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Conserved domains on  [gi|21314632|ref|NP_003029|]
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neutral amino acid transporter A isoform 1 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
72-471 4.77e-108

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 328.23  E-value: 4.77e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  72 VTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAqtlqs 150
Cdd:COG1301  28 AAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLYFLVTTTIALVIGLVVANLFQPGAGL----- 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 151 sDLGLEDSGPPPVPKETvdSFLDLARNLFPSNlVVAAFrtyatdykvvtqnsSSGnvthekipigteiegmNILGLVLFA 230
Cdd:COG1301 103 -NLDLADAAAAEAAEAP--SLLDFLLNIIPSN-IFEAF--------------AEG----------------NMLQIIFFA 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKdiIVLVTSLGKYIFASILGHVIHGG 310
Cdd:COG1301 149 ILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG--LDALGSLGKLVLTVYLALLLHLF 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 311 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAA 390
Cdd:COG1301 227 VVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAA 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 391 VFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALG 470
Cdd:COG1301 307 LFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVA 386


                .
gi 21314632 471 A 471
Cdd:COG1301 387 T 387
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
72-471 4.77e-108

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 328.23  E-value: 4.77e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  72 VTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAqtlqs 150
Cdd:COG1301  28 AAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLYFLVTTTIALVIGLVVANLFQPGAGL----- 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 151 sDLGLEDSGPPPVPKETvdSFLDLARNLFPSNlVVAAFrtyatdykvvtqnsSSGnvthekipigteiegmNILGLVLFA 230
Cdd:COG1301 103 -NLDLADAAAAEAAEAP--SLLDFLLNIIPSN-IFEAF--------------AEG----------------NMLQIIFFA 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKdiIVLVTSLGKYIFASILGHVIHGG 310
Cdd:COG1301 149 ILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG--LDALGSLGKLVLTVYLALLLHLF 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 311 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAA 390
Cdd:COG1301 227 VVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAA 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 391 VFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALG 470
Cdd:COG1301 307 LFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVA 386


                .
gi 21314632 471 A 471
Cdd:COG1301 387 T 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
72-477 8.09e-107

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 324.47  E-value: 8.09e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632    72 VTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQtlqs 150
Cdd:pfam00375  23 AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFLVTTAIAALIGLLVANVFQPGSGLA---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   151 sdlgLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTyatdykvvtqnsssgnvthekipigteiegmNILGLVLFA 230
Cdd:pfam00375  99 ----LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG-------------------------------NVLAVIVFA 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMkdIIVLVTSLGKYIFASILGHVIHGG 310
Cdd:pfam00375 144 ILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKLAPIGVFALIANTVGTY--GLGILSSLAKFLLVVYLGLAIHLL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   311 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAA 390
Cdd:pfam00375 222 IVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAA 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   391 VFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALG 470
Cdd:pfam00375 302 IFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAA 381


                  ....*..
gi 21314632   471 AGILHHL 477
Cdd:pfam00375 382 AVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 79-493 1.09e-32

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 129.88  E-value: 1.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   79 GEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGaqtLQSSDLGLED 157
Cdd:PRK11283  45 GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITTVAIILGITLANVFQPGAG---IDMSQLATVD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  158 SGPPPVPKETVDS----FLDLARNLFPSNLVVAAFRTyatdykvvtqnsssgnvthEKIPIgteiegmnilglVLFALVL 233
Cdd:PRK11283 122 ISKYQSTTEEVQShshgLMGTILSLIPTNIFASMAKG-------------------EMLPI------------IFFSVLF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  234 GVALKKLGSEGED-LIRFFNSLNEATMVLVSWIMWYVPVGIMFLvgskivemkdIIVLVTSLGkyiFASI-----LGHVI 307
Cdd:PRK11283 171 GLGLSSLPATHREpLVTVFRSVSETMFKVTHMVMRYAPVGVFAL----------IAVTVANFG---FASLwplakLVLLV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  308 HGGI------VLPLIYFVFtRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEnNGVDKRISRFILPIGATVNMDG 381
Cdd:PRK11283 238 YFAIlffalvVLGIVARLC-GLSIWILIRILKDELILAYSTASSETVLPRIIEKMEA-YGAPKSITSFVVPTGYSFNLDG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  382 AAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTV 461
Cdd:PRK11283 316 STLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTA 395

