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Conserved domains on  [gi|1859470809|ref|NP_001371343|]
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WD repeat-containing protein 5 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

PubMed:  10322433

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
37-331 1.60e-106

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 312.73  E-value: 1.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 197 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 276
Cdd:cd00200   161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470809 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 331
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
37-331 1.60e-106

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 312.73  E-value: 1.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 197 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 276
Cdd:cd00200   161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470809 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 331
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-331 4.98e-50

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 172.97  E-value: 4.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDDKTLKIW 114
Cdd:COG2319   147 LIRTLEGHSESVTSLAFSPDGKLLASgSSLDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLW 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 115 DVSSGKCLK-TLKGHSNYVFCCnFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
Cdd:COG2319   227 DLSTGKLLRsTLSGHSDSVVSS-FSPDGSLLASGSSDGTIRLWDLRSSSsLLRTLSGHSSSVLSVAFSPDGKLLASGSSD 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 193 GLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvtG 270
Cdd:COG2319   306 GTVRLWDLETGKLLSSLtLKGHEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHSNVLSVSFSP----D 381
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1859470809 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 331
Cdd:COG2319   382 GRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSS--DNTIRLWD 440
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
41-287 8.98e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 87.06  E-value: 8.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 112
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 190
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 191 YDGLCRIWDTASGQC-LKTLIDDdNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 263
Cdd:PLN00181  638 ADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713
                         250       260
                  ....*....|....*....|....
gi 1859470809 264 ANFSVTGGkWIVSGSEDNLVYIWN 287
Cdd:PLN00181  714 VGLSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
118-157 2.37e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470809  118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 2.27e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470809 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
103-229 4.20e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 103 VSASDDKTLKIWDVSSGKCLKTLK------GhsnyvfcCNFNPQSNLI-VSGSFDESVRIWDVKTGKCLKTLPAHSDP-V 174
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPvgqrprG-------ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLPSGPDPeQ 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470809 175 SAVHFNrDGSLIVSSSYDGLCRIWDTASGQCLKTLidddnpPVSF----VKFSPNGKYI 229
Cdd:TIGR03866  88 FALHPN-GKILYIANEDDALVTVIDIETRKVLAQI------DVGVepegMAVSPDGKIV 139
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
37-331 1.60e-106

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 312.73  E-value: 1.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 197 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 276
Cdd:cd00200   161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470809 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 331
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
33-199 6.71e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.31  E-value: 6.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282

                  ....*..
gi 1859470809 193 GLCRIWD 199
Cdd:cd00200   283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-331 4.98e-50

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 172.97  E-value: 4.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDDKTLKIW 114
Cdd:COG2319   147 LIRTLEGHSESVTSLAFSPDGKLLASgSSLDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLW 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 115 DVSSGKCLK-TLKGHSNYVFCCnFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
Cdd:COG2319   227 DLSTGKLLRsTLSGHSDSVVSS-FSPDGSLLASGSSDGTIRLWDLRSSSsLLRTLSGHSSSVLSVAFSPDGKLLASGSSD 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 193 GLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvtG 270
Cdd:COG2319   306 GTVRLWDLETGKLLSSLtLKGHEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHSNVLSVSFSP----D 381
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1859470809 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 331
Cdd:COG2319   382 GRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSS--DNTIRLWD 440
WD40 COG2319
WD40 repeat [General function prediction only];
16-331 1.41e-46

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 164.11  E-value: 1.41e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDV 93
Cdd:COG2319    36 SESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSleGLHDSSVSKL 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  94 AWSS---DSNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGS-FDESVRIWDVKTGKCLKTLP 168
Cdd:COG2319   116 ALSSpdgNSILLASSSLDGTVKLWDLSTpGKLIRTLEGHSESVTSLAFSPDGKLLASGSsLDGTIKLWDLRTGKPLSTLA 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 169 AHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVkFSPNGKYILAATLDNTLKLWDY-SKG 246
Cdd:COG2319   196 GHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSS-FSPDGSLLASGSSDGTIRLWDLrSSS 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 247 KCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVISTACHPTENIIASAAlEND 324
Cdd:COG2319   275 SLLRTLSGHSSSVLSVAFS---PDGKLLASGSSDGTVRLWDLETGKLLSslTLKGHEGPVSSLSFSPDGSLLVSGG-SDD 350

