WD repeat-containing protein 5 isoform 4 [Homo sapiens]
WD40 repeat domain-containing protein( domain architecture ID 10077586)
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
37-288 | 1.02e-87 | |||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. : Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 263.43 E-value: 1.02e-87
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Name | Accession | Description | Interval | E-value | |||||
WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
37-288 | 1.02e-87 | |||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 263.43 E-value: 1.02e-87
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
37-288 | 4.45e-46 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 161.02 E-value: 4.45e-46
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
41-244 | 1.04e-13 | |||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 71.27 E-value: 1.04e-13
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
75-114 | 9.43e-11 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.78 E-value: 9.43e-11
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WD40 | pfam00400 | WD domain, G-beta repeat; |
76-114 | 9.44e-10 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 53.12 E-value: 9.44e-10
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Name | Accession | Description | Interval | E-value | |||||
WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
37-288 | 1.02e-87 | |||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 263.43 E-value: 1.02e-87
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
33-199 | 1.25e-52 | |||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 173.68 E-value: 1.25e-52
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
37-288 | 4.45e-46 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 161.02 E-value: 4.45e-46
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
40-288 | 2.89e-41 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 148.31 E-value: 2.89e-41
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
16-290 | 3.04e-39 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 142.92 E-value: 3.04e-39
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
37-254 | 1.25e-35 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 133.29 E-value: 1.25e-35
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
37-290 | 1.49e-30 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 119.42 E-value: 1.49e-30
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
31-202 | 5.81e-26 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 106.33 E-value: 5.81e-26
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
38-194 | 3.08e-18 | |||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 84.37 E-value: 3.08e-18
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
41-244 | 1.04e-13 | |||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 71.27 E-value: 1.04e-13
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PTZ00421 | PTZ00421 | coronin; Provisional |
41-160 | 4.91e-12 | |||||
coronin; Provisional Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 65.68 E-value: 4.91e-12
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
75-114 | 9.43e-11 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.78 E-value: 9.43e-11
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
117-156 | 2.61e-10 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 54.63 E-value: 2.61e-10
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WD40 | pfam00400 | WD domain, G-beta repeat; |
76-114 | 9.44e-10 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 53.12 E-value: 9.44e-10
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WD40 | pfam00400 | WD domain, G-beta repeat; |
118-156 | 1.21e-09 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 52.73 E-value: 1.21e-09
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PTZ00421 | PTZ00421 | coronin; Provisional |
41-179 | 3.90e-09 | |||||
coronin; Provisional Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 57.21 E-value: 3.90e-09
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
72-287 | 2.17e-08 | |||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 55.09 E-value: 2.17e-08
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WD40 | pfam00400 | WD domain, G-beta repeat; |
37-72 | 3.13e-08 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 48.88 E-value: 3.13e-08
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
37-72 | 4.62e-08 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.46 E-value: 4.62e-08
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PTZ00420 | PTZ00420 | coronin; Provisional |
41-119 | 2.20e-06 | |||||
coronin; Provisional Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 48.79 E-value: 2.20e-06
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
40-146 | 4.82e-06 | |||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.77 E-value: 4.82e-06
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PTZ00420 | PTZ00420 | coronin; Provisional |
82-156 | 2.70e-05 | |||||
coronin; Provisional Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 45.33 E-value: 2.70e-05
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CDC55 | COG5170 | Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; |
174-238 | 2.73e-05 | |||||
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; Pssm-ID: 227498 [Multi-domain] Cd Length: 460 Bit Score: 45.02 E-value: 2.73e-05
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COG5354 | COG5354 | Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]; |
48-260 | 4.46e-05 | |||||
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]; Pssm-ID: 227657 [Multi-domain] Cd Length: 561 Bit Score: 44.48 E-value: 4.46e-05
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
159-199 | 6.08e-05 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.60 E-value: 6.08e-05
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WD40 | pfam00400 | WD domain, G-beta repeat; |
203-244 | 8.55e-05 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 8.55e-05
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WD40 | pfam00400 | WD domain, G-beta repeat; |
160-199 | 9.07e-05 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 38.87 E-value: 9.07e-05
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
247-288 | 9.57e-05 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 9.57e-05
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ANAPC4_WD40 | pfam12894 | Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
69-137 | 1.94e-04 | |||||
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC, Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 39.57 E-value: 1.94e-04
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CDC55 | COG5170 | Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; |
41-117 | 2.57e-04 | |||||
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; Pssm-ID: 227498 [Multi-domain] Cd Length: 460 Bit Score: 42.32 E-value: 2.57e-04
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
202-244 | 2.58e-04 | |||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 2.58e-04
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COG5354 | COG5354 | Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]; |
165-251 | 2.00e-03 | |||||
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]; Pssm-ID: 227657 [Multi-domain] Cd Length: 561 Bit Score: 39.47 E-value: 2.00e-03
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WD40 | pfam00400 | WD domain, G-beta repeat; |
248-287 | 2.12e-03 | |||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 35.01 E-value: 2.12e-03
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ANAPC4_WD40 | pfam12894 | Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
94-166 | 9.69e-03 | |||||
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC, Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 34.56 E-value: 9.69e-03
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Blast search parameters | ||||
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