|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
948-1234 |
7.97e-147 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 448.57 E-value: 7.97e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNT 1025
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDksGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1026 WLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDP 1105
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1106 VITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSQSASADD-------SASLDVE 1178
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLA-GSEKRPEALKKLDELAISEDGTKHWSRPPPSEEgpsyywqAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1893031262 1179 ISSYVLLAVLTADSlttADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02897 240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
938-1234 |
1.68e-122 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 384.34 E-value: 1.68e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 938 VSVIGDILGRALQ----NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDG 1013
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1014 AYSTFGYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITA 1093
Cdd:pfam07678 81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1094 SLLELET-----PVTDPVITKGLSCLRS-VIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSA 1167
Cdd:pfam07678 161 ALLEALDingllQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERDE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1893031262 1168 SADDSA---------SLDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:pfam07678 241 KSDPQGvpeyppqapSLEVETTAYALLA-----YLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1386 |
2.99e-46 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 182.97 E-value: 2.99e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 128 FIQTDKPIYMPGQIVNFRVVTMD-TNFAPVDQQYSIIVLeDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF 206
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDaDGKAPAGLPLTLELT-DPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 207 IGERMIL--HDFQVKKYVLPKFEVTLKKPKTVSVVEEELLIEVCAKYTYGQPVPGK--SW---VKVCRDPLP----YIFF 275
Cdd:COG2373 451 VDPKPALgsKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvEGevtLRPARTAFPgypgYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 276 FPLCLGETLEI----TKT---GCAIHNFGLSMILN--STLKnnlkdsLHVEAVVTEE-GTEITRTKSESVHltyeiGKAT 345
Cdd:COG2373 531 DPDEEFEPEELdlgeGTLdadGKASLSLPLPDAPDapGPLR------ATVEASVFESgGRPVTRSATVPVH-----PADF 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 346 LI----DLPKTYEHGSVIKGKIKLFDFKDAPIPNKEV-------------YLLEGENWSS------KLLLN--LTTDSDG 400
Cdd:COG2373 600 YVgirlPLFDGDPEGAPATFEVVAVDPDGKPVAGKGLkvelyreewryvwYKSDDGGWRYesqekeEPVAEgtLTTGADG 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 401 LASFSLNTSS-------LSKKDISLIASVypdtRYYGYKTPYFSTDKKTVqlFQIAT---AYSPtlseliiedieqpikc 470
Cdd:COG2373 680 PASLSLTPVEwgryrleVKDPDGGLATSV----RFYAGGNASWGAERPDR--LELSLdkeSYKP---------------- 737
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 471 GTEITATVKYYFVGE---TVEdfstdivymvlSRGVIVHhgfEKVEVKSSSNgvasgtmSFKLSVGADLTP-------VV 540
Cdd:COG2373 738 GETAKLLIQSPFAGRalvTVE-----------RDGVLET---QWVDVKGGGT-------TVEIPVTEDWAPnayvsatLV 796
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 541 Q----------ILAYCVLPSeNVIAANKTLdtekcfgnKVSLQfSPAKAVPGEKNTLQLSAQPGSlcG------LSAVDQ 604
Cdd:COG2373 797 RpgdstandmpARAYGVAPL-PVDPPARRL--------KVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDE 864
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 605 SVLilesgkrleadkifnllpvhSVSDY----PYSvedgqaclYVRPRRSLLTDnTYETLKSVGLKMAtnlavrvpecll 680
Cdd:COG2373 865 GIL--------------------NLTGYktpdPLD--------FFYGKRALGVE-TRDLYGRLIGAFG------------ 903
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 681 ykglayhknfvmYRQNAPAPGmfaqgmaGVDGLVGNSPSVTIRTVFPETWIWE-LAEVGDSGSAEVPVKVPDTITTWETE 759
Cdd:COG2373 904 ------------GAAGALRSG-------GDGALGRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVM 964
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 760 AFCLSSTGLGLAPpAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSscLC 839
Cdd:COG2373 965 AVAWSDDRFGSAE-ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LA 1041
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 840 ANGRKTFKWILTPSVLGVVNVTVSAEAE---ASQTVcdneivsvpergRIDIVTRSLLVqaegiekTETNSWLLCPKGds 916
Cdd:COG2373 1042 AGGRATVRFPLKAPDAGDAKVTVTATGGgesDAREV------------ELPVRPANPLV-------TRATSGVLAPGE-- 1100
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 917 lSEKVDLTLPKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQyLENTKQLTSAIREKASS 996
Cdd:COG2373 1101 -SWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRA 1178
