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Conserved domains on  [gi|1905437391|ref|NP_001373892|]
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solute carrier organic anion transporter family member 1A2 isoform 12 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-451 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17458:

Pssm-ID: 452895 [Multi-domain]  Cd Length: 527  Bit Score: 785.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIV 80
Cdd:cd17458    71 VIGLGCLIMSLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17458   151 RGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWL 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILV 237
Cdd:cd17458   231 GFLICAGVNFLAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIV 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 238 SVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFL 317
Cdd:cd17458   311 TVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFS 390
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 318 SFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNC 397
Cdd:cd17458   391 AFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNC 470
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 398 SCIQTSGNSSAV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 451
Cdd:cd17458   471 SCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
1-451 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 785.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIV 80
Cdd:cd17458    71 VIGLGCLIMSLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17458   151 RGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWL 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILV 237
Cdd:cd17458   231 GFLICAGVNFLAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIV 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 238 SVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFL 317
Cdd:cd17458   311 TVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFS 390
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 318 SFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNC 397
Cdd:cd17458   391 AFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNC 470
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 398 SCIQTSGNSSAV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 451
Cdd:cd17458   471 SCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-514 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 764.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNI 79
Cdd:TIGR00805 100 VIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNI 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  80 VRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWW 159
Cdd:TIGR00805 180 LRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWW 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 160 FGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSV 239
Cdd:TIGR00805 260 IGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQV 339
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 240 IQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSF 319
Cdd:TIGR00805 340 IDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKF 419
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 320 LMTCENSSVVGINTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 399
Cdd:TIGR00805 420 LITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSC 495
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 400 IQTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIY 479
Cdd:TIGR00805 496 IQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPIL 573
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1905437391 480 FGALMDSTCLHWGTLKCGESGACRIYDSTTFRLSF 514
Cdd:TIGR00805 574 FGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIY 608
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
1-510 3.01e-171

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 493.64  E-value: 3.01e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIV 80
Cdd:pfam03137  68 WIGVGSLLMGLGSLLFALPHFL--------------------------------------------------SFFLGQLL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWF 160
Cdd:pfam03137  98 LGIGGTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSVSLT---LTPKDPRWVGAWWL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT--KDFLPFMKSLSCNPIYMLFILVS 238
Cdd:pfam03137 175 GFLIAGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEKTKSLKLGKslKDFPRALKRLLKNPVYMLLTLAS 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 239 VIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLS 318
Cdd:pfam03137 255 VSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLL 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 319 FLMTCENSSVVGINTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSA--CLAGCETSIGTGINMVFQN 396
Cdd:pfam03137 335 FFLGCPNSPVAGITVPYGGTQQ---LSGNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPcpCGAGCSSSSGAGKSTYNCS 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 397 CSCI----QTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFA 472
Cdd:pfam03137 412 CCCScgssTSGGNGSATPGKCP--SDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLG 489
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1905437391 473 GIPAPIYFGALMDSTCLHWGTlKCGESGACRIYDSTTF 510
Cdd:pfam03137 490 FIPGPIIFGALIDSTCLLWTK-TCGGRGNCWLYDNDKL 526
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
1-451 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 785.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIV 80
Cdd:cd17458    71 VIGLGCLIMSLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17458   151 RGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWL 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILV 237
Cdd:cd17458   231 GFLICAGVNFLAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIV 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 238 SVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFL 317
Cdd:cd17458   311 TVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFS 390
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 318 SFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNC 397
Cdd:cd17458   391 AFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNC 470
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 398 SCIQTSGNSSAV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 451
Cdd:cd17458   471 SCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-514 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 764.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNI 79
Cdd:TIGR00805 100 VIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVSNI 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  80 VRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWW 159
Cdd:TIGR00805 180 LRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWW 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 160 FGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSV 239
Cdd:TIGR00805 260 IGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFIKRLLCNKIYMLVILAQV 339
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 240 IQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSF 319
Cdd:TIGR00805 340 IDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKF 419
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 320 LMTCENSSVVGINTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 399
Cdd:TIGR00805 420 LITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSC 495
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 400 IQTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIY 479
Cdd:TIGR00805 496 IQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPIL 573
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1905437391 480 FGALMDSTCLHWGTLKCGESGACRIYDSTTFRLSF 514
Cdd:TIGR00805 574 FGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIY 608
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
1-450 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 570.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMWVYVLVGNIV 80
Cdd:cd17400    70 MIGIGCVIMGLGCFLKALPHFFMNQYEY---------------------------------------SLMWIYVFVGNIL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17400   111 RGIGETPILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVI 240
Cdd:cd17400   191 GFLICGGVSVLTAIPFFFLP------------------------------------------------PIYMLFILVSVI 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFL 320
Cdd:cd17400   223 QFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFL 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI 400
Cdd:cd17400   303 MTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCI 382
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1905437391 401 QTSGNSSAVLGLCDKG----PDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17400   383 QTSGNSSANLSLCDGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
1-451 4.15e-173

