|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
2-1140 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 2062.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 2 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKI 81
Cdd:TIGR00918 28 GKATGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVEVGGRVSQELAYTRQKI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 82 GEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCL 161
Cdd:TIGR00918 108 GEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPSTEGGYIEQILEKLIPCL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 162 IITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 241
Cdd:TIGR00918 188 IITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQGYMERPCLNPADPDCPDT 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 242 APNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINW 321
Cdd:TIGR00918 268 APNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQMYEHFKGYYKVHHIGW 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 322 NEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQG 401
Cdd:TIGR00918 348 NEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDCAKSQG 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 402 AVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkrIPFEDRTGECLKRTGAS 481
Cdd:TIGR00918 428 SVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN--IPFEERTGECLKRTGAS 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 482 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEP 561
Cdd:TIGR00918 506 VVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPCSARVIQIEP 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 562 QAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPvtitQDTLSCQSPESTSS 641
Cdd:TIGR00918 586 QAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP----SDPLSCQSPDIAGS 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 642 TRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 721
Cdd:TIGR00918 647 TRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNE 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 722 YDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETG 800
Cdd:TIGR00918 727 HDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDG 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 801 RIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRP 880
Cdd:TIGR00918 807 RITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPP 886
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 881 EWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRH 960
Cdd:TIGR00918 887 EWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRH 965
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 961 WLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLT 1040
Cdd:TIGR00918 966 WLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLT 1045
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 1041 AIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSP 1120
Cdd:TIGR00918 1046 AIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSP 1125
|
1130 1140
....*....|....*....|
gi 1939872640 1121 ANGLNRLPTPSPEPPPSVVR 1140
Cdd:TIGR00918 1126 AEGRSRLPTPSPEPPPGGVR 1145
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
332-1113 |
7.77e-68 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 250.98 E-value: 7.77e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 332 AWQRTYVEVVHQSVAPNsTQKVLSFTT-TTLDDILKSFSDVSVIRVASGYLLMLAYACLTM-----LRWDCSKSQGAVGL 405
Cdd:TIGR00917 533 AWEKAFIQLAKDELLPM-VQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKVLLGL 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 406 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---------SETGQNKRIPFEDRTGECLK 476
Cdd:TIGR00917 612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqVGVDNEQELTLERRLSRALM 691
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 477 RTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCftspcvsrv 556
Cdd:TIGR00917 692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC--------- 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 557 iqvepqaytephsntrysppppysshsfahethitmqstvqLRTEYDphthvyyttaeprseisvqpvTITQDTLSCQSP 636
Cdd:TIGR00917 763 -----------------------------------------IKTSKS---------------------SISAEKGSGQRK 780
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 637 EStsstrdllsqfsdsslhcleppctkwTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVP 716
Cdd:TIGR00917 781 AG--------------------------LLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 717 RETREYDFIAAQFKYFSFYNMYIVTQKADYPniqhllYDLHKSFSSVKYVMLEENKQLPQM-------------WLHYFR 783
Cdd:TIGR00917 835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYN------YTDFESQNKLCTMGGCDKDSIVNVfnnlsyiakpassWLDDYL 908
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 784 DWLQGLQDAFDSDWETGRimpnnYKNGSDDGVLAYKllvqtgsrdkpiDISQLTKQRlvdadgiINPSAFYIYLTAWVSN 863
Cdd:TIGR00917 909 VWLSPQASCCCRKFTNGT-----FCNGPDPQCFRCA------------DLSSDAQGR-------PSTTQFKEKLPWFLNA 964
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 864 DP--------VAYAASQANIRPHrpewvhdkadympetrlripaAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNY 935
Cdd:TIGR00917 965 LPsadcakggHAAYSSAVDLQGY---------------------ATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKV 1023
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 936 T-SLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVELFGMMGLIGIKLS 1013
Cdd:TIGR00917 1024 SrSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLN 1103
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 1014 AVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAVLA 1091
Cdd:TIGR00917 1104 AVSVVNSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYFRMYL 1183
|
810 820
....*....|....*....|..
gi 1939872640 1092 ILTVLGVLNGLVLLPVLLSFFG 1113
Cdd:TIGR00917 1184 ALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
396-550 |
2.22e-49 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 172.00 E-value: 2.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 396 CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECL 475
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939872640 476 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 550
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
318-1075 |
7.20e-46 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 178.70 E-value: 7.20e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 318 HINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQkVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT-----ML 392
Cdd:pfam02460 162 FLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQ-FTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSY 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 393 RWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTG 472
Cdd:pfam02460 241 TIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMG 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 473 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspc 552
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI-------------------- 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 553 vsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLS 632
Cdd:pfam02460 378 -----------------------------------------------------------CAKP--EAEGRHCLFVWATSS 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 633 CQSPESTSSTRDllsqfsdsSLHCLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT 712
Cdd:pfam02460 397 PQRIDSEGSEPD--------KSHNIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPD 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 713 DIVPRETREYDFIAAQFKYFSFY--NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQ 787
Cdd:pfam02460 464 KLVLEDSPLVEYLSLREKHFWPEglQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLS 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 788 GLQDAFDSDWETGRIMpnnykngsddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpva 867
Cdd:pfam02460 541 TLNMEEEEDEEKEWSY----------GNLPSFLKAPGNS--------------------------------HWAGD---- 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 868 yaasqanirphrpeWVHDKADYMpetrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGY 947
Cdd:pfam02460 575 --------------LVWDDNTTM------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDA 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 948 PFLfwEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIG 1027
Cdd:pfam02460 629 PFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1939872640 1028 VEFTVHVALAFLTAIGDKNH-RAMLALEHMFAPVLDGAVSTLLGVLMLA 1075
Cdd:pfam02460 707 VDFSAHIAYHFVRSRGDTPAeRVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
362-1094 |
1.61e-19 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 94.93 E-value: 1.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 362 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLA 441
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 442 LGVGVDD-VFLLAHAFSETGQNKriPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFA 520
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFL 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 521 MVLLIFPAILSMdLYRREDRRldifccftspcvsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrt 600
Cdd:COG1033 360 TSLTLLPALLSL-LPRPKPKT----------------------------------------------------------- 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 601 eydphthvyyttaeprseisvqpvtitqdtlscQSPESTSSTRDLLSQFSDsslhcleppctkwtlssFAEKHYapfllr 680
Cdd:COG1033 380 ---------------------------------RRLKKPPELGRLLAKLAR-----------------FVLRRP------ 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 681 pkakVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREY---DFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLH 757
Cdd:COG1033 404 ----KVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFGGSDPLEVVVDTGEPDGLKDPEVLKEID 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 758 KsfssvkyvMLEENKQLPQ----MWLHYFRDWLQGLQDAFDSDWETgriMPNNykngsDDGVLAYKLLVQTGSRDkpidi 833
Cdd:COG1033 480 R--------LQDYLESLPEvgkvLSLADLVKELNQALNEGDPKYYA---LPES-----RELLAQLLLLLSSPPGD----- 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 834 sqlTKQRLVDADGiinpsafyiyltawvsndpvayaaSQANIRphrpewvhdkadympetrlripaaepieyaqfpFYLN 913
Cdd:COG1033 539 ---DLSRFVDEDY------------------------SAARVT---------------------------------VRLK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 914 GLrDTSDFVEAIEKVR-VICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNpWTAGIIVM 992
Cdd:COG1033 559 DL-DSEEIKALVEEVRaFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRS-LRLGLISL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 993 VLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI--GDKNHRAML-ALEHMFAPVLDGAVSTL 1068
Cdd:COG1033 637 IPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkGGDLEEAIRrALRTTGKAILFTSLTLA 716
|
730 740
....*....|....*....|....*.
gi 1939872640 1069 LGVLMLAGSEFDFIVRyfFAVLAILT 1094
Cdd:COG1033 717 AGFGVLLFSSFPPLAD--FGLLLALG 740
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
403-541 |
6.29e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 73.74 E-value: 6.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 403 VGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPfLALGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGECLKRTGASV 482
Cdd:COG1033 631 LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYRE-ERRKGGDLEEAIRRALRTTGKAI 708
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1939872640 483 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdLYRREDRR 541
Cdd:COG1033 709 LFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
907-1114 |
2.46e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 71.81 E-value: 2.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 907 QFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWT 986
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 987 AGIIVMVLALMTVELFGMMGLIGIKLS----AVPVVILiasvGIGVEFTVHVALAFLTAI---GDKNHRAMLALEHMFAP 1059
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYREERrkgLDKREALREALRKLGPP 320
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1939872640 1060 VLDGAVSTLLGVLMLAGSEFDfIVRYF---------FAVLAILTvlgvlnglvLLPVLLSFFGP 1114
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDFgivaaigvlLAFLTSLT---------LLPALLSLLPR 374
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
363-546 |
2.45e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 55.23 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 363 DILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaL 442
Cdd:TIGR00921 186 DIEREFGKDMGTTMAISGILVVLVLLLDFKRW-------WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-I 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 443 GVGVDDVFLLAHAFSETGQNKRiPFEDRTGECLKRTGASVALTSISNVtAFFMAALIPI-PALRAFSLQAAVVVVFNFAM 521
Cdd:TIGR00921 258 GVGIDYGIQTLNRYEEERDIGR-AKGEAIVTAVRRTGRAVLIALLTTS-AGFAALALSEfPMVSEFGLGLVAGLITAYLL 335
|
170 180
....*....|....*....|....*.
gi 1939872640 522 VLLIFPAIL-SMDLYRREDRRLDIFC 546
Cdd:TIGR00921 336 TLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
403-530 |
3.49e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.76 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 403 VGLAGVLLVALSVAAGLGLCSLIGISFNAaTTQVLPFLALGVGVDDVFLLAHAFSETgQNKRIPFEDRTgECLKRTGASV 482
Cdd:TIGR00921 593 KAVFPLIAIGSGILWAIGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEE-RKEHGPKEAIT-HTMERTGPGI 669
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1939872640 483 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 530
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
957-1077 |
8.08e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 8.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 957 SLRH--WLLLAISVVLActFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFtvhv 1034
Cdd:COG4258 636 RYRNdaLWLLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDY---- 709
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1939872640 1035 ALAFLTAIGDKNHRAmlalEHMFAPVLdGAVSTLLGVLMLAGS 1077
Cdd:COG4258 710 ALFFTEGLLDKGELA----RTLLSILL-AALTTLLGFGLLAFS 747
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
375-528 |
8.72e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.24 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 375 RVASGYLLMLAYA---CLTMLRwdcskSQGAVGLAGVLLV-ALSVAAGLGLCSLIGISFNAATTQVLpFLALGVGVD-DV 449
Cdd:COG4258 638 RNDALWLLLLALLlilLLLLLR-----LRSLRRALRVLLPpLLAVLLTLAILGLLGIPLNLFHLIAL-LLVLGIGIDyAL 711
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1939872640 450 FllahaFSETGQNKRIpfedrtgecLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA 528
Cdd:COG4258 712 F-----FTEGLLDKGE---------LARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
335-530 |
2.18e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 49.23 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 335 RTYVEVVhQSVAPNSTQKVLSFTTTTlDDILKSFsdvsvIRVASGYLLMLAYACLTMLRwdcSKSQGAVGLAGVLLVALS 414
Cdd:TIGR03480 683 RRFVRAV-RKVAPDATGAPVSILESG-DTVVGAF-----LQAFIYALVAITVLLLLTLR---RVRDVLLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 415 VAAglgLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGEclkrtgaSVALTSISNVTAFF 494
Cdd:TIGR03480 753 TVA---AMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRN-GVDSGNLLQSSTAR-------AVFFSALTTATAFG 820
|
170 180 190
....*....|....*....|....*....|....*.
gi 1939872640 495 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 530
Cdd:TIGR03480 821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
401-532 |
4.91e-05 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 47.84 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 401 GAVGLAGV--LLVALSVAAGLGLCSLIG--ISFNAATTQVLPFLALGVGVD-DVFLLAhAFSE---TGQNKripfEDRTG 472
Cdd:COG2409 191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLVS-RYREelrAGEDR----EEAVA 265
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1939872640 473 ECLKRTGASVAltsISNVT---AFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 532
Cdd:COG2409 266 RAVATAGRAVL---FSGLTvaiALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLAL 325
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
369-541 |
2.09e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.00 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 369 SDVSVIRVASGY----LLMLAYACLTMLrwdcsksqgavgLAGVLLVALSVAAGLGLCSLI-----GISFNAATTqvlpf 439
Cdd:COG4258 249 HDISTIGLISLLgillLLLLVFRSLRPL------------LLGLLPVAVGALAGLAAVSLVfgsvhGITLGFGSS----- 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 440 LaLGVGVD-DVFLLAHAFSETGQNKRIPfedrtgecLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFN 518
Cdd:COG4258 312 L-IGVAVDySLHYLTHRRAAGEWDPRAA--------LRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAA 382
|
170 180
....*....|....*....|...
gi 1939872640 519 FAMVLLIFPAilsmdLYRREDRR 541
Cdd:COG4258 383 ALTTLLWLPL-----LLPRAAPR 400
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
324-532 |
2.80e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 44.59 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 324 DRAAAILEAwqrtyvevVHQSVAPNSTQKVLSFTTTTLDDILKSFS-DVSVIRVASgylLMLAYACLTMLRwdcsksqGA 402
Cdd:pfam03176 104 ESVAAVRDA--------VEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVT---LVVIFIILLIVY-------RS 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 403 VGLAGVLL--VALSVAAGLGLCS-LIGISFNAATTQVLPF---LALGVGVD-DVFLLA--HAFSETGQNKripfEDRTGE 473
Cdd:pfam03176 166 VVAALLPLltVGLSLGAAQGLVAiLAHILGIGLSTFALNLlvvLLIAVGTDyALFLVSryREELRAGEDR----EEAVIR 241
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1939872640 474 CLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 532
Cdd:pfam03176 242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
963-1085 |
4.75e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872640 963 LLAISVVLactflVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1039
Cdd:TIGR00921 198 TMAISGIL-----VVLVLLLdfKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE 272
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1939872640 1040 TAIG---DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY 1085
Cdd:TIGR00921 273 EERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| |
