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Conserved domains on  [gi|1919270899|ref|NP_001375282|]
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ensconsin isoform 22 [Homo sapiens]

Protein Classification

MAP7 domain-containing protein( domain architecture ID 12064852)

MAP7 domain-containing protein such as MAP7D1 (microtubule-associated protein 7 domain containing 1) identified as a novel substrate of doublecortin-like kinase 1 (DCLK1)

Gene Ontology:  GO:0005737

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 330-364 3.14e-11

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 61.60  E-value: 3.14e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1919270899 330 QEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 364
Cdd:pfam05672 119 QEREKIMQQEEQERLERKKRIEEIMKRTRKSDQAE 153
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 87-173 9.12e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.11  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899  87 DRQRLARERREEREKQLAAREIVWLErEERARQHYEKHLEERKKRLEEqrqkEERRRAAVEEKRRQR-LEEDKERHEAVV 165
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIE-EERKRKLLEKEMEERQKAIYE----EERRREAEEERRKQQeMEERRRIQEQMR 559


                  ....*...
gi 1919270899 166 RRTMERSQ 173
Cdd:pfam17380 560 KATEERSR 567
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 330-364 3.14e-11

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 61.60  E-value: 3.14e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1919270899 330 QEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 364
Cdd:pfam05672 119 QEREKIMQQEEQERLERKKRIEEIMKRTRKSDQAE 153
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 87-173 9.12e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.11  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899  87 DRQRLARERREEREKQLAAREIVWLErEERARQHYEKHLEERKKRLEEqrqkEERRRAAVEEKRRQR-LEEDKERHEAVV 165
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIE-EERKRKLLEKEMEERQKAIYE----EERRREAEEERRKQQeMEERRRIQEQMR 559


                  ....*...
gi 1919270899 166 RRTMERSQ 173
Cdd:pfam17380 560 KATEERSR 567
PTZ00121 PTZ00121
MAEBL; Provisional
 86-179 2.74e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899   86 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVV 165
Cdd:PTZ00121  1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKK 1751

                           90
                   ....*....|....
gi 1919270899  166 rrtmERSQKPKQKH 179
Cdd:PTZ00121  1752 ----DEEEKKKIAH 1761
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 330-364 3.14e-11

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 61.60  E-value: 3.14e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1919270899 330 QEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 364
Cdd:pfam05672 119 QEREKIMQQEEQERLERKKRIEEIMKRTRKSDQAE 153
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 87-173 9.12e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.11  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899  87 DRQRLARERREEREKQLAAREIVWLErEERARQHYEKHLEERKKRLEEqrqkEERRRAAVEEKRRQR-LEEDKERHEAVV 165
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIE-EERKRKLLEKEMEERQKAIYE----EERRREAEEERRKQQeMEERRRIQEQMR 559


                  ....*...
gi 1919270899 166 RRTMERSQ 173
Cdd:pfam17380 560 KATEERSR 567
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 112-174 5.22e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 40.42  E-value: 5.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919270899 112 EREERARQHYEKHLEERKKRLEEQRQKE-ERRRAAVEEKRRQrlEEDKERHEAVVRRTMERSQK 174
Cdd:pfam15346  74 EEERKKREELERILEENNRKIEEAQRKEaEERLAMLEEQRRM--KEERQRREKEEEEREKREQQ 135
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 104-156 2.45e-03

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 39.25  E-value: 2.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1919270899 104 AAREIVWLEREERARQH--YEKHLEERKKRLEEQRQ-KEERRRAAVEEKRRQRLEE 156
Cdd:pfam09756  19 QQREAEEEEREEREKLEekREEEYKEREEREEEAEKeKEEEERKQEEEQERKEQEE 74
PTZ00121 PTZ00121
MAEBL; Provisional
 86-179 2.74e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899   86 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVV 165
Cdd:PTZ00121  1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKK 1751

                           90
                   ....*....|....
gi 1919270899  166 rrtmERSQKPKQKH 179
Cdd:PTZ00121  1752 ----DEEEKKKIAH 1761
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 115-178 3.23e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.20  E-value: 3.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1919270899 115 ERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVR--RTMERSQKPKQK 178
Cdd:PRK00409  540 EALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADEIIKelRQLQKGGYASVK 605
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 112-181 5.31e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.16  E-value: 5.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899 112 EREERARQHYEKhlEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 181
Cdd:pfam15709 356 EQEEQRRLQQEQ--LERAEKMREELELEQQRRFEEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQ 423
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 84-181 5.80e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899  84 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHL-----EERKKRLEEQRQKEERRRAavEEKRRQRLEED- 157
Cdd:pfam17380 424 QIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLrqqeeERKRKKLELEKEKRDRKRA--EEQRRKILEKEl 501

                          90       100
                  ....*....|....*....|....
gi 1919270899 158 KERHEAVVRRTMERSQKPKQKHNR 181
Cdd:pfam17380 502 EERKQAMIEEERKRKLLEKEMEER 525
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 86-178 7.05e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 37.08  E-value: 7.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919270899  86 DDRQRLARERREEREKQLAAREIVWLEREERARQhyEKHLEERkkRLEEQRQKEERRraaVEEKRRQRL--EEDKERHEA 163
Cdd:pfam15236  48 ERKRQKALEHQNAIKKQLEEKERQKKLEEERRRQ--EEQEEEE--RLRREREEEQKQ---FEEERRKQKekEEAMTRKTQ 120

                          90
                  ....*....|....*
gi 1919270899 164 VVRRTMERSQKPKQK 178
Cdd:pfam15236 121 ALLQAMQKAQELAQR 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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