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Conserved domains on  [gi|1904926768|ref|NP_001373815|]
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solute carrier organic anion transporter family member 1A2 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
18-536 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17458:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 527  Bit Score: 923.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17458     3 KIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17458    83 CFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17458   163 ISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMI 334
Cdd:cd17458   243 GLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 335 SFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 414
Cdd:cd17458   323 SFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVA 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 415 GINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV 494
Cdd:cd17458   403 GLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQN 482
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 495 ---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 536
Cdd:cd17458   483 ssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-536 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 923.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17458     3 KIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17458    83 CFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17458   163 ISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMI 334
Cdd:cd17458   243 GLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 335 SFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 414
Cdd:cd17458   323 SFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVA 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 415 GINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV 494
Cdd:cd17458   403 GLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQN 482
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 495 ---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 536
Cdd:cd17458   483 ssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
18-623 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 917.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:TIGR00805  32 KMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLG 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPL 176
Cdd:TIGR00805 112 SLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 177 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 256
Cdd:TIGR00805 192 GISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALL 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 257 TAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISF 336
Cdd:TIGR00805 272 TSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITF 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 337 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 416
Cdd:TIGR00805 352 LPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGV 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 417 NTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLG 496
Cdd:TIGR00805 432 NN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKG 507
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 497 LCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHW 576
Cdd:TIGR00805 508 LCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHW 585
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926768 577 GTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRK 623
Cdd:TIGR00805 586 QTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
19-595 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 602.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 98
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  99 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 178
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 179 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 258
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 259 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 335
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 336 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 415
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 416 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 490
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 491 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 570
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1904926768 571 STCLHWGTlKCGESGACRIYDSTTF 595
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-403 2.00e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.01  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 98
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  99 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 178
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 179 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 258
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 259 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 403
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-536 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 923.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17458     3 KIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17458    83 CFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17458   163 ISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMI 334
Cdd:cd17458   243 GLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 335 SFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 414
Cdd:cd17458   323 SFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVA 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 415 GINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAV 494
Cdd:cd17458   403 GLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQN 482
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 495 ---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 536
Cdd:cd17458   483 ssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
18-623 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 917.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:TIGR00805  32 KMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLG 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPL 176
Cdd:TIGR00805 112 SLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 177 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 256
Cdd:TIGR00805 192 GISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALL 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 257 TAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISF 336
Cdd:TIGR00805 272 TSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITF 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 337 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 416
Cdd:TIGR00805 352 LPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGV 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 417 NTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLG 496
Cdd:TIGR00805 432 NN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKG 507
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 497 LCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHW 576
Cdd:TIGR00805 508 LCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHW 585
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926768 577 GTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRK 623
Cdd:TIGR00805 586 QTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
18-535 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 700.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17400     2 KMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17400    82 CFLKALPHFFMNQYEY---------------------------------------SLMWIYVFVGNILRGIGETPILPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17400   123 ISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLT 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17400   203 AIPFFFLP------------------------------------------------PIYMLFILVSVIQFNSFVGMITYM 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 417
Cdd:cd17400   235 PKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLT 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 418 TSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGL 497
Cdd:cd17400   315 TSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSL 394
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1904926768 498 CDKG----PDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17400   395 CDGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
18-536 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 606.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17459     2 KIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP-----TQDPSECTKEVKSLMWVYVLVGNIVRGMGETP 172
Cdd:cd17459    82 TFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSiessdSKTGTGCEKEPGSSMWIYVFLGNLLRGIGETP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 173 ILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAG 252
Cdd:cd17459   162 VQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAGV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 253 VNVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN 332
Cdd:cd17459   242 ITLLSAVPFWFLPKSLP-------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLIG 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 333 MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSS 412
Cdd:cd17459   291 MVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSD 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 413 VVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI----QTS 488
Cdd:cd17459   371 VAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNCSCIgipsSAS 450
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1904926768 489 GNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 536
Cdd:cd17459   451 GSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
19-595 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 602.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 98
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  99 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 178
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 179 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 258
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 259 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 335
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 336 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 415
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 416 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 490
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 491 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 570
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1904926768 571 STCLHWGTlKCGESGACRIYDSTTF 595
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
18-535 2.89e-178

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 514.78  E-value: 2.89e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17457     2 KMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpseCTKEVKSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17457    82 SVLTALPHFFMGYYKYG--------------------------------CLKESGSYMWVYVLMGNMLRGIGETPIVPLG 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17457   130 ISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIIS 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17457   210 AIPFFFLP------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYK 253
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 417
Cdd:cd17457   254 PKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGIT 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 418 TSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSG----NSSA 493
Cdd:cd17457   334 MTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYSA 413
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1904926768 494 VLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17457   414 HLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
18-535 7.06e-138

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 409.71  E-value: 7.06e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17336     2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPLG 177
Cdd:cd17336    82 CFLLALPHFL----------------------------------------------------FVGQFLLGIGSSPLYTLG 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17336   110 ITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWLGFLILGILLLIV 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17336   187 SIPLFFFP------------------------------------------------PIFILLLLAIVFESFAISGFSTFL 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 417
Cdd:cd17336   219 PKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVT 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 418 TSYEGIPqdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQT-SGNSSAVLG 496
Cdd:cd17336   299 TPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCINSgTATSSGCPP 372
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1904926768 497 LCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17336   373 DCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
18-535 1.22e-101

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 318.67  E-value: 1.22e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17461     3 KVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLALG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17461    83 AFLLTLPHFLSEPYQYS----------------------------------------MWVLMVVAQLLAGIGTVPIQPFG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17461   123 ISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLT 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKE---GLETNADIIKNENEDKQKEEVkkekyGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMI 334
Cdd:cd17461   203 SLPYFFFPREMLVGkkpSPEGDMLRKKEDEKKEEGSLL-----DFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLS 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 335 SFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 414
Cdd:cd17461   278 TFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVA 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 415 GINTSYEGIPQDLYvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSI---GTGINMVFQNCSCIQT-SGN 490
Cdd:cd17461   358 GVYPKTSNSSDGPH------LSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCIPDlSGE 431
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 491 SSAVLGLCDKgpDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17461   432 KPAKTGSCPN--SCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
18-535 1.15e-96

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 305.93  E-value: 1.15e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17460     2 KFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17460    82 GFLMALPHFISEPYEY-------------------------------------------GILFLGQLLLGIGGVPIQPFG 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17460   119 ISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALS 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKEGLE-------TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLScNPIYMLFILVSVIQFNAF 330
Cdd:cd17460   199 AVPYFFFPREMPKEVVElqprekkLAKTMLKKLKSLSDILQNLSLLQFIKKFPRILLRTLR-NPIYLLVVLAQVNLSAMV 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 331 VNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFL-MTCE 409
Cdd:cd17460   278 AGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAM-CVLGMLLCLFFALPLLfIGCS 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 410 NSSVVGINTSYEGIPQdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTGINMVFQNCSCIQ 486
Cdd:cd17460   357 TQKIAGITHRTSSSPG-----LELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCVS 431
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1904926768 487 TSGN-SSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17460   432 EGGPvGAASPGTCGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
18-535 7.85e-90

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 286.82  E-value: 7.85e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17402     2 KIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEyestvsvsgnlssnsflcmengtqilrptqdpsectkevKSLMWVYVLVGNIVRGMGETPILPLG 177
Cdd:cd17402    82 ALLSALPEFLTHQYK---------------------------------------TNMMYLLLIGAQVLLGIGATPVQPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17402   123 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFS 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKegletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17402   203 ALLMFGFPQSLQQ-----------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFL 253
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 417
Cdd:cd17402   254 GKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 418 TSYeGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGinmvfqnCSCIQT--SGNSSAVL 495
Cdd:cd17402   334 VPY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSSvpAENATVVP 405
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1904926768 496 GLCDKgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17402   406 GKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
18-535 1.07e-89

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 285.79  E-value: 1.07e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITC-AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 96
Cdd:cd17404     1 KAFLVCMCLlIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  97 GCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvlVGNIVRGMGETPILPL 176
Cdd:cd17404    81 GSFLFSLPHFFI----------------------------------------------------LAQILIGMGGTPIFTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 177 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTgfvNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 256
Cdd:cd17404   109 GTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDP---LSTPPDISPGDPRWIGAWWGGFLLCGIALLL 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 257 TAIPFFFLPNtlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISF 336
Cdd:cd17404   186 VAFPFFTFPK-----------------------------------------------MTFLVVSLGYCMELAIVSGFITF 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 337 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 416
Cdd:cd17404   219 LPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGI 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 417 NTSYEGIPQ-DLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV-FQNCSCIQTSGNSS-- 492
Cdd:cd17404   299 TIPYTTGPSlSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRnYTNCACLQSRSSISpp 378
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926768 493 --AVLGLCDKGP--DCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17404   379 tvGQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
18-535 2.14e-89

