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Conserved domains on  [gi|2106682914|ref|NP_001383171|]
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speedy protein E2 [Homo sapiens]

Protein Classification

Spy1 domain-containing protein( domain architecture ID 10568376)

Spy1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
194-398 1.37e-67

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


:

Pssm-ID: 463263  Cd Length: 131  Bit Score: 210.17  E-value: 1.37e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 194 EHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFL 273
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 274 YRKNRsripllrkpwfqlghsmnprarknrsripllrkrrfqlyrstnprarknrsripllrkrrfqlyrsmnsrarknR 353
Cdd:pfam11357  81 LGENW--------------------------------------------------------------------------R 86
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2106682914 354 SQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDR 398
Cdd:pfam11357  87 DQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
194-398 1.37e-67

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 210.17  E-value: 1.37e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 194 EHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFL 273
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 274 YRKNRsripllrkpwfqlghsmnprarknrsripllrkrrfqlyrstnprarknrsripllrkrrfqlyrsmnsrarknR 353
Cdd:pfam11357  81 LGENW--------------------------------------------------------------------------R 86
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2106682914 354 SQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDR 398
Cdd:pfam11357  87 DQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
194-398 1.37e-67

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 210.17  E-value: 1.37e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 194 EHHEAFNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFL 273
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106682914 274 YRKNRsripllrkpwfqlghsmnprarknrsripllrkrrfqlyrstnprarknrsripllrkrrfqlyrsmnsrarknR 353
Cdd:pfam11357  81 LGENW--------------------------------------------------------------------------R 86
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2106682914 354 SQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDR 398
Cdd:pfam11357  87 DQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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