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Conserved domains on  [gi|1931364268|ref|NP_001375415|]
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uncharacterized protein LOC100043761 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.09e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1931364268   3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-571 3.91e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 185 KPYECNQCGKAFARSCHLRIHKRTHTGEKPYEC--KQCGKAFVSSGDLQKHKRTHTGEKPYEC-KQCGKAFSQSSHLRIH 261
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 262 KRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSS----------------------HLHIHER 319
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 320 RHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLR 399
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 400 IHKRTHTEE-------KPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIHKRTHTGEKP 466
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 467 YECKQC------GKAFAGSSHLRIHKR-THTGQKPYEC--NQCGKAFAKSSTLQIHNRTHTGEKPYECY--QCGKAFITR 535
Cdd:COG5048   352 AKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1931364268 536 RVLQIHKRTHTGEKPYECKQCGKaFASSSDLQKHKR 571
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 7.48e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 565 DLQKHKRTHSGEKPYECKQCGKAFAQ 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 3.43e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 118 LQIHKRTHTGEKPYDCKQCGKAFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
53-199 8.66e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268  53 EDHFQTSRSHGRHERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHNGEKHHDC--NQCGKDFR----TWNVLQIHKR-TH 125
Cdd:COG5048   302 SSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnNEPPQSLQQYkDL 381

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1931364268 126 TGEKPYDC--KQCGKAFARSCHLRMHNRTHAGEKQYECN--QCGKAFKRRSDLQIHKQTHTGEKPYECNQCGKAFARS 199
Cdd:COG5048   382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.09e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1931364268   3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.14e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 8.14e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1931364268    4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-571 3.91e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 185 KPYECNQCGKAFARSCHLRIHKRTHTGEKPYEC--KQCGKAFVSSGDLQKHKRTHTGEKPYEC-KQCGKAFSQSSHLRIH 261
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 262 KRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSS----------------------HLHIHER 319
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 320 RHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLR 399
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 400 IHKRTHTEE-------KPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIHKRTHTGEKP 466
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 467 YECKQC------GKAFAGSSHLRIHKR-THTGQKPYEC--NQCGKAFAKSSTLQIHNRTHTGEKPYECY--QCGKAFITR 535
Cdd:COG5048   352 AKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1931364268 536 RVLQIHKRTHTGEKPYECKQCGKaFASSSDLQKHKR 571
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.39e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.96  E-value: 1.39e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1931364268   4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 285 DLQKHKRTHTGEKPYECKQCGKAFAH 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 7.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 565 DLQKHKRTHSGEKPYECKQCGKAFAQ 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 118 LQIHKRTHTGEKPYDCKQCGKAFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
53-199 8.66e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268  53 EDHFQTSRSHGRHERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHNGEKHHDC--NQCGKDFR----TWNVLQIHKR-TH 125
Cdd:COG5048   302 SSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnNEPPQSLQQYkDL 381

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1931364268 126 TGEKPYDC--KQCGKAFARSCHLRMHNRTHAGEKQYECN--QCGKAFKRRSDLQIHKQTHTGEKPYECNQCGKAFARS 199
Cdd:COG5048   382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.09e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1931364268   3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.14e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 8.14e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1931364268    4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-571 3.91e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 185 KPYECNQCGKAFARSCHLRIHKRTHTGEKPYEC--KQCGKAFVSSGDLQKHKRTHTGEKPYEC-KQCGKAFSQSSHLRIH 261
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 262 KRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSS----------------------HLHIHER 319
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 320 RHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLR 399
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 400 IHKRTHTEE-------KPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIHKRTHTGEKP 466
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 467 YECKQC------GKAFAGSSHLRIHKR-THTGQKPYEC--NQCGKAFAKSSTLQIHNRTHTGEKPYECY--QCGKAFITR 535
Cdd:COG5048   352 AKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1931364268 536 RVLQIHKRTHTGEKPYECKQCGKaFASSSDLQKHKR 571
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-610 5.58e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 5.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 225 VSSGDLQKHKRTHTGE----KPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQ--CGKAFARSGDLQKHKRTHTGEKP 298
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 299 YECKQCGK--AFAHSSHLHIHERrHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAF------------ 364
Cdd:COG5048    92 DLNSKSLPlsNSKASSSSLSSSS-SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpp 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 365 ----------TVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLRIHKRTHTEEKPYECNQCGKAFARSGDQQEHKRT-- 432
Cdd:COG5048   171 lpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLss 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 433 ----HTGEKPYECNQCGKAFIRRRVLQIHKRTHTG-EKPYECKQCGKAFAGSSHLRIHKRT--HTGQ--KPYEC--NQCG 501
Cdd:COG5048   251 sdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 502 KAFAKSSTLQIHNRTHTGEKPYECYQC------GKAFITRRVLQIHKR-THTGEKPYEC--KQCGKAFASSSDLQKHKRT 572
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1931364268 573 HSGEKPYECK--QCGKAFAQSSHLRIHKQTHTGERPYECN 610
Cdd:COG5048   411 HLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.39e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.96  E-value: 1.39e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1931364268   4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-534 2.43e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 129 KPYDCKQCGKAFARSCHLRMHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKQTHTGEKPYECNQCGK--AFARSCHLRI 204
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 205 HKRTHTgekPYECKQCGKAFVSSGDLQKHK----RTHTGEKPYE-CKQCGKAFSQSSHLRIHKRTHtgekpyeCNQCGKA 279
Cdd:COG5048   112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN-------SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 280 FARSGDLqkHKRTHTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQ 359
Cdd:COG5048   182 SNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 360 CGKAFTVIYTLQMHKQTHTGE-------KPYECKQCGKAFSQSRHLRIHKRT--HTEE--KPYEC--NQCGKAFARSGDQ 426
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 427 QEHKRTHTGEKPYEC--NQCGK----AFIRRRVLQIHKR-THTGEKPYEC--KQCGKAFAGSSHLRIHKRTHTGQKPYEC 497
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSkfspLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1931364268 498 N--QCGKAFAKSSTLQIHNRTHTGEKPYECYQCGKAFIT 534
Cdd:COG5048   420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-487 3.85e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268  74 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKAFARSCHLRMHN 150
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 151 RTHAGEKQYECNQCGKAFKRRSDLQIHKQTHTGEKPYECNQC-GKAFARSCHLRIHKRTHTGEkpyeckQCGKAFVSSGD 229
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 230 LQKHKRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTgEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCG---- 305
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrssl 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 306 --KAFAHSSHLHIHERRHTG-DKPYECKQCGKAFAVFYTLQMHKRT--HTG--DKPYEC--KQCGKAFTVIYTLQMHKQT 376
Cdd:COG5048   266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 377 HTGEKPYECK--QCGKAFSQS----RHLRIHKR-THTEEKPYEC--NQCGKAFARSGDQQEHKRTHTGEKPYECN--QCG 445
Cdd:COG5048   346 HTSISPAKEKllNSSSKFSPLlnnePPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1931364268 446 KAFIRRRVLQIHKRTHTGEKPYECKQCGKaFAGSSHLRIHKR 487
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-610 6.34e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 252 FSQSSHLRI-HKRTHTGE----KPYECNQCGKAFARSGDLQKHKRTHTGEKPYEC--KQCGKAFAHSSHLHIHERRHTGD 324
Cdd:COG5048    10 SSNNSVLSStPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 325 KPYEC-KQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKAFSQS-------- 395
Cdd:COG5048    90 PSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhp 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 396 --------------RHLRIHKRTHTEEKPYECNQCGKAFARSGDQQEHKRTHTGEKPYECNQCGKAF----IRRRVLQIH 457
Cdd:COG5048   170 plpanslskdpssnLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 458 KRTHTGEKPYECKQCG--KAFAGSSHLRIHKRTHTGQ-KPYECNQCGKAFAKSSTLQIHNRT--HTGE--KPYEC--YQC 528
Cdd:COG5048   250 SSDSSSSASESPRSSLptASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLC 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268 529 GKAFITRRVLQIHKRTHTGEKPYECK--QCGKAFASSSDLQKHKRTH-----SGEKPYEC--KQCGKAFAQSSHLRIHKQ 599
Cdd:COG5048   330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHII 409

                         410
                  ....*....|.
gi 1931364268 600 THTGERPYECN 610
Cdd:COG5048   410 THLSFRPYNCK 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 285 DLQKHKRTHTGEKPYECKQCGKAFAH 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 3.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 229 DLQKHKRTHTGEKPYECKQCGKAFSQ 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 6.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 201 HLRIHKRTHTGEKPYECKQCGKAFVS 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 7.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 257 HLRIHKRTHTGEKPYECNQCGKAFAR 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 7.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 565 DLQKHKRTHSGEKPYECKQCGKAFAQ 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-562 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 538 LQIHKRTHTGEKPYECKQCGKAFAS 562
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-365 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....
gi 1931364268 342 LQMHKRTHTGDKPYECKQCGKAFT 365
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 370 LQMHKQTHTGEKPYECKQCGKAFSQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 481 HLRIHKRTHTGQKPYECNQCGKAFAK 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-477 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.18e-03
                          10        20
                  ....*....|....*....|....
gi 1931364268 454 LQIHKRTHTGEKPYECKQCGKAFA 477
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-422 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 397 HLRIHKRTHTEEKPYECNQCGKAFAR 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 118 LQIHKRTHTGEKPYDCKQCGKAFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-450 4.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.05e-03
                          10        20
                  ....*....|....*....|....
gi 1931364268 427 QEHKRTHTGEKPYECNQCGKAFIR 450
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1931364268 173 DLQIHKQTHTGEKPYECNQCGKAFAR 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
53-199 8.66e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931364268  53 EDHFQTSRSHGRHERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHNGEKHHDC--NQCGKDFR----TWNVLQIHKR-TH 125
Cdd:COG5048   302 SSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnNEPPQSLQQYkDL 381

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1931364268 126 TGEKPYDC--KQCGKAFARSCHLRMHNRTHAGEKQYECN--QCGKAFKRRSDLQIHKQTHTGEKPYECNQCGKAFARS 199
Cdd:COG5048   382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-534 9.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.63e-03
                          10        20
                  ....*....|....*....|....*
gi 1931364268 510 LQIHNRTHTGEKPYECYQCGKAFIT 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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