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 497.37  E-value: 4.15e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP-----TQDPSECTKEVKSLMWVYVL 75
Cdd:cd17459    70 IIGAGCLLMAIGTFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSiessdSKTGTGCEKEPGSSMWIYVF 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  76 VGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWV 155
Cdd:cd17459   150 LGNLLRGIGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWV 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 156 GAWWFGFLICAGVNVLTAIPFFFLPNTLPKegletnadiiknenedkqkeevkkekygitkDFLPFMKSLSCNPIYMLFI 235
Cdd:cd17459   230 GAWWLGYLIAGVITLLSAVPFWFLPKSLPK-------------------------------DFLPSLKNLLGNPVYFLYL 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 236 LVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLY 315
Cdd:cd17459   279 CTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLL 358
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 316 FLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQ 395
Cdd:cd17459   359 LSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFH 438
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 396 NCSCI----QTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 451
Cdd:cd17459   439 NCSCIgipsSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
1-510 3.01e-171

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 493.64  E-value: 3.01e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIV 80
Cdd:pfam03137  68 WIGVGSLLMGLGSLLFALPHFL--------------------------------------------------SFFLGQLL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWF 160
Cdd:pfam03137  98 LGIGGTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSVSLT---LTPKDPRWVGAWWL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT--KDFLPFMKSLSCNPIYMLFILVS 238
Cdd:pfam03137 175 GFLIAGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEKTKSLKLGKslKDFPRALKRLLKNPVYMLLTLAS 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 239 VIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLS 318
Cdd:pfam03137 255 VSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLL 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 319 FLMTCENSSVVGINTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSA--CLAGCETSIGTGINMVFQN 396
Cdd:pfam03137 335 FFLGCPNSPVAGITVPYGGTQQ---LSGNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPcpCGAGCSSSSGAGKSTYNCS 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 397 CSCI----QTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFA 472
Cdd:pfam03137 412 CCCScgssTSGGNGSATPGKCP--SDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLG 489
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1905437391 473 GIPAPIYFGALMDSTCLHWGTlKCGESGACRIYDSTTF 510
Cdd:pfam03137 490 FIPGPIIFGALIDSTCLLWTK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
1-450 3.44e-140

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 411.93  E-value: 3.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpseCTKEVKSLMWVYVLVGNIV 80
Cdd:cd17457    70 LIAAGCFIMGLGSVLTALPHFFMGYYKYG--------------------------------CLKESGSYMWVYVLMGNML 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17457   118 RGIGETPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWL 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkDFLPFMKSLSCNPIYMLFILVSVI 240
Cdd:cd17457   198 GFLVSGLFSIISAIPFFFLP------------------------------------GFFQSLKSILTNRLYVMFVCLTLL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFL 320
Cdd:cd17457   242 QVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFF 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI 400
Cdd:cd17457   322 IGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCL 401
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1905437391 401 QTSG----NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17457   402 EVTGsqnrNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
1-450 1.54e-106

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 324.19  E-value: 1.54e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvLVGNIV 80
Cdd:cd17336    70 WIGIGSILMGLGCFLLALPHFL----------------------------------------------------FVGQFL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWF 160
Cdd:cd17336    98 LGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVI 240
Cdd:cd17336   175 GFLILGILLLIVSIPLFFFP------------------------------------------------PIFILLLLAIVF 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFL 320
Cdd:cd17336   207 ESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFF 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGINTSYEGIPqdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI 400
Cdd:cd17336   287 LGCDNPPIAGVTTPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCI 360
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1905437391 401 QT-SGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17336   361 NSgTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
1-450 1.42e-79

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 256.66  E-value: 1.42e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIV 80
Cdd:cd17461    71 LIGIGGLLLALGAFLLTLPHFLSEPYQYS----------------------------------------MWVLMVVAQLL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17461   111 AGIGTVPIQPFGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKE---GLETNADIIKNENEDKQKEEVkkekyGITKDFLPFMKSLSCNPIYMLFILV 237
Cdd:cd17461   191 GLLISSGLLVLTSLPYFFFPREMLVGkkpSPEGDMLRKKEDEKKEEGSLL-----DFIKRFPKMFVKLLLNPLFMLLVLA 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 238 SVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFL 317
Cdd:cd17461   266 QCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVP 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 318 SFLMTCENSSVVGINTSYEGIPQDLYvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSI---GTGINMVF 394
Cdd:cd17461   346 LFFMGCSTQDVAGVYPKTSNSSDGPH------LSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIY 419
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 395 QNCSCIQT-SGNSSAVLGLCDKgpDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17461   420 SNCSCIPDlSGEKPAKTGSCPN--SCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
1-450 7.93e-78

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 252.00  E-value: 7.93e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLVGNIV 80
Cdd:cd17460    70 FIGCGAILVSLAGFLMALPHFISEPYEY-------------------------------------------GILFLGQLL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17460   107 LGIGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKEGLE-------TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLScNPIYML 233
Cdd:cd17460   187 GFLIAATLVALSAVPYFFFPREMPKEVVElqprekkLAKTMLKKLKSLSDILQNLSLLQFIKKFPRILLRTLR-NPIYLL 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 234 FILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYL 313
Cdd:cd17460   266 VVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAM-CVLGMLLCL 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 314 LYFLSFL-MTCENSSVVGINTSYEGIPQdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTG 389
Cdd:cd17460   345 FFALPLLfIGCSTQKIAGITHRTSSSPG-----LELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSvnvQALDN 419
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1905437391 390 INMVFQNCSCIQTSGN-SSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17460   420 SVVNYTDCSCVSEGGPvGAASPGTCGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
1-450 8.05e-71

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 232.14  E-value: 8.05e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIV 80
Cdd:cd17403    71 WLGIGAFIMGIGSLVFALPHFTV--------------------------------------------------FILAQLL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVnTDDLIITPTDTRWVGAWWF 160
Cdd:cd17403   101 HGAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-DSELGLTPDDPRWVGAWWL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVI 240
Cdd:cd17403   180 GFLISGALALIIAFPLLGFP------------------------------------------------PTFMFLNLAGAS 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLyFLSFL 320
Cdd:cd17403   212 EGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILL 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGINTSYEGIPqdLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI 400
Cdd:cd17403   291 IYCPNAPFAGVTVPYGNSP--LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCI 368
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1905437391 401 Q---TSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYsLAAIPGYMVLLR 450
Cdd:cd17403   369 QsnsSKTSTAATGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
1-450 9.30e-71

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 232.43  E-value: 9.30e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMwvyvLVGNIV 80
Cdd:cd17401    70 LIGIGGLFLAAGAFLLTLPHFISEPYQY---------------------------------------GIM----VVAQLL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17401   107 LGIGGVPIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLpkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVI 240
Cdd:cd17401   187 GFLIAAALLVLTSFPYFFFPRFI--------------------------------KRFPCIFLRTLRNPIFLLVVLAQVT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFL 320
Cdd:cd17401   235 LSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFF 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGIN---TSYEGIPQDlyvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET----SIGTGINMV 393
Cdd:cd17401   315 IGCSTPTIAGVYppsSSSSIHPQS--------PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNinmsTSATSKQVI 386
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 394 FQNCSCIqTSGNSSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17401   387 YTNCSCV-TGGSASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
1-450 7.97e-65

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 217.10  E-value: 7.97e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   1 MIGIGCVVMGLGCFLKSLPHFLMNQYEyestvsvsgnlssnsflcmengtqilrptqdpsectkevKSLMWVYVLVGNIV 80
Cdd:cd17402    70 LIGCGGIVMALGALLSALPEFLTHQYK---------------------------------------TNMMYLLLIGAQVL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  81 RGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWF 160
Cdd:cd17402   111 LGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWG 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 161 GFLICAGVNVLTAIPFFFLPNTLPKegletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVI 240
Cdd:cd17402   191 GFLLCGALLFFSALLMFGFPQSLQQ-----------------------------LRVIPKVTKHLLSNPVFTCIVLAACM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 241 QFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFL 320
Cdd:cd17402   242 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLF 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 321 MTCENSSVVGINTSYeGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGinmvfqnCSCI 400
Cdd:cd17402   322 LGCDTGPVAGVTVPY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACL 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1905437391 401 QT--SGNSSAVLGLCDKgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17402   394 SSvpAENATVVPGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
2-450 4.16e-64

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 214.52  E-value: 4.16e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391   2 IGIGCVVMGLGCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvlVGNIVR 81
Cdd:cd17404    71 IAVGGVLIALGSFLFSLPHFFI----------------------------------------------------LAQILI 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  82 GMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTgfvNTDDLIITPTDTRWVGAWWFG 161
Cdd:cd17404    99 GMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDP---LSTPPDISPGDPRWIGAWWGG 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 162 FLICAGVNVLTAIPFFFLPNtlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQ 241
Cdd:cd17404   176 FLLCGIALLLVAFPFFTFPK-----------------------------------------------MTFLVVSLGYCME 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 242 FNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLM 321
Cdd:cd17404   209 LAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFL 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 322 TCENSSVVGINTSYEGIPQ-DLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV-FQNCSC 399
Cdd:cd17404   289 GCESIKLAGITIPYTTGPSlSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRnYTNCAC 368
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1905437391 400 IQTSGNSS----AVLGLCDKGP--DCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17404   369 LQSRSSISpptvGQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
75-450 3.78e-51

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 180.32  E-value: 3.78e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  75 LVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLiiTPTDTRW 154
Cdd:cd17463    95 ILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDL--TEEDPRW 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 155 VGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLF 234
Cdd:cd17463   173 LGAWWIGFLMCWLIAWCLIAPFSCFPKHLP----------------------------GLLK-----------NPVFMCL 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 235 ILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLL 314
Cdd:cd17463   214 TISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLL 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 315 YFLSFLMTCENSSVVGINTSYEGIPQdlyvENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVF 394
Cdd:cd17463   294 LSVFIFAKCGNDPFAGVSETYNGTGK----IGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVY 369
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 395 QNCSCIQ-TSGNSSAVLGLCDKGPDCSLM---LQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17463   370 YNCSCIGnFTEEFSANTTKCEEGKKCETTcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
75-450 4.81e-50

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 177.33  E-value: 4.81e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  75 LVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGfVNTDdliITPTDTRW 154
Cdd:cd17462    95 MLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG-RQTE---LTPENPLW 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 155 VGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLF 234
Cdd:cd17462   171 VGAWWIGFLGAGAAALLIALPILGYPRQLP----------------------------GLLK-----------NPTFIFL 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 235 ILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLL 314
Cdd:cd17462   212 CLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKF-CLICTVVSLL 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 315 YFLSFLMTCENSSVVGINTSYEG--IPQDLYvenDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGIN- 391
Cdd:cd17462   291 AIFIFSLHCPNVPMAGVTASYRGsvLPEGSL---NLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNg 367
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1905437391 392 -MVFQNCSCIqtSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIY--SLAAIPGYMVLLR 450
Cdd:cd17462   368 qKVYQDCSCV--AGNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILftFLCSIPALTATLR 427
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
75-450 1.85e-31