                  ....*..
gi 1859470809 325 KTIKLWK 331
Cdd:COG2319   351 GTIRLWD 357
WD40 COG2319
WD40 repeat [General function prediction only];
44-331 1.46e-45

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 161.41  E-value: 1.46e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  44 HTKAVSSVKF-SPNGEWLAS--SSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLKIWDVSS 118
Cdd:COG2319   108 HDSSVSKLALsSPDGNSILLasSSLDGTVKLWDLStPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRT 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 119 GKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVhFNRDGSLIVSSSYDGLCR 196
Cdd:COG2319   188 GKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRsTLSGHSDSVVSS-FSPDGSLLASGSSDGTIR 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Cdd:COG2319   267 LWDLRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLKGHEGPVSSLSFSPDGSLLVSG 346
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470809 277 GSEDNLVYIWNLQTKEIVQKLQGHTDvVISTACHPTENIIASAalENDKTIKLWK 331
Cdd:COG2319   347 GSDDGTIRLWDLRTGKPLKTLEGHSN-VLSVSFSPDGRVVSSG--STDGTVRLWD 398
WD40 COG2319
WD40 repeat [General function prediction only];
40-297 8.37e-43

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 153.71  E-value: 8.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  40 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGK-FEKTISGHKlGISDVAWSSDSNLLVSASDDKTLKIWDV- 116
Cdd:COG2319   193 TLAGHTDPVSSLAFSPDGGLlIASGSSDGTIRLWDLSTGKlLRSTLSGHS-DSVVSSFSPDGSLLASGSSDGTIRLWDLr 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSS-SYDG 193
Cdd:COG2319   272 SSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLlsSLTLKGHEGPVSSLSFSPDGSLLVSGgSDDG 351
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 194 LCRIWDTASGQCLKTLIDDDNppVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSvtgGKW 273
Cdd:COG2319   352 TIRLWDLRTGKPLKTLEGHSN--VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPD---GKS 426
                         250       260
                  ....*....|....*....|....
gi 1859470809 274 IVSGSEDNLVYIWNLQTKEIVQKL 297
Cdd:COG2319   427 LASGSSDNTIRLWDLKTSLKSVSF 450
WD40 COG2319
WD40 repeat [General function prediction only];
37-333 8.30e-38

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 140.22  E-value: 8.30e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGaydgKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Cdd:COG2319    19 SELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPD----LSSLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 117 SSG-KCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVS-S 189
Cdd:COG2319    95 DNGeKLIKSLEGLHDSsvskLALSSPDGNSILLASSSLDGTVKLWDLSTpGKLIRTLEGHSESVTSLAFSPDGKLLASgS 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 190 SYDGLCRIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSKGKCLK-TYTGHKNEKYCIFANfs 267
Cdd:COG2319   175 SLDGTIKLWDLRTGKPLSTL-AGHTDPVSSLAFSPDGGLLIAsGSSDGTIRLWDLSTGKLLRsTLSGHSDSVVSSFSP-- 251
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1859470809 268 vtGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLWKSD 333
Cdd:COG2319   252 --DGSLLASGSSDGTIRLWDLRSsSSLLRTLSGHSSSVLSVAFSPDGKLLASGS--SDGTVRLWDLE 314
WD40 COG2319
WD40 repeat [General function prediction only];
62-333 3.29e-29

