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Conserved domains on  [gi|2053457492|ref|NP_001382160|]
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notch homolog 2 N-terminal-like protein A isoform 3 [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10041892)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Homo sapiens Notch homolog 2 N-terminal-like proteins and protein delta homologs

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-192 5.88e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2053457492 156 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 120-154 7.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.76  E-value: 7.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2053457492 120 DACLS-HPCANGSTCTTVANQFSCKCLTGFTGQKCE 154
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 83-117 9.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.38  E-value: 9.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2053457492  83 CFVSRPCLNGGTCHMLsRDTYECTCQVGFTGKECQ 117
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-192 5.88e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2053457492 156 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-193 4.64e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 4.64e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2053457492  156 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFT-GQYCD 193
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
156-186 9.06e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.06e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2053457492 156 DVNECDIPGH-CQHGGTCLNLPGSYQCQCLQG 186
Cdd:pfam07645   1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 120-154 7.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.76  E-value: 7.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2053457492 120 DACLS-HPCANGSTCTTVANQFSCKCLTGFTGQKCE 154
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 83-117 9.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.38  E-value: 9.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2053457492  83 CFVSRPCLNGGTCHMLsRDTYECTCQVGFTGKECQ 117
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-192 5.88e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2053457492 156 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-193 4.64e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 4.64e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2053457492  156 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFT-GQYCD 193
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 159-190 8.16e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 8.16e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2053457492 159 ECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 190
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA pfam07645
Calcium-binding EGF domain;
156-186 9.06e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.06e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2053457492 156 DVNECDIPGH-CQHGGTCLNLPGSYQCQCLQG 186
Cdd:pfam07645   1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 166-191 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 2053457492 166 CQHGGTCLNLPGSYQCQCLQGFTGQY 191
Cdd:pfam00008   6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 120-154 7.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.76  E-value: 7.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2053457492 120 DACLS-HPCANGSTCTTVANQFSCKCLTGFTGQKCE 154
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 83-117 9.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 33.38  E-value: 9.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2053457492  83 CFVSRPCLNGGTCHMLsRDTYECTCQVGFTGKECQ 117
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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