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Conserved domains on  [gi|51242945|ref|NP_003153|]
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striatin [Homo sapiens]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-779 3.28e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 3.28e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 455 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 534
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 535 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 614
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 615 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 692
Cdd:cd00200 133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 693 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 772
Cdd:cd00200 206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                ....*..
gi 51242945 773 DALAKVF 779
Cdd:cd00200 282 DGTIRIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.67e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 153.81  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945    49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 51242945   129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-779 3.28e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 3.28e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 455 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 534
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 535 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 614
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 615 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 692
Cdd:cd00200 133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 693 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 772
Cdd:cd00200 206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                ....*..
gi 51242945 773 DALAKVF 779
Cdd:cd00200 282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
451-778 4.25e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 4.25e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 451 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 530
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 531 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPaLSVFND 610
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTG 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 611 TKelGIPASVDlVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHEDRH 687
Cdd:COG2319 245 HS--GSVRSVA-FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG-------VNSVAFSPdgkLL---ASGSDDGT 311

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 688 IKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYI 767
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTL 387

                       330
                ....*....|.
gi 51242945 768 ASAGADALAKV 778
Cdd:COG2319 388 ASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.67e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 153.81  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945    49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 51242945   129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 695-734 1.27e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 51242945    695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 734
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
696-734 9.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51242945   696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 734
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-779 3.28e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 3.28e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 455 PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQktapakkstslDVEPIYTFRAHKGPVLCVVMSSNGEQCYSG 534
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 535 GTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtEVAPALSVFNdtkel 614
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLR----- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 615 GIPASVDLVSSDPSHMVASFSK--GYTSIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAHEDRHIKFYD 692
Cdd:cd00200 133 GHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTGKCVATLTGHTG-------EVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 693 NNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGA 772
Cdd:cd00200 206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSA 281


                ....*..
gi 51242945 773 DALAKVF 779
Cdd:cd00200 282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
451-778 4.25e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 4.25e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 451 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 530
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 531 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPaLSVFND 610
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL-LRTLTG 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 611 TKelGIPASVDlVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHEDRH 687
Cdd:COG2319 245 HS--GSVRSVA-FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG-------VNSVAFSPdgkLL---ASGSDDGT 311

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 688 IKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSKCYI 767
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTL 387

                       330
                ....*....|.
gi 51242945 768 ASAGADALAKV 778
Cdd:COG2319 388 ASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 49-173 2.67e-44

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 153.81  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945    49 LPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 128
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 51242945   129 dmkppsydsdegnetevqpqqnsqlMWKQGRQLLRQYLQEVGYTD 173
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
451-737 9.38e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 9.38e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 451 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 530
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 531 CYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtevapalsvfnD 610
Cdd:COG2319 219 LASGSADGTVRLWDLATGK-----------LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-----------A 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 611 TKEL-----GIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDttansscQINRVISHPTLPISITAH 683
Cdd:COG2319 277 TGELlrtltGHSGGVNSVAFSPdGKLLASGSDDGTvRLWDLATGKLLRTLTGHTG-------AVRSVAFSPDGKTLASGS 349

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 51242945 684 EDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
448-779 2.84e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 2.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 448 ALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSN 527
Cdd:COG2319  63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-----------LLLRTLTGHTGAVRSVAFSPD 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 528 GEQCYSGGTDGLIQGWNTTNPNidpydsydpsvLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTtevapalsv 607
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK-----------LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--------- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 608 fndtkelgipasvdlvssdpshmvasfskgytsifnmETQQRILTLESNVDTtansscqINRVISHP---TLpisITAHE 684
Cdd:COG2319 192 -------------------------------------ATGKLLRTLTGHTGA-------VRSVAFSPdgkLL---ASGSA 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 685 DRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHrkkfEESIHDVAFHPSK 764
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDG 300

                       330
                ....*....|....*
gi 51242945 765 CYIASAGADALAKVF 779
Cdd:COG2319 301 KLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
511-779 7.02e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 7.02e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 511 TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTtnpnidpydsyDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSAD 590
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-----------AAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 591 GTLRLWNtteVAPALSVFNDTKELGIPASVDlVSSDpSHMVASFSKGYT-SIFNMETQQRILTLESNVDTtansscqINR 669
Cdd:COG2319 100 GTVRLWD---LATGLLLRTLTGHTGAVRSVA-FSPD-GKTLASGSADGTvRLWDLATGKLLRTLTGHSGA-------VTS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 670 VISHP---TLpisITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTA 746
Cdd:COG2319 168 VAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 51242945 747 HrkkfEESIHDVAFHPSKCYIASAGADALAKVF 779
Cdd:COG2319 245 H----SGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 451-597 1.20e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.20e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 451 KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTapakkstsldvEPIYTFRAHKGPVLCVVMSSNGEQ 530
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-----------KCLGTLRGHENGVNSVAFSPDGYL 233

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51242945 531 CYSGGTDGLIQGWNTTNPnidpydsydpsVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597
Cdd:cd00200 234 LASGSEDGTIRVWDLRTG-----------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
576-779 3.72e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 576 AYSAAHQRLLSCSADGTLRLWNTTEVAPALSvfndTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLES 655
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLL----LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51242945 656 NVDttansscQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 735
Cdd:COG2319  77 HTA-------AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 51242945 736 ESKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGADALAKVF 779
Cdd:COG2319 150 ATGKLLRTLTGH----SGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 695-734 1.27e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 51242945    695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 734
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
696-734 9.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 9.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51242945   696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWN 734
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 452-491 6.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 6.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 51242945    452 TWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWN 491
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 567-597 3.03e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.03e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 51242945    567 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
565-597 3.92e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.92e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 51242945   565 LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
453-491 5.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51242945   453 WNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWN 491
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 507-544 1.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.91e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 51242945    507 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 544
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
507-544 1.97e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.97e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 51242945   507 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 544
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 737-779 1.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 51242945    737 SKTCIQEFTAHrkkfEESIHDVAFHPSKCYIASAGADALAKVF 779
Cdd:smart00320   1 SGELLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
450-493 3.10e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 3.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 51242945 450 RKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQ 493
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
738-779 5.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 51242945   738 KTCIQEFTAHRKkfeeSIHDVAFHPSKCYIASAGADALAKVF 779
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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