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Conserved domains on  [gi|4506587|ref|NP_002938|]
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replication protein A 14 kDa subunit [Homo sapiens]

Protein Classification

RPA3 domain-containing protein( domain architecture ID 10554616)

RPA3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rep_fac-A_3 pfam08661
Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, ...
 5-113 1.10e-42

Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, recombination and repair.


:

Pssm-ID: 462551  Cd Length: 105  Bit Score: 135.86  E-value: 1.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506587      5 MDLPRSRINAGMLAQFIDKPVCFVGRLEKIhPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSY 84
Cdd:pfam08661   1 MDAPTPRINGSMLSQFVGQTVRIVGKVESV-PSGKTLILQSTDGGNVTIRLSPDLDLEVSGWVEVIGKVSDDLTIRALSV 79

                          90       100
                  ....*....|....*....|....*....
gi 4506587     85 VQFKEDshpFDLGLYNEAVKIIHDFPQFY 113
Cdd:pfam08661  80 IDFGED---FDLDGYNALVQLSHKFPELY 105
 
Name Accession Description Interval E-value
Rep_fac-A_3 pfam08661
Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, ...
 5-113 1.10e-42

Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, recombination and repair.


Pssm-ID: 462551  Cd Length: 105  Bit Score: 135.86  E-value: 1.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506587      5 MDLPRSRINAGMLAQFIDKPVCFVGRLEKIhPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSY 84
Cdd:pfam08661   1 MDAPTPRINGSMLSQFVGQTVRIVGKVESV-PSGKTLILQSTDGGNVTIRLSPDLDLEVSGWVEVIGKVSDDLTIRALSV 79

                          90       100
                  ....*....|....*....|....*....
gi 4506587     85 VQFKEDshpFDLGLYNEAVKIIHDFPQFY 113
Cdd:pfam08661  80 IDFGED---FDLDGYNALVQLSHKFPELY 105
RPA3 cd04479
RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest ...
 8-113 5.05e-41

RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). RPA3 is believed to have a structural role in assembly of the RPA heterotrimer.


Pssm-ID: 239925  Cd Length: 101  Bit Score: 131.23  E-value: 5.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506587    8 PRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGegKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQF 87
Cdd:cd04479   1 PTPRINGAMLSQFVGKTVRIVGKVEKVDGDSLTLISSDG--VNVTVELNRPLDLPISGYVEVIGKVSPDLTIRVLSYIDF 78

                        90       100
                ....*....|....*....|....*.
gi 4506587   88 KEDshpFDLGLYNEAVKIIHDFPQFY 113
Cdd:cd04479  79 GDD---FDMDLYNELVKLSHKFKNLF 101
 
Name Accession Description Interval E-value
Rep_fac-A_3 pfam08661
Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, ...
 5-113 1.10e-42

Replication factor A protein 3; Replication factor A is involved in eukaryotic DNA replication, recombination and repair.


Pssm-ID: 462551  Cd Length: 105  Bit Score: 135.86  E-value: 1.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506587      5 MDLPRSRINAGMLAQFIDKPVCFVGRLEKIhPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSY 84
Cdd:pfam08661   1 MDAPTPRINGSMLSQFVGQTVRIVGKVESV-PSGKTLILQSTDGGNVTIRLSPDLDLEVSGWVEVIGKVSDDLTIRALSV 79

                          90       100
                  ....*....|....*....|....*....
gi 4506587     85 VQFKEDshpFDLGLYNEAVKIIHDFPQFY 113
Cdd:pfam08661  80 IDFGED---FDLDGYNALVQLSHKFPELY 105
RPA3 cd04479
RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest ...
 8-113 5.05e-41

RPA3: A subfamily of OB folds similar to human RPA3 (also called RPA14). RPA3 is the smallest subunit of Replication protein A (RPA). RPA is a nuclear ssDNA binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). RPA3 is believed to have a structural role in assembly of the RPA heterotrimer.


Pssm-ID: 239925  Cd Length: 101  Bit Score: 131.23  E-value: 5.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506587    8 PRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGegKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQF 87
Cdd:cd04479   1 PTPRINGAMLSQFVGKTVRIVGKVEKVDGDSLTLISSDG--VNVTVELNRPLDLPISGYVEVIGKVSPDLTIRVLSYIDF 78

                        90       100
                ....*....|....*....|....*.
gi 4506587   88 KEDshpFDLGLYNEAVKIIHDFPQFY 113
Cdd:cd04479  79 GDD---FDMDLYNELVKLSHKFKNLF 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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