYECN--QCGKAFSQHSHLQYHKRTHTGE 393
Cdd:COG5048   365 PllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNH 444

                         330
                  ....*....|....*
gi 1845766250 394 KPYECNQCGKAFAQL 408
Cdd:COG5048   445 APLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
142-426 4.77e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 4.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 142 KTHEHNQCGKAFPTPSHLQYHERTHTGEKPYECPQCGQA--FKKCSHLQRYKRTRTGEKPYKCNQ--------------- 204
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 205 -CGKAFTSHNGLQYHKTTHTGEKPYECNQCGKAFAQFCSLQYHKRTHTGEK-------PYECNQCGKAFAQLRSLKCHNR 276
Cdd:COG5048   112 sSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 277 THTGEKPYECNQCGKAFALLSGLQCHKRTHTGEKPYKCHQCGKAFTSHNGLQYHKRT------HTGEKPYECHQCGKAFA 350
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 351 QLISLQYHKRKHTG-EKPYECNQCGKAFSQHSHLQYHKRT--HTGE--KPYEC--NQCGKAFAQLCSLQCHKRTHTGEKP 423
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351


                  ...
gi 1845766250 424 YEC 426
Cdd:COG5048   352 AKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 308-391 6.15e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.64  E-value: 6.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 308 GEKPYKCH--QCGKAFTSHNGLQYHKRthtgekpyECHqCGKAFAQLISLQYHKRKHTGEKPYECNQCGKAFSQHSHLQY 385
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1845766250 386 HkRTHT 391
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 196-251 2.94e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 2.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1845766250 196 GEKPYKCN--QCGKAFTSHNGLQYHK--------TTHT-----------GEKPYECNQCGKAFAQFCSLQYHkRTHT 251
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqkLHENpspekmnifsaKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 2.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 1845766250 382 HLQYHKRTHTGEKPYECNQCGKAFAQ 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-335 2.48e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1845766250 280 GEKPYECN--QCGKAFALLSGLQCHK-------RTH------------TGEKPYKCHQCGKAFTSHNGLQYHkRTHT 335
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 3.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1845766250 242 SLQYHKRTHTGEKPYECNQCGKAFAQ 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-351 3.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|....*
gi 1845766250 327 LQYHKRTHTGEKPYECHQCGKAFAQ 351
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-379 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 1845766250 354 SLQYHKRKHTGEKPYECNQCGKAFSQ 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
158-183 5.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1845766250 158 HLQYHERTHTGEKPYECPQCGQAFKK 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-298 8.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 144 HEHNQCGKAFPTPSHLQYHERT--HTGE--KPYECP--QCGQAFKKCSHLQRYKRTRTGEKPYKC--NQCGKAFTS---- 211
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnn 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 212 -HNGLQYHKTTHTGEKPYEC--NQCGKAFAQFCSLQYHKRTHTGEKPYECN--QCGKAFAQLRSLKCHNRTHTGEKPYEC 286
Cdd:COG5048   370 ePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                         170
                  ....*....|..
gi 1845766250 287 NQCGKAFALLSG 298
Cdd:COG5048   450 SILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-223 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 155 TPSHLQYHerthTGEKPYECP--QCGQAFKKCSHLQRYKRT-------------------RTGEKPYKCNQCGKAFTSHN 213
Cdd:COG5189   337 TPSRMLKV----KDGKPYKCPveGCNKKYKNQNGLKYHMLHghqnqklhenpspekmnifSAKDKPYRCEVCDKRYKNLN 412

                          90
                  ....*....|
gi 1845766250 214 GLQYHKTTHT 223
Cdd:COG5189   413 GLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-403 1.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 322 TSHNGLQYHKRTHTGE----KPYECHQCGKAFAQLISLQYHKRKHTGEKPYECNQ--CGKAFSQHSHLQYHKRTHTGEKP 395
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91


                  ....*...
gi 1845766250 396 YECNQCGK 403
Cdd:COG5048    92 DLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
366-431 1.85e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1845766250 366 KPYECNQCGKAFSQHSHLQYHKRTHTGEKPYECNQ--CGKAFAQLCSLQCHKRTHTGEKPYECNQCGK 431
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-323 2.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|..
gi 1845766250 302 HKRTHTGEKPYKCHQCGKAFTS 323
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 2.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|....*
gi 1845766250 215 LQYHKTTHTGEKPYECNQCGKAFAQ 239
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-435 3.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|..
gi 1845766250 414 HKRTHTGEKPYECNQCGKAFAQ 435
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 364-443 5.40e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 364 GEKPYECN--QCGKAFSQHSHLQYHKRThtgekpyecNQCGKAFAQLCSLQCHKRTHTGEKPYECNQCGKAFAQHSHLQY 441
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1845766250 442 HK 443
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-452 7.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 198 KPYKCNQCGKAFTSHNGLQYHKTTHTGEKPYECNQ--CGKAFAQFCSLQYHKRTHTGEKPYECN-QCGKAFAQLRSLKCH 274
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 275 NRTHTGEKPYECNQCGKAFALLSGLQCHKRTHTGEKPYKCHQCGKAF----------------------TSHNGLQYHKR 332
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 333 THTGEKPYECHQCGKAFAQLISLQYHKRKHTGEKPYECNQCG----------------------------------KAFS 378
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 379 QHSHLQYHKRTHTG-EKPYECNQCGKAFAQLCSLQCHKRT--HTGE--KPYEC--NQCGKAFAQHSHLQYHKRIHTGEKP 451
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351


                  .
gi 1845766250 452 Y 452
Cdd:COG5048   352 A 352
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
210-291 8.11e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845766250 210 TSHNGLQYHKTTHTGE----KPYECNQCGKAFAQFCSLQYHKRTHTGEKPYECNQCGKAFAQLR--SLKCHNRTHTGEKP 283
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPS 91


                  ....*...
gi 1845766250 284 YECNQCGK 291
Cdd:COG5048    92 DLNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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