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Conserved domains on  [gi|2041085744|ref|NP_001381923|]
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nucleoporin SEH1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 7.24e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 7.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRVYEAPDvmNLSQWSLQHEIScklCCSCISW 170
Cdd:COG2319   194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 171 NPSSSRahppmIAVGSDDSSpnsmakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319   255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319   316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 7.24e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 7.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRVYEAPDvmNLSQWSLQHEIScklCCSCISW 170
Cdd:COG2319   194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 171 NPSSSRahppmIAVGSDDSSpnsmakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319   255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319   316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-306 3.93e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 3.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRVYeapdvmNLSQWSLQHEISC-KLCCSCIS 169
Cdd:cd00200   125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 170 WNPSSSRahppmIAVGSDDSSpnsmakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRI 247
Cdd:cd00200   185 FSPDGEK-----LLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSPDG----YLLASGSEDgtIRV 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2041085744 248 FTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:cd00200   246 WDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-306 6.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2041085744  271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-305 2.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2041085744 271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 7.24e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 7.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRVYEAPDvmNLSQWSLQHEIScklCCSCISW 170
Cdd:COG2319   194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 171 NPSSSRahppmIAVGSDDSSpnsmakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319   255 SPDGRL-----LASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLW 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319   316 DLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 COG2319
WD40 repeat [General function prediction only];
11-308 1.90e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEeiv 90
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWD--- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 gesndkLRGQSHwvkRTTLVDSRTSVTDVKFAPKhmGLMLATCSADGIVRVYEAPDvmNLSQWSLQHEISCklcCSCISW 170
Cdd:COG2319   233 ------LATGKL---LRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLAT--GELLRTLTGHSGG---VNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 171 NPSSSRahppmIAVGSDDSSpnsmakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIF 248
Cdd:COG2319   297 SPDGKL-----LASGSDDGT------VRLW----DLATGKLLRTLTGHTGAVRSVAFSPD-GK---TLASGSDDgtVRLW 357

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 249 TLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
Cdd:COG2319   358 DLATGE---------------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-306 3.93e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 3.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRVYeapdvmNLSQWSLQHEISC-KLCCSCIS 169
Cdd:cd00200   125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 170 WNPSSSRahppmIAVGSDDSSpnsmakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRI 247
Cdd:cd00200   185 FSPDGEK-----LLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSPDG----YLLASGSEDgtIRV 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2041085744 248 FTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:cd00200   246 WDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-327 4.68e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 4.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESgdwHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRVYEAPDVMnlsqwsLQHEISCKLC-CSCIS 169
Cdd:cd00200    83 GECVRTLTGHTSY------------VSSVAFSPD--GRILSSSSRDKTIKVWDVETGK------CLTTLRGHTDwVNSVA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 170 WNPSSSrahppMIAVGSDDSSpnsmakvqIFEYNENTRKYAKaeTLMTVTDPVHDIAFAPNLGRsfHILAIATKDVRIFT 249
Cdd:cd00200   143 FSPDGT-----FVASSSQDGT--------IKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEK--LLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2041085744 250 LKpvrkeltssggptkfEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVN 327
Cdd:cd00200   206 LS---------------TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD---LRTGECVQTLSGHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
9-146 1.07e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744   9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEE 88
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVRSVAF-SPD-GKTLASGSDDGTVRLWDL 359

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2041085744  89 IVGESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRVYEAPD 146
Cdd:COG2319   360 ATGELLRTLTGHTGA------------VTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-190 2.33e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSEsgdWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEei 89
Cdd:cd00200   133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT---GKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWD-- 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744  90 vgesndkLRGQsHWVKrtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIVRVYeapDVMNLSQW-SLQ-HEIScklcCSC 167
Cdd:cd00200   206 -------LSTG-KCLG--TLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVW---DLRTGECVqTLSgHTNS----VTS 266

                         170       180
                  ....*....|....*....|...
gi 2041085744 168 ISWNPSSSRahppmIAVGSDDSS 190
Cdd:cd00200   267 LAWSPDGKR-----LASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
214-328 8.62e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 8.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 214 TLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLKpvrkeltsSGGPtkfeihiVAQFDNHNSQVWRVSWNITGT 291
Cdd:COG2319   115 TLTGHTGAVRSVAFSPD-GK---TLASGSADgtVRLWDLA--------TGKL-------LRTLTGHSGAVTSVAFSPDGK 175

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2041085744 292 VLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319   176 LLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRS 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-306 6.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2041085744  271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-40 2.08e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2041085744   11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-305 2.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2041085744 271 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
11-40 5.59e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.59e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2041085744  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
210-328 6.01e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2041085744 210 AKAETLMTVTDPVHDIAFAPNLGRSfhILAIATKDVRIFTLkpvrkeltsSGGptkfeiHIVAQFDNHNSQVWRVSWNIT 289
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLL--ASASADGTVRLWDL---------ATG------LLLRTLTGHTGAVRSVAFSPD 131

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2041085744 290 GTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 328
Cdd:COG2319   132 GKTLASGSADGTVRLWDL---ATGKLLRTLTGHSGAVTS 167
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-87 2.61e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2041085744   46 DWHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWE 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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