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Conserved domains on  [gi|1908122241|ref|NP_001374042|]
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DNA polymerase kappa isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 2.71e-148

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.03  E-value: 2.71e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 181 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 261 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 421 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1908122241 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 7.38e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 7.38e-05
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  621 ILTCPVCFRAQgciSLEALNKHVDECL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 776-802 2.00e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  776 ALVCPVCNVEQKtsdLTLFNVHVDVCL 802
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 2.71e-148

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.03  E-value: 2.71e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 181 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 261 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 421 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1908122241 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-522 5.95e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 5.95e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 184 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 263
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 264 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 343
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 344 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 418
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 419 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 495
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 1908122241 496 idadfpHPLRLRLMGVRISSFPNEEDR 522
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-514 3.57e-96

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 3.57e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 179 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 258
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 259 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 338
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 339 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 417
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 418 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 496
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 1908122241 497 DADFPHPLRLRLMGVRIS 514
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-325 5.67e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 5.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 183 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 261
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1908122241 262 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 325
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 7.38e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 7.38e-05
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  621 ILTCPVCFRAQgciSLEALNKHVDECL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 776-802 2.00e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  776 ALVCPVCNVEQKtsdLTLFNVHVDVCL 802
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 2.71e-148

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.03  E-value: 2.71e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 181 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 261 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 421 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1908122241 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-522 5.95e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 5.95e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 184 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 263
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 264 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 343
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 344 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 418
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 419 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 495
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 1908122241 496 idadfpHPLRLRLMGVRISSFPNEEDR 522
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-514 3.57e-96

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 3.57e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 179 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 258
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 259 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 338
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 339 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 417
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 418 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 496
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 1908122241 497 DADFPHPLRLRLMGVRIS 514
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 17-538 2.43e-84

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 281.14  E-value: 2.43e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241  17 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDR 88
Cdd:PTZ00205   42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241  89 FAMELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 168
Cdd:PTZ00205  122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 169 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwpedkrryfikmgssvendnpgkevnklsehersi 248
Cdd:PTZ00205  201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER-------------------------------------- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 249 spllFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfGT-SAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKN 327
Cdd:PTZ00205  243 ----FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNIN 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 328 KPNGQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGL---- 402
Cdd:PTZ00205  287 KPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGImqwp 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 403 --------GSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTV 474
Cdd:PTZ00205  367 daataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSL 446

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1908122241 475 SSVVSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQ 538
Cdd:PTZ00205  447 IQYSDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 101-529 6.23e-66

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 224.21  E-value: 6.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 101 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 177
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 178 SKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwPEDkrryfikmgssvendnpgkevnklsehersispllfeesp 257
Cdd:PRK14133   83 SKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE----PIK---------------------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 258 sdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqeVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIlp 337
Cdd:PRK14133  119 -----------------------------------IAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKII-- 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 338 NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTHLTRDGERKSM 416
Cdd:PRK14133  162 TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERKSI 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 417 SVERTFS-EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKtE 495
Cdd:PRK14133  241 GKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILE-H 319

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1908122241 496 IDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 529
Cdd:PRK14133  320 INIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 102-516 7.11e-65

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 223.66  E-value: 7.11e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 180 EVKEILADYDPNFMAMSLDEAYLNitkhleerqnwpedkrryfikmgssvendnpgkevnkLSEHERsispllfeespsd 259
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLD-------------------------------------LSGTER------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 260 vqppgdpfqvnfeeqnnpqilqnsvVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILPNR 339
Cdd:PRK02794  147 -------------------------LHGAPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPRG-FSVIGRA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 340 QAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTHLTRDGERKSMS 417
Cdd:PRK02794  201 EAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSPDREAKSVS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 418 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEI 496
Cdd:PRK02794  278 AETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEKET 357

                         410       420
                  ....*....|....*....|
gi 1908122241 497 DadfphPLRLRLMGVRISSF 516
Cdd:PRK02794  358 D-----GTAFRLIGIGVSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 102-516 1.77e-52

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 190.15  E-value: 1.77e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 177
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 178 SKEVKEILADYDPNFMAMSLDEAYlnitkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeesp 257
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAF-------------------------------------------------------- 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 258 sdVQPPGdpfqvnfeeqnnpqilqnsvVFGTSAQEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQ 334
Cdd:PRK03348  110 --VEPAE--------------------LAGASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRV 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 335 ILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqRALlsllfSETSWHYFLHISLGLGSTHLTR----- 409
Cdd:PRK03348  168 VPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDL---AAL-----SEAEVANLLGATVGPALHRLARgiddr 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 410 ----DGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEI 484
Cdd:PRK03348  238 pvaeRAEAKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVL 317

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1908122241 485 FAIAKELLkteIDADFPHPlrLRLMGVRISSF 516
Cdd:PRK03348  318 AATARRLL---LDPDEIGP--IRLVGVGFSGL 344
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 104-514 2.63e-49

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 177.94  E-value: 2.63e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTS----NYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCviacSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 180 EVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsd 259
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTG----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 260 vqppgdpfqvnfeeqnnpqilqnSVVFGTSAQEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSDKNKPNGQYQILPn 338
Cdd:cd00424   108 -----------------------SARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTILDP- 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 339 rQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislGLGSTHLTRDGERK 414
Cdd:cd00424   164 -EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPPRPRK 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 415 SMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVN------FEVKTRASTVSSVVSTaEEIFAI 487
Cdd:cd00424   240 SFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GELLHA 318

                         410       420
                  ....*....|....*....|....*..
gi 1908122241 488 AKELLKTEIDAdfPHPLRLRLMGVRIS 514
Cdd:cd00424   319 LDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK01810 PRK01810
DNA polymerase IV; Validated
 100-511 7.35e-49

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 178.30  E-value: 7.35e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 100 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY 174
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 175 RAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklseherSISPLlfe 254
Cdd:PRK01810   84 REASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-------------------------------------LGSPL--- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 255 espsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQ 334
Cdd:PRK01810  124 -------------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG-IT 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 335 ILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETswhyflhislGL-------GSTH 406
Cdd:PRK01810  166 VLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGIN----------GVrlqrranGIDD 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 407 LTRDGER----KSMSVERTFSEiNKAEEQ--YSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST 480
Cdd:PRK01810  235 RPVDPEAiyqfKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWE 313

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1908122241 481 AEEIFAIAKELLKTEIDADfphplRLRLMGV 511
Cdd:PRK01810  314 KRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 81-514 9.96e-48

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 175.19  E-value: 9.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241  81 KAQLQvDRFAMELEQSRN----------LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLSTSNYHARRF 146
Cdd:cd01701    18 KARLK-DFFRELSNGSKEadpsnsihpdLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 147 GVRAAMpgFI--AKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQnwpedkrryfik 224
Cdd:cd01701    97 GIKNGM--WVgqAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETY------------ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 225 mgssvendnpgkevnklsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQK 304
Cdd:cd01701   163 ---------------------------------------------------------------ELPEELAEAIRNEIRET 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 305 TTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ----R 380
Cdd:cd01701   180 TGCSASVGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkE 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 381 ALLSLLFSETSWHyFLHISLGLGSTHLTRDGERKSMSVertfsEIN------KAEEQYSLCQELCSELAQDLQKERLKGR 454
Cdd:cd01701   258 KLQKVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSA-----EINygirftNVDDVEQFLQRLSEELSKRLEESNVTGR 331

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908122241 455 TVTIKLKN------------------VNFevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphPLRLRLMGVRIS 514
Cdd:cd01701   332 QITLKLMKrapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---PEELRGVGIQVT 402
PRK03858 PRK03858
DNA polymerase IV; Validated
 102-526 4.72e-47

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 172.86  E-value: 4.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 181
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 182 KEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRyfikmgssvendnpgkevnklsehersispllfeespsdvq 261
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFLDVG-----------GLRR----------------------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 262 ppgdpfqvnfeeqnnpqilqnsvVFGTSAQeVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQa 341
Cdd:PRK03858  112 -----------------------ISGTPVQ-IAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 342 vMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGSTHLTRDGERKSMSV 418
Cdd:PRK03858  167 -LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPRRVETGRRRRSVGA 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 419 ERTFSEINKAEEQY--SLCQeLCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 496
Cdd:PRK03858  244 QRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARDLV---- 318

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1908122241 497 DADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 526
Cdd:PRK03858  319 AAAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-325 5.67e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 5.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 183 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 261
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1908122241 262 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 325
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 104-518 2.97e-35

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 137.83  E-value: 2.97e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 169
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 170 ---------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNItkhleerqnwpedkrryfikmgssvendnpgkevnk 240
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDL------------------------------------ 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 241 lsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLA 320
Cdd:cd01702   125 -------------------------------------------------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLA 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 321 KVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL---FSET--SWHY 394
Cdd:cd01702   156 KLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWLY 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 395 flHISLGLGSTHLTRDGERKSMSVERTFS-EINKAEEQ-YSLCQELCSELAQDLQKER----LKGRTVTIKLKNVNFEVK 468
Cdd:cd01702   234 --NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDvQHWLLVLASELNSRLEDDRyennRRPKTLVLSLRQRGDGVR 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1908122241 469 TRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 518
Cdd:cd01702   312 RSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK03352 PRK03352
DNA polymerase IV; Validated
 103-520 1.39e-34

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 135.54  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 255
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD-------------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 256 spsdvqpPGDPFqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 335
Cdd:PRK03352  117 -------TDDPE------------------------ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 336 lpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDG-ER 413
Cdd:PRK03352  166 --TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVSAEPwVP 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 414 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKE-RLKGRtVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 491
Cdd:PRK03352  244 RSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEgRPVTR-VAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDV 322

                         410       420
                  ....*....|....*....|....*....
gi 1908122241 492 LKtEIDADFPhplrLRLMGVRISSFPNEE 520
Cdd:PRK03352  323 LD-RFELDRP----VRLLGVRLELAMPDE 346
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 103-529 1.99e-33

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 133.59  E-value: 1.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 176
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 177 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmGSSvendnpgkevnklsehersispLLFees 256
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVT--------------------GSQ----------------------KLF--- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 257 psdvqppGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD---KNKPNGQY 333
Cdd:PRK03103  119 -------GSP------------------------LEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKNPDGLF 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 334 QIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFLHISLGLGSTHLTR 409
Cdd:PRK03103  168 TL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGIDYSPVTP 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 410 DG--ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKT---RASTVSSVVSTAEE 483
Cdd:PRK03103  242 HSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAME 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1908122241 484 IFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 529
Cdd:PRK03103  322 VYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 104-511 2.96e-32

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 129.51  E-value: 2.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 182
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 183 EILADYDPNFMA--MSLDEAYLNITkhleerqnwpeDKRryfikmgssvendnpgkevnklsehersispLLFeespsdv 260
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVT-----------EMR-------------------------------LLV------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 261 qppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILP-NR 339
Cdd:cd01703   112 -----------------------------ASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPpSC 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 340 QAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLG-----STHLT-----R 409
Cdd:cd01703   163 ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEfgegiGQRIWkllfgR 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 410 DGER--------KSMSVERTF-----SEINKAEEQYS---------LCQELCSELAQDLQKERLKGRTV---TIKLKNVN 464
Cdd:cd01703   242 DTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIEellasllerMKQDLQEVKAGDGRRPHTLRLTLrryTSTKKHYN 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1908122241 465 FEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 511
Cdd:cd01703   322 RESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PRK01216 PRK01216
DNA polymerase IV; Validated
 103-370 3.31e-31

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 125.67  E-value: 3.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 255
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVK---------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 256 spsdvqppgdpfqvNFEEqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 335
Cdd:PRK01216  117 --------------NYQD----------------AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVI 166

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1908122241 336 LPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 370
Cdd:PRK01216  167 DD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 106-458 2.03e-26

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 111.49  E-value: 2.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 106 IDMDAFYAAVEMRDNPELKDKPIAVgsmsmLSTS-------NYHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRA 176
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 177 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfees 256
Cdd:cd01700    78 MSRRIMSILERFSPDVEVYSIDESFLDLT--------------------------------------------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 257 psDVQPPGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----KNKPNGQ 332
Cdd:cd01700   107 --GSLRFGDL------------------------EELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGV 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 333 YQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-IS-LGLG 403
Cdd:cd01700   161 VDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgIDcLPLE 235

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1908122241 404 STHltrdGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTI 458
Cdd:cd01700   236 EYP----PPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 413-520 8.18e-22

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 91.08  E-value: 8.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 413 RKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 491
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 1908122241 492 LKteidaDFPHPLRLRLMGVRISSFPNEE 520
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 339-370 9.00e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 9.00e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1908122241 339 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 370
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
105-379 5.98e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 46.30  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 105 HIDMDAFYAAVEMRDNPELKDKPIAVGSMS--MLSTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSKE 180
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgCVIARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSNR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 181 VKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgsSVENdnpgkevnklsehersispllfeespsdv 260
Cdd:PRK03609   84 VMSTLEELSPRVEIYSIDEAFCDLT----------------------GVRN----------------------------- 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 261 qppgdpfQVNFEEqnnpqilqnsvvFGtsaqevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKP----NGQYQIL 336
Cdd:PRK03609  113 -------CRDLTD------------FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqTGGVVDL 166

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1908122241 337 PNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 379
Cdd:PRK03609  167 SNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 7.38e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 7.38e-05
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  621 ILTCPVCFRAQgciSLEALNKHVDECL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 776-802 2.00e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 1908122241  776 ALVCPVCNVEQKtsdLTLFNVHVDVCL 802
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 297-493 4.24e-04

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 43.52  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 297 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLPIRkVSGIGKVTEKMLKALGIIT--- 372
Cdd:cd03468   119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122241 373 CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTHLTRDG----ERKSMSVERTFsEINKAEEQYSLCQELCSELAQDL 446
Cdd:cd03468   197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQL-EEPIARGLLFPLRRLLEQLCAFL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1908122241 447 QKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 493
Cdd:cd03468   269 ALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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