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Conserved domains on  [gi|62865866|ref|NP_006352|]
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homeobox protein Hox-B13 [Homo sapiens]

Protein Classification

HoxA13_N and homeodomain domain-containing protein( domain architecture ID 10968813)

HoxA13_N and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
217-273 1.52e-22

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.52e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866   217 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HoxA13_N super family cl13688
Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this ...
 12-123 1.22e-14

Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.


The actual alignment was detected with superfamily member pfam12284:

Pssm-ID: 463521  Cd Length: 122  Bit Score: 68.76  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865866    12 AKDIEGLLG----AGGGRNLVAHsPLTSHPAAPTlMPAVNYAPLDLPGSA--EPPKQCHPCPGvPQGTSPAPVP-YGYFG 84
Cdd:pfam12284   1 SKNMEGLGGgnfaANQCRNLMAH-ALSSHPAPLA-SSGSFYSRSDSPGSGsaEPQKQCSPCPA-PQSSSSASLPyGYFFG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 62865866    85 GGYYSCRVS---RSSLKPCAQAATLAAYP---AETPTAGEEYPSR 123
Cdd:pfam12284  78 NGYYPCRMShhqRSQQKSCASPAGHEDPAekyMDTSGSGEEFSSR 122
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
217-273 1.52e-22

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.52e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866   217 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 216-272 6.95e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 6.95e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866    216 GRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEK 272
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 217-273 9.63e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 83.06  E-value: 9.63e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866 217 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HoxA13_N pfam12284
Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this ...
 12-123 1.22e-14

Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.


Pssm-ID: 463521  Cd Length: 122  Bit Score: 68.76  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865866    12 AKDIEGLLG----AGGGRNLVAHsPLTSHPAAPTlMPAVNYAPLDLPGSA--EPPKQCHPCPGvPQGTSPAPVP-YGYFG 84
Cdd:pfam12284   1 SKNMEGLGGgnfaANQCRNLMAH-ALSSHPAPLA-SSGSFYSRSDSPGSGsaEPQKQCSPCPA-PQSSSSASLPyGYFFG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 62865866    85 GGYYSCRVS---RSSLKPCAQAATLAAYP---AETPTAGEEYPSR 123
Cdd:pfam12284  78 NGYYPCRMShhqRSQQKSCASPAGHEDPAekyMDTSGSGEEFSSR 122
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
214-284 1.47e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 1.47e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62865866 214 RRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKvLAKVKNSATP 284
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRP 118
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
217-273 1.52e-22

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.52e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866   217 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 216-272 6.95e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 6.95e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866    216 GRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEK 272
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 217-273 9.63e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 83.06  E-value: 9.63e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62865866 217 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HoxA13_N pfam12284
Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this ...
 12-123 1.22e-14

Hox protein A13 N terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.


Pssm-ID: 463521  Cd Length: 122  Bit Score: 68.76  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865866    12 AKDIEGLLG----AGGGRNLVAHsPLTSHPAAPTlMPAVNYAPLDLPGSA--EPPKQCHPCPGvPQGTSPAPVP-YGYFG 84
Cdd:pfam12284   1 SKNMEGLGGgnfaANQCRNLMAH-ALSSHPAPLA-SSGSFYSRSDSPGSGsaEPQKQCSPCPA-PQSSSSASLPyGYFFG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 62865866    85 GGYYSCRVS---RSSLKPCAQAATLAAYP---AETPTAGEEYPSR 123
Cdd:pfam12284  78 NGYYPCRMShhqRSQQKSCASPAGHEDPAekyMDTSGSGEEFSSR 122
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
214-284 1.47e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 1.47e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62865866 214 RRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKvLAKVKNSATP 284
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK-KRSGKVEQRP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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