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 285.59  E-value: 2.14e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  18 KMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:cd17401     2 KVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMwvyvLVGNIVRGMGETPILPLG 177
Cdd:cd17401    82 AFLLTLPHFISEPYQY---------------------------------------GIM----VVAQLLLGIGGVPIQPFG 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLT 257
Cdd:cd17401   119 ISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLT 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLpkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17401   199 SFPYFFFPRFI--------------------------------KRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFL 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGIN 417
Cdd:cd17401   247 NKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVY 326
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 418 ---TSYEGIPQDlyvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET----SIGTGINMVFQNCSCIqTSGN 490
Cdd:cd17401   327 ppsSSSSIHPQS--------PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNinmsTSATSKQVIYTNCSCV-TGGS 397
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 491 SSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17401   398 ASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
17-535 5.98e-89

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 283.76  E-value: 5.98e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  17 AKMFLLAIT-CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 95
Cdd:cd17403     1 PKGFLFFLCiFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  96 LGCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILP 175
Cdd:cd17403    81 IGSLVFALPHFTV--------------------------------------------------FILAQLLHGAGATPLYT 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 176 LGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVnTDDLIITPTDTRWVGAWWFGFLICAGVNV 255
Cdd:cd17403   111 LGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-DSELGLTPDDPRWVGAWWLGFLISGALAL 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 256 LTAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMIS 335
Cdd:cd17403   190 IIAFPLLGFP------------------------------------------------PTFMFLNLAGASEGMLLAGFAT 221
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 336 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLyFLSFLMTCENSSVVG 415
Cdd:cd17403   222 FLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILLIYCPNAPFAG 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 416 INTSYEGIPqdLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ---TSGNSS 492
Cdd:cd17403   301 VTVPYGNSP--LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQsnsSKTSTA 378
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1904926768 493 AVLGLCDKGPDCSLMLQYFLILSAMSSFIYsLAAIPGYMVLLR 535
Cdd:cd17403   379 ATGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
27-535 2.64e-64

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 218.94  E-value: 2.64e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  27 AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHF 106
Cdd:cd17462    12 SFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 107 lmnqyeyesTVsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFAK 186
Cdd:cd17462    92 ---------TV-----------------------------------------FMLGQFLHGIGATPLYTLGVTYLDENVK 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 187 FENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGfVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPN 266
Cdd:cd17462   122 SNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG-RQTE---LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPR 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 267 TLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYG 346
Cdd:cd17462   198 QLP----------------------------GLLK-----------NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFS 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 347 ISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEG--IP 424
Cdd:cd17462   239 LSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKF-CLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGsvLP 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 425 QDLYvenDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGIN--MVFQNCSCIqtSGNSSAVLGLCDKGP 502
Cdd:cd17462   318 EGSL---NLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqKVYQDCSCV--AGNLSVGFGEASAGK 392
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1904926768 503 DCSL-----MLQYFLILSAMSSFiysLAAIPGYMVLLR 535
Cdd:cd17462   393 CTSNcnhmpLLLAFVFLVILFTF---LCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
21-535 1.27e-62

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 214.22  E-value: 1.27e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  21 LLAITCAFVSKTLsgsyMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL 100
Cdd:cd17463    10 LLAVVQGIVVNGL----VNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 101 KSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLvGNIVRGMGETPILPLGISY 180
Cdd:cd17463    86 FSLPHFF-------------------------------------------------VFIL-GQLLLGVGGTPLYTLGTAY 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 181 IEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLiiTPTDTRWVGAWWFGFLICAGVNVLTAIP 260
Cdd:cd17463   116 IDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDL--TEEDPRWLGAWWIGFLMCWLIAWCLIAP 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 261 FFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKY 340
Cdd:cd17463   194 FSCFPKHLP----------------------------GLLK-----------NPVFMCLTISSCSEALITTGFATFLPKF 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 341 LEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSY 420
Cdd:cd17463   235 IENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETY 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 421 EGIPQdlyvENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ-TSGNSSAVLGLCD 499
Cdd:cd17463   315 NGTGK----IGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIGnFTEEFSANTTKCE 390
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1904926768 500 KGPDCSLM---LQYFLILSAMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17463   391 EGKKCETTcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
46-535 7.43e-35

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 137.29  E-value: 7.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  46 ERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFlmnqyeyestvsvsgnlss 125
Cdd:cd17405    30 QVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF------------------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 126 nsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGP 205
Cdd:cd17405    91 -------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGY 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 206 LIGLLLASfcANVYVDtgfVNTDDLIITPTDT--RWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiikne 283
Cdd:cd17405   140 LLGYVGGL--PNFQPP---PNEKSVEIEVNKVyqLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP-------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 284 nedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPP 363
Cdd:cd17405   201 --------------GLLK-----------NPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPG 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 364 ICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQdlyvENDIFADCNVDCNC 443
Cdd:cd17405   256 GAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQ----LGNLTAPCNEYCDC 331
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 444 PSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS--------AVLGLCDKgpDCsLMLQYFLILS 515
Cdd:cd17405   332 TSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIKEGLAAAddegdfidAIAGKCDS--KC-YKLPLFFAFY 408
                         490       500
                  ....*....|....*....|
gi 1904926768 516 AMSSFIYSLAAIPGYMVLLR 535
Cdd:cd17405   409 FSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
433-486 7.26e-23

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 91.98  E-value: 7.26e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1904926768 433 IFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ 486
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
24-404 1.65e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 99.81  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  24 ITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSL 103
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 104 PHflmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPLGISYIED 183
Cdd:cd06174    81 AP-------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIAD 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 184 FAKFENSPLYIGLVETGAIIGPLIGLLLASFCAnvyvdtgfvntddliitptdTRWVGAWWFGFLICAGVNVLTAIPFFF 263
Cdd:cd06174   112 LFPERERGRALGLLQAFGSVGGILGPLLGGILA--------------------SSLGFGWRAVFLIAAALALLAAILLLL 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 264 LPNTLPKEGLETNADIIKnenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQ 343
Cdd:cd06174   172 VVPDPPESARAKNEEASS-------------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1904926768 344 QYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFkITVKQAAHIGCWLSLLEYLLYFLSF 404
Cdd:cd06174   233 LGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAP 291
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-403 2.00e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.01  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 98
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  99 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 178
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 179 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 258
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 259 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 403
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
438-484 3.99e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 64.05  E-value: 3.99e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1904926768 438 NVDCNCPSKIWDPVCGNNGLSYLSAC---LAGCETSIGTGINMVFQNCSC 484
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS_1 pfam07690
Major Facilitator Superfamily;
26-406 1.11e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.59  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  26 CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLkslph 105
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 106 fLMnqyeyestvsvsgnLSSNSFLcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFA 185
Cdd:pfam07690  79 -LL--------------FASSLWL-----------------------------LLVLRVLQGLGAGALFPAALALIADWF 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 186 KFENSPLYIGLVETGAIIGPLIGLLLASFcanvyvdtgfvntddlIITPTDTRWVgawwfgFLICAGVNVLTAIPFFFLP 265
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGL----------------LASLFGWRAA------FLILAILSLLAAVLLLLPR 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 266 NTLPKEGLETNADIIknenedkqkeevkkekygitKDFLPFMKSLSCNPIyMLFILVSVIQFNAFVNMISFMPKYLEqQY 345
Cdd:pfam07690 173 PPPESKRPKPAEEAR--------------------LSLIVAWKALLRDPV-LWLLLALLLFGFAFFGLLTYLPLYQE-VL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1904926768 346 GISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLM 406
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS 291
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
443-484 7.49e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.81  E-value: 7.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1904926768 443 CPsKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 484
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
156-376 1.82e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.57  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 156 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVET----GAIIGPLIGLLLASFcanvyvdtgfvntddli 231
