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Conserved domains on  [gi|4507503|ref|NP_003588|]
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Krueppel-like factor 11 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-394 1.47e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


:

Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 314.24  E-value: 1.47e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503   40 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 119
Cdd:cd21584   1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  120 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 199
Cdd:cd21584  78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  200 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 279
Cdd:cd21584 101 -----------------------------------------------------------------------------PVP 103

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  280 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 359
Cdd:cd21584 104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                       330       340       350
                ....*....|....*....|....*....|....*
gi 4507503  360 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 394
Cdd:cd21584 183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-449 4.03e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.03e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507503  393 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 449
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 454-476 7.65e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 7.65e-05
                          10        20
                  ....*....|....*....|...
gi 4507503    454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-394 1.47e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 314.24  E-value: 1.47e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503   40 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 119
Cdd:cd21584   1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  120 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 199
Cdd:cd21584  78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  200 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 279
Cdd:cd21584 101 -----------------------------------------------------------------------------PVP 103

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  280 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 359
Cdd:cd21584 104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                       330       340       350
                ....*....|....*....|....*....|....*
gi 4507503  360 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 394
Cdd:cd21584 183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-449 4.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.03e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507503  393 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 449
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-437 3.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.81e-05
                          10        20
                  ....*....|....*....|....*...
gi 4507503    410 HLKAHLRTHTGEKPFNCswDGCDKKFAR 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 454-476 7.65e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 7.65e-05
                          10        20
                  ....*....|....*....|...
gi 4507503    454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
454-476 6.21e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.21e-03
                           10        20
                   ....*....|....*....|...
gi 4507503     454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 40-394 1.47e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 314.24  E-value: 1.47e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503   40 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 119
Cdd:cd21584   1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  120 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 199
Cdd:cd21584  78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  200 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 279
Cdd:cd21584 101 -----------------------------------------------------------------------------PVP 103

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  280 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 359
Cdd:cd21584 104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                       330       340       350
                ....*....|....*....|....*....|....*
gi 4507503  360 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 394
Cdd:cd21584 183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 41-394 1.13e-79

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 248.31  E-value: 1.13e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503   41 EQTDMEAVEALVCMSSWGQRSQKgDLLRIRPLTPVSDSGDvtttvhmDAATPELPKDFHSLSTLCITPPQSPDLVEPSTR 120
Cdd:cd21974   1 EQGDLEAVEALVSMSSWWKRRQK-RLRKPRPLTPSSDSSD-------EDDAPESPKDFHSLSSLCMTPPYSPPFFEASHS 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  121 TPVSPQVTDSKACTATDVLQSSAvvaralsggaergllglEPVPSSPCRAKGTSVIRHTGESPaacfptiqtpdcrlsds 200
Cdd:cd21974  73 PSVASLHPPSAASSQPPPEPESS-----------------EPPAASPQRAQATSVIRHTADPV----------------- 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  201 regeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttplisvSV 280
Cdd:cd21974 119 ------------------------------------------------------------------------------PV 120

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  281 PAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILaqaaPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAaNVMA 360
Cdd:cd21974 121 SPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQKPAL----PQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQP-TVVT 195

                       330       340       350
                ....*....|....*....|....*....|....
gi 4507503  361 AGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 394
Cdd:cd21974 196 PGGTKLLPIAPAPGFIPSGQSSAPQPDFSRRRNH 229
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 40-393 1.21e-26

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 108.15  E-value: 1.21e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503   40 LEQTDMEAVEALVCMSS-WGQRSQKgdLLRIRPLTPVSDSGDvtttvhmDAATPeLPKDFHSLSTLCITPPQSPDLVEPS 118
Cdd:cd21572   1 MGAGDMEAVEALMSMTKhWKTRSFR--LRHFRPLTPSSDSSE-------DDDLP-SPADFHDSPPFCMTPPYSPPHFEAT 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  119 TRTPVSPQVTDSKACTATDVLQSsavvaralsggaergllglePVPSSPCRAKGTSVIRHTgespaacfptiqtpdcrlS 198
Cdd:cd21572  71 HPPSAATLHPPAAQPPEEQHLSA--------------------ETAASQQRFQCTSVIRHT------------------A 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  199 DsregeeqllghfetlqdthltdsllstnlvsCQPClhksggllltdkgqqagwpgavqTCSPKNyENDLPRKTTPLISV 278
Cdd:cd21572 113 D-------------------------------AQPC-----------------------SCSSCP-SSPSVVPSVPAGVA 137

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  279 SVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSvgtvrpilAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANV 358
Cdd:cd21572 138 GVSPVPVYCQILPVSSSSTTVVAAQAPLPQPQ--------QQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLV 209

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 4507503  359 MAAGnTKLLPLAPAPVFITSSQNCVP-QVDFSRRRN 393
Cdd:cd21572 210 TPGG-TKLAAIAPAPGHTPSEQRKSPpQPEVSRVRS 244
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-449 4.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.03e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507503  393 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 449
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-437 3.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.81e-05
                          10        20
                  ....*....|....*....|....*...
gi 4507503    410 HLKAHLRTHTGEKPFNCswDGCDKKFAR 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-472 5.55e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 5.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  378 SSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTgEKKFVCP 457
Cdd:COG5048 371 PPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLC 449

                        90
                ....*....|....*
gi 4507503  458 VCDRRFMRSDHLTKH 472
Cdd:COG5048 450 SILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 454-476 7.65e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 7.65e-05
                          10        20
                  ....*....|....*....|...
gi 4507503    454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
371-450 8.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503  371 PAPVFITSSQNCVPQVDfSRRRNYVCSFPGCRKTYFKSSHLKAHLRT--HTGE--KPFNCSWDGCDKKFARSDELSRHRR 446
Cdd:COG5048 266 PTASSQSSSPNESDSSS-EKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHIL 344


                ....
gi 4507503  447 THTG 450
Cdd:COG5048 345 LHTS 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 420-478 3.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507503  420 GEKPFNCSWDGCDKKFARSDELSRHR-------RTH------------TGEKKFVCPVCDRRFMRSDHLTKHaRRHMT 478
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHSH 422
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 396-472 1.12e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507503    396 CSFPGCRKTYFKSSHLKAHLRTHTGE------KPFNCSWDGCDKKFARSDELSRHRRTHTGEKK-FVCPVCDRRFMRSDH 468
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 4507503    469 LTKH 472
Cdd:pfam15909  82 LFKH 85
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 424-448 3.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.47e-03
                          10        20
                  ....*....|....*....|....*
gi 4507503    424 FNCswDGCDKKFARSDELSRHRRTH 448
Cdd:pfam00096   1 YKC--PDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
454-476 6.21e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.21e-03
                           10        20
                   ....*....|....*....|...
gi 4507503     454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 454-476 9.33e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 33.77  E-value: 9.33e-03
                          10        20
                  ....*....|....*....|...
gi 4507503    454 FVCPVCDRRFMRSDHLTKHARRH 476
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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