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Conserved domains on  [gi|1862457439|ref|NP_001371696|]
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putative solute carrier family 22 member 31 isoform e [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-275 1.74e-85

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17443:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 343  Bit Score: 261.25  E-value: 1.74e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAG 240
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAG 295

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1862457439 241 LGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17443   296 LGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFAS 330
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-275 1.74e-85

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 261.25  E-value: 1.74e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAG 240
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAG 295

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1862457439 241 LGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17443   296 LGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFAS 330
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-297 1.03e-17

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 83.91  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  84 LEenslateLTMLSARSPQPRYHSPLGLLRTRVTWRNGLIL---GFSSLVGggirasfRRSLAPQVPTF----YLPYFLE 156
Cdd:TIGR00898 299 LS-------LSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmmlWFTTAFS-------YYGLVLDLGNLggniYLDLFIS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 157 AGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPgWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVI 236
Cdd:TIGR00898 365 GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLY-FLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1862457439 237 RGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 297
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
Sugar_tr pfam00083
Sugar (and other) transporter;
24-257 7.03e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 47.27  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 167 LLLTADCCGRRPVLLLGTMV-TGLASLLLLAGAQYLPGWTVL-FLSVLGLLASRAVSALS-----SLFAAEVFPTVIRGA 239
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLGAAGmAICFVILGIVALLGVSKSDWAgIVAIVFIALFIAFFAMGwgpvpWVIVSELFPLSVRSK 386

                         250
                  ....*....|....*...
gi 1862457439 240 GLGLVLGAGFLGQAAGPL 257
Cdd:pfam00083 387 AMALATAANWLANFLIGF 404
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-275 1.74e-85

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 261.25  E-value: 1.74e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAG 240
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAG 295

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1862457439 241 LGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17443   296 LGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFAS 330
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 1-275 1.66e-72

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 228.17  E-value: 1.66e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17373   117 MVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFP---------------------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVP-TFYLPYFLEAGL 159
Cdd:cd17373   163 --------------------------------------KNILILGFNSLTGYGIRHCFARSMMGHEPeNFYLDYYLTAGI 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 160 EAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPG---------------WTVLFLSVLGLLASRAVSALS 224
Cdd:cd17373   205 AAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKysqhpdsgmsdsvkdKFSIAFSVLGLFASHAVGSLS 284

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1862457439 225 SLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17373   285 VLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVFAC 335
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 1-275 8.54e-31

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 119.11  E-value: 8.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLlFWGFPALfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17445   128 MAGGLTMVGGHFLLLGLALGCGSWRVLQGTITAPLSLFL-CYGCPGV--------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIR---ASFRRSLAPQVPTFYLPYFLEA 157
Cdd:cd17445   174 --------------------------------------KNLLILGFTTFIAHAIShcyQSFSDDVRGTPSTFYLSYLLST 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 158 GLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 237
Cdd:cd17445   216 GTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIR 295

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1862457439 238 GAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17445   296 GSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLAS 333
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 1-274 1.06e-18

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 85.67  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17444   128 MVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCI---FP------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSL------APQVPTFYLPYF 154
Cdd:cd17444   174 --------------------------------------KNIVVLCVNSLTGYGIHHCFAKSMmdhemkGSFLHNFYAEYY 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 155 LEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLF---------------LSVLGLLASRA 219
Cdd:cd17444   216 TMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPdsgmsdevkdkfsvtFSIVGMFSSHA 295

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1862457439 220 VSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFA 274
Cdd:cd17444   296 VGSLSVFFCAEITPTVIRGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHHIIFA 350
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-297 1.03e-17

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 83.91  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  84 LEenslateLTMLSARSPQPRYHSPLGLLRTRVTWRNGLIL---GFSSLVGggirasfRRSLAPQVPTF----YLPYFLE 156
Cdd:TIGR00898 299 LS-------LSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmmlWFTTAFS-------YYGLVLDLGNLggniYLDLFIS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 157 AGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPgWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVI 236
Cdd:TIGR00898 365 GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLY-FLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1862457439 237 RGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 297
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 149-275 3.79e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.21  E-value: 3.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 149 FYLPYFLEAGLEAAALVFLLLTADCCGRRPvLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFA 228
Cdd:cd17317   193 LYLNFFLSGLVEIPAYFLALLLLDRLGRRW-TLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYT 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1862457439 229 AEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17317   272 AELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGV 318
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 150-274 4.59e-07

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 50.82  E-value: 4.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 150 YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAA 229
Cdd:cd17378   204 YLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTV 283

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1862457439 230 EVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFA 274
Cdd:cd17378   284 ELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFG 328
Sugar_tr pfam00083
Sugar (and other) transporter;
24-257 7.03e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 47.27  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 167 LLLTADCCGRRPVLLLGTMV-TGLASLLLLAGAQYLPGWTVL-FLSVLGLLASRAVSALS-----SLFAAEVFPTVIRGA 239
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLGAAGmAICFVILGIVALLGVSKSDWAgIVAIVFIALFIAFFAMGwgpvpWVIVSELFPLSVRSK 386

                         250
                  ....*....|....*...
gi 1862457439 240 GLGLVLGAGFLGQAAGPL 257
Cdd:pfam00083 387 AMALATAANWLANFLIGF 404
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 150-275 1.59e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 43.05  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 150 YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLfLSVLGLLASRAVSALSSLFAA 229
Cdd:cd17374   204 FLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTV-LAVLGKGSSAAAFTISYVYTA 282

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1862457439 230 EVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFAS 275
Cdd:cd17374   283 ELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGV 328
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 162-257 1.06e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 162 AALVFLLLtADCCGRRPVLLLGTMVTGLASLLLLAGAQyLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGL 241
Cdd:cd17316   229 GALIAGLL-SDRIGRKKTLVIGLILSGILALPLFYLLS-GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306

                          90
                  ....*....|....*.
gi 1862457439 242 GLVLGAGFLGQAAGPL 257
Cdd:cd17316   307 GLSYNLGRLGGGGAPP 322
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 5-252 1.85e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 40.02  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439   5 LFSVVGTLLLPG------LAALVQDWRLLQGLgALMSGLLLLFWGFpaLFPESPCWLLATGQVARARKILWRFAEASGVG 78
Cdd:TIGR00879 170 LAITFGILVAYGfgsgkvSLNNTLGWRIPLGL-QLIPAGLLFLGLF--FLPESPRWLVGKGRVEEARKSLARLRGTSGED 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439  79 PGdsSLEENSLATELTMLSARSPQPRYHSPLGLLRtRVTWR--NGLILGFsSLVGGGIRA------SFRRSLAPQVPTFY 150
Cdd:TIGR00879 247 KE--LLDELELIDIKRSIEKRSVQPSWGSLFSSTR-RIRRRlfLGVVLQW-FQQFTGINAimyyspTIFENAGVSTDHAF 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862457439 151 LPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMV--------TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSA 222
Cdd:TIGR00879 323 LVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGmaiclfvlGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGP 402

                         250       260       270
                  ....*....|....*....|....*....|
gi 1862457439 223 LSSLFAAEVFPTVIRGAGLGLVLGAGFLGQ 252
Cdd:TIGR00879 403 VPWVIVSEIFPLSLRPKGISIAVAANWLAN 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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