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Conserved domains on  [gi|29171717|ref|NP_001494|]
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phosphatidylinositol-glycan-specific phospholipase D precursor [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 10467975)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-211 4.96e-18

Zinc dependent phospholipase C;


:

Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 4.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717    28 THVEIGHRALEFLQLHNGRvnyRELLLEHQDAYQAGIVFPDCFYpsICKGGKFHDVSESTHWT---PFLNASVHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717   105 plpWEKDTEKLVAFLFGITSHMAADVSWHSLGleqgflRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180
                  ....*....|....*....|....*..
gi 29171717   185 PVKDLLGIYEKLYGRKVITENVIVDCS 211
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLA 164
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-499 4.76e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.76e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29171717    446 PSGRFGSALA-VLDFNVDGVPDLAVGAPSVGSEQLTykGAVYVYFGSKQGGMSSS 499
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGGNSIP 53
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 4.93e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.07  E-value: 4.93e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171717    377 PYARLGWAMTSA-DLNQDGHGDLVVGAPGYSRPGhiHIGRVYLIYGNDLGLPPVDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAG--ETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-550 4.38e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 40.96  E-value: 4.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 29171717   514 GWTLLAADVNGDSEPDLVIGSPFapGGGKQKGIVAAF 550
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-211 4.96e-18

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 4.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717    28 THVEIGHRALEFLQLHNGRvnyRELLLEHQDAYQAGIVFPDCFYpsICKGGKFHDVSESTHWT---PFLNASVHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717   105 plpWEKDTEKLVAFLFGITSHMAADVSWHSLGleqgflRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180
                  ....*....|....*....|....*..
gi 29171717   185 PVKDLLGIYEKLYGRKVITENVIVDCS 211
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLA 164
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-499 4.76e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.76e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29171717    446 PSGRFGSALA-VLDFNVDGVPDLAVGAPSVGSEQLTykGAVYVYFGSKQGGMSSS 499
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGGNSIP 53
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 450-488 3.96e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.82  E-value: 3.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 29171717   450 FGSALAVLDFNVDGVPDLAVGAPSVGSeqlTYKGAVYVY 488
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 4.93e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.07  E-value: 4.93e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171717    377 PYARLGWAMTSA-DLNQDGHGDLVVGAPGYSRPGhiHIGRVYLIYGNDLGLPPVDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAG--ETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 382-419 6.66e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 43.27  E-value: 6.66e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29171717   382 GWAMTSADLNQDGHGDLVVGAPGYSRPGhihIGRVYLI 419
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-550 4.38e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 40.96  E-value: 4.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 29171717   514 GWTLLAADVNGDSEPDLVIGSPFapGGGKQKGIVAAF 550
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 509-564 1.51e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 1.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171717    509 IYCNLGWTL-LAADVNGDSEPDLVIGSPFApGGGKQKGIVAAFYSGPSLSDKEKLNV 564
Cdd:smart00191   1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRA-NDAGETGAVYVYFGSSGGGNSIPLQN 56
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-211 4.96e-18

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 4.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717    28 THVEIGHRALEFLQLHNGRvnyRELLLEHQDAYQAGIVFPDCFYpsICKGGKFHDVSESTHWT---PFLNASVHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717   105 plpWEKDTEKLVAFLFGITSHMAADVSWHSLGleqgflRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180
                  ....*....|....*....|....*..
gi 29171717   185 PVKDLLGIYEKLYGRKVITENVIVDCS 211
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLA 164
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-499 4.76e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.76e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29171717    446 PSGRFGSALA-VLDFNVDGVPDLAVGAPSVGSEQLTykGAVYVYFGSKQGGMSSS 499
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGGNSIP 53
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 450-488 3.96e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.82  E-value: 3.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 29171717   450 FGSALAVLDFNVDGVPDLAVGAPSVGSeqlTYKGAVYVY 488
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 4.93e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.07  E-value: 4.93e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171717    377 PYARLGWAMTSA-DLNQDGHGDLVVGAPGYSRPGhiHIGRVYLIYGNDLGLPPVDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAG--ETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 382-419 6.66e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 43.27  E-value: 6.66e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29171717   382 GWAMTSADLNQDGHGDLVVGAPGYSRPGhihIGRVYLI 419
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-550 4.38e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 40.96  E-value: 4.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 29171717   514 GWTLLAADVNGDSEPDLVIGSPFapGGGKQKGIVAAF 550
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 458-532 1.20e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 1.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29171717   458 DFNVDGVPDLAVGAPsvgseqltykGAVYVYFGSKQGGMSSSPNITISCQDIycnlGWTLLAADVNGDSEPDLVI 532
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYLNNGDGTFTFITSVSLGGGGG----GLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 389-469 1.24e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171717   389 DLNQDGHGDLVVGAPGYSRpghihigrVYLIYGNDLGLPPVDLDLdkeahrilegfqPSGRFGSALAVLDFNVDGVPDLA 468
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLR--------LYLNNGDGTFTFITSVSL------------GGGGGGLSVAVGDLDGDGRLDLL 60


                  .
gi 29171717   469 V 469
Cdd:pfam13517  61 V 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 509-564 1.51e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 1.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171717    509 IYCNLGWTL-LAADVNGDSEPDLVIGSPFApGGGKQKGIVAAFYSGPSLSDKEKLNV 564
Cdd:smart00191   1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRA-NDAGETGAVYVYFGSSGGGNSIPLQN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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