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 997 FLKSGYQRQLNYKHFDGAYSTF-GYGDGNTWLTAFVLRSFGKAQKYTF-IDPQIIQSAKDWLISR-RDSDGCFIQQGRLF 1073
Cdd:COG2373 1179 RIQAAIARLLSMQNSDGGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYLRNYlRNPWEIEYDDAYRL 1258
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1074 NNRmkggvndnvtmtAYITASLLELETPVTDPvitkgLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDL 1153
Cdd:COG2373 1259 AVR------------AYALYVLARAGKADLGD-----LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALAR 1321
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1154 AISDGPLVHWSQSASAD--DSAsldveissyvllAVLTADSLTTADLGFANRIVSWLVKQQNAyGGFSSTQDTVVALQAL 1231
Cdd:COG2373 1322 LRETGARDYWYGDYGSPlrDQA------------LALALLAELGPDAPLAPKLARWLAKALKS-GRWLSTQETAWALLAL 1388
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1232 SLYATKvFSSDGSSTVTVQSAGDSHHFDVNQD-NKLLYQEKQLAnvPGKYSIEVKGSACVSVQIAQFY---NIPTPTEAK 1307
Cdd:COG2373 1389 AAYARA-AGASPDFTATLTLDGKTLPLTGRGPlARVTLPAAELL--AGPLTITNTGDGPLYYTLTLSGypaEGPPPAASN 1465
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1308 TLSID--------AKIEGDCEALGQNFIFDFTVKYDGPEEkTNMAIVDIkLLSGFTADTSALGTSSGTYV-----SLVER 1374
Cdd:COG2373 1466 GLEIErryydldgKPIDPASLKQGDLVVVRLTVTAPSGRV-ENVAVVDP-LPAGFEIENPRLATSGDLGDwlgdsWQPDH 1543
|
1370
....*....|..
gi 1893031262 1375 VDSKDDHVIVYL 1386
Cdd:COG2373 1544 QEFRDDRVVAAF 1555
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
729-817 |
2.46e-41 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 146.96 E-value: 2.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 729 TWIWELAEVGDSGSAEVPVKVPDTITTWETEAFCLS-STGLGLAPPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNY 807
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|
gi 1893031262 808 LSKCIMVKVS 817
Cdd:pfam00207 81 LDKCLKVRVR 90
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
948-1234 |
7.97e-147 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 448.57 E-value: 7.97e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNT 1025
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDksGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1026 WLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDP 1105
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1106 VITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSQSASADD-------SASLDVE 1178
Cdd:cd02897 161 VVEKALSCLEAALDSISDPYTLALAAYALTLA-GSEKRPEALKKLDELAISEDGTKHWSRPPPSEEgpsyywqAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1893031262 1179 ISSYVLLAVLTADSlttADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02897 240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
938-1234 |
1.68e-122 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 384.34 E-value: 1.68e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 938 VSVIGDILGRALQ----NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDG 1013
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1014 AYSTFGYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITA 1093
Cdd:pfam07678 81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1094 SLLELET-----PVTDPVITKGLSCLRS-VIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSA 1167
Cdd:pfam07678 161 ALLEALDingllQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERDE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1893031262 1168 SADDSA---------SLDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:pfam07678 241 KSDPQGvpeyppqapSLEVETTAYALLA-----YLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
948-1234 |
1.17e-107 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 342.45 E-value: 1.17e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFG-YGDGNTW 1026
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGnSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1027 LTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVtDPV 1106
Cdd:cd02891 81 LTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC-DAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1107 ITKGLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASADDSASLDVEISSYVLLA 1186
Cdd:cd02891 160 IEKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSLSWPGDYGSSLRVEATAYALLA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1893031262 1187 VLTADslttaDLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02891 240 LLKLG-----DLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
951-1234 |
8.01e-77 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 256.82 E-value: 8.01e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 951 NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQ---LTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGDGNTWL 1027
