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Conserved domains on  [gi|4506391|ref|NP_002867|]
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DNA repair protein RAD51 homolog 3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
recomb_radA super family cl31184
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 21-134 1.24e-14

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR02236:

Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 68.62  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     21 PAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnkpryagtsESHKKCTALELLEQEHTQGFI 100
Cdd:TIGR02236   9 PATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAA-----------DLGGFETADDVLERRKTIGKI 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 4506391    101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:TIGR02236  78 TTGSKELDELLGGGIETQAITEVFGEFGSGKTQI 111
 
Name Accession Description Interval E-value
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 21-134 1.24e-14

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 68.62  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     21 PAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnkpryagtsESHKKCTALELLEQEHTQGFI 100
Cdd:TIGR02236   9 PATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAA-----------DLGGFETADDVLERRKTIGKI 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 4506391    101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:TIGR02236  78 TTGSKELDELLGGGIETQAITEVFGEFGSGKTQI 111
radA PRK04301
DNA repair and recombination protein RadA; Validated
 10-134 5.13e-14

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 66.82  E-value: 5.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391    10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301   4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 4506391    87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PRK04301  71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQI 118
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 86-134 3.30e-07

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 47.30  E-value: 3.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4506391     86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:pfam08423   5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQL 53
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 107-134 1.20e-06

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 45.75  E-value: 1.20e-06
                        10        20
                ....*....|....*....|....*...
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19491   1 LDELLGGGIPVGGITEIAGESGAGKTQL 28
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
107-134 3.03e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 36.05  E-value: 3.03e-03
                        10        20
                ....*....|....*....|....*...
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:COG0467   9 LDELLGGGLPRGSSTLLSGPPGTGKTTL 36
 
Name Accession Description Interval E-value
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 21-134 1.24e-14

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 68.62  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     21 PAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnkpryagtsESHKKCTALELLEQEHTQGFI 100
Cdd:TIGR02236   9 PATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAA-----------DLGGFETADDVLERRKTIGKI 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 4506391    101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:TIGR02236  78 TTGSKELDELLGGGIETQAITEVFGEFGSGKTQI 111
radA PRK04301
DNA repair and recombination protein RadA; Validated
 10-134 5.13e-14

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 66.82  E-value: 5.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391    10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301   4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 4506391    87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PRK04301  71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQI 118
PTZ00035 PTZ00035
Rad51 protein; Provisional
 26-134 1.06e-07

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 49.23  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391    26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKpryagtseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PTZ00035  38 KLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGF------------ISATEYLEARKNIIRITTGST 105

                         90       100
                 ....*....|....*....|....*....
gi 4506391   106 ALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PTZ00035 106 QLDKLLGGGIETGSITELFGEFRTGKTQL 134
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 86-134 3.30e-07

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 47.30  E-value: 3.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4506391     86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:pfam08423   5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQL 53
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 26-134 6.07e-07

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 47.03  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391    26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIirreclTNKPRYAGTseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PLN03186  43 KLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILEA------ASKLVPLGF------TTASQLHAQRQEIIQITTGSR 110

                         90       100
                 ....*....|....*....|....*....
gi 4506391   106 ALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PLN03186 111 ELDKILEGGIETGSITEIYGEFRTGKTQL 139
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 107-134 1.20e-06

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 45.75  E-value: 1.20e-06
                        10        20
                ....*....|....*....|....*...
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19491   1 LDELLGGGIPVGGITEIAGESGAGKTQL 28
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 8-134 3.09e-06

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 44.77  E-value: 3.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     8 FEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRecLTNKpryagtseshKKCTA 87
Cdd:PLN03187  28 FESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEK--LLNQ----------GFITG 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 4506391    88 LELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PLN03187  96 SDALLKRKSVVRITTGSQALDELLGGGIETRCITEAFGEFRSGKTQL 142
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 108-134 3.27e-06

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 44.62  E-value: 3.27e-06
                        10        20
                ....*....|....*....|....*..
gi 4506391  108 DDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19493   1 DTALAGGLPLGAITEITGASGSGKTQF 27
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 26-134 5.45e-06

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 44.00  E-value: 5.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnKPRYAgtseshkkcTALELLEQEHTQGFIITFCS 105
Cdd:TIGR02238  16 KLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKII---NPGFI---------TAFEISQKRKKVLKITTGSQ 83

                          90       100
                  ....*....|....*....|....*....
gi 4506391    106 ALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:TIGR02238  84 ALDGILGGGIESMSITEVFGEFRCGKTQL 112
radB PRK09361
DNA repair and recombination protein RadB; Provisional
 100-134 1.56e-05

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 42.54  E-value: 1.56e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4506391   100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:PRK09361   5 LPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNI 39
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 118-134 1.72e-05

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 42.21  E-value: 1.72e-05
                        10
                ....*....|....*..
gi 4506391  118 MKTTEICGAPGVGKTQL 134
Cdd:cd19492   1 GKITEICGVPGVGKTQL 17
PRK09302 PRK09302
circadian clock protein KaiC; Reviewed
 107-132 3.38e-05

circadian clock protein KaiC; Reviewed


Pssm-ID: 236461 [Multi-domain]  Cd Length: 509  Bit Score: 41.79  E-value: 3.38e-05
                         10        20
                 ....*....|....*....|....*.
gi 4506391   107 LDDILGGGVPLMKTTEICGAPGVGKT 132
Cdd:PRK09302  20 FDDITHGGLPKGRPTLVSGTAGTGKT 45
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 100-134 9.58e-05

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 40.42  E-value: 9.58e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 4506391  100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19514   1 ISTGSTELDKLLGGGIESMSITEVFGEFRTGKTQL 35
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 100-134 1.45e-04

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 39.60  E-value: 1.45e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 4506391  100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd01394   1 LSTGSKSLDSLLGGGVERGTITQIYGPPGSGKTNI 35
KaiC-N cd19485
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most ...
 107-132 1.75e-04

N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410893 [Multi-domain]  Cd Length: 226  Bit Score: 39.66  E-value: 1.75e-04
                        10        20
                ....*....|....*....|....*.
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKT 132
Cdd:cd19485   8 FDDITHGGLPKGRPTLICGTAGTGKT 33
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 26-134 3.11e-04

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 38.94  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506391     26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLqiirrecltnkpryagtSESHKK-----CTALELLEQEHTQGFI 100
Cdd:TIGR02239  16 KLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKIL-----------------AEAAKLvpmgfTTATEFHQRRQEVIQL 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 4506391    101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:TIGR02239  79 TTGSKELDKLLGGGIETGSITEIFGEFRTGKTQL 112
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 100-134 6.00e-04

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 38.11  E-value: 6.00e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 4506391  100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19515   1 ISTGSKELDKLLGGGIETQAITEVFGEFGSGKTQL 35
ATPase pfam06745
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ...
 107-132 1.02e-03

KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.


Pssm-ID: 429095 [Multi-domain]  Cd Length: 231  Bit Score: 37.23  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 4506391    107 LDDILGGGVPLMKTTEICGAPGVGKT 132
Cdd:pfam06745   8 LDEILKGGFPEGRVVLITGGPGTGKT 33
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
107-134 3.03e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 36.05  E-value: 3.03e-03
                        10        20
                ....*....|....*....|....*...
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:COG0467   9 LDELLGGGLPRGSSTLLSGPPGTGKTTL 36
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 107-132 3.75e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 35.70  E-value: 3.75e-03
                        10        20
                ....*....|....*....|....*.
gi 4506391  107 LDDILGGGVPLMKTTEICGAPGVGKT 132
Cdd:cd01124   8 LDELLGGGIPKGSVTLLTGGPGTGKT 33
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 100-134 6.52e-03

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 35.20  E-value: 6.52e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 4506391  100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd01123   1 ITTGSKELDKLLGGGIETGSITEMFGEFRTGKTQL 35
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 112-134 6.91e-03

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 34.92  E-value: 6.91e-03
                        10        20
                ....*....|....*....|...
gi 4506391  112 GGGVPLMKTTEICGAPGVGKTQL 134
Cdd:cd19489   1 GGGLRTGEITELVGESSSGKTQL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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