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Conserved domains on  [gi|2096790474|ref|NP_001382962|]
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cell surface glycoprotein MUC18 precursor 2 precursor [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 153-241 4.23e-16

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 73.61  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 153 PEIIPNSAGIPAQsnDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDktkilTTLVRESNGLYTVVSTLFSKVTREDRN 232
Cdd:pfam08205   1 PTIEPPASLLEGE--GPEVVATCSSAGGKPAPRITWYLDGKPLEAAET-----SSEQDPESGLVTVTSELKLVPSRSDHG 73


                  ....*....
gi 2096790474 233 SLFHCTVHY 241
Cdd:pfam08205  74 QSLTCQVSY 82
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-145 4.04e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  40 YMPAVLEVEIGSTARLECSFSIPGNASFTSIEWFYVNRGHSDRvrlCVITASGVRIDETEYSERLSVGEDKA-----LSI 114
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPT---FLIAYYSNGSEEGVKKGRFSGRGDPSngdgsLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2096790474 115 SKVTRQDNArTFICQVGADSQGVGESRTELY 145
Cdd:pfam07686  78 QNLTLSDSG-TYTCAVIPSGEGVFGKGTRLT 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-356 8.37e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  277 VKEGDDVKLVCDADGNPAPVFSFFRRelGDSW----QDMTSLADTNDGVLMLHNVSKSSSGLYRCQTldLDDMTQHEGDV 352
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--GGKLlaesGRFSVSRSGSTSTLTISNVTPEDSGTYTCAA--TNSSGSASSGT 81


                   ....
gi 2096790474  353 ELVV 356
Cdd:smart00410  82 TLTV 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 368-443 1.31e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.23  E-value: 1.31e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 368 PSSPLHEGDSVRLSCTAHSPVKLDYQWRdaRGRKVAEGNQ-LLLTNLTFETSSNFSCRVKARSvpGLEQSKQVAVAV 443
Cdd:pfam13895   7 SPTVVTEGEPVTLTCSAPGNPPPSYTWY--KDGSAISSSPnFFTLSVSAEDSGTYTCVARNGR--GGKVSNPVELTV 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 446-518 7.68e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 446 KPRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSINGTT-----HEYMENQHMASNLT---VRVSHdllrAGA-MCRV 516
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPissgsTRSRSLSGSNSTLTisnVTRSD----AGTyTCVA 76


                  ..
gi 2096790474 517 SN 518
Cdd:pfam13927  77 SN 78
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 153-241 4.23e-16

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 73.61  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 153 PEIIPNSAGIPAQsnDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDktkilTTLVRESNGLYTVVSTLFSKVTREDRN 232
Cdd:pfam08205   1 PTIEPPASLLEGE--GPEVVATCSSAGGKPAPRITWYLDGKPLEAAET-----SSEQDPESGLVTVTSELKLVPSRSDHG 73


                  ....*....
gi 2096790474 233 SLFHCTVHY 241
Cdd:pfam08205  74 QSLTCQVSY 82
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-145 4.04e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  40 YMPAVLEVEIGSTARLECSFSIPGNASFTSIEWFYVNRGHSDRvrlCVITASGVRIDETEYSERLSVGEDKA-----LSI 114
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPT---FLIAYYSNGSEEGVKKGRFSGRGDPSngdgsLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2096790474 115 SKVTRQDNArTFICQVGADSQGVGESRTELY 145
Cdd:pfam07686  78 QNLTLSDSG-TYTCAVIPSGEGVFGKGTRLT 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-356 8.37e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  277 VKEGDDVKLVCDADGNPAPVFSFFRRelGDSW----QDMTSLADTNDGVLMLHNVSKSSSGLYRCQTldLDDMTQHEGDV 352
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--GGKLlaesGRFSVSRSGSTSTLTISNVTPEDSGTYTCAA--TNSSGSASSGT 81


                   ....
gi 2096790474  353 ELVV 356
Cdd:smart00410  82 TLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 276-338 1.12e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 52.18  E-value: 1.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVFSFFR-RELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPPTITWYKnGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 149-257 8.50e-07

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 47.66  E-value: 8.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 149 IPAPPEIIPNSAGIPAQSNDMLKiaqCTSENSFPSPNITWYKNGEPLlqEEDKTKILttlvRESNG-LYTVVSTLFSKVT 227
Cdd:cd07705     3 IPQKPQITGYESAFKEKDKAKLR---CTSSGSKPAANIKWRKGDQEL--EGAPTSVQ----EDGNGkTFTVSSSVEFQVT 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2096790474 228 REDRNSLFHCTV-HYWLQGQMRTKdSPRVNV 257
Cdd:cd07705    74 REDDGAEITCSVgHESLHDSDRST-SQRIEV 103
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 37-130 9.69e-07

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 47.81  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  37 LEVYMPAVLEVEIGSTARLECSFS----IPGNASFTsieWFYVNRGHSDRVRLCVITASGVRIDETE-YSERLS-VGE-- 108
Cdd:cd05715     1 MEVYTPRELNVLNGSDVRLTCTFTscytVGDAFSVT---WTYQPEGGNTTESMFHYSKGKPYILKVGrFKDRVSwAGNps 77

                          90       100
                  ....*....|....*....|....
gi 2096790474 109 --DKALSISKVTRQDNArTFICQV 130
Cdd:cd05715    78 kkDASIVISNLQFSDNG-TYTCDV 100
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 368-443 1.31e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.23  E-value: 1.31e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 368 PSSPLHEGDSVRLSCTAHSPVKLDYQWRdaRGRKVAEGNQ-LLLTNLTFETSSNFSCRVKARSvpGLEQSKQVAVAV 443
Cdd:pfam13895   7 SPTVVTEGEPVTLTCSAPGNPPPSYTWY--KDGSAISSSPnFFTLSVSAEDSGTYTCVARNGR--GGKVSNPVELTV 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 446-518 7.68e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 446 KPRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSINGTT-----HEYMENQHMASNLT---VRVSHdllrAGA-MCRV 516
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPissgsTRSRSLSGSNSTLTisnVTRSD----AGTyTCVA 76


                  ..
gi 2096790474 517 SN 518
Cdd:pfam13927  77 SN 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 283-338 1.65e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 283 VKLVCDADGNPAPVFSFFR-RELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:cd00096     1 VTLTCSASGNPPPTITWYKnGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 451-529 6.11e-04

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 39.03  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 451 AISAPL-----YVRQDEVINLTCKAIAFPQPSFHWSING-------TTHEYMENQHMASNLTVRVSHDllraGA-MCRVS 517
Cdd:cd20970     2 VISTPQpsftvTAREGENATFMCRAEGSPEPEISWTRNGnliiefnTRYIVRENGTTLTIRNIRRSDM----GIyLCIAS 77

                          90
                  ....*....|...
gi 2096790474 518 N-ALGVSEKHIQL 529
Cdd:cd20970    78 NgVPGSVEKRITL 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 42-145 7.86e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 7.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474   42 PAVLEVEIGSTARLECSFSipgNASFTSIEWFyvnrghsdRVRLCVITASGvRIDETEYSERLSvgedkaLSISKVTRQD 121
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWY--------KQGGKLLAESG-RFSVSRSGSTST------LTISNVTPED 62

                           90       100
                   ....*....|....*....|....
gi 2096790474  122 NArTFICQVGaDSQGVGESRTELY 145
Cdd:smart00410  63 SG-TYTCAAT-NSSGSASSGTTLT 84
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 368-443 5.59e-03

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 35.94  E-value: 5.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2096790474 368 PSSPLHEGDSVRLSCTAHSPVKLDYQWRdARGRKVAEGNQLLLTNLTFETSSNFSCRVKaRSVPGLEQSKQVAVAV 443
Cdd:cd20948     3 SDTYYLSGENLNLSCHAASNPPAQYSWT-INGTFQTSSQELFLPAITENNEGTYTCSAH-NSLTGKNISLVLSVTV 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 374-426 7.26e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 7.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474  374 EGDSVRLSCTAHSPVKLDYQWRDARGRKVAEGN-----------QLLLTNLTFETSSNFSCRVK 426
Cdd:smart00410   8 EGESVTLSCEASGSPPPEVTWYKQGGKLLAESGrfsvsrsgstsTLTISNVTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 153-241 4.23e-16

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 73.61  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 153 PEIIPNSAGIPAQsnDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDktkilTTLVRESNGLYTVVSTLFSKVTREDRN 232
Cdd:pfam08205   1 PTIEPPASLLEGE--GPEVVATCSSAGGKPAPRITWYLDGKPLEAAET-----SSEQDPESGLVTVTSELKLVPSRSDHG 73


                  ....*....
gi 2096790474 233 SLFHCTVHY 241
Cdd:pfam08205  74 QSLTCQVSY 82
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-145 4.04e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  40 YMPAVLEVEIGSTARLECSFSIPGNASFTSIEWFYVNRGHSDRvrlCVITASGVRIDETEYSERLSVGEDKA-----LSI 114
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPT---FLIAYYSNGSEEGVKKGRFSGRGDPSngdgsLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2096790474 115 SKVTRQDNArTFICQVGADSQGVGESRTELY 145
Cdd:pfam07686  78 QNLTLSDSG-TYTCAVIPSGEGVFGKGTRLT 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 277-356 8.37e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  277 VKEGDDVKLVCDADGNPAPVFSFFRRelGDSW----QDMTSLADTNDGVLMLHNVSKSSSGLYRCQTldLDDMTQHEGDV 352
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--GGKLlaesGRFSVSRSGSTSTLTISNVTPEDSGTYTCAA--TNSSGSASSGT 81


                   ....
gi 2096790474  353 ELVV 356
Cdd:smart00410  82 TLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 276-338 1.12e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 52.18  E-value: 1.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVFSFFR-RELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPPTITWYKnGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 149-257 8.50e-07

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 47.66  E-value: 8.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 149 IPAPPEIIPNSAGIPAQSNDMLKiaqCTSENSFPSPNITWYKNGEPLlqEEDKTKILttlvRESNG-LYTVVSTLFSKVT 227
Cdd:cd07705     3 IPQKPQITGYESAFKEKDKAKLR---CTSSGSKPAANIKWRKGDQEL--EGAPTSVQ----EDGNGkTFTVSSSVEFQVT 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2096790474 228 REDRNSLFHCTV-HYWLQGQMRTKdSPRVNV 257
Cdd:cd07705    74 REDDGAEITCSVgHESLHDSDRST-SQRIEV 103
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 37-130 9.69e-07

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 47.81  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474  37 LEVYMPAVLEVEIGSTARLECSFS----IPGNASFTsieWFYVNRGHSDRVRLCVITASGVRIDETE-YSERLS-VGE-- 108
Cdd:cd05715     1 MEVYTPRELNVLNGSDVRLTCTFTscytVGDAFSVT---WTYQPEGGNTTESMFHYSKGKPYILKVGrFKDRVSwAGNps 77

                          90       100
                  ....*....|....*....|....
gi 2096790474 109 --DKALSISKVTRQDNArTFICQV 130
Cdd:cd05715    78 kkDASIVISNLQFSDNG-TYTCDV 100
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 368-443 1.31e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.23  E-value: 1.31e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 368 PSSPLHEGDSVRLSCTAHSPVKLDYQWRdaRGRKVAEGNQ-LLLTNLTFETSSNFSCRVKARSvpGLEQSKQVAVAV 443
Cdd:pfam13895   7 SPTVVTEGEPVTLTCSAPGNPPPSYTWY--KDGSAISSSPnFFTLSVSAEDSGTYTCVARNGR--GGKVSNPVELTV 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 446-518 7.68e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.09  E-value: 7.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 446 KPRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSINGTT-----HEYMENQHMASNLT---VRVSHdllrAGA-MCRV 516
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPissgsTRSRSLSGSNSTLTisnVTRSD----AGTyTCVA 76


                  ..
gi 2096790474 517 SN 518
Cdd:pfam13927  77 SN 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 283-338 1.65e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 283 VKLVCDADGNPAPVFSFFR-RELGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:cd00096     1 VTLTCSASGNPPPTITWYKnGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 175-250 1.79e-05

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 43.60  E-value: 1.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 175 CTSENSFPSP-NITWYKNGEPLLQEEdktkILTTLVRESNGLYTVVSTLFSKVTREDRNSLFHCTVHYWLQGQMRTK 250
Cdd:cd00098    21 CLVSGFYPKDiTVTWLKNGVPLTSGV----STSSPVEPNDGTYSVTSSLTVPPSDWDEGATYTCVVTHESLKSPLSK 93
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 175-239 2.57e-05

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 43.19  E-value: 2.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 175 CTSENSFPSPNITWYKN-----GEPLLQEEDKTKIlttlvresnglYTVVSTLFSKVTREDRNSLFHCTV 239
Cdd:cd05761    26 CTTSGSKPAADIRWFKNdkelkGVKEVQESGAGKT-----------FTVTSTLRFRVDRDDDGVAVICRV 84
I-set pfam07679
Immunoglobulin I-set domain;
277-338 2.63e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.01  E-value: 2.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2096790474 277 VKEGDDVKLVCDADGNPAPVFSFFRRElgdswQDMTS------LADTNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:pfam07679  12 VQEGESARFTCTVTGTPDPEVSWFKDG-----QPLRSsdrfkvTYEGGTYTLTISNVQPDDSGKYTCV 74
IgC1_2_Nectin-1_like cd05890
Second immunoglobulin (Ig) domain of nectin-1, and similar domains; member of the C1-set of Ig ...
 164-257 2.85e-05

Second immunoglobulin (Ig) domain of nectin-1, and similar domains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectin-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.


Pssm-ID: 143298  Cd Length: 98  Bit Score: 43.06  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 164 AQSNDMLkIAQCTSENSFPSPNITWYK--NGEPLLQEedktkilttlVRESNGLYTVVSTLFSKVTREDRNSLFHCTVHY 241
Cdd:cd05890    17 GQDDKVL-VATCTSANGKPPSVVSWDTrlKGEAEFQE----------IRNPNGTVTVISRYRLVPSREAHQQSLACIVNY 85

                          90
                  ....*....|....*.
gi 2096790474 242 WLQgqmRTKDSPRVNV 257
Cdd:cd05890    86 HMD---RFTDSLTLNV 98
IgC2_CD22_d3 cd20937
Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 ...
 266-358 3.71e-05

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409531  Cd Length: 88  Bit Score: 42.48  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 266 VELRVATNAGIVKEGDDVKLVCDADGNpAPVFSFFrrelgdSW-QDMTSLADTNDGVLMLHNVSKSSSGLYRCQTLDlDD 344
Cdd:cd20937     3 LEIKVTPSDAIVREGDSVTMTCEVSSS-NPEYTTV------SWlKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSN-DV 74

                          90
                  ....*....|....
gi 2096790474 345 MTQHEGDVELVVNY 358
Cdd:cd20937    75 GPGRSEEVFLQVQY 88
IgC1_CD80 cd16083
Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) ...
 157-241 4.51e-05

Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin constant (IgC)-like domain of the antigen receptor Cluster of Differentiation (CD) 80. CD80 (also known as glycoprotein B7-1) and CD86 (also known as glycoprotein B7-2) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules, and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 409505  Cd Length: 91  Bit Score: 42.45  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 157 PNSAGIPAQSNDMLKIaQCTSENSFPSPNITWYKNGEPLlqeedkTKILTTLVRE-SNGLYTVVSTLFSKVTredRNSLF 235
Cdd:cd16083     4 PSITEFGNPSPNIKRI-ICSTSGGFPEPRLSWLENGEEL------NAINTTVSQDpETELYTVSSELDFNVT---YNHSI 73


                  ....*.
gi 2096790474 236 HCTVHY 241
Cdd:cd16083    74 VCLIKY 79
C1-set pfam07654
Immunoglobulin C1-set domain;
181-242 4.93e-05

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 41.85  E-value: 4.93e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 181 FPSP-NITWYKNGEPLLQEEDktkiLTTLVRESNGLYTVVSTL-FSKVTREDRNSlFHCTVHYW 242
Cdd:pfam07654  25 YPPDiTVTWLKNGQEVTEGVK----TTPPSPNSDWTYQLSSYLtVTPSDWESGDE-YTCRVEHE 83
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
 276-338 2.39e-04

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 40.14  E-value: 2.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVF-SFFRRELGDSWQDMTSLAdtNDGVLMLHNVSKSSSGLYRCQ 338
Cdd:cd04979     7 SVKEGDTVILSCSVKSNNAPVTwIHNGKKVPRYRSPRLVLK--TERGLLIRSAQEADAGVYECH 68
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 276-337 2.73e-04

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 39.70  E-value: 2.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVFSfFRRELGDSWQDMTSLADTNDgVLMLHNVSKSSSGLYRC 337
Cdd:cd05731     6 MVLRGGVLLLECIAEGLPTPDIR-WIKLGGELPKGRTKFENFNK-TLKIENVSEADSGEYQC 65
IgI_4_Robo cd05726
Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 276-342 3.30e-04

Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; Members here are composed the fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1, Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409391 [Multi-domain]  Cd Length: 98  Bit Score: 39.94  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVFsFFRRE-------LGDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRCQTLDL 342
Cdd:cd05726    10 VVALGRTVTFQCETKGNPQPAI-FWQKEgsqnllfPYQPPQPSSRFSVSPTGDLTITNVQRSDVGYYICQALNV 82
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 174-246 4.79e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.85  E-value: 4.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474 174 QCTSENSfPSPNITWYKNGEPLLQEEdktkilttlvRESNGLYTVVSTL-FSKVTREDrNSLFHCTVHYWLQGQ 246
Cdd:cd00096     4 TCSASGN-PPPTITWYKNGKPLPPSS----------RDSRRSELGNGTLtISNVTLED-SGTYTCVASNSAGGS 65
IgI_7_Dscam cd20954
Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar ...
 277-338 5.14e-04

Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the seventh immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409546 [Multi-domain]  Cd Length: 96  Bit Score: 39.60  E-value: 5.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2096790474 277 VKEGDDVKLVCDADGNPAPVFSfFRRELGDS---WQDMTSLADTN---DGVLMLHNVSKSSSGLYRCQ 338
Cdd:cd20954    13 VAAGQDVMLHCQADGFPTPTVT-WKKATGSTpgeYKDLLYDPNVRilpNGTLVFGHVQKENEGHYLCE 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 152-219 6.02e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 6.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2096790474 152 PPEIIPNSAGIPAQSNDMLKIaQCTSEnSFPSPNITWYKNGEPLLQEEDK---------TKILTTLVRESNGLYTVV 219
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTL-TCEAT-GSPPPTITWYKNGEPISSGSTRsrslsgsnsTLTISNVTRSDAGTYTCV 75
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 451-529 6.11e-04

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 39.03  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 451 AISAPL-----YVRQDEVINLTCKAIAFPQPSFHWSING-------TTHEYMENQHMASNLTVRVSHDllraGA-MCRVS 517
Cdd:cd20970     2 VISTPQpsftvTAREGENATFMCRAEGSPEPEISWTRNGnliiefnTRYIVRENGTTLTIRNIRRSDM----GIyLCIAS 77

                          90
                  ....*....|...
gi 2096790474 518 N-ALGVSEKHIQL 529
Cdd:cd20970    78 NgVPGSVEKRITL 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 42-145 7.86e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 7.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474   42 PAVLEVEIGSTARLECSFSipgNASFTSIEWFyvnrghsdRVRLCVITASGvRIDETEYSERLSvgedkaLSISKVTRQD 121
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWY--------KQGGKLLAESG-RFSVSRSGSTST------LTISNVTPED 62

                           90       100
                   ....*....|....*....|....
gi 2096790474  122 NArTFICQVGaDSQGVGESRTELY 145
Cdd:smart00410  63 SG-TYTCAAT-NSSGSASSGTTLT 84
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
 152-201 8.24e-04

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 38.76  E-value: 8.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2096790474 152 PPEIIPNSAGIPAQSNDMLKIAQCTSENSFPSPNITWYKNGEPLLQEEDK 201
Cdd:cd05730     1 PPTIRARQSEVNATANLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEK 50
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 276-339 8.37e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.53  E-value: 8.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2096790474 276 IVKEGDDVKLVCDADGNPAPVFSFFR--RELGDSwQDMTSLadtndgvlmlhNVSKSSSGLYRCQT 339
Cdd:pfam13895  10 VVTEGEPVTLTCSAPGNPPPSYTWYKdgSAISSS-PNFFTL-----------SVSAEDSGTYTCVA 63
IgC2_3_Dscam cd20957
Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 150-239 1.03e-03

Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C, and C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409549 [Multi-domain]  Cd Length: 88  Bit Score: 38.28  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 150 PAPPEIIPnsagiPAQSNDMLKIAQCT-SENSFPSPNITWYKNGEPllqeedktkilttLVRESNGLYTVVSTL-FSKVT 227
Cdd:cd20957     1 PLSATIDP-----PVQTVDFGRTAVFNcSVTGNPIHTVLWMKDGKP-------------LGHSSRVQILSEDVLvIPSVK 62

                          90
                  ....*....|..
gi 2096790474 228 REDRnSLFHCTV 239
Cdd:cd20957    63 REDK-GMYQCFV 73
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 269-337 1.49e-03

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 37.99  E-value: 1.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2096790474 269 RVATNAGIVkEGDDVKLVCDADGNPAPVFSFFRRElgDSWQDMTSLADTNDGVLMLHNVSKSSSGLYRC 337
Cdd:cd20968     4 RPPTNVTII-EGLKAVLPCTTMGNPKPSVSWIKGD--DLIKENNRIAVLESGSLRIHNVQKEDAGQYRC 69
IgI_3_Contactin cd04968
Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) ...
 280-339 1.86e-03

Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409357 [Multi-domain]  Cd Length: 88  Bit Score: 37.53  E-value: 1.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2096790474 280 GDDVKLVCDADGNPAPVFSfFRRELG---DSWQDMTSladtnDGVLMLHNVSKSSSGLYRCQT 339
Cdd:cd04968    16 GQTVTLECFALGNPVPQIK-WRKVDGspsSQWEITTS-----EPVLEIPNVQFEDEGTYECEA 72
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 365-425 2.38e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.17  E-value: 2.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2096790474 365 KMEPSSPLHEGDSVRLSCTAHSPVKL-DYQWRDARGRKVAE-----------GNQLLLTNLTFETSSNFSCRV 425
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGpDVTWSKEGGTLIESlkvkhdngrttQSSLLISNVTKEDAGTYTCVV 73
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 277-337 3.23e-03

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 37.09  E-value: 3.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2096790474 277 VKEGDDVKLVCDADGNPAPVFSFFRRELGDSWQD--MTSLadtNDGVLMLHNVSKSSSGLYRC 337
Cdd:cd20952    11 VAVGGTVVLNCQATGEPVPTISWLKDGVPLLGKDerITTL---ENGSLQIKGAEKSDTGEYTC 70
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 363-426 3.63e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 3.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2096790474 363 QVKMEPSSP-LHEGDSVRLSCTAHSPVKLDYQW----------RDARGRKVAEGNQLLLTNLTFETSSNFSCRVK 426
Cdd:pfam13927   3 VITVSPSSVtVREGETVTLTCEATGSPPPTITWykngepissgSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
IgC1_SIRP_domain_2 cd05772
Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig ...
 175-248 4.49e-03

Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in Signal-Regulatory Protein (SIRP), domain 2 (C1 repeat 1). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three Immunoglobulin superfamily domains, a single V-set and two C1-set IgSF domains. Their cytoplasmic tails contain either ITIMs or transmembrane regions that have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47, but with much less affinity.


Pssm-ID: 409429  Cd Length: 102  Bit Score: 36.92  E-value: 4.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2096790474 175 CTSENSFPSpNIT--WYKNGEPLlqeedkTKILTTLVRESNGL-YTVVSTLFSKVTREDRNSLFHCTV-HYWLQGQMR 248
Cdd:cd05772    24 CKSHGFSPR-DITlkWFKNGNEL------SALQTTVFPEGDSVsYSVSSTVQVVLTKDDVHSQLTCEVaHVTLQAPLR 94
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 174-250 4.54e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.40  E-value: 4.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2096790474 174 QCTSENSFPSPNITWYKngepllqeEDKTKILTTLVRESNGLYTVVSTLFSKVTREDRNSLFhCTVHY-WLQGQMRTK 250
Cdd:pfam00047  17 TCSASTGSPGPDVTWSK--------EGGTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYT-CVVNNpGGSATLSTS 85
I-set pfam07679
Immunoglobulin I-set domain;
447-529 4.63e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.47  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096790474 447 PRIVAISAPLYVRQDEVINLTCKAIAFPQPSFHWSINGttheymenQHMASNLTVRVSHD-------LLRAGA------M 513
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVSWFKDG--------QPLRSSDRFKVTYEggtytltISNVQPddsgkyT 72

                          90
                  ....*....|....*.
gi 2096790474 514 CRVSNALGVSEKHIQL 529
Cdd:pfam07679  73 CVATNSAGEAEASAEL 88
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 368-443 5.59e-03

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 35.94  E-value: 5.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2096790474 368 PSSPLHEGDSVRLSCTAHSPVKLDYQWRdARGRKVAEGNQLLLTNLTFETSSNFSCRVKaRSVPGLEQSKQVAVAV 443
Cdd:cd20948     3 SDTYYLSGENLNLSCHAASNPPAQYSWT-INGTFQTSSQELFLPAITENNEGTYTCSAH-NSLTGKNISLVLSVTV 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 374-426 7.26e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 7.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2096790474  374 EGDSVRLSCTAHSPVKLDYQWRDARGRKVAEGN-----------QLLLTNLTFETSSNFSCRVK 426
Cdd:smart00410   8 EGESVTLSCEASGSPPPEVTWYKQGGKLLAESGrfsvsrsgstsTLTISNVTPEDSGTYTCAAT 71
IgI_VEGFR cd04976
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor (VEGFR); member ...
 180-232 8.64e-03

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor (VEGFR); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor (VEGFR). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4). VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic, and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409365  Cd Length: 90  Bit Score: 36.04  E-value: 8.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2096790474 180 SFPSPNITWYKNGEPLlqEEDKTK------ILTTLVRESNGLYTVVstLFSKVTREDRN 232
Cdd:cd04976    29 AYPPPEVVWYKDGLPL--TEKARYltrhslIIKEVTEEDTGNYTIL--LSNKQSNVFKN 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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