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Conserved domains on  [gi|2086547936|ref|NP_001382831|]
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DNA polymerase kappa isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 14-426 1.32e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.42  E-value: 1.32e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 90
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  91 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 170
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 171 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 250
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 251 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 330
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 331 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 409
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547936 410 fphPLRLRLMGVRISSF 426
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 531-557 9.34e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 9.34e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  531 ILTCPVCFRAQgciSLEALNKHVDECL 557
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 686-712 2.49e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  686 ALVCPVCNVEQKtsdLTLFNVHVDVCL 712
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 14-426 1.32e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.42  E-value: 1.32e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 90
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  91 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 170
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 171 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 250
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 251 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 330
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 331 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 409
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547936 410 fphPLRLRLMGVRISSF 426
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 18-432 8.41e-101

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 8.41e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  18 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 93
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  94 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 173
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 174 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 253
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 254 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 328
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 329 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 405
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 2086547936 406 idadfpHPLRLRLMGVRISSFPNEEDR 432
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 12-424 5.40e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 5.40e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  12 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 88
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  89 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 168
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 169 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 248
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 249 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 327
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 328 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 406
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 2086547936 407 DADFPHPLRLRLMGVRIS 424
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 16-235 3.54e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 3.54e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  16 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 92
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  93 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 171
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547936 172 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 235
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 531-557 9.34e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 9.34e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  531 ILTCPVCFRAQgciSLEALNKHVDECL 557
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 686-712 2.49e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  686 ALVCPVCNVEQKtsdLTLFNVHVDVCL 712
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 14-426 1.32e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.42  E-value: 1.32e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 90
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  91 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 170
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 171 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 250
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 251 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 330
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 331 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 409
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547936 410 fphPLRLRLMGVRISSF 426
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 18-432 8.41e-101

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 8.41e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  18 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 93
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  94 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 173
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 174 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 253
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 254 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 328
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 329 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 405
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 2086547936 406 idadfpHPLRLRLMGVRISSFPNEEDR 432
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 12-424 5.40e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 5.40e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  12 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 88
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  89 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 168
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 169 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 248
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 249 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 327
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 328 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 406
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 2086547936 407 DADFPHPLRLRLMGVRIS 424
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 2-448 4.94e-72

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 246.08  E-value: 4.94e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936   2 ELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNF 81
Cdd:PTZ00205  125 ELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDF 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  82 DKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwpedkrryfikmgssvendnpgkevnklsehersispl 161
Cdd:PTZ00205  204 DAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER----------------------------------------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 162 lFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfGT-SAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN 240
Cdd:PTZ00205  243 -FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPN 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 241 GQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGL------- 312
Cdd:PTZ00205  290 GQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGImqwpdaa 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 313 -----GSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSV 387
Cdd:PTZ00205  370 taantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSLIQY 449

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547936 388 VSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQ 448
Cdd:PTZ00205  450 SDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 11-439 5.61e-67

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 225.75  E-value: 5.61e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  11 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 87
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  88 SKEVKEILADYDPNFMAMSLDEAYLNITkHLEErqnwpedkrryfikmgssvendnpgkevnklsehersispllfeesp 167
Cdd:PRK14133   83 SKNIFKILYEVTPIVEPVSIDEAYLDIT-NIKE----------------------------------------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 168 sdvqppgdpfqvnfeeqnNPQilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIlp 247
Cdd:PRK14133  115 ------------------EPI-------------KIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKII-- 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 248 NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTHLTRDGERKSM 326
Cdd:PRK14133  162 TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERKSI 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 327 SVERTFS-EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKtE 405
Cdd:PRK14133  241 GKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILE-H 319

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2086547936 406 IDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 439
Cdd:PRK14133  320 INIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 12-426 2.21e-65

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 223.66  E-value: 2.21e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  12 TIVHIDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 89
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  90 EVKEILADYDPNFMAMSLDEAYLNitkhleerqnwpedkrryfikmgssvendnpgkevnkLSEHERsispllfeespsd 169
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLD-------------------------------------LSGTER------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 170 vqppgdpfqvnfeeqnnpqilqnsvVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILPNR 249
Cdd:PRK02794  147 -------------------------LHGAPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPRG-FSVIGRA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 250 QAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTHLTRDGERKSMS 327
Cdd:PRK02794  201 EAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSPDREAKSVS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 328 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEI 406
Cdd:PRK02794  278 AETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEKET 357

                         410       420
                  ....*....|....*....|
gi 2086547936 407 DadfphPLRLRLMGVRISSF 426
Cdd:PRK02794  358 D-----GTAFRLIGIGVSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 12-426 8.22e-53

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 190.15  E-value: 8.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  12 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 87
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  88 SKEVKEILADYDPNFMAMSLDEAYlnitkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeesp 167
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAF-------------------------------------------------------- 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 168 sdVQPPGdpfqvnfeeqnnpqilqnsvVFGTSAQEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQ 244
Cdd:PRK03348  110 --VEPAE--------------------LAGASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRV 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 245 ILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqRALlsllfSETSWHYFLHISLGLGSTHLTR----- 319
Cdd:PRK03348  168 VPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDL---AAL-----SEAEVANLLGATVGPALHRLARgiddr 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 320 ----DGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEI 394
Cdd:PRK03348  238 pvaeRAEAKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVL 317

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2086547936 395 FAIAKELLkteIDADFPHPlrLRLMGVRISSF 426
Cdd:PRK03348  318 AATARRLL---LDPDEIGP--IRLVGVGFSGL 344
PRK01810 PRK01810
DNA polymerase IV; Validated
 10-421 1.40e-49

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 179.84  E-value: 1.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  10 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY 84
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  85 RAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklseherSISPLlfe 164
Cdd:PRK01810   84 REASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-------------------------------------LGSPL--- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 165 espsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQ 244
Cdd:PRK01810  124 -------------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG-IT 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 245 ILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETswhyflhislGL-------GSTH 316
Cdd:PRK01810  166 VLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGIN----------GVrlqrranGIDD 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 317 LTRDGER----KSMSVERTFSEiNKAEEQ--YSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST 390
Cdd:PRK01810  235 RPVDPEAiyqfKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWE 313

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2086547936 391 AEEIFAIAKELLKTEIDADfphplRLRLMGV 421
Cdd:PRK01810  314 KRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 14-424 1.44e-49

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 177.94  E-value: 1.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTS----NYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 89
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCviacSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  90 EVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsd 169
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTG----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 170 vqppgdpfqvnfeeqnnpqilqnSVVFGTSAQEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSDKNKPNGQYQILPn 248
Cdd:cd00424   108 -----------------------SARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTILDP- 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 249 rQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislGLGSTHLTRDGERK 324
Cdd:cd00424   164 -EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPPRPRK 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 325 SMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVN------FEVKTRASTVSSVVSTaEEIFAI 397
Cdd:cd00424   240 SFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GELLHA 318

                         410       420
                  ....*....|....*....|....*..
gi 2086547936 398 AKELLKTEIDAdfPHPLRLRLMGVRIS 424
Cdd:cd00424   319 LDKLWRALLDD--KGPRRLRRLGVRLS 343
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 9-424 9.28e-48

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 174.42  E-value: 9.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936   9 LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLSTSNYHARRFGVRAAMpgFI--AKRLCPQLIIVPPNFD 82
Cdd:cd01701    45 LQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSYGIKNGM--WVgqAKKLCPQLVTLPYDFE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  83 KYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQnwpedkrryfikmgssvendnpgkevnklsehersispll 162
Cdd:cd01701   123 AYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETY---------------------------------------- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 163 feespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQ 242
Cdd:cd01701   163 -----------------------------------ELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDGQ 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 243 YQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ----RALLSLLFSETSWHyFLHISLGLGSTHLT 318
Cdd:cd01701   208 YHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkEKLQKVLGPKTGEK-LYDYCRGIDDRPVT 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 319 RDGERKSMSVertfsEIN------KAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKN------------------VN 374
Cdd:cd01701   285 GEKERKSVSA-----EINygirftNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLMKrapgapieppkymghgicDS 359

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2086547936 375 FevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphPLRLRLMGVRIS 424
Cdd:cd01701   360 F---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---PEELRGVGIQVT 402
PRK03858 PRK03858
DNA polymerase IV; Validated
 12-436 2.73e-47

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 172.86  E-value: 2.73e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  12 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 91
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  92 KEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRyfikmgssvendnpgkevnklsehersispllfeespsdvq 171
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFLDVG-----------GLRR----------------------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 172 ppgdpfqvnfeeqnnpqilqnsvVFGTSAQeVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQa 251
Cdd:PRK03858  112 -----------------------ISGTPVQ-IAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 252 vMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGSTHLTRDGERKSMSV 328
Cdd:PRK03858  167 -LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPRRVETGRRRRSVGA 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 329 ERTFSEINKAEEQY--SLCQeLCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 406
Cdd:PRK03858  244 QRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARDLV---- 318

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2086547936 407 DADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 436
Cdd:PRK03858  319 AAAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 16-235 3.54e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 3.54e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  16 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 92
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  93 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 171
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547936 172 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 235
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 14-428 1.54e-35

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 138.22  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 79
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  80 ---------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNItkhleerqnwpedkrryfikmgssvendnpgkevnk 150
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDL------------------------------------ 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 151 lsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLA 230
Cdd:cd01702   125 -------------------------------------------------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLA 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 231 KVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL---FSET--SWHY 304
Cdd:cd01702   156 KLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWLY 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 305 flHISLGLGSTHLTRDGERKSMSVERTFS-EINKAEEQ-YSLCQELCSELAQDLQKER----LKGRTVTIKLKNVNFEVK 378
Cdd:cd01702   234 --NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDvQHWLLVLASELNSRLEDDRyennRRPKTLVLSLRQRGDGVR 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2086547936 379 TRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 428
Cdd:cd01702   312 RSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK03352 PRK03352
DNA polymerase IV; Validated
 13-430 1.13e-34

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 135.54  E-value: 1.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  13 IVHIDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 85
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  86 AVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 165
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD-------------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 166 spsdvqpPGDPFqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 245
Cdd:PRK03352  117 -------TDDPE------------------------ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 246 lpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDG-ER 323
Cdd:PRK03352  166 --TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVSAEPwVP 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 324 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKE-RLKGRtVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 401
Cdd:PRK03352  244 RSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEgRPVTR-VAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDV 322

                         410       420
                  ....*....|....*....|....*....
gi 2086547936 402 LKtEIDADFPhplrLRLMGVRISSFPNEE 430
Cdd:PRK03352  323 LD-RFELDRP----VRLLGVRLELAMPDE 346
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 13-439 1.61e-33

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 133.59  E-value: 1.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  13 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 86
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  87 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmGSSvendnpgkevnklsehersispLLFees 166
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVT--------------------GSQ----------------------KLF--- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 167 psdvqppGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD---KNKPNGQY 243
Cdd:PRK03103  119 -------GSP------------------------LEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKNPDGLF 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 244 QIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFLHISLGLGSTHLTR 319
Cdd:PRK03103  168 TL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGIDYSPVTP 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 320 DG--ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKT---RASTVSSVVSTAEE 393
Cdd:PRK03103  242 HSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAME 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2086547936 394 IFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 439
Cdd:PRK03103  322 VYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 14-421 1.72e-32

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 129.90  E-value: 1.72e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  14 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 92
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  93 EILADYDPNFMA--MSLDEAYLNITkhleerqnwpeDKRryfikmgssvendnpgkevnklsehersispLLFeespsdv 170
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVT-----------EMR-------------------------------LLV------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 171 qppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILP-NR 249
Cdd:cd01703   112 -----------------------------ASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPpSC 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 250 QAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLG-----STHLT-----R 319
Cdd:cd01703   163 ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEfgegiGQRIWkllfgR 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 320 DGER--------KSMSVERTF-----SEINKAEEQYS---------LCQELCSELAQDLQKERLKGRTV---TIKLKNVN 374
Cdd:cd01703   242 DTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIEellasllerMKQDLQEVKAGDGRRPHTLRLTLrryTSTKKHYN 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2086547936 375 FEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 421
Cdd:cd01703   322 RESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PRK01216 PRK01216
DNA polymerase IV; Validated
 13-280 1.13e-31

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 126.83  E-value: 1.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  13 IVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 85
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  86 AVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 165
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVK---------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 166 spsdvqppgdpfqvNFEEqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 245
Cdd:PRK01216  117 --------------NYQD----------------AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVI 166

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2086547936 246 LPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 280
Cdd:PRK01216  167 DD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 16-368 1.73e-26

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 111.49  E-value: 1.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  16 IDMDAFYAAVEMRDNPELKDKPIAVgsmsmLSTS-------NYHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRA 86
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  87 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfees 166
Cdd:cd01700    78 MSRRIMSILERFSPDVEVYSIDESFLDLT--------------------------------------------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 167 psDVQPPGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----KNKPNGQ 242
Cdd:cd01700   107 --GSLRFGDL------------------------EELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGV 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 243 YQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-IS-LGLG 313
Cdd:cd01700   161 VDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgIDcLPLE 235

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2086547936 314 STHltrdGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTI 368
Cdd:cd01700   236 EYP----PPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 323-430 6.81e-22

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 91.08  E-value: 6.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 323 RKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 401
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 2086547936 402 LKteidaDFPHPLRLRLMGVRISSFPNEE 430
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 249-280 8.08e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 8.08e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2086547936 249 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 280
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
15-289 4.20e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 46.68  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  15 HIDMDAFYAAVEMRDNPELKDKPIAVGSMS--MLSTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSKE 90
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgCVIARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSNR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936  91 VKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgsSVENdnpgkevnklsehersispllfeespsdv 170
Cdd:PRK03609   84 VMSTLEELSPRVEIYSIDEAFCDLT----------------------GVRN----------------------------- 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 171 qppgdpfQVNFEEqnnpqilqnsvvFGtsaqevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKpNGQYQI----- 245
Cdd:PRK03609  113 -------CRDLTD------------FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAK-KWQRQTggvvd 165

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2086547936 246 LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 289
Cdd:PRK03609  166 LSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 531-557 9.34e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 9.34e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  531 ILTCPVCFRAQgciSLEALNKHVDECL 557
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 686-712 2.49e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547936  686 ALVCPVCNVEQKtsdLTLFNVHVDVCL 712
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 207-403 3.71e-04

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 43.52  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 207 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLPIRkVSGIGKVTEKMLKALGIIT--- 282
Cdd:cd03468   119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547936 283 CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTHLTRDG----ERKSMSVERTFsEINKAEEQYSLCQELCSELAQDL 356
Cdd:cd03468   197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQL-EEPIARGLLFPLRRLLEQLCAFL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2086547936 357 QKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 403
Cdd:cd03468   269 ALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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