                        410       420       430
                 ....*....|....*....|....*....|...
gi 21314632  462 VNVEGDALGAGILHHL-NQKATKKGEQELAEVK 493
Cdd:PRK11283 396 LNVVGNALAVLVIAKWeHKFDRKKALAYEREVL 428
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
72-471 4.77e-108

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 328.23  E-value: 4.77e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  72 VTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAqtlqs 150
Cdd:COG1301  28 AAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLYFLVTTTIALVIGLVVANLFQPGAGL----- 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 151 sDLGLEDSGPPPVPKETvdSFLDLARNLFPSNlVVAAFrtyatdykvvtqnsSSGnvthekipigteiegmNILGLVLFA 230
Cdd:COG1301 103 -NLDLADAAAAEAAEAP--SLLDFLLNIIPSN-IFEAF--------------AEG----------------NMLQIIFFA 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKdiIVLVTSLGKYIFASILGHVIHGG 310
Cdd:COG1301 149 ILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG--LDALGSLGKLVLTVYLALLLHLF 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 311 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAA 390
Cdd:COG1301 227 VVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAA 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 391 VFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALG 470
Cdd:COG1301 307 LFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVA 386


                .
gi 21314632 471 A 471
Cdd:COG1301 387 T 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
72-477 8.09e-107

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 324.47  E-value: 8.09e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632    72 VTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQtlqs 150
Cdd:pfam00375  23 AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFLVTTAIAALIGLLVANVFQPGSGLA---- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   151 sdlgLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTyatdykvvtqnsssgnvthekipigteiegmNILGLVLFA 230
Cdd:pfam00375  99 ----LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG-------------------------------NVLAVIVFA 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMkdIIVLVTSLGKYIFASILGHVIHGG 310
Cdd:pfam00375 144 ILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKLAPIGVFALIANTVGTY--GLGILSSLAKFLLVVYLGLAIHLL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   311 IVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAA 390
Cdd:pfam00375 222 IVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAA 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   391 VFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALG 470
Cdd:pfam00375 302 IFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAA 381


                  ....*..
gi 21314632   471 AGILHHL 477
Cdd:pfam00375 382 AVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 79-493 1.09e-32

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 129.88  E-value: 1.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   79 GEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGaqtLQSSDLGLED 157
Cdd:PRK11283  45 GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITTVAIILGITLANVFQPGAG---IDMSQLATVD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  158 SGPPPVPKETVDS----FLDLARNLFPSNLVVAAFRTyatdykvvtqnsssgnvthEKIPIgteiegmnilglVLFALVL 233
Cdd:PRK11283 122 ISKYQSTTEEVQShshgLMGTILSLIPTNIFASMAKG-------------------EMLPI------------IFFSVLF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  234 GVALKKLGSEGED-LIRFFNSLNEATMVLVSWIMWYVPVGIMFLvgskivemkdIIVLVTSLGkyiFASI-----LGHVI 307
Cdd:PRK11283 171 GLGLSSLPATHREpLVTVFRSVSETMFKVTHMVMRYAPVGVFAL----------IAVTVANFG---FASLwplakLVLLV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  308 HGGI------VLPLIYFVFtRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEnNGVDKRISRFILPIGATVNMDG 381
Cdd:PRK11283 238 YFAIlffalvVLGIVARLC-GLSIWILIRILKDELILAYSTASSETVLPRIIEKMEA-YGAPKSITSFVVPTGYSFNLDG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  382 AAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTV 461
Cdd:PRK11283 316 STLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTA 395

                        410       420       430
                 ....*....|....*....|....*....|...
gi 21314632  462 VNVEGDALGAGILHHL-NQKATKKGEQELAEVK 493
Cdd:PRK11283 396 LNVVGNALAVLVIAKWeHKFDRKKALAYEREVL 428
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 79-468 2.35e-32

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 128.87  E-value: 2.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   79 GEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSG----AQTLQSSDL 153
Cdd:PRK01663  38 GDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTIALIIGLIVVNVVQPGAGmnidPATLDAKAV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  154 GLEdsgpppVPKETVDSFLDLARNLFPSNlVVAAFrtyatdykvvtqnsSSGnvthekipigteiegmNILGLVLFALVL 233
Cdd:PRK01663 118 AQY------AAQAHEQGTVDFLMDIIPTT-VVGAF--------------ASG----------------DILQVLLFAVLF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  234 GVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVG----IMFLVGskivemKDIIVLVTSLGKYIFASILGHVIHG 309
Cdd:PRK01663 161 GFALARLGEKGKPVFDFIESLSHVLFGIVNMIMKLAPIGafgaMAFTIG------KYGVGSLVQLGQLIGCFYITCILFV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  310 GIVLPLI--YFVFtrkNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIeENNGVDKRISRFILPIGATVNMDGAAIFQC 387
Cdd:PRK01663 235 FVVLGAIarLTGF---SIFKFIRYIKEELLIVLGTSSSESALPRMMEKM-EKLGCKKSVVGLVIPTGYSFNLDGTSIYLT 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  388 VAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIG-LPTHDLPLILAVDWIVDRTTTVVNVEG 466
Cdd:PRK01663 311 MAAVFIAQATNTPLSIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIG 390


                 ..
gi 21314632  467 DA 468
Cdd:PRK01663 391 NG 392
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 79-468 3.87e-31

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 125.17  E-value: 3.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632   79 GEMLLRMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGA----QTLQSSDL 153
Cdd:PRK13027  37 GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTIALVIGLVLAYLTGPGVGMnidlRSLDAASL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  154 GLEDSgpppvPKETVDSFLDLARNLFPsNLVVAAFrtyatdykvvtqnsSSGnvthekipigteiegmNILGLVLFALVL 233
Cdd:PRK13027 117 AGYAK-----NAQSLKGTAGFLLKLIP-TTAVDAF--------------AKG----------------DILQVLLFSVLF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  234 GVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVG----IMFLVGS-KIVEMKDI--IVLVTSLGKYIF-ASILGH 305
Cdd:PRK13027 161 GSALSLLGERAKRVNRLIDELSHVLFRIMGFIIKLAPLGvlgaIAFTTGKyGVGSLKQLgmLVAVFYLTCFVFvVVVLGA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  306 V--IHGGIVLPLIYFvftrknpfrfllgLLAPFATAFATCSSSATLPSMMKCIeENNGVDKRISRFILPIGATVNMDGAA 383
Cdd:PRK13027 241 VmrLAGFSVFKLIRY-------------LREELLIVLGTASSDAVLPQVMRKL-EHMGIKDSTVGLVIPTGYSFNLDGFS 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  384 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIG-LPTHDLPLILAVDWIVDRTTTVV 462
Cdd:PRK13027 307 IYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALT 386


                 ....*.
gi 21314632  463 NVEGDA 468
Cdd:PRK13027 387 NLIGNC 392
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 84-496 3.23e-17

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 84.11  E-value: 3.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  84 RMLRMIILPLVVCSLVSGAASL-DASCLGRLGGIAVAYFGLTTLSASALAVALAFI-------IKPGSgAQTLQSSDL-- 153
Cdd:COG1823  75 RLLQMIVMPLVFVSILSAITKLkNASSLGKISGLIIGILLGTTAIAALVGILVALLfgltaegLTQGA-AETARGEALee 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 154 GLEDSGPPPVPKETVDsfldlarnLFPSNlVVAAFrtyatdykvVTQNSSSgnvthekipigteiegmnILGLVLFALVL 233
Cdd:COG1823 154 RLGEVEDLSLPQQILS--------FIPTN-PFADL---------TGARPTS------------------TIAVVIFAAFL 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 234 GVA----LKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVgSKIV---EMKDIIvlvtSLGKYIFAS----I 302
Cdd:COG1823 198 GIAalglRRKKPEQAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALM-TKVVatsDFADIL----NLGKFVVASyvalI 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 303 LGHVIHGGIVLpliyfvFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDG- 381
Cdd:COG1823 273 IMFIVHLLLLA------LAGLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGc 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 382 AAIFQCVAAVFIAQLNNVE-LNAGQIFTILVTATASSVGAAGVpaGGVLTIA--IILEAIGLPTHDLPLILAVDWIVDRT 458
Cdd:COG1823 347 AGIYPAMLAVMIAPTVGINpLDPSFILTLIAVVTISSFGVAGV--GGGATFAalIVLSAMGLPVALAGLLISIEPLIDMG 424

                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 21314632 459 TTVVNVEGdALGAGIL--HHLNQKATKKGEQELAEVKVEA 496
Cdd:COG1823 425 RTALNVSG-SMTAGTVtsRLLGQLDKDIYNSDEEVELEEA 463
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 222-469 2.72e-14

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 73.93  E-value: 2.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  222 NILGLVLFALVLGVALKKLGSEGEDLIRffnSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKdiIVLVTSLGKYIFAS 301
Cdd:PRK14695  60 NYIGILSWAVIFGIAMREASKNSKELLK---TIADVTSKIVEWIINLAPFGILGLVFKTISDKG--VGSLANYGILLVLL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  302 ILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLL-APFATAFATCSSSATLPSMMKcIEENNGVDKRISRFILPIGATVNMD 380
Cdd:PRK14695 135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLrVSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMA 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  381 GAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIV----D 456
Cdd:PRK14695 214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqD 293

                        250
                 ....*....|...
gi 21314632  457 RTTTVVNVEGDAL 469
Cdd:PRK14695 294 SCETALNSSTDVL 306
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 213-431 5.06e-14

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 73.74  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  213 PIGTEIEGmNILGLVLFALVLGVALKKLGSEGEDLirfFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVE--------- 283
Cdd:PRK13628 138 PINALLNA-NYIGILAWAIGLGLALRHASDTTKNV---VNDLSEAVSQIVKWVIRFAPIGIFGLVASTLAEtgfsalagy 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  284 MKDIIVLVtslGKYIFASIlghvihggIVLPLIYFVFTRKNPFRFLLGLLAPFA-TAFATCSSSATLPSMMK-CieENNG 361
Cdd:PRK13628 214 AQLLAVLV---GCMLFVAL--------VVNPLIVFWKIRRNPYPLVFTCLRESGvTAFFTRSSAANIPVNMAlC--EKLG 280

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632  362 VDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTI 431
Cdd:PRK13628 281 LDEDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAISACGASGVAGGSLLLI 350
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
222-431 1.13e-13

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 72.90  E-value: 1.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 222 NILGLVLFALVLGVALKKlGSEGEDliRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVE-----MKD----IIVLVt 292
Cdd:COG3633 145 NYIGILAWAIGLGLALRH-ASDTTK--TVLSDLSDAVSKIVRWVIRFAPLGIFGLVASTVATtgfsaLLGyahlLAVLV- 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314632 293 slGKYIFASIlghvihggIVLPLIYFVFTRKNPFRFLLGLLAPFA-TAFATCSSSATLPSMMK-CieENNGVDKRISRFI 370
Cdd:COG3633 221 --GCMLFVAL--------VVNPLIVFLKIRRNPYPLVFTCLRESGiTAFFTRSSAANIPVNMAlC--EKLGLDEDTYSVS 288

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314632 371 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTI 431
Cdd:COG3633 289 IPLGATINMAGAAITITVLTLAAVHTLGIEVDLPTALLLSVVAAVSACGASGVAGGSLLLI 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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