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSSTWL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1028 TAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDN---VTMTAYITASLLE------L 1098
Cdd:cd02896 84 TAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVEGSegdVSLTAFVLIALQEarsicpP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1099 ETPVTDPVITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSQSASADD----SAS 1174
Cdd:cd02896 164 EVQNLDQSIRKAISYLENQLPNLQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYWpvpgPSA 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1175 LDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02896 243 ITVETTAYALLA-----LLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
948-1234 |
8.28e-65 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 222.43 E-value: 8.28e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 948 ALQNLHGLLRMPYG--------CGEQNMAVLSPNIYILQYLENTKqltsaIREKASSFLKSGYQRQLNYKHFDGAYSTF- 1018
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1019 GYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNrmKGGVNDNVTMTAYITASLLEL 1098
Cdd:cd00688 76 GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALALL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1099 ETPVTDPVITKGLSCLRSVIEE--------VKNTYTTALLAYTFSLARDTN--TRQQLFNKLEDLAISDGPLVHWSQSAS 1168
Cdd:cd00688 154 GKLDPDPLIEKALDYLLSCQNYdggfgpggESHGYGTACAAAALALLGDLDspDAKKALRWLLSRQRPDGGWGEGRDRTN 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1893031262 1169 aDDSASLDVEISSYVLLAVLTADslttaDLGFANRIVSWLVKQQNAYGGFSS-------TQDTVVALQALSLY 1234
Cdd:cd00688 234 -KLSDSCYTEWAAYALLALGKLG-----DLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1386 |
2.99e-46 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 182.97 E-value: 2.99e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 128 FIQTDKPIYMPGQIVNFRVVTMD-TNFAPVDQQYSIIVLeDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF 206
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDaDGKAPAGLPLTLELT-DPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 207 IGERMIL--HDFQVKKYVLPKFEVTLKKPKTVSVVEEELLIEVCAKYTYGQPVPGK--SW---VKVCRDPLP----YIFF 275
Cdd:COG2373 451 VDPKPALgsKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvEGevtLRPARTAFPgypgYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 276 FPLCLGETLEI----TKT---GCAIHNFGLSMILN--STLKnnlkdsLHVEAVVTEE-GTEITRTKSESVHltyeiGKAT 345
Cdd:COG2373 531 DPDEEFEPEELdlgeGTLdadGKASLSLPLPDAPDapGPLR------ATVEASVFESgGRPVTRSATVPVH-----PADF 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 346 LI----DLPKTYEHGSVIKGKIKLFDFKDAPIPNKEV-------------YLLEGENWSS------KLLLN--LTTDSDG 400
Cdd:COG2373 600 YVgirlPLFDGDPEGAPATFEVVAVDPDGKPVAGKGLkvelyreewryvwYKSDDGGWRYesqekeEPVAEgtLTTGADG 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 401 LASFSLNTSS-------LSKKDISLIASVypdtRYYGYKTPYFSTDKKTVqlFQIAT---AYSPtlseliiedieqpikc 470
Cdd:COG2373 680 PASLSLTPVEwgryrleVKDPDGGLATSV----RFYAGGNASWGAERPDR--LELSLdkeSYKP---------------- 737
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 471 GTEITATVKYYFVGE---TVEdfstdivymvlSRGVIVHhgfEKVEVKSSSNgvasgtmSFKLSVGADLTP-------VV 540
Cdd:COG2373 738 GETAKLLIQSPFAGRalvTVE-----------RDGVLET---QWVDVKGGGT-------TVEIPVTEDWAPnayvsatLV 796
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 541 Q----------ILAYCVLPSeNVIAANKTLdtekcfgnKVSLQfSPAKAVPGEKNTLQLSAQPGSlcG------LSAVDQ 604
Cdd:COG2373 797 RpgdstandmpARAYGVAPL-PVDPPARRL--------KVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDE 864
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 605 SVLilesgkrleadkifnllpvhSVSDY----PYSvedgqaclYVRPRRSLLTDnTYETLKSVGLKMAtnlavrvpecll 680
Cdd:COG2373 865 GIL--------------------NLTGYktpdPLD--------FFYGKRALGVE-TRDLYGRLIGAFG------------ 903
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 681 ykglayhknfvmYRQNAPAPGmfaqgmaGVDGLVGNSPSVTIRTVFPETWIWE-LAEVGDSGSAEVPVKVPDTITTWETE 759
Cdd:COG2373 904 ------------GAAGALRSG-------GDGALGRGGNPKPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVM 964
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 760 AFCLSSTGLGLAPpAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSscLC 839
Cdd:COG2373 965 AVAWSDDRFGSAE-ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LA 1041
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 840 ANGRKTFKWILTPSVLGVVNVTVSAEAE---ASQTVcdneivsvpergRIDIVTRSLLVqaegiekTETNSWLLCPKGds 916
Cdd:COG2373 1042 AGGRATVRFPLKAPDAGDAKVTVTATGGgesDAREV------------ELPVRPANPLV-------TRATSGVLAPGE-- 1100
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 917 lSEKVDLTLPKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQyLENTKQLTSAIREKASS 996
Cdd:COG2373 1101 -SWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRA 1178