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 116.73  E-value: 3.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGkclkTLKGHSNYVFCCNFNPQS 141
Cdd:COG2319     2 VDNSSTSSENKSKLLKKSELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSL----LLRGHEDSITSIAFSPDG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 142 NLIVSGSFDESVRIWDVKTG-KCLKTLP-AHSDPVSAVHF-NRDGSLIVS--SSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Cdd:COG2319    78 ELLLSGSSDGTIKLWDLDNGeKLIKSLEgLHDSSVSKLALsSPDGNSILLasSSLDGTVKLWDLSTPGKLIRTLEGHSES 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 217 VSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Cdd:COG2319   158 VTSLAFSPDGKLLASGsSLDGTIKLWDLRTGKPLSTLAGHTDPVSSL--AFSPDGGLLIASGSSDGTIRLWDLSTGKLLR 235
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1859470809 296 -KLQGHTDVVIStACHPTENIIASAalENDKTIKLWKSD 333
Cdd:COG2319   236 sTLSGHSDSVVS-SFSPDGSLLASG--SSDGTIRLWDLR 271
WD40 COG2319
WD40 repeat [General function prediction only];
31-237 1.07e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 106.71  E-value: 1.07e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGISDVAWSSD-SNLLVSASD 107
Cdd:COG2319   270 LRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLlsSLTLKGHEGPVSSLSFSPDgSLLVSGGSD 349
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 108 DKTLKIWDVSSGKCLKTLKGHSNyVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187
Cdd:COG2319   350 DGTIRLWDLRTGKPLKTLEGHSN-VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLA 428
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1859470809 188 SSSYDGLCRIWDTASgqclktlidddnpPVSFVKFSPNGKYILAATLDNT 237
Cdd:COG2319   429 SGSSDNTIRLWDLKT-------------SLKSVSFSPDGKVLASKSSDLS 465
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
41-287 8.98e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 87.06  E-value: 8.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 112
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 190
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 191 YDGLCRIWDTASGQC-LKTLIDDdNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 263
Cdd:PLN00181  638 ADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713
                         250       260
                  ....*....|....*....|....
gi 1859470809 264 ANFSVTGGkWIVSGSEDNLVYIWN 287
Cdd:PLN00181  714 VGLSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
118-157 2.37e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470809  118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
160-199 6.28e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 6.28e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470809  160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
41-222 7.72e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.91  E-value: 7.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTIS-------GH--KLGISDVAWSSdSNLLVSASDDKT 110
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHtkKVGIVSFHPSA-MNVLASAGADMV 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS--AVHFNRDGSLI-- 186
Cdd:PTZ00421  150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIItl 229
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1859470809 187 -VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222
Cdd:PTZ00421  230 gCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPF 266
WD40 pfam00400
WD domain, G-beta repeat;
119-157 2.27e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470809 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
76-115 2.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470809   76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
161-199 2.77e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470809 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
77-115 6.77e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 6.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470809  77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
37-72 2.24e-08

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.24e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1859470809  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
37-72 3.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 3.54e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1859470809   37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
115-330 4.34e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 115 DVSSGKCLKTlkghSNYVFCCNFNPQSNLIVSGSFDESVRIWD----VKTGKCLKtLP----AHSDPVSAVHFNRD-GSL 185
Cdd:PLN00181  473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIH-YPvvelASRSKLSGICWNSYiKSQ 547
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 186 IVSSSYDGLCRIWDTASGQcLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNeKYCIfa 264
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQ-LVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKAN-ICCV-- 623
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1859470809 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTENIIASAaleNDKTIKLW 330
Cdd:PLN00181  624 QFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSS---TDNTLKLW 687
PTZ00420 PTZ00420
coronin; Provisional
83-162 2.31e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  83 ISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDV----SSGKCLK----TLKGHSNYVFCCNFNPQSNLIV-SGSFDES 152
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149
                          90
                  ....*....|
gi 1859470809 153 VRIWDVKTGK 162
Cdd:PTZ00420  150 VNIWDIENEK 159
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
93-180 3.10e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  93 VAWSSDSNLLVSASDDKTL--------KIWDVSsgkclktLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLS-------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
                          90
                  ....*....|....*.
gi 1859470809 165 KTLPAHSDPVSAVHFN 180
Cdd:pfam12894  74 HHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
125-199 3.95e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 125 LKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD----------VKTGKCLktLPAHSDPVSAVHFNRDGSLIV-SSSYD 192
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesvkeIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFD 147

                  ....*..
gi 1859470809 193 GLCRIWD 199
Cdd:PTZ00420  148 SFVNIWD 154
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
217-281 4.62e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.02  E-value: 4.62e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859470809 217 VSFVKFSPNGKYILAATLdNTLKLWDYSKGK-CLKTYTGHKN---------EKYCIFANFSVT---GGKWIVSGSEDN 281
Cdd:COG5170   283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
202-242 1.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1859470809  202 SGQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 242
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
70-138 1.23e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470809  70 KIWGAYDGKfektisgHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
246-287 1.72e-04

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.72e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1859470809 246 GKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 287
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
290-331 1.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.82e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1859470809  290 TKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLWK 331
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-242 1.83e-04

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470809 203 GQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 242
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
245-287 4.95e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.95e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1859470809  245 KGKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 287
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
90-124 1.77e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 39.75  E-value: 1.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1859470809  90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT 124
Cdd:pfam11715 225 APAVTTVGGQNFLFTLSLDHTLRVWDLLTGKCLAT 259
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
38-98 2.15e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1859470809  38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
76-244 2.30e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 400822 [Multi-domain]  Cd Length: 194  Bit Score: 38.41  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809  76 DGKFEKTISGHKLG-ISDVAWSSDSN--LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFccnFNPQSNLIVSGSFDE- 151
Cdd:pfam08662  47 TGGPDCVVELDKEGpIHDVAWSPNGKefAVIYGYMPAKVSFFDLKGNVIHSFGEQPRNTIF---WSPFGRLVLLAGFGNl 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 152 --SVRIWDVKTGKCLKTlpahsdpvsAVHFNrdgslivsssydglcriwdtasgqclktlidddnppVSFVKFSPNGKYI 229
Cdd:pfam08662 124 agDIEFWDVVNKKKIAT---------AEASN------------------------------------ATLCEWSPDGRYF 158
                         170       180
                  ....*....|....*....|.
gi 1859470809 230 LAATL------DNTLKLWDYS 244
Cdd:pfam08662 159 LTATTaprlrvDNGFKIWHYN 179
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
208-294 2.56e-03

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 39.47  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNtLKLWDY-SKGKCLKTYtgHKNEKYCIFAnfsvTGGKWIVSGS-------- 278
Cdd:COG5354    26 TRFESENWPVAYVSESPLGTYLFSEHAAG-VECWGGpSKAKLVRFR--HPDVKYLDFS----PNEKYLVTWSrepiiepe 98
                          90       100
                  ....*....|....*....|...
gi 1859470809 279 -------EDNLVYIWNLQTKEIV 294
Cdd:COG5354    99 ieispftSKNNVFVWDIASGMIV 121
WD40 pfam00400
WD domain, G-beta repeat;
291-330 4.02e-03

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470809 291 KEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 330
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVW 38
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
103-229 4.20e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470809 103 VSASDDKTLKIWDVSSGKCLKTLK------GhsnyvfcCNFNPQSNLI-VSGSFDESVRIWDVKTGKCLKTLPAHSDP-V 174
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPvgqrprG-------ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLPSGPDPeQ 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470809 175 SAVHFNrDGSLIVSSSYDGLCRIWDTASGQCLKTLidddnpPVSF----VKFSPNGKYI 229
Cdd:TIGR03866  88 FALHPN-GKILYIANEDDALVTVIDIETRKVLAQI------DVGVepegMAVSPDGKIV 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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