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaiglGFLIGPLLGGLLADA----------------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 232 itptdtrwvGAWWFGFLICAGVNVLTAIPFFFLPNtlpkeglETNADIIKNENEDkqkeevkkekygitKDFLPFMKSLS 311
Cdd:cd17325   147 ---------LGYRAPFLVCAALALLALVLALLLLP-------EPRPPPNKRAVSA--------------ARLRSGLRLLL 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1904926768 312 CNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMK 376
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-379 2.01e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.54  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  16 SAKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 95
Cdd:COG0738     5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  96 LGCFLkslphflmnqyeyestVSVSGNlssnsflcmengtqilrptqdpsectkevkslmWVYVLVGNIVRGMG----ET 171
Cdd:COG0738    85 LGLLL----------------FALAPS---------------------------------YPLLLLALFLLGLGlgllDV 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 172 PILPLGISyIEDfakfENSPLYIGLVET----GAIIGPLIGLLLASFCANVyvdtgfvntddliitptdtrwvgAWWFGF 247
Cdd:COG0738   116 AANPYVAA-LGP----ETAASRLNLLHAffslGALLGPLLGGLLILLGLSL-----------------------SWHLPY 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 248 LICAGVNVLTAIPFFFLPntLPKEGLETNADIIKNENedkqkeevkkekygitkdflpfMKSLSCNPIYMLFILVSVIQF 327
Cdd:COG0738   168 LILAVLLLLLALLFLRSK--LPEIEEEEEEAAGSAAS----------------------LKSLLKNPRLLLGGLAIFLYV 223
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1904926768 328 NAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLpPICIGYIIGGLIMKKFK 379
Cdd:COG0738   224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFG 274
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-378 9.42e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 9.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAITCAFVSktLSGSYMNSML-TQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 97
Cdd:COG2223     6 VLLLATLAFFLA--FGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  98 CFLKSLphflmnqyeyestvsvsgnlsSNSFlcmengtqilrptqdpsectkevkslmWVYVLVGNIVrGMGETPILPLG 177
Cdd:COG2223    84 LLLLAL---------------------AVSY---------------------------WLLLLLGLLL-GIGGGGSFAVG 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 178 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLT 257
Cdd:COG2223   115 IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF----------------------GWRNAFLILGILLLVV 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 258 AIPFFFLPNTLPKEGLETNAdiiknenedkqkeevkkekygitKDFLPFMKSLScNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:COG2223   173 AVLAWLFLRDPPAGAAAAAK-----------------------ASLRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWL 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKF 378
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLAALFALLGA-LGRPLGGWLSDRI 268
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
19-406 1.01e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  19 MFLLAItCAFVSKTlSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 98
Cdd:cd17324     1 LLALAL-AAFAIGT-TEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  99 FLKSLphflmnqyeyestvsvsgnlsSNSFLCMengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPLGI 178
Cdd:cd17324    79 LLAAL---------------------APSFALL----------------------------LLARALAGLAHGGFWAIAA 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 179 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtGFvntddliitptdtRWVgawwfgFLICAGVNVLTA 258
Cdd:cd17324   110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---GW-------------RAA------FLAIAVLALLAA 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 259 IPF-FFLPNTLPKEGletnadiiknenedkqkeevkkekygITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 337
Cdd:cd17324   168 LLLwRLLPSLPPKKP--------------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYL 221
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1904926768 338 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKITVKQAAhiGCWLSLLEYLLYFLSFLM 406
Cdd:cd17324   222 APFLTDVPGFSSSAIIGLLLLFGVAGV-VGSPLAGRLADRGGRRALLIA--LLLLAAALLLLTLLGPSP 287
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-402 2.18e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768  38 MNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLphflmnqyeyestv 117
Cdd:COG2271    29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-------------- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 118 svsgnlsSNSFLcmengtqilrptqdpsectkevkSLMWVYVLVGnivrgMGETPILPLGISYIEDFAKFENSPLYIGLV 197
Cdd:COG2271    95 -------ATSFW-----------------------QLLLLRFLLG-----LGEAGFFPAALKLIAEWFPPKERGRALGIF 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 198 ETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTAIPFFFLpntlpkegletna 277
Cdd:COG2271   140 NAGGPLGGALAPPLLGWLLAAF----------------------GWRAAFLILGLPGLLLALLRFWL------------- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926768 278 diiknenedkqkeevkkekygitkdflpfmkslscnpIYMLFILVSVIQFNafvnMISFMPKYLEQQYGISSSDAIFLMG 357
Cdd:COG2271   185 -------------------------------------LALAYFLVYFALYG----FLTWLPTYLVEVRGLSLAQAGLLLS 223
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1904926768 358 IYNLpPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFL 402
Cdd:COG2271   224 LPFL-AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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