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 997 FLKSGYQRQLNYKHFDGAYSTF-GYGDGNTWLTAFVLRSFGKAQKYTF-IDPQIIQSAKDWLISR-RDSDGCFIQQGRLF 1073
Cdd:COG2373 1179 RIQAAIARLLSMQNSDGGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYLRNYlRNPWEIEYDDAYRL 1258
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1074 NNRmkggvndnvtmtAYITASLLELETPVTDPvitkgLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDL 1153
Cdd:COG2373 1259 AVR------------AYALYVLARAGKADLGD-----LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALAR 1321
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1154 AISDGPLVHWSQSASAD--DSAsldveissyvllAVLTADSLTTADLGFANRIVSWLVKQQNAyGGFSSTQDTVVALQAL 1231
Cdd:COG2373 1322 LRETGARDYWYGDYGSPlrDQA------------LALALLAELGPDAPLAPKLARWLAKALKS-GRWLSTQETAWALLAL 1388
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1232 SLYATKvFSSDGSSTVTVQSAGDSHHFDVNQD-NKLLYQEKQLAnvPGKYSIEVKGSACVSVQIAQFY---NIPTPTEAK 1307
Cdd:COG2373 1389 AAYARA-AGASPDFTATLTLDGKTLPLTGRGPlARVTLPAAELL--AGPLTITNTGDGPLYYTLTLSGypaEGPPPAASN 1465
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1308 TLSID--------AKIEGDCEALGQNFIFDFTVKYDGPEEkTNMAIVDIkLLSGFTADTSALGTSSGTYV-----SLVER 1374
Cdd:COG2373 1466 GLEIErryydldgKPIDPASLKQGDLVVVRLTVTAPSGRV-ENVAVVDP-LPAGFEIENPRLATSGDLGDwlgdsWQPDH 1543
|
1370
....*....|..
gi 1893031262 1375 VDSKDDHVIVYL 1386
Cdd:COG2373 1544 QEFRDDRVVAAF 1555
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
729-817 |
2.46e-41 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 146.96 E-value: 2.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 729 TWIWELAEVGDSGSAEVPVKVPDTITTWETEAFCLS-STGLGLAPPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNY 807
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|
gi 1893031262 808 LSKCIMVKVS 817
Cdd:pfam00207 81 LDKCLKVRVR 90
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
459-609 |
5.30e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.60 E-value: 5.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 459 LIIEDIEQPIKCGTEITATVKYYFVGETVEDFSTdivYMVLSRGVIVHHGfekvevksssngVASGTMSFKLSVGADLTP 538
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFT---YLVLSKGQIVVVG------------RGGVTTSFSLPVTAEMAP 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1893031262 539 VVQILAYCV---LPSENVIAANKTLDTEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLIL 609
Cdd:pfam07703 66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1339-1432 |
1.51e-28 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 110.35 E-value: 1.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 1339 EKTNMAIVDIKLLSGFTADTSALGT-SSGTYVSLVERVDskDDHVIVYLKEIPKNvAMNYQIQMKQVLPVKNLKPAVVKV 1417
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlGVDPLIKRVETVD--DGKVILYLDKLSGE-PLCFSFRAEQTFPVANLKPAPVKV 77
|
90
....*....|....*
gi 1893031262 1418 YDYYQTSDQSEIEYS 1432
Cdd:pfam07677 78 YDYYEPERRATTFYS 92
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
220-301 |
1.85e-19 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 84.25 E-value: 1.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 220 KYVLPKFEVTLKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVCRDplpYIFFFPLCLGETLEITKTGCAIHNFGLS 299
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLK---DDSKRKCFESFSKELDKDGCGSASLSTE 77
|
..
gi 1893031262 300 MI 301
Cdd:pfam17791 78 EF 79
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
128-218 |
1.64e-18 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 81.98 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 128 FIQTDKPIYMPGQIVNFRVVTMDTNFAPVDQQYSIIVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF- 206
Cdd:pfam01835 3 FVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRd 82
|
90
....*....|...
gi 1893031262 207 -IGERMILHDFQV 218
Cdd:pfam01835 83 gAGGSLGSGSFRV 95
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
345-414 |
2.25e-06 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 47.25 E-value: 2.25e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893031262 345 TLIDLPKTYEHGSVIKGKIKLFDFKDAPIPNKEVYLlegENWSSKLLLNLTTDSDGLASFSLNTSSLSKK 414
Cdd:pfam17789 2 TFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFI---EAGNTEFNQNLTTDEDGTAQFSINTPGNAAS 68
|
|
| SVA |
pfam05326 |
Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and ... |
774-848 |
6.17e-04 |
|
Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganizms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4.
Pssm-ID: 398804 Cd Length: 124 Bit Score: 41.23 E-value: 6.17e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1893031262 774 AQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPApsSDYTLKASSDDQYSSCLCANGRKTFKW 848
Cdd:pfam05326 26 GQDNRNKPLSLDLKVPSTAKKNNEVTVTLTVKTNVKECMVVKAYLE--SNPPIKGSFNYIYTACLCNDYPRTFFW 98
|
|
| |
