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Conserved domains on  [gi|1885785180|ref|NP_001372984|]
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alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3 [Homo sapiens]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2OG-FeII_Oxy super family cl21496
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
 23-224 2.78e-10

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.


The actual alignment was detected with superfamily member pfam13532:

Pssm-ID: 473886  Cd Length: 191  Bit Score: 57.71  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  23 IYYVPDFISKEEEEYLLRQVFNapKPKWTQ---LSGRKL----QNWGGL---PHPRG--------MVPERLPPW---LQR 81
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLE--EGPFRQpttQGGRPMsvrmTNCGQLgwvTDGPGyrysgvdpVTGEPWPPFpeaLLQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  82 YVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqprppprpt 159
Cdd:pfam13532  80 LAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT---------- 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1885785180 160 TSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 224
Cdd:pfam13532 147 ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
23-224 2.78e-10

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 57.71  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  23 IYYVPDFISKEEEEYLLRQVFNapKPKWTQ---LSGRKL----QNWGGL---PHPRG--------MVPERLPPW---LQR 81
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLE--EGPFRQpttQGGRPMsvrmTNCGQLgwvTDGPGyrysgvdpVTGEPWPPFpeaLLQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  82 YVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqprppprpt 159
Cdd:pfam13532  80 LAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT---------- 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1885785180 160 TSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 224
Cdd:pfam13532 147 ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
9-226 3.67e-08

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 51.70  E-value: 3.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180   9 PALEPFRVEQAPPVIYYVPDFISKEEEEYLLRQVF-NAPkpkWTQ----LSGRK-----LQNWGGLPH------PRGMVP 72
Cdd:COG3145     4 DDPRPENLELPDGGAVYLPGFLSPEEADALLAALRaEAP---WRQpvipIFGKTmsvprLNAWYGWVGagyrysGTDPEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  73 ERLPPWLQRYVDKVSNLSlfgGLPANHVLVNQYLPGEGIM-------PHEDgplYYPTVSTISLGSHTVLDFyepRRPED 145
Cdd:COG3145    81 PPWPPALLALKRRVEAAA---GFPFNSCLLNLYRDGQDRMgwhqddeEELG---FNPPIASVSLGATRRFRF---GHKER 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180 146 DDPTEqprppprpttSLLLEPRSLLVLRGPAYTRLLHGIAaarvdaldaassppnaaacPSARpgaclVRGTRVSLTIRR 225
Cdd:COG3145   152 KDPTR----------SLPLEHGDLLVMGGPTQLAWQHGVP-------------------KTKK-----GTGPRINLTFRR 197


                  .
gi 1885785180 226 V 226
Cdd:COG3145   198 I 198
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
23-224 2.78e-10

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 57.71  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  23 IYYVPDFISKEEEEYLLRQVFNapKPKWTQ---LSGRKL----QNWGGL---PHPRG--------MVPERLPPW---LQR 81
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLE--EGPFRQpttQGGRPMsvrmTNCGQLgwvTDGPGyrysgvdpVTGEPWPPFpeaLLQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  82 YVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqprppprpt 159
Cdd:pfam13532  80 LAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT---------- 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1885785180 160 TSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 224
Cdd:pfam13532 147 ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
9-226 3.67e-08

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 51.70  E-value: 3.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180   9 PALEPFRVEQAPPVIYYVPDFISKEEEEYLLRQVF-NAPkpkWTQ----LSGRK-----LQNWGGLPH------PRGMVP 72
Cdd:COG3145     4 DDPRPENLELPDGGAVYLPGFLSPEEADALLAALRaEAP---WRQpvipIFGKTmsvprLNAWYGWVGagyrysGTDPEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180  73 ERLPPWLQRYVDKVSNLSlfgGLPANHVLVNQYLPGEGIM-------PHEDgplYYPTVSTISLGSHTVLDFyepRRPED 145
Cdd:COG3145    81 PPWPPALLALKRRVEAAA---GFPFNSCLLNLYRDGQDRMgwhqddeEELG---FNPPIASVSLGATRRFRF---GHKER 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885785180 146 DDPTEqprppprpttSLLLEPRSLLVLRGPAYTRLLHGIAaarvdaldaassppnaaacPSARpgaclVRGTRVSLTIRR 225
Cdd:COG3145   152 KDPTR----------SLPLEHGDLLVMGGPTQLAWQHGVP-------------------KTKK-----GTGPRINLTFRR 197


                  .
gi 1885785180 226 V 226
Cdd:COG3145   198 I 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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