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 126.12  E-value: 1.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  75 LVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASfcANVYVDtgfVNTDDLIITPTDT-- 152
Cdd:cd17405    94 IAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGL--PNFQPP---PNEKSVEIEVNKVyq 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 153 RWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYM 232
Cdd:cd17405   169 LWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP----------------------------GLLK-----------NPLLL 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 233 LFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEY 312
Cdd:cd17405   210 CQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 313 LLYFLSFLMTCENSSVVGINTSYEGIPQdlyvENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINM 392
Cdd:cd17405   290 GLFVLIFFVECQTVTFAGINEDYDGYGQ----LGNLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEK 365
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1905437391 393 VFQNCSCIQTSGNSS--------AVLGLCDKgpDCsLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 450
Cdd:cd17405   366 TYYNCSCIKEGLAAAddegdfidAIAGKCDS--KC-YKLPLFFAFYFSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
348-401 3.43e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 89.67  E-value: 3.43e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1905437391 348 IFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ 401
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
71-319 3.35e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.92  E-value: 3.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  71 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCAnvyvdtgfvntddliitpt 150
Cdd:cd06174    84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------------------- 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 151 dTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKnenedkqkeevkkekygitKDFLPFMKSLSCNPI 230
Cdd:cd06174   145 -SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS-------------------KSVLKLLKRVLKNPG 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 231 YMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFkITVKQAAHIGCWLSLL 310
Cdd:cd06174   205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRL-IGRKPLLLIGLLLMAL 282

                  ....*....
gi 1905437391 311 EYLLYFLSF 319
Cdd:cd06174   283 GLALLLLAP 291
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
353-399 7.92e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 62.90  E-value: 7.92e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1905437391 353 NVDCNCPSKIWDPVCGNNGLSYLSAC---LAGCETSIGTGINMVFQNCSC 399
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
358-399 1.24e-07

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.04  E-value: 1.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1905437391 358 CPsKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 399
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_1 pfam07690
Major Facilitator Superfamily;
71-321 1.97e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  71 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFcanvyvdtgfvntddlIITPT 150
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL----------------LASLF 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 151 DTRWVgawwfgFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIknenedkqkeevkkekygitKDFLPFMKSLSCNPI 230
Cdd:pfam07690 149 GWRAA------FLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR--------------------LSLIVAWKALLRDPV 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 231 yMLFILVSVIQFNAFVNMISFMPKYLEqQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLL 310
Cdd:pfam07690 203 -LWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280
                         250
                  ....*....|.
gi 1905437391 311 EYLLYFLSFLM 321
Cdd:pfam07690 281 GLLLLSLTLSS 291
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
71-291 4.20e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  71 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVET----GAIIGPLIGLLLASFcanvyvdtgfvntddli 146
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaiglGFLIGPLLGGLLADA----------------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 147 itptdtrwvGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKnenedkqkeevkkekygitkdFLPFMKSLS 226
Cdd:cd17325   147 ---------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR---------------------LRSGLRLLL 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1905437391 227 CNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMK 291
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
71-321 5.33e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 5.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391  71 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtGFvntddliitpt 150
Cdd:cd17324    87 FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---GW----------- 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 151 dtRWVgawwfgFLICAGVNVLTAIPF-FFLPNTLPKEGletnadiiknenedkqkeevkkekygITKDFLPFMKSLSCNP 229
Cdd:cd17324   153 --RAA------FLAIAVLALLAALLLwRLLPSLPPKKP--------------------------GSLGLLSSLLLLLRNP 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905437391 230 IYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKITVKQAAhiGCWLSL 309
Cdd:cd17324   199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV-VGSPLAGRLADRGGRRALLIA--LLLLAA 275
                         250
                  ....*....|..
gi 1905437391 310 LEYLLYFLSFLM 321
Cdd:cd17324   276 ALLLLTLLGPSP 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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