NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2008348519|ref|NP_001380792|]
View 

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982    82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2008348519 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982   160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982    82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2008348519 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982   160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 6.85e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.23  E-value: 6.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  82 SAYELPFgtKGSEDLLLRVLAITSysipesIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 162 KTTIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 233 NPFFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 2008348519 312 SQEAVAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 1.94e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 403.28  E-value: 1.94e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982    82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2008348519 277 HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRM 321
Cdd:cd23982   160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 117-321 7.33e-111

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 320.78  E-value: 7.33e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23967     2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDP-EEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23967    81 LLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCDE 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2008348519 276 VHIAGFGYPDAyNKKQTIHYYEQITLKSMAGS-GHNVSQEAVAIKRM 321
Cdd:cd23967   160 VDIAGFGYDPS-DPNAPLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 117-321 3.30e-80

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 242.73  E-value: 3.30e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDP-SHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPR-KIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKeKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2008348519 276 VHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEAVAIKRM 321
Cdd:cd23984   161 VHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 6.85e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.23  E-value: 6.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  82 SAYELPFgtKGSEDLLLRVLAITSysipesIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 162 KTTIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 233 NPFFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 2008348519 312 SQEAVAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 117-321 1.81e-65

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 205.36  E-value: 1.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPK--IENNPDTLLVLVAFKA 194
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKseQEYDPTSLFVAVLFKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 195 MDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPR---KIKQKPTTGLLAITL 268
Cdd:cd23983    79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRlwgWDKNVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2008348519 269 ALHLCDLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEAVAIKRM 321
Cdd:cd23983   159 ATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 117-321 5.40e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 186.28  E-value: 5.40e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKiENNPDTLLVLVAFKAMD 196
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPE-QYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALHLCD 274
Cdd:cd23981    81 FKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNCD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2008348519 275 LVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEAVAIKRM 321
Cdd:cd23981   161 EVAVAGFGY-DMNTPNAPLHYYETIKMSAIKESwTHNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 117-328 1.59e-45

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 156.29  E-value: 1.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESA-HFDpkiennPDTLLVLVAFKAM 195
Cdd:cd23966    77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAvDLD------PGVHLVLVPFKVL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 196 DFHWIETILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23966   151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 276 VHIAGFGypdAYNKKQTIHYYEQitlksMAGSG-------HNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23966   222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 67-328 3.87e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 145.09  E-value: 3.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  67 PIFLQLKDYF--WVKTPSAYELPFGTKG-SEDLLLRVLAITSYSIPESIQSLE-----CRRCVVVGNGHRLKNSSLGGVI 138
Cdd:cd23964    24 KVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVERLLRNLNLTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 139 NKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAH----FDPKIENnpDTLLVLVAFKAMDFHWIETILSDKKRVR--- 211
Cdd:cd23964   104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHnsllKHVPQDK--DTKYLFIPFKIRDYDYLDAVLSGKPVPDgcd 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 212 KGFWKQPPLIWDVNPKQIRILNPFFME-IAADKLLSLPIqqprkikQKPTTGLLAITLALHLCDLVHIAGFGypdaYNKK 290
Cdd:cd23964   182 KGKRPPPLFGPKLNATNVRLLHPDFIRyLFNRWLNSSTS-------YRPTTGALMLLTALHTCDQVSVYGFG----YDPR 250

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2008348519 291 QTIHYYE-QITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23964   251 FSLHYYDkTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 120-321 1.68e-38

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 135.18  E-value: 1.68e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 120 CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHF--------DPKIENNPDTLLVLVA 191
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrgprcgCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 192 FKAMDFHWIetilsdkKRVRKGFWKQPPLiwdVNPKQIRILNpFFMEIaADKLLSLPIQQPRkikqKPTTGLLAITLALH 271
Cdd:cd19952    81 AAAADFKRL-------KRRKKRHDNAVLL---LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQ 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2008348519 272 LCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSgHNVSQEAVAIKRM 321
Cdd:cd19952   145 LCDSVDLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 114-297 9.27e-31

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 117.29  E-value: 9.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 114 SLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpkiENNPDTLLVLVAFK 193
Cdd:cd23980    78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 194 AMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHLC 273
Cdd:cd23980   153 TLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-------QGHGRYPSTGILSVIFSLHVC 223

                         170       180
                  ....*....|....*....|....
gi 2008348519 274 DLVHIAGFGypdAYNKKQTIHYYE 297
Cdd:cd23980   224 DEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 115-298 2.05e-30

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 116.51  E-value: 2.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkiennPDTLLVLVAFKA 194
Cdd:cd23979    78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKT 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 195 MDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLlslpiqqPRKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23979   153 LDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDRW-------TEHHGRYPSTGMLVLFFALHVCD 223

                         170       180
                  ....*....|....*....|....
gi 2008348519 275 LVHIAGFGypdAYNKKQTIHYYEQ 298
Cdd:cd23979   224 EVNVYGFG---ADSRGNWHHYWEN 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 118-328 4.84e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 104.65  E-value: 4.84e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKT---TI------RLFYPESAHFDPK-----IENNP 183
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnltTLnpsilkRRYNSLKKNRDRDkflnrLKEYN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 184 DTLLVLVAFkamdfhwietilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLlslpiqQPRKIKQKPTTGL 263
Cdd:cd23963   144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2008348519 264 LAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAGSgHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23963   206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-321 9.97e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.81  E-value: 9.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL-----FYPESAHFDPKIENNPDTLLV---- 188
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLVwdps 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 189 ------LVAFKAMDFHWIET-----ILSDKKRVrkgFWKQPPLIWDVnpkqIRILNPFFmeiaadkllslpiqqPRKIKQ 257
Cdd:cd23968   126 synvnlEKWYKKPDFDFFPNyikyrRRHPEEPF---YLIDPRFLWRL----WDILQEYT---------------PEKIKP 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2008348519 258 K-PTTGLLAITLALHLCDLVHIAGFGYPDAYNKKqtIHYYEQITLKSMA-GSGHNVSQEAVAIKRM 321
Cdd:cd23968   184 NpPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR--CHYYDVEKDLACTlGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 114-295 1.16e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 98.67  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 114 SLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTirlFYPESAH-------------FDpKIE 180
Cdd:cd23973    80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHsitsslmilqkrgFK-NIP 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 181 NNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFFMEIAADKLL-SLPIQQPRKIK 256
Cdd:cd23973   156 QDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLrSKTLKGKYWAI 235

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2008348519 257 QKPTTGLLAITLALHLCDLVHIAGF------GYPDAY---NKKQTIHY 295
Cdd:cd23973   236 YRPTTGAFLLLTALHLCDTVSAYGFitedyrKYPDHYydkKKTKLVFY 283
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 71-297 1.49e-21

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 92.08  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  71 QLKDYFWVKTPSAYELPFGTKGSEDLLlrvlaiTSYSIPESIQSLecRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNA 150
Cdd:cd23985     7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPL--GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 151 PVAGYEGDVGSKTTIRLFYP-----ESAHFDPKIENNPDTLLVL--VAFKAMDFHWIET----ILSDKKRVRKgfwkqpp 219
Cdd:cd23985    79 PTAGFQQDVGTKTTIRLINSqlvttEKHKFLKDSLYNEGILIVWdpAPYHSDIPEWYKNpdynFFENYKTYRR------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 220 liwdVNPKQ-IRILNPFF--------MEIAADKllslpIQqprkiKQKPTTGLLAITLALHLCDLVHIAGFgYPdayNKK 290
Cdd:cd23985   152 ----LNPNQpFYILHPQMqwelwdiiQENSPEE-----IQ-----PNPPSSGMLGIILMMTLCDQVDVYEF-LP---SKR 213


                  ....*....
gi 2008348519 291 QT--IHYYE 297
Cdd:cd23985   214 KTdvCHYYQ 222
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 117-302 4.42e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 87.30  E-value: 4.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFypesAHFD-PKIENNPDTLLVLVAFKAM 195
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 196 DFHWietiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfFMEIAADKLLSLPIQQPRKI-KQKPTTGLLAITLAL 270
Cdd:cd23965    77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSRIKsGTWLSTGWFTMLLAL 150

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2008348519 271 HLCDLVHIAGFGYPDaY-----NKKQTIHYYEQITLK 302
Cdd:cd23965   151 DVCDEIKVYGMVPEN-YcrehpNSKVPYHYYEPGGLK 186
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 116-328 1.30e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 84.80  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 116 ECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFY-------------------PESAH-- 174
Cdd:cd23974    83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgfngpPQSKEtr 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 175 --FDPkiENNPDTLLVLVAfkamdfhwIETILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFFMEIAADKLLSLPIQ 250
Cdd:cd23974   163 yiFLP--DHDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPIL 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 251 QP--RKIkQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTiHYYEQITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23974   230 NTkqRDI-YRPSTGAVMLLAALHTCDQVSAYGFMTPD-YGKYSD-HYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-321 1.37e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 84.12  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  63 SREQpIFLQLKDYFWVKTPSAYELPFGTKGSEDLLLRvlaitsysIPES-IQSLECRRCVVVGNGHRLKNSSLGGVINKY 141
Cdd:cd23986     3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSkLHLRGFRSCAVVTSAGAILNSSLGKEIDSH 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 142 DVVIRLNNAPVAGYEGDVGSKTTIRLFYPE-----SAHFdpkIENNPDTLLVLVAFK----AMDFH-WIE----TILSDK 207
Cdd:cd23986    74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHF---IDSSLYKDVILVAWDpapySANLHkWYKkpdyNLFTPY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 208 KRVRKGFWKQPPLIwdVNPKQIRILNPFFMEIAADKLlslpiqQPrkikQKPTTGLLAITLALHLCDLVHIagFGYPDAY 287
Cdd:cd23986   151 VQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QP----NPPSSGFIGILIMMSMCREVHV--YEYIPSV 216

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2008348519 288 NKKQTIHYYEQ-----ITLksmaGSGHNVSQEAVAIKRM 321
Cdd:cd23986   217 RQTDLCHYHERyydaaCTL----GAYHPLLYEKLLIQRM 251
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 118-331 4.52e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 82.46  E-value: 4.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIrlfypesahfdpkIENNPDtlLVLVAFKAMDF 197
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-------------TTMNPS--VIPHAYGDLVN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 198 -HWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNpffmEIAADKLLSLPIQQP-----RKIK----------QKPTT 261
Cdd:cd23969   130 aTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN----EIILKHKLNVKTAYPplrlnHAIRgywlttkfriKRPST 205

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2008348519 262 GLLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAgSGHNVSQEAVAIKRMLEMGAVKNLT 331
Cdd:cd23969   206 GLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 108-328 3.38e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 77.43  E-value: 3.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 108 IPES--IQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDT 185
Cdd:cd23970    57 LPEVspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILE---KYYNNLLT 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 186 LLVLVAFkamdfhwietiLSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPI---------------- 249
Cdd:cd23970   134 IQDRNNF-----------FLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWpgnimqhvnrywktkh 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 250 QQPRKIkqkpTTGLLAITLALHLCDLVHIAGFgYPDAYNKKQT---IHYYEQITLKSMAG--SGHNVSQEAVAIKRMLEM 324
Cdd:cd23970   203 LSPKRL----STGILMYTLASAICEEIHLYGF-WPFGFDPTGTplpYHYYDKKGTKFTTKwqESHQLPAEFVLLYKMHGA 277


                  ....
gi 2008348519 325 GAVK 328
Cdd:cd23970   278 GVLK 281
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 99-328 4.32e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 76.92  E-value: 4.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  99 RVLAITS--YSIPESIQSLECRR---CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP--- 170
Cdd:cd23988    41 RTLNISQnlHSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPsvv 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 171 -----------ESAHFDPKIENNPDTLLVLVAF--KAMDFH--WI-ETILSDKKRVRKGFwkqPPLiwdvnpKQIRILNP 234
Cdd:cd23988   121 qrafggfrnesDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRG 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 235 FFMeiaADKllsLPIqqprkikQKPTTGLLAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:cd23988   192 YWL---TNK---VNI-------KRPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHRM 258

                         250
                  ....*....|....*..
gi 2008348519 312 SQEAVAIKRMLEMGAVK 328
Cdd:cd23988   259 PLEFKTLNVLHNRGALK 275
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 82-328 2.13e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 75.63  E-value: 2.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519  82 SAYELPFGTKG--SEDL--LLRVLAITSYS--IPESIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGY 155
Cdd:cd23972    41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 156 EGDVGSKTTirlFYpesaHFDPKIENNPdtllvLVAFKAMDFH-----------WIETILSDKKRVRKGFWKQP-PLIWD 223
Cdd:cd23972   121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 224 ------------VNPKQIRILNPFFMEIAADKLL-SLPIQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKK 290
Cdd:cd23972   189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLkSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITSN-YWKF 267

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2008348519 291 QTiHYYEQITLKSMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23972   268 SD-HYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-328 1.29e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 72.68  E-value: 1.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 119 RCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAgYEGDVGSKTT--------IRLFYPE----SAHFDPKIENNPDTL 186
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNlvtanpsiLREKFHNlkkrRRPFVERMKVYGNAL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 187 LVLVAFKamdFHwIETILSDK-KRVRKGFWKQPPLIWdVNPKQIRILNPFFmeiaadklLSLPIQQPRkikqkPTTGLLA 265
Cdd:cd23971   145 LLLPAFS---YT-SNTEPSLRaLYTLEDFGSPQKVLF-FNPEYLRNLSRYW--------KSKGLKARR-----LSTGLML 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2008348519 266 ITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQItlksMAGSG-HNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23971   207 VSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNV----LPKKGvHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 117-297 1.41e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.11  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVLVAFKAMD 196
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FhW--IETILSDKKRVRKGFWKQPPLI------WDVNPKQIRILNPFF-MEIAADKllslpiqqpRKIKQKPTTGLLAIT 267
Cdd:cd23978    78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR---------KKSHSWLSTGWFTMV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2008348519 268 LALHLCDLVHIAGFGYPDAYNKKQTI-----HYYE 297
Cdd:cd23978   148 IAVELCDNVHVYGMVPPNYCSKRPTPkkmpyHYYE 182
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 120-328 1.92e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 69.58  E-value: 1.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 120 CVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP---ESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23987    67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvQRAFEDLVNETWKEKFLQRLQSLNGS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPK----QIRILNPFFMEIAADKLLslpiqqprkIKqKPTTGLLAITLALHL 272
Cdd:cd23987   147 ILWIPAFMAKGGEERVEWVNDLILKHHINVRtaypSLRLLHAVRGYWLTNKVH---------IK-RPTTGLLMYTLATRF 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 273 CDLVHIAGFgYP---DAYNKKQTIHYYEQITLK-SMAGSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23987   217 CNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-328 4.08e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 65.55  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEG-DVGSKTT--------IRLFYPE----SAHFDPKIENNPD 184
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNlvtanpsiISIKYAKlnerRKPFLETVSVYGD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 185 TLLVLVAFK-----AMDFHWIETILSDKKRVRKGFWkqppliwdvNPKQIRILNPFFmeiaadklLSLPIQQPRKikqkp 259
Cdd:cd23991   145 AFLLLPAFSyrsntALSFKVYYTLEDFKAKQKVIFF---------HPIYLKHLAQFW--------RSKGVQVYRL----- 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2008348519 260 TTGLLAITLALHLCDLVHIAGFgYPDAYN---KKQTIHYYEQITLKSmagSGHNVSQEAVAIKRMLEMGAVK 328
Cdd:cd23991   203 STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 117-167 8.02e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.03  E-value: 8.02e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL 167
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-297 5.41e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 58.73  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVlVAFKA 194
Cdd:cd23976    13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 195 MDFHWIETilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFFMeIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALH 271
Cdd:cd23976    89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 2008348519 272 LCDLVHIAGFGYP----DAYNKKQTIHYYE 297
Cdd:cd23976   166 LCDRINVYGMVPPdfcrDPNHPSVPYHYYE 195
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 115-299 1.55e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.92  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 115 LECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVA-GYEGDVGSKTTIRLFYPESahfdpkIENNPDTLL-----V 188
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANPSI------IDKRFQNLLwsrksF 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 189 LVAFKAMDFHWIET-ILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFFMEiaadkllslPIQQPRKIK----QKPTTG 262
Cdd:cd23989   135 VESMKVYGRSYIYMpAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLR---------NVGKFWKSKgvhaKRLSTG 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2008348519 263 LLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQI 299
Cdd:cd23989   205 LFLVSAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNV 243
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 118-299 1.15e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 55.23  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 118 RRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAG-YEGDVGSKTTIRLFYP----ESAH--------FDPKIENNPD 184
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2008348519 185 TLLVLVAFkamdFHWIETILSDK-KRVRKGFwkqppliwdVNPKQIRILNPFFMEIAADKLLSLPIQQPRkikqkPTTGL 263
Cdd:cd23990   145 ASVVLPAF----YNTRNTDVSIRvKYVLDDF---------ESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----ISSGL 206

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2008348519 264 LAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQI 299
Cdd:cd23990   207 MLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYDNV 244
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 117-184 1.27e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.47  E-value: 1.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2008348519 117 CRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPKIENNPD 184
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH