NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19923669|ref|NP_005056|]
View 

protein sel-1 homolog 1 isoform 1 precursor [Homo sapiens]

Protein Classification

FN2 and TPR domain-containing protein( domain architecture ID 12186032)

FN2 and TPR domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-513 1.37e-41

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 152.00  E-value: 1.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 440
Cdd:COG0790  87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923669 441 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 513
Cdd:COG0790 165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.56e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.56e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 19923669    120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 664-697 5.38e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


:

Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 5.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19923669   664 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 697
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 629-662 1.26e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19923669    629 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 662
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 466-708 5.07e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 5.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 466 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 541
Cdd:COG2956  23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 542 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 617
Cdd:COG2956  95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 618 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 694
Cdd:COG2956 167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                       250
                ....*....|....
gi 19923669 695 AEASPDAQVPVFLA 708
Cdd:COG2956 239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 255-290 6.10e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 6.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19923669    255 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 290
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-513 1.37e-41

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 152.00  E-value: 1.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 440
Cdd:COG0790  87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923669 441 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 513
Cdd:COG0790 165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.56e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.56e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 19923669    120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 121-168 1.03e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 94.29  E-value: 1.03e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 19923669 121 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
127-168 1.41e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 88.01  E-value: 1.41e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19923669   127 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 483-518 7.76e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.71  E-value: 7.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19923669    483 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 518
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 447-481 4.21e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.21e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19923669   447 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 481
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 664-697 5.38e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 5.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19923669   664 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 697
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 664-696 8.15e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 8.15e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 19923669    664 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 696
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 629-662 1.26e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19923669    629 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 662
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 466-708 5.07e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 5.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 466 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 541
Cdd:COG2956  23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 542 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 617
Cdd:COG2956  95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 618 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 694
Cdd:COG2956 167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                       250
                ....*....|....
gi 19923669 695 AEASPDAQVPVFLA 708
Cdd:COG2956 239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 523-553 3.12e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.00  E-value: 3.12e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 19923669    523 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 553
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 255-290 6.10e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 6.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19923669    255 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 290
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 629-660 7.32e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 7.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 19923669   629 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 660
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-513 1.37e-41

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 152.00  E-value: 1.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 440
Cdd:COG0790  87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923669 441 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 513
Cdd:COG0790 165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
TPR COG0790
TPR repeat [General function prediction only];
362-553 5.95e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 147.38  E-value: 5.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 362 QYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKA 441
Cdd:COG0790  15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRG-VPKDYEKALEWFEKA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 442 ADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILA 521
Cdd:COG0790  94 AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA 173

                       170       180       190
                ....*....|....*....|....*....|..
gi 19923669 522 FYNLAQMHASGTGVMRSCHTAVELFKNVCERG 553
Cdd:COG0790 174 QYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205
TPR COG0790
TPR repeat [General function prediction only];
397-698 1.98e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 143.15  E-value: 1.98e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 397 AFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 476
Cdd:COG0790  13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 477 AAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKnvcergrws 556
Cdd:COG0790  93 AAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR--------- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 557 erlmtaynsykdgdynaaviqylllaeqgyevaqsnaafildqreasivgenetyprallhwnRAASQGYTVARIKLGDY 636
Cdd:COG0790 164 ---------------------------------------------------------------KAAEQGDADAQYNLGVL 180

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923669 637 HFYGFGTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEAS 698
Cdd:COG0790 181 YENGRGVPKDPAKALEWYRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
157-480 3.84e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 119.26  E-value: 3.84e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 157 YDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLP 236
Cdd:COG0790   1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 237 QNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKAlvyytfgalggnliahmvlgyrywagigvlqscesalt 316
Cdd:COG0790  81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKA-------------------------------------- 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 317 hyrlvanhvasdisltggsvvqrirlpdevenpgmnsgmleedlIQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQR 396
Cdd:COG0790 123 --------------------------------------------LEWYEKAAEQGDADAQYNLGLLYLN-GEGVPKDPAK 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 397 AFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 476
Cdd:COG0790 158 AAEWYRKAAEQGDADAQYNLGVLYENGRG-VPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRK 236


                ....
gi 19923669 477 AAEQ 480
Cdd:COG0790 237 AAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.56e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.56e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 19923669    120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 121-168 1.03e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 94.29  E-value: 1.03e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 19923669 121 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
127-168 1.41e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 88.01  E-value: 1.41e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19923669   127 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 483-518 7.76e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 48.71  E-value: 7.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19923669    483 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 518
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 447-481 2.54e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 47.55  E-value: 2.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19923669    447 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 481
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 447-481 4.21e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.21e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19923669   447 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 481
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 664-697 5.38e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.36  E-value: 5.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19923669   664 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 697
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 664-696 8.15e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 8.15e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 19923669    664 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 696
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 358-530 8.87e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 8.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 358 EDLIQYYQFLAEKGD--VQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDIvpqsnET 433
Cdd:COG2956  59 DRAIRIHQKLLERDPdrAEALLELAQDYLKAGL-----LDRAEELLEklLELDPDDAEALRLLAEIYEQEGDW-----EK 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 434 ALHYFKKAADMGNPVGQSGLGMAYLYGRgvQVNYDLALKYFQKA--AEQGWVDGQLQLGSMYYNgigvKRDYKQALKYFN 511
Cdd:COG2956 129 AIEVLERLLKLGPENAHAYCELAELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLE----QGDYEEAIAALE 202

                       170       180
                ....*....|....*....|.
gi 19923669 512 --LASQGGHILAFYNLAQMHA 530
Cdd:COG2956 203 raLEQDPDYLPALPRLAELYE 223
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 483-517 1.11e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.89  E-value: 1.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19923669   483 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGG 517
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 410-446 2.48e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.78  E-value: 2.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19923669    410 SHAMAFLGKMYSEGsDIVPQSNETALHYFKKAADMGN 446
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 410-445 8.09e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 8.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19923669   410 SHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMG 445
Cdd:pfam08238   1 AEAQYRLGYLYLYGLG-VPKDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
372-624 8.24e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 8.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 372 DVQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDivpqsNETALHYFKKAADM--GNP 447
Cdd:COG0457   7 DAEAYNNLGLAYRRLGR-----YEEAIEDYEkaLELDPDDAEALYNLGLAYLRLGR-----YEEALADYEQALELdpDDA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 448 VGQSGLGMAYLYgRGvqvNYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFY 523
Cdd:COG0457  77 EALNNLGLALQA-LG---RYEEALEDYDKALELdpDDAEALYNLGLALLE----LGRYDEAIEAYEraLELDPDDADALY 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 524 NLAQMHASgtgvMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREAS 603
Cdd:COG0457 149 NLGIALEK----LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLL 224

                       250       260
                ....*....|....*....|.
gi 19923669 604 IVGENETYPRALLHWNRAASQ 624
Cdd:COG0457 225 LALALLLALRLAALALYQYRA 245
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 373-409 9.42e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 40.23  E-value: 9.42e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19923669    373 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGN 409
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 629-662 1.26e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19923669    629 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 662
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 373-408 3.05e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 3.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19923669   373 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAG 408
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 466-708 5.07e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 5.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 466 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 541
Cdd:COG2956  23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 542 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 617
Cdd:COG2956  95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923669 618 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 694
Cdd:COG2956 167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                       250
                ....*....|....
gi 19923669 695 AEASPDAQVPVFLA 708
Cdd:COG2956 239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 523-553 3.12e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.00  E-value: 3.12e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 19923669    523 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 553
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 255-290 6.10e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 6.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 19923669    255 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 290
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 629-660 7.32e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 7.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 19923669   629 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 660
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH