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Conserved domains on  [gi|2086547926|ref|NP_001382830|]
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DNA polymerase kappa isoform 8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-436 2.18e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 422.32  E-value: 2.18e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 181 VKEILADYDPNFMAMSLDEAYLNITKHLEERQNwPED-----KRRYFIKMG--SSVenGIAPNTMLAKVCSDKNKPNGQY 253
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETGltASA--GIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 254 QILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGER 333
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 334 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELL 412
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|....
gi 2086547926 413 KTEIDadfphPLRLRLMGVRISSF 436
Cdd:cd03586   316 EELLD-----GRPIRLLGVRLSGL 334
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 541-567 8.83e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.83e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  541 ILTCPVCFRAQgciSLEALNKHVDECL 567
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 696-722 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  696 ALVCPVCNVEQKtsdLTLFNVHVDVCL 722
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-436 2.18e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 422.32  E-value: 2.18e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 181 VKEILADYDPNFMAMSLDEAYLNITKHLEERQNwPED-----KRRYFIKMG--SSVenGIAPNTMLAKVCSDKNKPNGQY 253
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETGltASA--GIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 254 QILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGER 333
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 334 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELL 412
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|....
gi 2086547926 413 KTEIDadfphPLRLRLMGVRISSF 436
Cdd:cd03586   316 EELLD-----GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-442 3.52e-96

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 302.81  E-value: 3.52e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 184 ILADYDPNFMAMSLDEAYLNITkhlEERQNWP-------EDKRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQYQIL 256
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT---DNKLCIGsatliaqEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVIT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 257 PNRqaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDG 331
Cdd:PRK02406  158 PEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIA 408
Cdd:PRK02406  231 ERKSVGVERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLA 309

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2086547926 409 KELLKTEidadfpHPLRLRLMGVRISSFPNEEDR 442
Cdd:PRK02406  310 QALLRRL------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-434 2.58e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 300.52  E-value: 2.58e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 179 KEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPE---DKRRYFIKMG---SSVenGIAPNTMLAKVCSDKNKPNGQ 252
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAiarRIRRRIRRETgltVSV--GIAPNKFLAKIASDLAKPDGL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 253 YQILPNRQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDG 331
Cdd:COG0389   160 TVIPPGEVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE 410
Cdd:COG0389   237 PRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARE 316

                         330       340
                  ....*....|....*....|....
gi 2086547926 411 LLkteiDADFPHPLRLRLMGVRIS 434
Cdd:COG0389   317 LL----ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-245 5.95e-47

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 163.90  E-value: 5.95e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2086547926 183 EILADY-DPNFMAMSLDEAYLNITkHLEERQNWPED-----KRRYFIKMGSSVENGIAPNTMLAKVCSD 245
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEAlakrlRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 541-567 8.83e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.83e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  541 ILTCPVCFRAQgciSLEALNKHVDECL 567
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 696-722 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  696 ALVCPVCNVEQKtsdLTLFNVHVDVCL 722
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-436 2.18e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 422.32  E-value: 2.18e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 181 VKEILADYDPNFMAMSLDEAYLNITKHLEERQNwPED-----KRRYFIKMG--SSVenGIAPNTMLAKVCSDKNKPNGQY 253
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETGltASA--GIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 254 QILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGER 333
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 334 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELL 412
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|....
gi 2086547926 413 KTEIDadfphPLRLRLMGVRISSF 436
Cdd:cd03586   316 EELLD-----GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-442 3.52e-96

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 302.81  E-value: 3.52e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 184 ILADYDPNFMAMSLDEAYLNITkhlEERQNWP-------EDKRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQYQIL 256
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT---DNKLCIGsatliaqEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVIT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 257 PNRqaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDG 331
Cdd:PRK02406  158 PEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIA 408
Cdd:PRK02406  231 ERKSVGVERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLA 309

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2086547926 409 KELLKTEidadfpHPLRLRLMGVRISSFPNEEDR 442
Cdd:PRK02406  310 QALLRRL------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-434 2.58e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 300.52  E-value: 2.58e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 179 KEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPE---DKRRYFIKMG---SSVenGIAPNTMLAKVCSDKNKPNGQ 252
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAiarRIRRRIRRETgltVSV--GIAPNKFLAKIASDLAKPDGL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 253 YQILPNRQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDG 331
Cdd:COG0389   160 TVIPPGEVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE 410
Cdd:COG0389   237 PRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARE 316

                         330       340
                  ....*....|....*....|....
gi 2086547926 411 LLkteiDADFPHPLRLRLMGVRIS 434
Cdd:COG0389   317 LL----ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 17-458 1.05e-85

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 283.06  E-value: 1.05e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926  17 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDR 88
Cdd:PTZ00205   42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926  89 FAMELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 168
Cdd:PTZ00205  122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 169 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLE--ERQNWPED-----KRRYFIKMGSSVENGIAPNTMLAK 241
Cdd:PTZ00205  201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIErfEGTKTAEDvaselRVRVFGETKLTASAGIGPTAALAK 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 242 VCSDKNKPNGQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISL 320
Cdd:PTZ00205  281 IASNINKPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASI 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 321 GL------------GSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVK 388
Cdd:PTZ00205  361 GImqwpdaataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQ 440

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086547926 389 TRASTVSSVVSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQ 458
Cdd:PTZ00205  441 QYTKSLIQYSDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 101-449 7.83e-72

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 238.85  E-value: 7.83e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 101 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 177
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 178 SKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwPED-----KRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQ 252
Cdd:PRK14133   83 SKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE----PIKiakyiKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 253 YQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTHLTRDG 331
Cdd:PRK14133  159 KII--TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSR 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFS-EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE 410
Cdd:PRK14133  236 ERKSIGKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACE 315

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2086547926 411 LLKtEIDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 449
Cdd:PRK14133  316 ILE-HINIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 102-436 1.11e-67

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 229.82  E-value: 1.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 180 EVKEILADYDPNFMAMSLDEAYLNI--TKHLEERqnwPEDK------RRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNG 251
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLDLsgTERLHGA---PPAVvlarfaRRVEREIGITVSVGLSYNKFLAKIASDLDKPRG 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 252 qYQILPNRQAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTHLTR 329
Cdd:PRK02794  194 -FSVIGRAEAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 330 DGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIA 408
Cdd:PRK02794  270 DREAKSVSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTA 349

                         330       340
                  ....*....|....*....|....*...
gi 2086547926 409 KELLKTEIDadfphPLRLRLMGVRISSF 436
Cdd:PRK02794  350 RELLEKETD-----GTAFRLIGIGVSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 102-436 7.45e-54

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 193.23  E-value: 7.45e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 177
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 178 SKEVKEILADYDPNFMAMSLDEAYLNITKHL----EERQNWPEDKRRYfIK----MGSSVenGIAPNTMLAKVCSDKNKP 249
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAFVEPAELAgasaEEVEAFAERLRAR-VReetgLPASV--GAGSGKQIAKIASGLAKP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 250 NGQYQILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqRALlsllfSETSWHYFLHISLGLGSTHLTR 329
Cdd:PRK03348  163 DGIRVVPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDL---AAL-----SEAEVANLLGATVGPALHRLAR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 330 ---------DGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVS 399
Cdd:PRK03348  233 giddrpvaeRAEAKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATD 312

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2086547926 400 TAEEIFAIAKELLkteIDADFPHPlrLRLMGVRISSF 436
Cdd:PRK03348  313 DAAVLAATARRLL---LDPDEIGP--IRLVGVGFSGL 344
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 104-434 1.19e-53

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 189.11  E-value: 1.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTS----NYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCviacSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 180 EVKEILADYDPNFMAMSLDEAYLNITK---HLEERQNWPED-KRRYFIKMGS-SVENGIAPNTMLAKVCSDKNKPNGQYQ 254
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTGsarLLGLGSEVALRiKRHIAEQLGGiTASIGIASNKLLAKLAAKYAKPDGLTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 255 ILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislGLGSTHLTRD 330
Cdd:cd00424   161 LDP--EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 331 GERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVN------FEVKTRASTVSSVVSTaEE 403
Cdd:cd00424   236 RPRKSFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GE 314

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2086547926 404 IFAIAKELLKTEIDAdfPHPLRLRLMGVRIS 434
Cdd:cd00424   315 LLHALDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK01810 PRK01810
DNA polymerase IV; Validated
 100-431 1.55e-52

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 188.31  E-value: 1.55e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 100 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY 174
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 175 RAVSKEVKEILADYDPNFMAMSLDEAYLNIT---------KHLEERQnwpedkRRYFIKMGSSVENGIAPNTMLAKVCSD 245
Cdd:PRK01810   84 REASRQMFQILSEFTPLVQPVSIDEGYLDITdcyalgsplEIAKMIQ------QRLLTELQLPCSIGIAPNKFLAKMASD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 246 KNKPNGqYQILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETswhyflhislGL-- 322
Cdd:PRK01810  158 MKKPLG-ITVLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGIN----------GVrl 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 323 -----GSTHLTRDGER----KSMSVERTFSEiNKAEEQ--YSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRA 391
Cdd:PRK01810  226 qrranGIDDRPVDPEAiyqfKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRS 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2086547926 392 STVSSVVSTAEEIFAIAKELLKTEIDADfphplRLRLMGV 431
Cdd:PRK01810  305 KTLKNPIWEKRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PRK03858 PRK03858
DNA polymerase IV; Validated
 102-446 3.06e-52

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 187.12  E-value: 3.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 181
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 182 KEILADYDPNFMAMSLDEAYLNIT--KHLEERqnwPED-----KRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQYQ 254
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFLDVGglRRISGT---PVQiaarlRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 255 ILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGSTHLTRDG 331
Cdd:PRK03858  161 VPPDRE--LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPRRVETGR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 332 ERKSMSVERTFSEINKAEEQY--SLCQeLCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAK 409
Cdd:PRK03858  237 RRRSVGAQRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAAR 315

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2086547926 410 ELLkteiDADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 446
Cdd:PRK03858  316 DLV----AAAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 81-434 3.03e-51

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 184.44  E-value: 3.03e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926  81 KAQLQvDRFAMELEQSRN----------LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLSTSNYHARRF 146
Cdd:cd01701    18 KARLK-DFFRELSNGSKEadpsnsihpdLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 147 GVRAAMpgFI--AKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPED-----KR 219
Cdd:cd01701    97 GIKNGM--WVgqAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYELPEElaeaiRN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 220 RYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 299
Cdd:cd01701   175 EIRETTGCSASVGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 300 ----RALLSLLFSETSWHyFLHISLGLGSTHLTRDGERKSMSVertfsEIN------KAEEQYSLCQELCSELAQDLQKE 369
Cdd:cd01701   253 sktkEKLQKVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSA-----EINygirftNVDDVEQFLQRLSEELSKRLEES 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 370 RLKGRTVTIKLKN------------------VNFevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphPLRLRLMGV 431
Cdd:cd01701   327 NVTGRQITLKLMKrapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---PEELRGVGI 399


                  ...
gi 2086547926 432 RIS 434
Cdd:cd01701   400 QVT 402
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-245 5.95e-47

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 163.90  E-value: 5.95e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2086547926 183 EILADY-DPNFMAMSLDEAYLNITkHLEERQNWPED-----KRRYFIKMGSSVENGIAPNTMLAKVCSD 245
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEAlakrlRREIAEETGLTCSIGIAPNKLLAKLASD 148
PRK03352 PRK03352
DNA polymerase IV; Validated
 103-440 3.70e-37

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 142.85  E-value: 3.70e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwPEDKRRYFIK----------MGSSVenGIAPNTMLAKVCSD 245
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD---------TDDPEALAEEiraavlertgLSCSV--GIGDNKLRAKIATG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 246 KNKPNGQYQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGLGS 324
Cdd:PRK03352  156 FAKPAGVFRL--TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 325 THLTRDG-ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKE-RLKGRtVTIKLKNVNFEVKTRASTVSSVVSTA 401
Cdd:PRK03352  234 TEVSAEPwVPRSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEgRPVTR-VAVKVRTATFYTRTKIRKLPEPTTDP 312

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2086547926 402 EEIFAIAKELLKtEIDADFPhplrLRLMGVRISSFPNEE 440
Cdd:PRK03352  313 DVIEAAALDVLD-RFELDRP----VRLLGVRLELAMPDE 346
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 104-438 6.12e-37

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 142.45  E-value: 6.12e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 169
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 170 ---------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEER-QNWPEDKRRYfikmgsSVENGIAPNTML 239
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRIVEEiRQQVYDELGY------TCSAGIAHNKML 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 240 AKVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL---FSET--SWH 313
Cdd:cd01702   155 AKLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 314 YflHISLGLGSTHLTRDGERKSMSVERTFS-EINKAEEQ-YSLCQELCSELAQDLQKER----LKGRTVTIKLKNVNFEV 387
Cdd:cd01702   233 Y--NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDvQHWLLVLASELNSRLEDDRyennRRPKTLVLSLRQRGDGV 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2086547926 388 KTRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 438
Cdd:cd01702   311 RRSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK01216 PRK01216
DNA polymerase IV; Validated
 103-290 9.14e-36

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 138.77  E-value: 9.14e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQN----WPEDKRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNG 251
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDaynlGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2086547926 252 QYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 290
Cdd:PRK01216  163 IKVIDD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 103-449 6.06e-35

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 137.83  E-value: 6.06e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 176
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 177 VSKEVKEILADYDPNFMAMSLDEAYLNIT--KHL-----EERQNWPEDKRRYFikmGSSVENGIAPNTMLAKVCSD---K 246
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVTgsQKLfgsplEIAQKIQQRIMRET---GVYARVGIGPNKLLAKMACDnfaK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 247 NKPNGQYQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFLHISLGL 322
Cdd:PRK03103  161 KNPDGLFTL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 323 GSTHLTRDG--ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKT---RASTVSS 396
Cdd:PRK03103  235 DYSPVTPHSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPE 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 397 VVSTAEEIFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 449
Cdd:PRK03103  315 PTNLAMEVYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 104-431 7.05e-35

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 136.83  E-value: 7.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 182
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 183 EILADYDPNFMA--MSLDEAYLNITK-------HL--EERQnwpedkrRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNG 251
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVTEmrllvasHIayEMRE-------RIENELGLTCCAGIASNKLLAKLVGSVNKPNQ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 252 QYQILP-NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLG-----ST 325
Cdd:cd01703   154 QTTLLPpSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEfgegiGQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 326 HLT-----RDGER--------KSMSVERTF-----SEINKAEEQYS---------LCQELCSELAQDLQKERLKGRTV-- 376
Cdd:cd01703   233 RIWkllfgRDTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIEellasllerMKQDLQEVKAGDGRRPHTLRLTLrr 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547926 377 -TIKLKNVNFEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 431
Cdd:cd01703   313 yTSTKKHYNRESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 106-378 7.63e-28

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 115.34  E-value: 7.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 106 IDMDAFYAAVEMRDNPELKDKPIAVgsmsmLSTS-------NYHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRA 176
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 177 VSKEVKEILADYDPNFMAMSLDEAYLNIT--KHLEERQNWPED-KRRYFIKMGSSVENGIAPNTMLAKVCSD----KNKP 249
Cdd:cd01700    78 MSRRIMSILERFSPDVEVYSIDESFLDLTgsLRFGDLEELARKiRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 250 NGQYQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-IS-L 320
Cdd:cd01700   158 GGVVDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgIDcL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2086547926 321 GLGSTHltrdGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTI 378
Cdd:cd01700   233 PLEEYP----PPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 333-440 9.89e-22

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 90.70  E-value: 9.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 333 RKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 411
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 2086547926 412 LKteidaDFPHPLRLRLMGVRISSFPNEE 440
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 118-413 1.68e-09

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 60.09  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 118 RDNPELKDKPIAV----GSMSMLSTsNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFM 193
Cdd:cd03468    15 RNRPADDEAPLAVverkKAGRILAC-NAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 194 AMSLDEAYLNITKHLEERQNWP---EDKRRYFIKMGSSVENGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLP 270
Cdd:cd03468    94 LDGPDGLLLDVTGCLHLFGGEDalaASLRAALATLGLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 271 IRkVSGIGKVTEKMLKALGIIT---CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTHLTRDG----ERKSMSVERT 341
Cdd:cd03468   173 VA-ALRLPPETVELLARLGLRTlgdLAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQ 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086547926 342 FsEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 413
Cdd:cd03468   245 L-EEPIARGLLFPLRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
105-299 9.41e-09

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 58.24  E-value: 9.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 105 HIDMDAFYAAVEMRDNPELKDKPIAVGSMS--MLSTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSKE 180
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgCVIARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSNR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547926 181 VKEILADYDPNFMAMSLDEAYLNIT-----KHLEE--RQNWPEDKRRYFIKMGSsvenGIAPNTMLAKVCSDKNKP---- 249
Cdd:PRK03609   84 VMSTLEELSPRVEIYSIDEAFCDLTgvrncRDLTDfgREIRATVLQRTHLTVGV----GIAQTKTLAKLANHAAKKwqrq 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2086547926 250 NGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 299
Cdd:PRK03609  160 TGGVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 259-290 8.18e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 8.18e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2086547926 259 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 290
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 541-567 8.83e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.83e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  541 ILTCPVCFRAQgciSLEALNKHVDECL 567
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 696-722 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547926  696 ALVCPVCNVEQKtsdLTLFNVHVDVCL 722
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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