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Conserved domains on  [gi|1859470566|ref|NP_001371347|]
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WD repeat-containing protein 5 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-287 4.06e-96

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 288.73  E-value: 4.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  40 TLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 118
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 119 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 198
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 199 DYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAl 278
Cdd:COG2319   316 DLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS- 391


                  ....*....
gi 1859470566 279 eNDKTIKLW 287
Cdd:COG2319   392 -ADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-287 4.06e-96

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 288.73  E-value: 4.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  40 TLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 118
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 119 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 198
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 199 DYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAl 278
Cdd:COG2319   316 DLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS- 391


                  ....*....
gi 1859470566 279 eNDKTIKLW 287
Cdd:COG2319   392 -ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-288 1.06e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 263.43  E-value: 1.06e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 115
Cdd:cd00200    43 LLRTLKGHTGPVRDVAASADGTYLASgSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 116 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTL 195
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 196 KLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 275
Cdd:cd00200   202 KLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         250
                  ....*....|...
gi 1859470566 276 AALenDKTIKLWK 288
Cdd:cd00200   279 GSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-244 1.08e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 71.27  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSPNGEWLASS-YDKTLKIWDVSS----GKCLK----TLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 111
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAgVNKKIKIFECESiikdGRDIHypvvELASRSKLSGICWNSYIKSQVASSNFEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 112 IWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTL------------------------ 166
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIktkaniccvqfpsesgrslafgsa 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 167 ------IDDDNPP------------VSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciFAN 222
Cdd:PLN00181  639 dhkvyyYDLRNPKlplctmighsktVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FVG 715

                         250       260
                  ....*....|....*....|..
gi 1859470566 223 FSVTGGkWIVSGSEDNLVYIWN 244
Cdd:PLN00181  716 LSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 75-114 9.83e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 9.83e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470566   75 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
76-114 9.83e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 9.83e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470566  76 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-287 4.06e-96

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 288.73  E-value: 4.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  40 TLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 118
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 119 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 198
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 199 DYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAl 278
Cdd:COG2319   316 DLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS- 391


                  ....*....
gi 1859470566 279 eNDKTIKLW 287
Cdd:COG2319   392 -ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
36-287 8.08e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 280.26  E-value: 8.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  36 ALKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASgSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 115 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNT 194
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGT 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 195 LKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 274
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSGGVNSV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                         250
                  ....*....|...
gi 1859470566 275 SAAleNDKTIKLW 287
Cdd:COG2319   347 SGS--DDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-288 1.06e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 263.43  E-value: 1.06e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 115
Cdd:cd00200    43 LLRTLKGHTGPVRDVAASADGTYLASgSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 116 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTL 195
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 196 KLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 275
Cdd:cd00200   202 KLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         250
                  ....*....|...
gi 1859470566 276 AALenDKTIKLWK 288
Cdd:cd00200   279 GSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
36-287 9.73e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.15  E-value: 9.73e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  36 ALKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASaSADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 115 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNT 194
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGT 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 195 LKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 274
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSV--AFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         250
                  ....*....|...
gi 1859470566 275 SAAleNDKTIKLW 287
Cdd:COG2319   305 SGS--DDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
12-287 6.47e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.00  E-value: 6.47e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVF 90
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAgAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  91 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 170
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 171 NPPVSfVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEI 250
Cdd:COG2319   163 GAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGTVRLWDLATGKL 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1859470566 251 VQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 287
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
37-199 6.91e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.90  E-value: 6.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 115
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 116 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTL 195
Cdd:COG2319   318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTV 396


                  ....
gi 1859470566 196 KLWD 199
Cdd:COG2319   397 RLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-199 1.30e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.68  E-value: 1.30e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  33 PNYALKFTLAGHTKAVSSVKFSPNGEWLA-SSYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 111
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVAsSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 112 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATL 191
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-SVTSLAWSPDGKRLASGSA 281


                  ....*...
gi 1859470566 192 DNTLKLWD 199
Cdd:cd00200   282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-159 3.04e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 3.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 115
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1859470566 116 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 159
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-244 1.08e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 71.27  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSPNGEWLASS-YDKTLKIWDVSS----GKCLK----TLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 111
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAgVNKKIKIFECESiikdGRDIHypvvELASRSKLSGICWNSYIKSQVASSNFEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 112 IWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTL------------------------ 166
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIktkaniccvqfpsesgrslafgsa 638

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 167 ------IDDDNPP------------VSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciFAN 222
Cdd:PLN00181  639 dhkvyyYDLRNPKlplctmighsktVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FVG 715

                         250       260
                  ....*....|....*....|..
gi 1859470566 223 FSVTGGkWIVSGSEDNLVYIWN 244
Cdd:PLN00181  716 LSVSDG-YIATGSETNEVFVYH 736
PTZ00421 PTZ00421
coronin; Provisional
 41-160 5.12e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 65.68  E-value: 5.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSP--NGEWLASSYDKTLKIWDV-------SSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESV 110
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfdPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1859470566 111 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 160
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 75-114 9.83e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 9.83e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470566   75 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 117-156 2.72e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 2.72e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470566  117 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 156
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
76-114 9.83e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 9.83e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470566  76 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 114
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
118-156 1.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 1.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470566 118 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 156
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 41-179 4.07e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.21  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSPNGE-WLASS-YDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 118
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMnVLASAgADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1859470566 119 KCLKTLPAHSDPVS--AVHFNRDGSLI---VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 179
Cdd:PTZ00421  201 TIVSSVEAHASAKSqrCLWAKRKDLIItlgCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPF 266
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
59-203 6.81e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 6.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  59 WLASSYDKTLKIWDVSSGKCLKTLK--GHSNYVFccnFNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVh 135
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPvgGGPRGLA---VDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA- 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 136 FNRDGS-LIVSSSYDGlcRIW------DTASGQCLKTLIDDDNPpvSFVKFSPNGKYILAA--------TLDNTLKLWDY 200
Cdd:COG3391   159 VDPDGKrLYVANSGSN--TVSvivsviDTATGKVVATIPVGGGP--VGVAVSPDGRRLYVAnrgsntsnGGSNTVSVIDL 234


                  ...
gi 1859470566 201 SKG 203
Cdd:COG3391   235 ATL 237
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 72-287 2.26e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  72 DVSSGKCLKTlkghSNYVFCCNFNPQSNLIVSGSFDESVRIWD----VKTGKCLKtLP----AHSDPVSAVHFNRD-GSL 142
Cdd:PLN00181  473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIH-YPvvelASRSKLSGICWNSYiKSQ 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 143 IVSSSYDGLCRIWDTASGQcLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNeKYCIfa 221
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQ-LVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKAN-ICCV-- 623

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1859470566 222 NFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTENIIASAaleNDKTIKLW 287
Cdd:PLN00181  624 QFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSS---TDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
37-72 3.27e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1859470566  37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWD 72
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASgSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 37-72 4.82e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1859470566   37 LKFTLAGHTKAVSSVKFSPNGEWLAS-SYDKTLKIWD 72
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASgSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
100-193 5.79e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 5.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 100 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPvSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPpvSFVK 178
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGP--HGIA 158

                          90
                  ....*....|....*
gi 1859470566 179 FSPNGKYILAATLDN 193
Cdd:COG3391   159 VDPDGKRLYVANSGS 173
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 54-274 2.06e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.53  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  54 SPNGEWLAS--SYDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK--------- 122
Cdd:pfam20426  90 TPSENFLIScgNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqte 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 123 --------------TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 188
Cdd:pfam20426 170 fprkdhviaetpfhILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLY 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 189 AtlDNTLKLWDYS-KGKCLKTYT--GHKNekyCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 265
Cdd:pfam20426 250 A--DDDLSLHLYSiNGKHIASSEsnGRLN---CI--ELS-SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLT 321


                  ....*....
gi 1859470566 266 CHPTENIIA 274
Cdd:pfam20426 322 VTPEECFLA 330
PTZ00420 PTZ00420
coronin; Provisional
 41-119 2.30e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSP-NGEWLAS-SYDKTLKIWDV----SSGKCLK----TLKGHSNYVFCCNFNPQSNLIV-SGSFDES 109
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASgSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                          90
                  ....*....|
gi 1859470566 110 VRIWDVKTGK 119
Cdd:PTZ00420  150 VNIWDIENEK 159
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-146 5.03e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  40 TLAGHTKAVSSVKFSPNGEWLASSYDKTLKIWDVS---SG---KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 113
Cdd:PLN00181  656 TMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsiSGineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1859470566 114 DvktgkclKTLPA--------HSDPVSAVHFNrDGSLIVSS 146
Cdd:PLN00181  736 H-------KAFPMpvlsykfkTIDPVSGLEVD-DASQFISS 768
PTZ00420 PTZ00420
coronin; Provisional
 82-156 2.81e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  82 LKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD----------VKTGKCLktLPAHSDPVSAVHFNRDGSLIV-SSSYD 149
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesvkeIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFD 147


                  ....*..
gi 1859470566 150 GLCRIWD 156
Cdd:PTZ00420  148 SFVNIWD 154
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
174-238 2.85e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.02  E-value: 2.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859470566 174 VSFVKFSPNGKYILAATLdNTLKLWDYSKGK-CLKTYTGHKN---------EKYCIFANFSVT---GGKWIVSGSEDN 238
Cdd:COG5170   283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
48-260 4.65e-05

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 44.48  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  48 VSSVKFSPNGEWLASSYDKTLKIWDVSSGKCLKTLKghSNYVFCCNFNPQSNLIVSGSfDESVRiwdvktgkclktlpah 127
Cdd:COG5354    35 VAYVSESPLGTYLFSEHAAGVECWGGPSKAKLVRFR--HPDVKYLDFSPNEKYLVTWS-REPII---------------- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 128 sdpvsavHFNRDGSlivSSSYDGLCRIWDTASGQCLKTLIDDDNPPV--SFVKFSPNGKYiLAATLDNTLKLWDYSK--- 202
Cdd:COG5354    96 -------EPEIEIS---PFTSKNNVFVWDIASGMIVFSFNGISQPYLgwPVLKFSIDDKY-VARVVGSSLYIHEITDnie 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 203 ----------------------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS---EDNLVYIWNLQTKEIVQKLQGH 257
Cdd:COG5354   165 ehpfknlrpvgildfsispegnHDELAYWTPEKLNKPAMVRILSIPKNSVLVTKNlfkVSGVQLKWQVLGKYLLVLVMTH 244


                  ...
gi 1859470566 258 TDV 260
Cdd:COG5354   245 TKS 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-199 6.34e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.34e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1859470566  159 SGQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 199
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-244 8.92e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 8.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1859470566 203 GKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 244
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
160-199 9.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 9.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470566 160 GQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 199
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 247-288 9.98e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 9.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1859470566  247 TKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLWK 288
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 94-183 1.00e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.96  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  94 FNPQSNLIVSGSFDESVRIWDVKTGKcLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRiWDTASGQcLKTLIDDDNPP 173
Cdd:COG3386    15 WDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVR-FDPADGE-VTVLADEYGKP 91

                          90
                  ....*....|...
gi 1859470566 174 VSF---VKFSPNG 183
Cdd:COG3386    92 LNRpndGVVDPDG 104
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 69-137 2.02e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 2.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470566  69 KIWDVSsgkclktLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 137
Cdd:pfam12894  28 RVWTLS-------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 75-160 2.53e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  75 SGKCLKTLKGHSNyvfccNFnpqsnLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 154
Cdd:pfam20426  81 GAQCFATLQTPSE-----NF-----LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150


                  ....*.
gi 1859470566 155 WDTASG 160
Cdd:pfam20426 151 WEVLRG 156
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
41-117 2.68e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 42.32  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  41 LAGHTKAVSSVKFSPNGEWLASSYDKTLKIWDVSSGK-CLKTLKGHSNYV---------------FCCNFNPQSNLIVSG 104
Cdd:COG5170   276 FEEIVSSISDFKFSDNGRYILSRDYLTVKIWDVNMAKnPIKTIPMHCDLMdelndvyendaifdkFEISFSGDDKHVLSG 355

                          90
                  ....*....|...
gi 1859470566 105 SFDESVRIWDVKT 117
Cdd:COG5170   356 SYSNNFGIYPTDS 368
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-244 2.69e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1859470566  202 KGKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
86-250 3.29e-04

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 42.28  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  86 SNYVFCCNFNPQSNLIVS---GSFDESVRIWDVKTGKcLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRiWDTAS 159
Cdd:COG3292   266 GNSVRSIAEDSDGNLWIRlwiGTYGGGLFRLDPKTGK-FKRYNPNGlpsNSVYSILEDSDGNLWIGTSGGGLYR-YDPKT 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 160 GQCLKTLIDD--DNPPVSFVKFSPNGKyILAATlDNTLKLWDYSKGKcLKTYTGHKNEK-------YCIFANFSvtGGKW 230
Cdd:COG3292   344 GKFTKFSEDNglSNNFIRSILEDSDGN-LWVGT-NGGLYRLDPKTGK-FTNFTHDPDKNglssnyiNSIFEDSD--GRLW 418

                         170       180
                  ....*....|....*....|
gi 1859470566 231 IvsGSEDNLVYIWNLQTKEI 250
Cdd:COG3292   419 I--GTDGGGLYRYDPKTGKF 436
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 100-198 6.64e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 100 LIVSGSFDESVRIW--DVKTGKcLKTLPAHSDPVSAVHFNRDGSLIV-SSSYDGLCRIW--DTASGQclKTLIDDDNPPV 174
Cdd:COG0823     1 LAFTLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGE--PRRLTFGGGYN 77

                          90       100
                  ....*....|....*....|....*
gi 1859470566 175 SFVKFSPNGKYIL-AATLDNTLKLW 198
Cdd:COG0823    78 ASPSWSPDGKRLAfVSRSDGRFDIY 102
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
165-251 2.08e-03

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 39.47  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 165 TLIDDDNPPVSFVKFSPNGKYILAATLDNtLKLWDY-SKGKCLKTYtgHKNEKYCIFAnfsvTGGKWIVSGS-------- 235
Cdd:COG5354    26 TRFESENWPVAYVSESPLGTYLFSEHAAG-VECWGGpSKAKLVRFR--HPDVKYLDFS----PNEKYLVTWSrepiiepe 98

                          90       100
                  ....*....|....*....|...
gi 1859470566 236 -------EDNLVYIWNLQTKEIV 251
Cdd:COG5354    99 ieispftSKNNVFVWDIASGMIV 121
WD40 pfam00400
WD domain, G-beta repeat;
248-287 2.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470566 248 KEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 287
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVW 38
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 61-190 2.32e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.73  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566  61 ASSYDKTLKIW--DVSSGKcLKTLKGHSNYVFCCNFNPQSNLIV-----SGSFDesVRIWDVKTGKcLKTLPAHSDPVSA 133
Cdd:COG0823     4 TLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAftsdrGGGPQ--IYVVDADGGE-PRRLTFGGGYNAS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470566 134 VHFNRDGSLIVSSSY-DGLCRIW--DTASGQcLKTLIDDDNPPVsfvkFSPNGKYILAAT 190
Cdd:COG0823    80 PSWSPDGKRLAFVSRsDGRFDIYvlDLDGGA-PRRLTDGPGSPS----WSPDGRRIVFSS 134
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 178-252 3.44e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.87  E-value: 3.44e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470566  178 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYcIFANFSvTGGKWIV-SGSEDNL---VYIWNLQTKEIVQ 252
Cdd:COG4946    395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDGYGDGI-SDLAWS-PDSKWLAySKPGPNQlsqIFLYDVETGKTVQ 471
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 139-204 4.68e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.48  E-value: 4.68e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859470566  139 DGSLIVSSSYDGlcRIW--DTASGQClkTLIDDD--NPPVSFVKFSPNGKYIL-AATLDNTL---KLWDYSKGK 204
Cdd:COG4946    399 DGKKIAFTDNRG--RLWvvDLASGKV--RKVDTDgyGDGISDLAWSPDSKWLAySKPGPNQLsqiFLYDVETGK 468
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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