NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4504651|ref|NP_002181|]
View 

interleukin-17A precursor [Homo sapiens]

Protein Classification

interleukin-17 family protein( domain architecture ID 10532846)

interleukin-17 (IL-17) family protein such as IL-17A, a key cytokine that links T cell activation to neutrophil mobilization and activation, and IL-25, also known as IL-7E, which induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 69-147 6.37e-39

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


:

Pssm-ID: 461823  Cd Length: 81  Bit Score: 126.61  E-value: 6.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504651     69 RSTSPWNLHRNEDPERYPSVIWEAKCRHLGCIN-ADGNVDYHMNSVPIQQEILVLRREPP-HCPNSFRLEKILVSVGCTC 146
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINpATGQEDRSLNSVPIYQEILVLRRESCaGCRYSYRLEYETVTVGCTC 80


                  .
gi 4504651    147 V 147
Cdd:pfam06083  81 V 81
 
Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 69-147 6.37e-39

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


Pssm-ID: 461823  Cd Length: 81  Bit Score: 126.61  E-value: 6.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504651     69 RSTSPWNLHRNEDPERYPSVIWEAKCRHLGCIN-ADGNVDYHMNSVPIQQEILVLRREPP-HCPNSFRLEKILVSVGCTC 146
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINpATGQEDRSLNSVPIYQEILVLRRESCaGCRYSYRLEYETVTVGCTC 80


                  .
gi 4504651    147 V 147
Cdd:pfam06083  81 V 81
 
Name Accession Description Interval E-value
IL17 pfam06083
Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T ...
 69-147 6.37e-39

Interleukin-17; IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.


Pssm-ID: 461823  Cd Length: 81  Bit Score: 126.61  E-value: 6.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504651     69 RSTSPWNLHRNEDPERYPSVIWEAKCRHLGCIN-ADGNVDYHMNSVPIQQEILVLRREPP-HCPNSFRLEKILVSVGCTC 146
Cdd:pfam06083   1 RSLSPWTYRIDHDPNRYPQTIAEARCLCSGCINpATGQEDRSLNSVPIYQEILVLRRESCaGCRYSYRLEYETVTVGCTC 80


                  .
gi 4504651    147 V 147
Cdd:pfam06083  81 V 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH