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Conserved domains on  [gi|4506399|ref|NP_003601|]
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mRNA export factor RAE1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.85e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.85e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319 120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319 195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319 268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4506399  267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319 332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.85e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.85e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319 120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319 195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319 268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4506399  267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319 332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.52e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   40 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 119
Cdd:cd00200  10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 194
Cdd:cd00200  85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  195 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 272
Cdd:cd00200 162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506399  273 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200 221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 7.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.44e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 4506399      85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 4.50e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.50e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 4506399     85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.85e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.85e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319 120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319 195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319 268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4506399  267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319 332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
32-335 7.85e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 7.85e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   32 IEVTSSPDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqdSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPD---GRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  112 MWDLSSNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA------- 183
Cdd:COG2319 146 LWDLATGKLLRtLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT-----GAVRSVAfspdgkl 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  184 -VVATAERGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDkqnkptG--FALGSIEGRVAIHYINPPNPAKdnfTF 257
Cdd:COG2319 219 lASGSADGTVRLWDLAT-----GKLLRTLTGHSgsvRSVAFSPD------GrlLASGSADGTVRLWDLATGELLR---TL 284

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506399  258 KCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319 285 TGHSG------------GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.52e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   40 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 119
Cdd:cd00200  10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 194
Cdd:cd00200  85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  195 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 272
Cdd:cd00200 162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506399  273 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200 221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
38-160 1.38e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 1.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   38 PDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS 117
Cdd:COG2319 287 HSGGVNSVAFSPD---GKLLASGSDDGTVRLWDL-ATGKLL-RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4506399  118 NQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRS 160
Cdd:COG2319 362 GELLRtLTGHTGAVTSVAF--SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
32-168 7.98e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 7.98e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   32 IEVTSSPDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPD---GRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4506399  112 MWDLSSNQAIQIAQ-HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 168
Cdd:COG2319 314 LWDLATGKLLRTLTgHTGAVRSVAF--SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-335 1.56e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 1.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTrssnp 163
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAAS--ADGTYLASGSSDKTIRLWDL----- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  164 mmvlqlpercycadviypmavvataerglivyqleNQPSEFRRIESplkHQH--RCVAIFKDKQnkptgFALGSIE-GRV 240
Cdd:cd00200  81 -----------------------------------ETGECVRTLTG---HTSyvSSVAFSPDGR-----ILSSSSRdKTI 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  241 AIHYINPPNPAkdnFTFKCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISA 320
Cdd:cd00200 118 KVWDVETGKCL---TTLRGHTD------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS 182

                       250
                ....*....|....*
gi 4506399  321 CCFNHNGNIFAYASS 335
Cdd:cd00200 183 VAFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-157 1.54e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpkaQQM--HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 116
Cdd:cd00200 177 TGEVNSVAFSPD---GEKLLSSSSDGTIKLWDL-STGKCL---GTLrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4506399  117 SNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:cd00200 250 TGECVQtLSGHTNSVTSLAW--SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
57-335 3.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 3.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399   57 LIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHW 135
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAF 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  136 ikAPNYSCVMTGSWDKTLKFWDTRssnpmmvlqlpercycadviypmavvataerglivyqlenqpsefrriesplkhqh 215
Cdd:COG2319 129 --SPDGKTLASGSADGTVRLWDLA-------------------------------------------------------- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506399  216 rcvaifkdkqnkpTGFALGSIEGrvaihyinppnpakdnftfkcHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDG 295
Cdd:COG2319 151 -------------TGKLLRTLTG---------------------HSG------------AVTSVAFSPDGKLLASGSDDG 184

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4506399  296 RFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319 185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 7.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.44e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 4506399      85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 4.50e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.50e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 4506399     85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-157 1.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4506399     126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:smart00320  11 HTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
126-157 2.87e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.87e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4506399    126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:pfam00400  10 HTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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